Franklin_LAB
@franklinlab.bsky.social
We are at the Institute of Innate Immunity, University of Bonn, Germany.
Interests: Innate immunity, Inflammasomes, Thrombo-inflammation, autoimmunity, and Data Science.
Interests: Innate immunity, Inflammasomes, Thrombo-inflammation, autoimmunity, and Data Science.
Pinned
Franklin_LAB
@franklinlab.bsky.social
· Dec 3
Excited to join bsky.social! 🌟
Our latest study, on the cover of @embopress.org , shows platelets transfer transcription factor (NF-κB, p38) signaling to monocytes, licensing monocyte inflammation, and restoring monocyte dysfunction in autoimmune Thrombocytopenia.
www.embopress.org/doi/full/10....
Our latest study, on the cover of @embopress.org , shows platelets transfer transcription factor (NF-κB, p38) signaling to monocytes, licensing monocyte inflammation, and restoring monocyte dysfunction in autoimmune Thrombocytopenia.
www.embopress.org/doi/full/10....
Reposted by Franklin_LAB
Thank you to our editor, Kirsty Minton, and the staff at NRI for the opportunity to share our thoughts on this emerging topic.
NEW Perspective by @alazozcan.bsky.social, Tommaso Vicanolo, Veronique Angeli, Yuval Rinkevich & @drusqui.bsky.social presents a model of immune cells as architects of tissue barriers, by depositing matrix components or by interactions with structural cells and the ECM
#structuralimmunity #immunosky
#structuralimmunity #immunosky
Structural immunity: immune cells as architects of tissue barriers - Nature Reviews Immunology
This Perspective presents a framework of ‘structural immunity’ that positions immune cells as architects of tissue structure. Beyond their roles in antimicrobial defence, we posit that immune cells co...
www.nature.com
October 28, 2025 at 4:41 PM
Thank you to our editor, Kirsty Minton, and the staff at NRI for the opportunity to share our thoughts on this emerging topic.
Check out this new thermo-hot paper from the @colllab.bsky.social Lab. Glad to contribute and work with her team.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
NLRP3 is a thermosensor that is negatively regulated by high temperature
Inflammation is an essential response to infection and injury, but unregulated inflammation is damaging and must be limited by negative feedback signalling. Inflammasome signalling drives local inflam...
www.biorxiv.org
October 1, 2025 at 6:56 AM
Check out this new thermo-hot paper from the @colllab.bsky.social Lab. Glad to contribute and work with her team.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Franklin_LAB
Too much Partying.. Now, back to work! 🙃
March 5, 2025 at 1:54 PM
Too much Partying.. Now, back to work! 🙃
Reposted by Franklin_LAB
I couldn't sleep that well last night with my worries about the Nazis taking over our govt. And the media refuses to report on it honestly. WTF!
www.mind-war.com/p/musk-to-un...
www.mind-war.com/p/musk-to-un...
Musk to Unions: The Nazis Are Coming
How Elon Musk’s DOGE logo is not a dogwhistle, it’s a slap in the face
www.mind-war.com
February 17, 2025 at 1:14 PM
I couldn't sleep that well last night with my worries about the Nazis taking over our govt. And the media refuses to report on it honestly. WTF!
www.mind-war.com/p/musk-to-un...
www.mind-war.com/p/musk-to-un...
We are happy to announce the second edition of the Joint Symposium of the Brazilian (SBI) and German (DGfI) Societies for Immunology.
The event will happen in Vienna, Austria August 15-16, 2025, and will bring together Brazilian and German immunologists.
The event will happen in Vienna, Austria August 15-16, 2025, and will bring together Brazilian and German immunologists.
February 17, 2025 at 12:42 PM
We are happy to announce the second edition of the Joint Symposium of the Brazilian (SBI) and German (DGfI) Societies for Immunology.
The event will happen in Vienna, Austria August 15-16, 2025, and will bring together Brazilian and German immunologists.
