Franklin_LAB
@franklinlab.bsky.social
We are at the Institute of Innate Immunity, University of Bonn, Germany.
Interests: Innate immunity, Inflammasomes, Thrombo-inflammation, autoimmunity, and Data Science.
Interests: Innate immunity, Inflammasomes, Thrombo-inflammation, autoimmunity, and Data Science.
Pinned
Franklin_LAB
@franklinlab.bsky.social
Β· Dec 3
Excited to join bsky.social! π
Our latest study, on the cover of @embopress.org , shows platelets transfer transcription factor (NF-ΞΊB, p38) signaling to monocytes, licensing monocyte inflammation, and restoring monocyte dysfunction in autoimmune Thrombocytopenia.
www.embopress.org/doi/full/10....
Our latest study, on the cover of @embopress.org , shows platelets transfer transcription factor (NF-ΞΊB, p38) signaling to monocytes, licensing monocyte inflammation, and restoring monocyte dysfunction in autoimmune Thrombocytopenia.
www.embopress.org/doi/full/10....
December 3, 2025 at 7:08 AM
I kind of suspected this non-lytical IL-1b secretion by viable cells was BS...
www.nature.com/articles/s41...
"...So, the long-suspected βnon-canonicalβ secretion pathways, invoking unconventional secretion routes, atypical inflammasome regulation, are probably a misinterpretation artefact..."
www.nature.com/articles/s41...
"...So, the long-suspected βnon-canonicalβ secretion pathways, invoking unconventional secretion routes, atypical inflammasome regulation, are probably a misinterpretation artefact..."
A few cells make the difference in monocyte interleukin release - Nature Immunology
Single-cell analysis shows that the release of interleukin-1Ξ² in human monocytes arises from a small subset of pyroptotic cells, rather than from non-canonical secretion pathways.
www.nature.com
November 24, 2025 at 11:13 AM
I kind of suspected this non-lytical IL-1b secretion by viable cells was BS...
www.nature.com/articles/s41...
"...So, the long-suspected βnon-canonicalβ secretion pathways, invoking unconventional secretion routes, atypical inflammasome regulation, are probably a misinterpretation artefact..."
www.nature.com/articles/s41...
"...So, the long-suspected βnon-canonicalβ secretion pathways, invoking unconventional secretion routes, atypical inflammasome regulation, are probably a misinterpretation artefact..."
Reposted by Franklin_LAB
Thank you to our editor, Kirsty Minton, and the staff at NRI for the opportunity to share our thoughts on this emerging topic.
NEW Perspective by @alazozcan.bsky.social, Tommaso Vicanolo, Veronique Angeli, Yuval Rinkevich & @drusqui.bsky.social presents a model of immune cells as architects of tissue barriers, by depositing matrix components or by interactions with structural cells and the ECM
#structuralimmunity #immunosky
#structuralimmunity #immunosky
Structural immunity: immune cells as architects of tissue barriers - Nature Reviews Immunology
This Perspective presents a framework of βstructural immunityβ that positions immune cells as architects of tissue structure. Beyond their roles in antimicrobial defence, we posit that immune cells co...
www.nature.com
October 28, 2025 at 4:41 PM
Thank you to our editor, Kirsty Minton, and the staff at NRI for the opportunity to share our thoughts on this emerging topic.
Check out this new thermo-hot paper from the @colllab.bsky.social Lab. Glad to contribute and work with her team.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
NLRP3 is a thermosensor that is negatively regulated by high temperature
Inflammation is an essential response to infection and injury, but unregulated inflammation is damaging and must be limited by negative feedback signalling. Inflammasome signalling drives local inflam...
www.biorxiv.org
October 1, 2025 at 6:56 AM
Check out this new thermo-hot paper from the @colllab.bsky.social Lab. Glad to contribute and work with her team.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
π Testimonials (anonymously or not) reporting abusive behavior.
π Evidence where possible.
π Evidence where possible.
March 14, 2025 at 3:10 PM
π Testimonials (anonymously or not) reporting abusive behavior.
π Evidence where possible.
π Evidence where possible.
β οΈ This is NOT a tool for personal vendettas or individual grievances.
β οΈ Only cases with substantial reports, patterns of abuse, and corroborated evidence will be listed.
β οΈ Only cases with substantial reports, patterns of abuse, and corroborated evidence will be listed.
March 14, 2025 at 3:10 PM
β οΈ This is NOT a tool for personal vendettas or individual grievances.
β οΈ Only cases with substantial reports, patterns of abuse, and corroborated evidence will be listed.
β οΈ Only cases with substantial reports, patterns of abuse, and corroborated evidence will be listed.
These toxic environments ruin careers, push talented scientists out of academia, and foster a culture of fear.
Introducing the "Bully Blacklist" Exposing Academic Abuse with Evidence.
A community-driven initiative to expose academic bullies based on cumulative evidence and multiple testimonials.
Introducing the "Bully Blacklist" Exposing Academic Abuse with Evidence.
A community-driven initiative to expose academic bullies based on cumulative evidence and multiple testimonials.
