Iva Hafner Bratkovič
@ivahb.bsky.social
Scientist, synthetic immunologist, loves minimalism. Interested in innate immunity, inflammasomes, cell death, inflammation, autoinflammatory diseases and cancer.
Reposted by Iva Hafner Bratkovič
Congrats @lauracanaday.bsky.social @andypedsid.bsky.social @hafeldman17.bsky.social
& team on our newest publication @jimmunol.bsky.social
Refined cell transfer model reveals roles for Ascl2 and Cxcr3 in splenic localization of mouse NK cells during virus infection
academic.oup.com/jimmunol/adv...
& team on our newest publication @jimmunol.bsky.social
Refined cell transfer model reveals roles for Ascl2 and Cxcr3 in splenic localization of mouse NK cells during virus infection
academic.oup.com/jimmunol/adv...
July 22, 2025 at 9:12 PM
Congrats @lauracanaday.bsky.social @andypedsid.bsky.social @hafeldman17.bsky.social
& team on our newest publication @jimmunol.bsky.social
Refined cell transfer model reveals roles for Ascl2 and Cxcr3 in splenic localization of mouse NK cells during virus infection
academic.oup.com/jimmunol/adv...
& team on our newest publication @jimmunol.bsky.social
Refined cell transfer model reveals roles for Ascl2 and Cxcr3 in splenic localization of mouse NK cells during virus infection
academic.oup.com/jimmunol/adv...
Reposted by Iva Hafner Bratkovič
We are excited to have our new paper out: Tethering of the pathogen sensor caspase-4 to the endomembrane damage sensor galectin-8 poises the host to rapidly detect pathogens that breach the endolysosomal network.
www.cell.com/cell-reports... #innate_immunity #inflammasome #celldeath #immunoSky 1/2
www.cell.com/cell-reports... #innate_immunity #inflammasome #celldeath #immunoSky 1/2
Endolysosomal damage surveillance enables rapid inflammasome sensing of pathogens
Shivcharan et al. report that endosomal damage sensing by the danger receptor galectin-8
licenses noncanonical inflammasome activation and pyroptosis during intracellular
bacterial infections in human...
www.cell.com
July 17, 2025 at 12:12 PM
We are excited to have our new paper out: Tethering of the pathogen sensor caspase-4 to the endomembrane damage sensor galectin-8 poises the host to rapidly detect pathogens that breach the endolysosomal network.
www.cell.com/cell-reports... #innate_immunity #inflammasome #celldeath #immunoSky 1/2
www.cell.com/cell-reports... #innate_immunity #inflammasome #celldeath #immunoSky 1/2
Reposted by Iva Hafner Bratkovič
One month left until early registration closes! Apply now if you would like to be considered for a talk.
It will be an amazing conference bringing together leading scientists in the field of protein design.
[Protein Emoji]
It will be an amazing conference bringing together leading scientists in the field of protein design.
[Protein Emoji]
July 11, 2025 at 11:51 AM
One month left until early registration closes! Apply now if you would like to be considered for a talk.
It will be an amazing conference bringing together leading scientists in the field of protein design.
[Protein Emoji]
It will be an amazing conference bringing together leading scientists in the field of protein design.
[Protein Emoji]
Reposted by Iva Hafner Bratkovič
NLRP3 inflammasomes can assemble on most organelles. A beautiful study by Hafner et al demonstrate the flexibility of organelles that can support inflammasome activation. Kudos to the authors on an intriguing study.
www.nature.com/articles/s41...
@ivahb.bsky.social @elvirab.bsky.social
www.nature.com/articles/s41...
@ivahb.bsky.social @elvirab.bsky.social
Clustering of NLRP3 induced by membrane or protein scaffolds promotes inflammasome assembly - Nature Communications
NLRP3 inflammasome activation is critical for the induction of protective immunity, but molecular insights are still lacking. Here, the authors express NLRP3 variants targeted to different cellular lo...
www.nature.com
May 27, 2025 at 1:31 PM
NLRP3 inflammasomes can assemble on most organelles. A beautiful study by Hafner et al demonstrate the flexibility of organelles that can support inflammasome activation. Kudos to the authors on an intriguing study.
www.nature.com/articles/s41...
@ivahb.bsky.social @elvirab.bsky.social
www.nature.com/articles/s41...
@ivahb.bsky.social @elvirab.bsky.social
Reposted by Iva Hafner Bratkovič
Subcellular location of NLRP3 is not essential, but clustering on different scaffolds is. This explains how NLRP3 can react to so many diverse stress signals.
9/9
9/9
May 27, 2025 at 8:46 AM
Subcellular location of NLRP3 is not essential, but clustering on different scaffolds is. This explains how NLRP3 can react to so many diverse stress signals.