The event will happen in Vienna, Austria August 15-16, 2025, and will bring together Brazilian and German immunologists.
Reposted by Franklin_LAB
2nd Brazilian-German Immunology Workshop
Vienna, Austria
August 15-16, 2025
DEADLINE for application: March 1
Pls apply to Tim Sparwasser (sparwasser.office’at’uni-mainz.de) or Bernardo Franklin (franklin’at’uni-bonn.de) by March 1 2025, stating the title of the lecture and a half-page abstract.
Vienna, Austria
August 15-16, 2025
DEADLINE for application: March 1
Pls apply to Tim Sparwasser (sparwasser.office’at’uni-mainz.de) or Bernardo Franklin (franklin’at’uni-bonn.de) by March 1 2025, stating the title of the lecture and a half-page abstract.
February 16, 2025 at 10:16 AM
2nd Brazilian-German Immunology Workshop
Vienna, Austria
August 15-16, 2025
DEADLINE for application: March 1
Pls apply to Tim Sparwasser (sparwasser.office’at’uni-mainz.de) or Bernardo Franklin (franklin’at’uni-bonn.de) by March 1 2025, stating the title of the lecture and a half-page abstract.
Vienna, Austria
August 15-16, 2025
DEADLINE for application: March 1
Pls apply to Tim Sparwasser (sparwasser.office’at’uni-mainz.de) or Bernardo Franklin (franklin’at’uni-bonn.de) by March 1 2025, stating the title of the lecture and a half-page abstract.
Reposted by Franklin_LAB
#WeekendRead. #EveryOrganIsAnImmuneOrgan. Medei &co show @naturecvr.bsky.social that IL1b initiates a positive feedback loop leading to IL1b production by, & response of, cardiac resident macrophages which drives atrial fibrillation. Targeting resident macrophages is protective.
#ScienceSavesLives
#ScienceSavesLives
IL-1β enhances susceptibility to atrial fibrillation in mice by acting through resident macrophages and promoting caspase-1 expression - Nature Cardiovascular Research
Moreno-Loaiza et al. found that interleukin-1β, acting upon cardiac resident macrophages, promotes atrial fibrillation in mice, and this mechanism may represent a common pathway connecting various ris...
www.nature.com
February 9, 2025 at 5:56 PM
#WeekendRead. #EveryOrganIsAnImmuneOrgan. Medei &co show @naturecvr.bsky.social that IL1b initiates a positive feedback loop leading to IL1b production by, & response of, cardiac resident macrophages which drives atrial fibrillation. Targeting resident macrophages is protective.
#ScienceSavesLives
#ScienceSavesLives
Reposted by Franklin_LAB
As my inaugural post on BlueSky, I’m happy to share the first cancer-related study from Pyrocellfluencers spearheaded by Sara Orehek.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cytokine-armed pyroptosis induces antitumor immunity against diverse types of tumors - Nature Communications
‘Gasdermin-mediated pyroptosis can induce anti-tumor immune responses. Here the authors report a toolbox of gasdermin D variants for induction of pyroptosis, showing that, when combined with intratumo...
www.nature.com
December 30, 2024 at 11:52 PM
As my inaugural post on BlueSky, I’m happy to share the first cancer-related study from Pyrocellfluencers spearheaded by Sara Orehek.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Franklin_LAB
It turns out the immune system is playing 4D chess while we thought it was just playing checkers. Using #spatialtranscriptomics from @10xgenomics.bsky.social and @vizgen.bsky.social we were able to peek into the secret lives of tissue resident T cells in the gut as they form after infection 1/n
Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted - Nature
Profiling of the location and transcriptome of tissue-resident memory CD8 T cell formation at single-transcript resolution finds regionalized signalling as the basis of immune diversity in t...
www.nature.com
January 22, 2025 at 5:37 PM
It turns out the immune system is playing 4D chess while we thought it was just playing checkers. Using #spatialtranscriptomics from @10xgenomics.bsky.social and @vizgen.bsky.social we were able to peek into the secret lives of tissue resident T cells in the gut as they form after infection 1/n
Aren't platelets just fantastic?
