François Leulier
@francoisleulier.bsky.social
Scientist, Biologist @CNRS
Director and Group leader @IGFLyon @ENSLyon
We study how the #Microbiome together with #Nutrition influence #Juvenile #Physiology using #InMice and #Drosophila as models.
Director and Group leader @IGFLyon @ENSLyon
We study how the #Microbiome together with #Nutrition influence #Juvenile #Physiology using #InMice and #Drosophila as models.
Pinned
After 11months on this platform, so happy to see the momentum finally happening!
Let’s repeat a proper introduction:
My lab studies how the #Microbiome together with #Nutrition influence #Development and Juvenile #Physiology using #Mice and #Drosophila as models… we also do lot’s of #Microbiology
Let’s repeat a proper introduction:
My lab studies how the #Microbiome together with #Nutrition influence #Development and Juvenile #Physiology using #Mice and #Drosophila as models… we also do lot’s of #Microbiology
Reposted by François Leulier
The Long-Term Evolution Experiment has returned home. Led by Professors Richard Lenski (@relenski.bsky.social) and Jeffrey Barrick, this groundbreaking work continues to reveal how bacteria evolve in real time. 12 flasks. 1 legacy.
🔗https://tinyurl.com/f6vjyjvr
🔗https://tinyurl.com/f6vjyjvr
November 10, 2025 at 3:25 PM
The Long-Term Evolution Experiment has returned home. Led by Professors Richard Lenski (@relenski.bsky.social) and Jeffrey Barrick, this groundbreaking work continues to reveal how bacteria evolve in real time. 12 flasks. 1 legacy.
🔗https://tinyurl.com/f6vjyjvr
🔗https://tinyurl.com/f6vjyjvr
Reposted by François Leulier
Want to join a happy bunch 🥳 to organise meetings, outreach activities and other initiatives about developmental biology in France? Apply and/or vote 🗳️!
🚨🚨🚨
The SFBD board needs to be renewed with 5 members
We wish to strengthen our board with young scientists
To apply: send a brief text introducing your research interests and motivations to sfbd@sfbd.fr by December 4th
Elections will be held online from December 10th to 17th
Please share the info
The SFBD board needs to be renewed with 5 members
We wish to strengthen our board with young scientists
To apply: send a brief text introducing your research interests and motivations to sfbd@sfbd.fr by December 4th
Elections will be held online from December 10th to 17th
Please share the info
November 10, 2025 at 12:00 PM
Want to join a happy bunch 🥳 to organise meetings, outreach activities and other initiatives about developmental biology in France? Apply and/or vote 🗳️!
Reposted by François Leulier
A retrograde, non-canonical integrated stress response cascade maintains synaptic strength under amino acid deprivation
#Drosophila
#Drosophila
A retrograde, non-canonical integrated stress response cascade maintains synaptic strength under amino acid deprivation
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
November 9, 2025 at 3:23 AM
A retrograde, non-canonical integrated stress response cascade maintains synaptic strength under amino acid deprivation
#Drosophila
#Drosophila
The 2nd edition of Comprehensive Molecular #Insect Science is out. As section editor for #Immunity and #Symbiosis, I had the privilege to work with outstanding contributors.
Other sections cover #genomics, #physiology, #neurobiology, and #ecology
🔗 www.sciencedirect.com/referencewor...
#SymbioSky
Other sections cover #genomics, #physiology, #neurobiology, and #ecology
🔗 www.sciencedirect.com/referencewor...
#SymbioSky
Comprehensive Molecular Insect Science
Comprehensive Molecular Insect Science, Second Edition is a unique resource that provides extensive review articles on contemporary topics in insect s...
www.sciencedirect.com
November 7, 2025 at 6:16 AM
The 2nd edition of Comprehensive Molecular #Insect Science is out. As section editor for #Immunity and #Symbiosis, I had the privilege to work with outstanding contributors.
Other sections cover #genomics, #physiology, #neurobiology, and #ecology
🔗 www.sciencedirect.com/referencewor...
#SymbioSky
Other sections cover #genomics, #physiology, #neurobiology, and #ecology
🔗 www.sciencedirect.com/referencewor...
#SymbioSky
Reposted by François Leulier
Layers of immunity: Deconstructing the Drosophila effector response
#Drosophila
#Drosophila
Layers of immunity: Deconstructing the Drosophila effector response
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
November 5, 2025 at 6:23 PM
Layers of immunity: Deconstructing the Drosophila effector response
#Drosophila
#Drosophila
Reposted by François Leulier
Systematic analysis of nutrient-microbiome interactions and their effects on host phenotypes in Drosophila
#Drosophila
#Drosophila
Systematic analysis of nutrient-microbiome interactions and their effects on host phenotypes in Drosophila
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
November 5, 2025 at 6:23 PM
Systematic analysis of nutrient-microbiome interactions and their effects on host phenotypes in Drosophila
#Drosophila
#Drosophila
Reposted by François Leulier
[Podcast] Avec Sciences | "La double vie d'une enzyme du métabolisme des graisses" par @alexandradelbot.bsky.social
La double vie d’une enzyme du métabolisme des graisses
Une nouvelle étude montre que l’enzyme HSL, connue pour libérer les graisses, agit aussi le stockage des lipides. Selon sa localisation, elle jouerait des rôles différents. Une découverte qui permet u...
www.radiofrance.fr
November 5, 2025 at 6:48 AM
[Podcast] Avec Sciences | "La double vie d'une enzyme du métabolisme des graisses" par @alexandradelbot.bsky.social
Reposted by François Leulier
The Initiative for Science in Europe, of which EMBO is a member, has just released its statement on the European Commission’s proposal for the next Multiannual Financial Framework (MFF 2028–34), including Framework Programme 10 (FP10).
