Dr Rebecca Coll
@colllab.bsky.social
Lecturer in Immunobiology at QUB - innate immunity, inflammasome, NLRP3, dose response curve, and bad pun enthusiast. Views expressed are mine alone.
Yay immunology! Tregs FTW! www.nobelprize.org/prizes/medic...
Nobel Prize in Physiology or Medicine 2025
The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
www.nobelprize.org
October 6, 2025 at 10:50 AM
Yay immunology! Tregs FTW! www.nobelprize.org/prizes/medic...
Very excited that this meeting will be in Belfast next year!
SAVE THE DATE!
The 2026 UK CellularMicrobiologyNetwork meeting will be held 22nd - 23rd of June at @wwiem-qub.bsky.social in Belfast.
Researchers from the UK and beyond are invited to share exciting work on the mechanisms of host-pathogen interactions.
Follow us to stay tuned! www.ukcellmicro.org
The 2026 UK CellularMicrobiologyNetwork meeting will be held 22nd - 23rd of June at @wwiem-qub.bsky.social in Belfast.
Researchers from the UK and beyond are invited to share exciting work on the mechanisms of host-pathogen interactions.
Follow us to stay tuned! www.ukcellmicro.org
October 6, 2025 at 10:33 AM
Very excited that this meeting will be in Belfast next year!
Reposted by Dr Rebecca Coll
Discovery of potent and selective inhibitors of human #NLRP3 with a novel mechanism of action by Kevin Wilhelmsen, Rebecca Coll @colllab.bsky.social @wwiem-qub.bsky.social et al: rupress.org/jem/article/...
From our #InnateImmunity collection: rupress.org/jem/collecti...
From our #InnateImmunity collection: rupress.org/jem/collecti...
October 3, 2025 at 1:33 PM
Discovery of potent and selective inhibitors of human #NLRP3 with a novel mechanism of action by Kevin Wilhelmsen, Rebecca Coll @colllab.bsky.social @wwiem-qub.bsky.social et al: rupress.org/jem/article/...
From our #InnateImmunity collection: rupress.org/jem/collecti...
From our #InnateImmunity collection: rupress.org/jem/collecti...
Reposted by Dr Rebecca Coll
Check out this new thermo-hot paper from the @colllab.bsky.social Lab. Glad to contribute and work with her team.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
NLRP3 is a thermosensor that is negatively regulated by high temperature
Inflammation is an essential response to infection and injury, but unregulated inflammation is damaging and must be limited by negative feedback signalling. Inflammasome signalling drives local inflam...
www.biorxiv.org
October 1, 2025 at 6:56 AM
Check out this new thermo-hot paper from the @colllab.bsky.social Lab. Glad to contribute and work with her team.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
So proud of the new Dr @emmamckay.bsky.social for smashing her PhD viva! Huge thank you to her examiners @kesslerbenedikt001.bsky.social @gunnarns.bsky.social for great discussions on NLRP3 inflammasomes and proteomics - first student co-supervised with Prof Ben Collins 😊
October 1, 2025 at 2:07 PM
So proud of the new Dr @emmamckay.bsky.social for smashing her PhD viva! Huge thank you to her examiners @kesslerbenedikt001.bsky.social @gunnarns.bsky.social for great discussions on NLRP3 inflammasomes and proteomics - first student co-supervised with Prof Ben Collins 😊
Nice to see our recent study on novel NLRP3 inhibitors with
Bioage Labs in @jem.org highlighted by @natrevdrugdiscov.nature.com - 🔦💊🔥 😍
Overcoming roadblocks to anti-inflammatory NLRP3 inhibitors nature.com/articles/d41...
Bioage Labs in @jem.org highlighted by @natrevdrugdiscov.nature.com - 🔦💊🔥 😍
Overcoming roadblocks to anti-inflammatory NLRP3 inhibitors nature.com/articles/d41...
Overcoming roadblocks to anti-inflammatory NLRP3 inhibitors
Discover the world’s best science and medicine | Nature.com
nature.com
September 25, 2025 at 4:15 PM
Nice to see our recent study on novel NLRP3 inhibitors with
Bioage Labs in @jem.org highlighted by @natrevdrugdiscov.nature.com - 🔦💊🔥 😍
Overcoming roadblocks to anti-inflammatory NLRP3 inhibitors nature.com/articles/d41...
Bioage Labs in @jem.org highlighted by @natrevdrugdiscov.nature.com - 🔦💊🔥 😍
Overcoming roadblocks to anti-inflammatory NLRP3 inhibitors nature.com/articles/d41...
Reposted by Dr Rebecca Coll
@colllab.bsky.social et al. show that both BAL-0028 & BAL-0598 inhibit select hyperactive #NLRP3 mutations associated with #autoinflammation more potently than MCC950. BAL-0028 & BAL-0598 represent a new modality for NLRP3 inhibition in inflammatory diseases rupress.org/jem/article/...