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Platelet partnerships and lasting memories - Nature Immunology
Pulendran and colleagues define a molecular signature that can be used to predict the durability of antibody responses to vaccination and reveal important insights into the mechanisms by which vaccine...
www.nature.com
January 9, 2025 at 10:43 AM
Aren't platelets just fantastic?
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Loved this infographics
Immunology is the study of host defence mechanisms
Immunity is the ability of the host to protect itself against Invasion (and more!)
The immune system comprises of tissues, cells and molecules which detect danger and mount the immune response
#Immunology101
Immunity is the ability of the host to protect itself against Invasion (and more!)
The immune system comprises of tissues, cells and molecules which detect danger and mount the immune response
#Immunology101
December 30, 2024 at 7:48 PM
Loved this infographics
Great news! Our exchange program with the Medical Faculty of Ribeirão Preto (USP) will be funded by the DAAD & FAPESP, through the PPP program www.daad.de/de/infos-ser....
December 20, 2024 at 11:28 AM
Great news! Our exchange program with the Medical Faculty of Ribeirão Preto (USP) will be funded by the DAAD & FAPESP, through the PPP program www.daad.de/de/infos-ser....
Now, Check this out!!! The skin has its own immune system!
The skin isn’t just a barrier—it’s an active player in immunity, with its very own immune system. 🌟 A surprising discovery that could reshape how we treat infections, allergies, & autoimmune diseases.
www.nature.com/articles/d41...
The skin isn’t just a barrier—it’s an active player in immunity, with its very own immune system. 🌟 A surprising discovery that could reshape how we treat infections, allergies, & autoimmune diseases.
www.nature.com/articles/d41...
The skin’s ‘surprise’ power: it has its very own immune system
The finding could lead to the development of needle-free vaccines.
www.nature.com
December 19, 2024 at 2:45 PM
Now, Check this out!!! The skin has its own immune system!
The skin isn’t just a barrier—it’s an active player in immunity, with its very own immune system. 🌟 A surprising discovery that could reshape how we treat infections, allergies, & autoimmune diseases.
www.nature.com/articles/d41...
The skin isn’t just a barrier—it’s an active player in immunity, with its very own immune system. 🌟 A surprising discovery that could reshape how we treat infections, allergies, & autoimmune diseases.
www.nature.com/articles/d41...
Great time today hosting Jose Carlos Alves Filho from the @USP Ribeirao Preto (FMRP), with us for a nice salad&talk.
December 4, 2024 at 2:51 PM
Great time today hosting Jose Carlos Alves Filho from the @USP Ribeirao Preto (FMRP), with us for a nice salad&talk.
Excited to join bsky.social! 🌟
Our latest study, on the cover of @embopress.org , shows platelets transfer transcription factor (NF-κB, p38) signaling to monocytes, licensing monocyte inflammation, and restoring monocyte dysfunction in autoimmune Thrombocytopenia.
www.embopress.org/doi/full/10....
Our latest study, on the cover of @embopress.org , shows platelets transfer transcription factor (NF-κB, p38) signaling to monocytes, licensing monocyte inflammation, and restoring monocyte dysfunction in autoimmune Thrombocytopenia.
www.embopress.org/doi/full/10....
December 3, 2024 at 5:00 PM
Excited to join bsky.social! 🌟
Our latest study, on the cover of @embopress.org , shows platelets transfer transcription factor (NF-κB, p38) signaling to monocytes, licensing monocyte inflammation, and restoring monocyte dysfunction in autoimmune Thrombocytopenia.
www.embopress.org/doi/full/10....
Our latest study, on the cover of @embopress.org , shows platelets transfer transcription factor (NF-κB, p38) signaling to monocytes, licensing monocyte inflammation, and restoring monocyte dysfunction in autoimmune Thrombocytopenia.
www.embopress.org/doi/full/10....