9/9
9/9
Reposted by Iva Hafner Bratkovič
Ever wondered where NLRP3 needs to be in the cell to activate the #inflammasome? Turns out, it does not really matter. Check out our latest study in
@natcomms.nature.com: nature.com/articles/s41...
See 🧵👇
1/9
@natcomms.nature.com: nature.com/articles/s41...
See 🧵👇
1/9
Clustering of NLRP3 induced by membrane or protein scaffolds promotes inflammasome assembly - Nature Communications
NLRP3 inflammasome activation is critical for the induction of protective immunity, but molecular insights are still lacking. Here, the authors express NLRP3 variants targeted to different cellular lo...
nature.com
May 27, 2025 at 8:41 AM
Ever wondered where NLRP3 needs to be in the cell to activate the #inflammasome? Turns out, it does not really matter. Check out our latest study in
@natcomms.nature.com: nature.com/articles/s41...
See 🧵👇
1/9
@natcomms.nature.com: nature.com/articles/s41...
See 🧵👇
1/9
Check out Elvira's explanation of the freshly published study below...
Ever wondered where NLRP3 needs to be in the cell to activate the #inflammasome? Turns out, it does not really matter. Check out our latest study in
@natcomms.nature.com: nature.com/articles/s41...
See 🧵👇
1/9
@natcomms.nature.com: nature.com/articles/s41...
See 🧵👇
1/9
Clustering of NLRP3 induced by membrane or protein scaffolds promotes inflammasome assembly - Nature Communications
NLRP3 inflammasome activation is critical for the induction of protective immunity, but molecular insights are still lacking. Here, the authors express NLRP3 variants targeted to different cellular lo...
nature.com
May 27, 2025 at 8:49 AM
Check out Elvira's explanation of the freshly published study below...
Are there spatial restrictions in NLRP3 #inflammasome activation? I am super excited to share our new study spearheaded by amazing @elvirab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Clustering of NLRP3 induced by membrane or protein scaffolds promotes inflammasome assembly - Nature Communications
NLRP3 inflammasome activation is critical for the induction of protective immunity, but molecular insights are still lacking. Here, the authors express NLRP3 variants targeted to different cellular lo...
www.nature.com
May 27, 2025 at 8:40 AM
Are there spatial restrictions in NLRP3 #inflammasome activation? I am super excited to share our new study spearheaded by amazing @elvirab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Iva Hafner Bratkovič
Two-dozen billion-dollar U.S. startups were founded by foreign students who studied at Harvard
--Axios.
Making America Poor Again
Making America Dumb Again
--Axios.
Making America Poor Again
Making America Dumb Again
May 24, 2025 at 11:04 PM
Two-dozen billion-dollar U.S. startups were founded by foreign students who studied at Harvard
--Axios.
Making America Poor Again
Making America Dumb Again
--Axios.
Making America Poor Again
Making America Dumb Again
Reposted by Iva Hafner Bratkovič
Just like we need women in STEM and "Girls Who Code", we need “Men Who Nurse” and “Guys Who Teach,” pipeline programs that can offer boys pathways forward in female-typed fields. @reshmasaujani.bsky.social
time.com/7286184/worr...
time.com/7286184/worr...
I Founded Girls Who Code. Now I’m Worried About Boys
Boys and men are less likely to turn to their communities for social connection and support.
time.com
May 20, 2025 at 2:50 AM
Just like we need women in STEM and "Girls Who Code", we need “Men Who Nurse” and “Guys Who Teach,” pipeline programs that can offer boys pathways forward in female-typed fields. @reshmasaujani.bsky.social
time.com/7286184/worr...
time.com/7286184/worr...
Reposted by Iva Hafner Bratkovič
Cryo-EM structures of a protein pore reveal a cluster of cholesterol molecules and diverse roles of membrane lipids pubmed.ncbi.nlm.nih.gov/40140423/ #cryoem
March 28, 2025 at 10:51 PM
Cryo-EM structures of a protein pore reveal a cluster of cholesterol molecules and diverse roles of membrane lipids pubmed.ncbi.nlm.nih.gov/40140423/ #cryoem
Reposted by Iva Hafner Bratkovič
Exciting times ahead! Kicking off our new EIC Pathfinder project SCALPEL:
www.linkedin.com/posts/scalpe...
www.linkedin.com/posts/scalpe...
#scalpel #groundbreaking #cancertreatment #photomedicine #immunotherapy… | SCALPEL-Project
✨ Lighting Up a New Era in Cancer Treatment ✨
We are excited to introduce #SCALPEL – a #groundbreaking, Europe-wide initiative that is set to redefine…
www.linkedin.com
March 19, 2025 at 11:32 AM
Exciting times ahead! Kicking off our new EIC Pathfinder project SCALPEL:
www.linkedin.com/posts/scalpe...
www.linkedin.com/posts/scalpe...