March 14, 2025 at 3:10 PM
These toxic environments ruin careers, push talented scientists out of academia, and foster a culture of fear.
Introducing the "Bully Blacklist" Exposing Academic Abuse with Evidence.
A community-driven initiative to expose academic bullies based on cumulative evidence and multiple testimonials.
Introducing the "Bully Blacklist" Exposing Academic Abuse with Evidence.
A community-driven initiative to expose academic bullies based on cumulative evidence and multiple testimonials.
The recent DW article sheds light on a harsh truth: academic bullying, harassment, and abuse are widespread, yet the perpetrators remain in power, protected by institutions that refuse to hold them accountable.
Uncovered: Abuse at top German science institution β DW β 03/13/2025
The Max Planck Society is Germany's preeminent research organization, boasting 31 Nobel laureates. But insufficient oversight leaves international scientists exposed to abuse and the whims of the inst...
www.dw.com
March 14, 2025 at 3:10 PM
The recent DW article sheds light on a harsh truth: academic bullying, harassment, and abuse are widespread, yet the perpetrators remain in power, protected by institutions that refuse to hold them accountable.
Reposted by Franklin_LAB
Too much Partying.. Now, back to work! π
March 5, 2025 at 1:54 PM
Too much Partying.. Now, back to work! π
Reposted by Franklin_LAB
I couldn't sleep that well last night with my worries about the Nazis taking over our govt. And the media refuses to report on it honestly. WTF!
www.mind-war.com/p/musk-to-un...
www.mind-war.com/p/musk-to-un...
Musk to Unions: The Nazis Are Coming
How Elon Muskβs DOGE logo is not a dogwhistle, itβs a slap in the face
www.mind-war.com
February 17, 2025 at 1:14 PM
I couldn't sleep that well last night with my worries about the Nazis taking over our govt. And the media refuses to report on it honestly. WTF!
www.mind-war.com/p/musk-to-un...
www.mind-war.com/p/musk-to-un...
Hurry up, as we have limited spots.
We look forward to hosting you in Vienna. π
We look forward to hosting you in Vienna. π
February 17, 2025 at 12:42 PM
Hurry up, as we have limited spots.
We look forward to hosting you in Vienna. π
We look forward to hosting you in Vienna. π
DEADLINE for application: March 1
Please apply directly to Tim Sparwasser Tim Sparwasser (sparwasser.office'at'uni-mainz.de) or Bernardo Franklin (franklin'at'uni-bonn.de) with the title of the lecture and a half-page abstract.
Please apply directly to Tim Sparwasser Tim Sparwasser (sparwasser.office'at'uni-mainz.de) or Bernardo Franklin (franklin'at'uni-bonn.de) with the title of the lecture and a half-page abstract.
February 17, 2025 at 12:42 PM
DEADLINE for application: March 1
Please apply directly to Tim Sparwasser Tim Sparwasser (sparwasser.office'at'uni-mainz.de) or Bernardo Franklin (franklin'at'uni-bonn.de) with the title of the lecture and a half-page abstract.
Please apply directly to Tim Sparwasser Tim Sparwasser (sparwasser.office'at'uni-mainz.de) or Bernardo Franklin (franklin'at'uni-bonn.de) with the title of the lecture and a half-page abstract.
We are happy to announce the second edition of the Joint Symposium of the Brazilian (SBI) and German (DGfI) Societies for Immunology.
The event will happen in Vienna, Austria August 15-16, 2025, and will bring together Brazilian and German immunologists.
The event will happen in Vienna, Austria August 15-16, 2025, and will bring together Brazilian and German immunologists.
February 17, 2025 at 12:42 PM
We are happy to announce the second edition of the Joint Symposium of the Brazilian (SBI) and German (DGfI) Societies for Immunology.
The event will happen in Vienna, Austria August 15-16, 2025, and will bring together Brazilian and German immunologists.
The event will happen in Vienna, Austria August 15-16, 2025, and will bring together Brazilian and German immunologists.
Reposted by Franklin_LAB
2nd Brazilian-German Immunology Workshop
Vienna, Austria
August 15-16, 2025
DEADLINE for application: March 1
Pls apply to Tim Sparwasser (sparwasser.officeβatβuni-mainz.de) or Bernardo Franklin (franklinβatβuni-bonn.de) by March 1 2025, stating the title of the lecture and a half-page abstract.
Vienna, Austria
August 15-16, 2025
DEADLINE for application: March 1
Pls apply to Tim Sparwasser (sparwasser.officeβatβuni-mainz.de) or Bernardo Franklin (franklinβatβuni-bonn.de) by March 1 2025, stating the title of the lecture and a half-page abstract.
February 16, 2025 at 10:16 AM
2nd Brazilian-German Immunology Workshop
Vienna, Austria
August 15-16, 2025
DEADLINE for application: March 1
Pls apply to Tim Sparwasser (sparwasser.officeβatβuni-mainz.de) or Bernardo Franklin (franklinβatβuni-bonn.de) by March 1 2025, stating the title of the lecture and a half-page abstract.