Reposted by Franklin_LAB
Experimental Medicine and Immunology in Bonn. A bit different from our building in Cambridge, @campathology.bsky.social?
December 3, 2024 at 8:46 AM
Experimental Medicine and Immunology in Bonn. A bit different from our building in Cambridge, @campathology.bsky.social?
Reposted by Franklin_LAB
This is a cool story - spatial proteomics to identify over-expressed pathways (type I IFN & JAK/STAT) proposing new therapies (JAKi) for Toxic Epidermal Necrolysis
🌟 Discovery science translated into clincial benfit. Love it! 🌟
#MedSky 🧪 #ImmunoSky #dermatology
www.nature.com/artic...
🌟 Discovery science translated into clincial benfit. Love it! 🌟
#MedSky 🧪 #ImmunoSky #dermatology
www.nature.com/artic...
Spatial proteomics identifies JAKi as treatment for a lethal skin disease
Nature - Cell-type-resolved spatial proteomics of the skin from patients with toxic epidermal necrolysis reveals that it is driven by JAK/STAT signaling, leading to successful treatment of this...
www.nature.com
November 30, 2024 at 12:54 PM
This is a cool story - spatial proteomics to identify over-expressed pathways (type I IFN & JAK/STAT) proposing new therapies (JAKi) for Toxic Epidermal Necrolysis
🌟 Discovery science translated into clincial benfit. Love it! 🌟
#MedSky 🧪 #ImmunoSky #dermatology
www.nature.com/artic...
🌟 Discovery science translated into clincial benfit. Love it! 🌟
#MedSky 🧪 #ImmunoSky #dermatology
www.nature.com/artic...
😳
This is one of the most impressive studies showing the impact of #NeuroCovid.
#SARSCoV2 persists in the body for years after infection, especially in the skull and meninges. Vaccines help but cannot stop it.
Which organs are affected by SARS-CoV-2 vs. H1N1 influenza? Check below.
#SARSCoV2 persists in the body for years after infection, especially in the skull and meninges. Vaccines help but cannot stop it.
Which organs are affected by SARS-CoV-2 vs. H1N1 influenza? Check below.
November 30, 2024 at 7:11 PM
😳
Reposted by Franklin_LAB
#WeekendRead #FungiPower! Liao Gao Iliev &co show @ Nature that the stomach of wild, not lab, mice is colonized by an immunosilent fungus! Mucus alterations via diet or antibiotics drive a Th2 -not Th17- response that worsens allergy but protects against parasites! doi.org/10.1038/s41586-024-08213-2
Fungal symbiont transmitted by free-living mice promotes type 2 immunity - Nature
Kazachstania pintolopesii is a highly prevalent fungal symbiont that can trigger type 2 immunity and influence the composition of the gut mycobiome, as well as immune and disease phenotypes.
doi.org
November 30, 2024 at 4:13 PM
#WeekendRead #FungiPower! Liao Gao Iliev &co show @ Nature that the stomach of wild, not lab, mice is colonized by an immunosilent fungus! Mucus alterations via diet or antibiotics drive a Th2 -not Th17- response that worsens allergy but protects against parasites! doi.org/10.1038/s41586-024-08213-2
Reposted by Franklin_LAB
“But the eggs were just so expensive.”
November 29, 2024 at 4:02 AM
“But the eggs were just so expensive.”
A study in @natureportfolio.bsky.social shows how cancer cells subvert monocyte function to prevent effective T cell activation. This finding sheds light on a novel mechanism of immune evasion employed by tumors.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cancer cells impair monocyte-mediated T cell stimulation to evade immunity - Nature
Inflammatory monocytes are identified as important players in T cell restimulation in the tumour microenvironment.
www.nature.com
November 28, 2024 at 6:40 PM
A study in @natureportfolio.bsky.social shows how cancer cells subvert monocyte function to prevent effective T cell activation. This finding sheds light on a novel mechanism of immune evasion employed by tumors.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