Congratulations to the Unesco L'Oreal For Women in Science (Slovenia) Awardees!
siol.net/novice/digis...
siol.net/novice/digis...
S čim so prepričale te tri mlade slovenske znanstvenice?
Za odličnost njihovega raziskovanja bodo letos nagrajene molekularna biologinja Tajda Klobučar, raziskovalka na področju biomedicine Sara Orehek in kognitivna nevroznanstvenica Manca Peskar.
siol.net
March 6, 2025 at 9:59 PM
Congratulations to the Unesco L'Oreal For Women in Science (Slovenia) Awardees!
siol.net/novice/digis...
siol.net/novice/digis...
Reposted by Iva Hafner Bratkovič
Damon Runyon Cancer Research Foundation awards $4.4M to top young scientists
www.damonrunyon.org/news/entries...
www.damonrunyon.org/news/entries...
Damon Runyon Cancer Research Foundation awards $4.4M to top young scientists
www.damonrunyon.org
March 5, 2025 at 7:42 PM
Damon Runyon Cancer Research Foundation awards $4.4M to top young scientists
www.damonrunyon.org/news/entries...
www.damonrunyon.org/news/entries...
Reposted by Iva Hafner Bratkovič
This is a list of blockbuster drugs in 2024. Guess how many can trace their origins to NIH funded research?
All of them.
All of them.
February 8, 2025 at 4:09 AM
This is a list of blockbuster drugs in 2024. Guess how many can trace their origins to NIH funded research?
All of them.
All of them.
Reposted by Iva Hafner Bratkovič
This administration is taking a blowtorch to the entire education path from early childhood programs to undergrad universities to higher ed as we look on. Any US company/institution that relies on a well-educated workforce is going to lose its competitive edge. This is a ⏰⏰⏰⏰🔥🔥national crisis
February 8, 2025 at 1:22 PM
This administration is taking a blowtorch to the entire education path from early childhood programs to undergrad universities to higher ed as we look on. Any US company/institution that relies on a well-educated workforce is going to lose its competitive edge. This is a ⏰⏰⏰⏰🔥🔥national crisis
Reposted by Iva Hafner Bratkovič
Excited to join bsky.social! 🌟
Our latest study, on the cover of @embopress.org , shows platelets transfer transcription factor (NF-κB, p38) signaling to monocytes, licensing monocyte inflammation, and restoring monocyte dysfunction in autoimmune Thrombocytopenia.
www.embopress.org/doi/full/10....
Our latest study, on the cover of @embopress.org , shows platelets transfer transcription factor (NF-κB, p38) signaling to monocytes, licensing monocyte inflammation, and restoring monocyte dysfunction in autoimmune Thrombocytopenia.
www.embopress.org/doi/full/10....
December 3, 2024 at 5:00 PM
Excited to join bsky.social! 🌟
Our latest study, on the cover of @embopress.org , shows platelets transfer transcription factor (NF-κB, p38) signaling to monocytes, licensing monocyte inflammation, and restoring monocyte dysfunction in autoimmune Thrombocytopenia.
www.embopress.org/doi/full/10....
Our latest study, on the cover of @embopress.org , shows platelets transfer transcription factor (NF-κB, p38) signaling to monocytes, licensing monocyte inflammation, and restoring monocyte dysfunction in autoimmune Thrombocytopenia.
www.embopress.org/doi/full/10....
Reposted by Iva Hafner Bratkovič
Researchers at the National Institute of Chemistry have developed a novel therapeutic strategy called cytokine-armed pyroptosis.
The study, published in @naturecomms.bsky.social , will be presented by first author Sara Orehek on January 23, 2025, at the Forum 40 lecture series.
bit.ly/4ho2e7m
The study, published in @naturecomms.bsky.social , will be presented by first author Sara Orehek on January 23, 2025, at the Forum 40 lecture series.
bit.ly/4ho2e7m
January 20, 2025 at 7:35 AM
Researchers at the National Institute of Chemistry have developed a novel therapeutic strategy called cytokine-armed pyroptosis.
The study, published in @naturecomms.bsky.social , will be presented by first author Sara Orehek on January 23, 2025, at the Forum 40 lecture series.
bit.ly/4ho2e7m
The study, published in @naturecomms.bsky.social , will be presented by first author Sara Orehek on January 23, 2025, at the Forum 40 lecture series.
bit.ly/4ho2e7m
Reposted by Iva Hafner Bratkovič
Check this video where he Head of the #CTGCT prof. dr. Mojca Benčina appeared in the news of the Slovenian national TV as one of the breakthrough discoveries by Slovenian scientists in 2024.
lnkd.in/dtx6VyNT
#research #ultrasound #innovation #cellandgentherapy
lnkd.in/dtx6VyNT
#research #ultrasound #innovation #cellandgentherapy
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
January 9, 2025 at 3:00 PM
Check this video where he Head of the #CTGCT prof. dr. Mojca Benčina appeared in the news of the Slovenian national TV as one of the breakthrough discoveries by Slovenian scientists in 2024.
lnkd.in/dtx6VyNT
#research #ultrasound #innovation #cellandgentherapy
lnkd.in/dtx6VyNT
#research #ultrasound #innovation #cellandgentherapy
Reposted by Iva Hafner Bratkovič
Researchers (from @ivahb.bsky.social's group and #CTGCT) developed a way to enhance the immune system's ability to combat cancer combining pyroptosis, with specific cytokines that boost immune activity.
www.nature.com/articles/s41...