#Inflammasome
#Inflammasome
September 16, 2025 at 7:03 PM
@colllab.bsky.social et al. show that both BAL-0028 & BAL-0598 inhibit select hyperactive #NLRP3 mutations associated with #autoinflammation more potently than MCC950. BAL-0028 & BAL-0598 represent a new modality for NLRP3 inhibition in inflammatory diseases rupress.org/jem/article/...
#Inflammasome
#Inflammasome
Reposted by Dr Rebecca Coll
Discovery of potent and selective inhibitors of human #NLRP3 with a novel mechanism of action. New study from Kevin Wilhelmsen (BioAge Labs), Rebecca Coll @colllab.bsky.social @wwiem-qub.bsky.social and colleagues: rupress.org/jem/article/...
#Inflammasome #Inflammation
#Inflammasome #Inflammation
September 9, 2025 at 3:15 PM
Discovery of potent and selective inhibitors of human #NLRP3 with a novel mechanism of action. New study from Kevin Wilhelmsen (BioAge Labs), Rebecca Coll @colllab.bsky.social @wwiem-qub.bsky.social and colleagues: rupress.org/jem/article/...
#Inflammasome #Inflammation
#Inflammasome #Inflammation
So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.
#NLRP3 is a target for antiinflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @colllab.bsky.social et al characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. rupress.org/jem/article/...
#Inflammasome
#Inflammasome
September 2, 2025 at 4:22 PM
So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.
Had a brilliant couple of days in Galway with the lab at the Irish Society for Immunology meeting - great science and great craic!!!
August 22, 2025 at 8:01 PM
Had a brilliant couple of days in Galway with the lab at the Irish Society for Immunology meeting - great science and great craic!!!
Very exciting to see a new NLRP3 inhibitor enter the clinic! Great work from BioAge Labs www.globenewswire.com/news-release...
BioAge Labs Announces First Participant Dosed in Phase 1 Clinical Trial of BGE-102, a Novel Brain-Penetrant NLRP3 Inhibitor
First-in-human study evaluating safety, tolerability, pharmacokinetics, and pharmacodynamics of BGE-102, an orally available small molecule with potential...
www.globenewswire.com
August 15, 2025 at 3:17 PM
Very exciting to see a new NLRP3 inhibitor enter the clinic! Great work from BioAge Labs www.globenewswire.com/news-release...
Congratulations to our latest cohort of summer students @WWIEM @qubelfastofficial.bsky.social for a fantastic final poster session - the standard was exceptionally high. Special shout out to Timothy Okafor who was a pleasure to host in my lab!!
August 15, 2025 at 3:14 PM
Congratulations to our latest cohort of summer students @WWIEM @qubelfastofficial.bsky.social for a fantastic final poster session - the standard was exceptionally high. Special shout out to Timothy Okafor who was a pleasure to host in my lab!!
Reposted by Dr Rebecca Coll
Absolutely dystopian juxtaposition from the Guardian front page. Difficult to understand how anyone of decency and conscience can defend this government at this point. Just sheer moral degeneracy to arm a state that does this and arrest people for objecting. Wtf are we doing as a country?
July 19, 2025 at 7:04 PM
Absolutely dystopian juxtaposition from the Guardian front page. Difficult to understand how anyone of decency and conscience can defend this government at this point. Just sheer moral degeneracy to arm a state that does this and arrest people for objecting. Wtf are we doing as a country?
Reposted by Dr Rebecca Coll
Congrats to @malvinapiz.bsky.social and @inflammasomelab.bsky.social on their new paper on the role of cardiolipin in non canonical inflammasome activation. We’re happy to have contributed to the story 🎉🦠!!
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11 | The EMBO Journal
imageimageAvailable caspase-4/11 (CASP4/11) inhibitors also block the activity of caspase-1
(CASP1), which complicates interpretation of results in functional studies and limits
their clinical potenti...
www.embopress.org
July 19, 2025 at 11:18 AM
Congrats to @malvinapiz.bsky.social and @inflammasomelab.bsky.social on their new paper on the role of cardiolipin in non canonical inflammasome activation. We’re happy to have contributed to the story 🎉🦠!!
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Huge congratulations to the new Dr Thea Mawhinney!! Thank you to her fantastic examiners Prof Suzanne Cloonan @suzcloo.bsky.social and Prof Cliff Taggart @wwiem-qub.bsky.social
June 25, 2025 at 7:39 PM
Huge congratulations to the new Dr Thea Mawhinney!! Thank you to her fantastic examiners Prof Suzanne Cloonan @suzcloo.bsky.social and Prof Cliff Taggart @wwiem-qub.bsky.social
Reposted by Dr Rebecca Coll
Cockatoos have learned to operate drinking fountains in Australia.