Vienna, Austria
August 15-16, 2025
DEADLINE for application: March 1
Pls apply to Tim Sparwasser (sparwasser.officeβatβuni-mainz.de) or Bernardo Franklin (franklinβatβuni-bonn.de) by March 1 2025, stating the title of the lecture and a half-page abstract.
Reposted by Franklin_LAB
#WeekendRead. #EveryOrganIsAnImmuneOrgan. Medei &co show @naturecvr.bsky.social that IL1b initiates a positive feedback loop leading to IL1b production by, & response of, cardiac resident macrophages which drives atrial fibrillation. Targeting resident macrophages is protective.
#ScienceSavesLives
#ScienceSavesLives
IL-1Ξ² enhances susceptibility to atrial fibrillation in mice by acting through resident macrophages and promoting caspase-1 expression - Nature Cardiovascular Research
Moreno-Loaiza et al. found that interleukin-1Ξ², acting upon cardiac resident macrophages, promotes atrial fibrillation in mice, and this mechanism may represent a common pathway connecting various ris...
www.nature.com
February 9, 2025 at 5:56 PM
#WeekendRead. #EveryOrganIsAnImmuneOrgan. Medei &co show @naturecvr.bsky.social that IL1b initiates a positive feedback loop leading to IL1b production by, & response of, cardiac resident macrophages which drives atrial fibrillation. Targeting resident macrophages is protective.
#ScienceSavesLives
#ScienceSavesLives
Please, can you add me? Thank you.
January 26, 2025 at 7:21 PM
Please, can you add me? Thank you.
Reposted by Franklin_LAB
As my inaugural post on BlueSky, Iβm happy to share the first cancer-related study from Pyrocellfluencers spearheaded by Sara Orehek.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cytokine-armed pyroptosis induces antitumor immunity against diverse types of tumors - Nature Communications
βGasdermin-mediated pyroptosis can induce anti-tumor immune responses. Here the authors report a toolbox of gasdermin D variants for induction of pyroptosis, showing that, when combined with intratumo...
www.nature.com
December 30, 2024 at 11:52 PM
As my inaugural post on BlueSky, Iβm happy to share the first cancer-related study from Pyrocellfluencers spearheaded by Sara Orehek.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Franklin_LAB
It turns out the immune system is playing 4D chess while we thought it was just playing checkers. Using #spatialtranscriptomics from @10xgenomics.bsky.social and @vizgen.bsky.social we were able to peek into the secret lives of tissue resident T cells in the gut as they form after infection 1/n
Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted - Nature
Profiling of the location and transcriptome of tissue-resident memory CD8 T cell formation at single-transcript resolution finds regionalized signalling as the basis of immune diversity in t...
www.nature.com
January 22, 2025 at 5:37 PM
It turns out the immune system is playing 4D chess while we thought it was just playing checkers. Using #spatialtranscriptomics from @10xgenomics.bsky.social and @vizgen.bsky.social we were able to peek into the secret lives of tissue resident T cells in the gut as they form after infection 1/n
Aren't platelets just fantastic?
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Platelet partnerships and lasting memories - Nature Immunology
Pulendran and colleagues define a molecular signature that can be used to predict the durability of antibody responses to vaccination and reveal important insights into the mechanisms by which vaccine...
www.nature.com
January 9, 2025 at 10:43 AM
Aren't platelets just fantastic?
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Loved this infographics
Immunology is the study of host defence mechanisms
Immunity is the ability of the host to protect itself against Invasion (and more!)
The immune system comprises of tissues, cells and molecules which detect danger and mount the immune response
#Immunology101
Immunity is the ability of the host to protect itself against Invasion (and more!)
The immune system comprises of tissues, cells and molecules which detect danger and mount the immune response
#Immunology101
December 30, 2024 at 7:48 PM
Loved this infographics
But of course, the best part of it, is to provide students and young scientist with the opportunity to extend their horizons and foster collaborations with the brilliant scientists at the CRID/FMRP. Looking forward to two years of exciting exchanges.
December 20, 2024 at 11:28 AM
But of course, the best part of it, is to provide students and young scientist with the opportunity to extend their horizons and foster collaborations with the brilliant scientists at the CRID/FMRP. Looking forward to two years of exciting exchanges.
This partnership will foster international collaboration and research on inflammatory diseases, and strengthen ties between Germany and Brazil. π©πͺπ€π§π·
@daadworldwide.bsky.social e.bsky.social @agenciafapesp.bsky.social y.social @immunosens.bsky.social
@daadworldwide.bsky.social e.bsky.social @agenciafapesp.bsky.social y.social @immunosens.bsky.social
Bluesky
e.bsky.social
December 20, 2024 at 11:28 AM
This partnership will foster international collaboration and research on inflammatory diseases, and strengthen ties between Germany and Brazil. π©πͺπ€π§π·
@daadworldwide.bsky.social e.bsky.social @agenciafapesp.bsky.social y.social @immunosens.bsky.social
@daadworldwide.bsky.social e.bsky.social @agenciafapesp.bsky.social y.social @immunosens.bsky.social