#CancerResearch #Immunotherapy #Innovation #Science
www.nature.com/articles/s41...
#CancerResearch #Immunotherapy #Innovation #Science
Cytokine-armed pyroptosis induces antitumor immunity against diverse types of tumors - Nature Communications
‘Gasdermin-mediated pyroptosis can induce anti-tumor immune responses. Here the authors report a toolbox of gasdermin D variants for induction of pyroptosis, showing that, when combined with intratumo...
www.nature.com
January 6, 2025 at 11:47 AM
Researchers (from @ivahb.bsky.social's group and #CTGCT) developed a way to enhance the immune system's ability to combat cancer combining pyroptosis, with specific cytokines that boost immune activity.
www.nature.com/articles/s41...
#CancerResearch #Immunotherapy #Innovation #Science
www.nature.com/articles/s41...
#CancerResearch #Immunotherapy #Innovation #Science
As my inaugural post on BlueSky, I’m happy to share the first cancer-related study from Pyrocellfluencers spearheaded by Sara Orehek.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cytokine-armed pyroptosis induces antitumor immunity against diverse types of tumors - Nature Communications
‘Gasdermin-mediated pyroptosis can induce anti-tumor immune responses. Here the authors report a toolbox of gasdermin D variants for induction of pyroptosis, showing that, when combined with intratumo...
www.nature.com
December 30, 2024 at 11:52 PM
As my inaugural post on BlueSky, I’m happy to share the first cancer-related study from Pyrocellfluencers spearheaded by Sara Orehek.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Iva Hafner Bratkovič
Such a great opportunity! I took this course in grad school in 2001. It was transformative for my thinking and led to some lifelong friendships. Highly recommend!
You want to learn about microbiology from a fantastic lineup of speakers on a beautiful Greek island? PhD students apply now for the @EMBO | @FEBSnews Lecture Course The New Microbiology!
Registration: 1 Apr 2025
Course: 03 – 11 Sep 2025 | Spetses, Greece
meetings.embo.org/event/25-new...
Registration: 1 Apr 2025
Course: 03 – 11 Sep 2025 | Spetses, Greece
meetings.embo.org/event/25-new...
December 17, 2024 at 11:36 AM
Such a great opportunity! I took this course in grad school in 2001. It was transformative for my thinking and led to some lifelong friendships. Highly recommend!
Reposted by Iva Hafner Bratkovič
Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies!
Link: rdcu.be/d2mjm
Link: rdcu.be/d2mjm
Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells
Nature Immunology - Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate...
rdcu.be
December 9, 2024 at 1:39 AM
Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies!
Link: rdcu.be/d2mjm
Link: rdcu.be/d2mjm
Reposted by Iva Hafner Bratkovič
#NoTimeToDie! @inflammasomelab, Holley, Monteleone &co show @natimmunol.bsky.social that cells that die by #pyroptosis, or #necroptosis, are crowned with F-actin filopodia that makes them visible by dendritic cells via CLEC9A to initiate adaptive immunity! www.nature.com/articles/s41...
Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells - Nature Immunology
Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate dendritic cells.
www.nature.com
December 5, 2024 at 4:55 PM
#NoTimeToDie! @inflammasomelab, Holley, Monteleone &co show @natimmunol.bsky.social that cells that die by #pyroptosis, or #necroptosis, are crowned with F-actin filopodia that makes them visible by dendritic cells via CLEC9A to initiate adaptive immunity! www.nature.com/articles/s41...
Reposted by Iva Hafner Bratkovič
PhD project with Ioannis Kourtzelis, our lab and Mesenbio in lovely York! Macrophage, EV and innate immune responses, what's not to love! www.findaphd.com/phds/project...
CASE Project: Unravelling the role of extracellular vesicles in the orchestration of macrophage – mediated immune regulation. at University of York on FindAPhD.com
PhD Project - CASE Project: Unravelling the role of extracellular vesicles in the orchestration of macrophage – mediated immune regulation. at University of York, listed on FindAPhD.com
www.findaphd.com
November 22, 2024 at 7:45 PM
PhD project with Ioannis Kourtzelis, our lab and Mesenbio in lovely York! Macrophage, EV and innate immune responses, what's not to love! www.findaphd.com/phds/project...