The behavior—never before seen in birds—may be a developing cultural tradition among one population: scim.ag/4kIi12G
The behavior—never before seen in birds—may be a developing cultural tradition among one population: scim.ag/4kIi12G
June 7, 2025 at 2:08 PM
Cockatoos have learned to operate drinking fountains in Australia.
The behavior—never before seen in birds—may be a developing cultural tradition among one population: scim.ag/4kIi12G
The behavior—never before seen in birds—may be a developing cultural tradition among one population: scim.ag/4kIi12G
I'm delighted to be hosting a #NLRP3 InflammaZoom spectacular next week! With Alex Weber and Ana Tapia Abellan - please join us on Monday 19th May. Register here: events.abcam.com/event/Inflam...
May 13, 2025 at 2:43 PM
I'm delighted to be hosting a #NLRP3 InflammaZoom spectacular next week! With Alex Weber and Ana Tapia Abellan - please join us on Monday 19th May. Register here: events.abcam.com/event/Inflam...
Reposted by Dr Rebecca Coll
Inflammatory signalling must eventually be turned off (e.g. by feedback inhibition) to prevent chronic inflammation. We didn't know how #inflammasomes turn off their signalling in vivo ... until now! (🧵: 1/3)
shorturl.at/8lWxW
shorturl.at/8lWxW
Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases
Signal shutdown mechanisms must exist to silence the potent inflammatory programs initiated by the caspase-1 (CASP1) protease, to allow inflammation to resolve and reinstate tissue homeostasis. It is ...
shorturl.at
May 1, 2025 at 11:17 PM
Inflammatory signalling must eventually be turned off (e.g. by feedback inhibition) to prevent chronic inflammation. We didn't know how #inflammasomes turn off their signalling in vivo ... until now! (🧵: 1/3)
shorturl.at/8lWxW
shorturl.at/8lWxW
Reposted by Dr Rebecca Coll
🔥 Open postdoc position in human inflammation-driven control of infection! 🔥
Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5)
Please share!
Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5)
Please share!
April 13, 2025 at 3:58 PM
🔥 Open postdoc position in human inflammation-driven control of infection! 🔥
Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5)
Please share!
Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5)
Please share!
You've got to love the Irish enthusiasm for a bit of good weather 16°C=summertime 😎
April 3, 2025 at 5:07 PM
You've got to love the Irish enthusiasm for a bit of good weather 16°C=summertime 😎
We are recruiting a student for a really exciting PhD project on understanding how high plasma suPAR predicts poor outcome in patients with ARDS @wwiem-qub.bsky.social #ARDS #criticialcare
- any questions please get in touch! (open to UK and RoI) www.findaphd.com/phds/project...
- any questions please get in touch! (open to UK and RoI) www.findaphd.com/phds/project...
Understanding how high plasma soluble urokinase plasminogen activator receptor (suPAR) predicts poor outcome in patients with ARDS. at Queen’s University Belfast on FindAPhD.com
PhD Project - Understanding how high plasma soluble urokinase plasminogen activator receptor (suPAR) predicts poor outcome in patients with ARDS. at Queen’s University Belfast, listed on FindAPhD.com
www.findaphd.com
March 12, 2025 at 3:53 PM
We are recruiting a student for a really exciting PhD project on understanding how high plasma suPAR predicts poor outcome in patients with ARDS @wwiem-qub.bsky.social #ARDS #criticialcare
- any questions please get in touch! (open to UK and RoI) www.findaphd.com/phds/project...
- any questions please get in touch! (open to UK and RoI) www.findaphd.com/phds/project...
Brilliant and elegant work from @jelenalab.bsky.social - showing yet again the complexity of how our immune system keeps itself in check!!
The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells. www.science.org/doi/10.1126/...
TBK1 and IKKε prevent premature cell death by limiting the activity of both RIPK1 and NLRP3 death pathways
TBK1 and IKKe prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.
www.science.org
March 8, 2025 at 8:25 AM
Brilliant and elegant work from @jelenalab.bsky.social - showing yet again the complexity of how our immune system keeps itself in check!!
Queen's University Belfast has launched it's call for MSCA postdoctoral fellowship applications - if anyone would like to discuss submitting a project please get in touch! #MCSA @wwiem-qub.bsky.social www.qub.ac.uk/Research/our...
Marie Skłodowska-Curie Actions (MSCA) Postdoctoral Fellowships | Research | Queen's University Belfast
www.qub.ac.uk
March 6, 2025 at 12:26 PM
Queen's University Belfast has launched it's call for MSCA postdoctoral fellowship applications - if anyone would like to discuss submitting a project please get in touch! #MCSA @wwiem-qub.bsky.social www.qub.ac.uk/Research/our...