Read the full statement here:
initiative-se.eu/wp-content/u...
Read the full statement here:
initiative-se.eu/wp-content/u...
November 4, 2025 at 4:51 PM
The Initiative for Science in Europe, of which EMBO is a member, has just released its statement on the European Commission’s proposal for the next Multiannual Financial Framework (MFF 2028–34), including Framework Programme 10 (FP10).
Read the full statement here:
initiative-se.eu/wp-content/u...
Read the full statement here:
initiative-se.eu/wp-content/u...
Reposted by François Leulier
'When Mendel began his investigation, his first inclination was to try breeding mice of different colors. However, before his mice experiment really got going, Mendel was forced to switch the subject of his experiments to peas by a prudish bishop uncomfortable with animals having sex in the abbey.'
Origins of the Lab Mouse
How the mouse found its way from Victorian novelty to a biomedical mainstay.
www.asimov.press
November 3, 2025 at 6:25 PM
'When Mendel began his investigation, his first inclination was to try breeding mice of different colors. However, before his mice experiment really got going, Mendel was forced to switch the subject of his experiments to peas by a prudish bishop uncomfortable with animals having sex in the abbey.'
Reposted by François Leulier
We’re excited for our very first “Metabolism in Development & Physiology” seminar next week!
🗓 13 Nov 2025, 16:00 CET
🎙 Alexander Aulehla (EMBL Heidelberg)
🎙 Christopher Bell (Uni of Oxford)
Register here to join the the talks: forms.gle/Y8QzucogKKrZ...
🗓 13 Nov 2025, 16:00 CET
🎙 Alexander Aulehla (EMBL Heidelberg)
🎙 Christopher Bell (Uni of Oxford)
Register here to join the the talks: forms.gle/Y8QzucogKKrZ...
November 3, 2025 at 2:09 PM
We’re excited for our very first “Metabolism in Development & Physiology” seminar next week!
🗓 13 Nov 2025, 16:00 CET
🎙 Alexander Aulehla (EMBL Heidelberg)
🎙 Christopher Bell (Uni of Oxford)
Register here to join the the talks: forms.gle/Y8QzucogKKrZ...
🗓 13 Nov 2025, 16:00 CET
🎙 Alexander Aulehla (EMBL Heidelberg)
🎙 Christopher Bell (Uni of Oxford)
Register here to join the the talks: forms.gle/Y8QzucogKKrZ...
Congrats Meiling, team and collaborators. Nice to see you are pushing the search for the mechanistic underpinnings of L.plantarum’s influence on mammalian developmental growth.
🐭 #Lactiplantibacillus plantarum Hi188 promotes post-weaning growth in mice.
🧪 The #metabolite 5-HIAA activates hepatic #AhR, boosting IGF-1 production.
🧑💻 Metagenomic and host transcriptome data reveal that 5-HIAA is co-produced by the host–microbiota axis.
🔗 doi.org/10.1002/imo2...
#microbiome
🧪 The #metabolite 5-HIAA activates hepatic #AhR, boosting IGF-1 production.
🧑💻 Metagenomic and host transcriptome data reveal that 5-HIAA is co-produced by the host–microbiota axis.
🔗 doi.org/10.1002/imo2...
#microbiome
Host–microbiota interaction drives 5‐hydroxyindole‐3‐acetic acid production to promote linear growth in infant mice
This study discovered that Lactiplantibacillus plantarum Hi188 promoted linear growth in postweaning mice. Transcriptomic analysis, untargeted metabolomics, and in vitro experiments showed that the e...
doi.org
November 1, 2025 at 6:12 PM
Congrats Meiling, team and collaborators. Nice to see you are pushing the search for the mechanistic underpinnings of L.plantarum’s influence on mammalian developmental growth.
Reposted by François Leulier
Join us in Montpellier if you are interested in #evolution #genomics #adaptation #invasive species or if you want to get to know a collegial group of #Drosophila enthusiasts
🪰 🧬16th #DrosEU2026 Workshop & Satellite #DrosophilaSuzukii Meeting Conference will take place 13–17 April 2026 in #Montpellier, France 🇫🇷.
We look forward to connecting with colleagues across Europe to discuss new research in #Drosophila #genomics #evolution & #CitizenScience +info 👉 droseu.net
We look forward to connecting with colleagues across Europe to discuss new research in #Drosophila #genomics #evolution & #CitizenScience +info 👉 droseu.net
October 31, 2025 at 5:59 PM
Join us in Montpellier if you are interested in #evolution #genomics #adaptation #invasive species or if you want to get to know a collegial group of #Drosophila enthusiasts
Reposted by François Leulier
So looking forward to this. Please sign up!!
I am very excited to announce the opening of the submission site for the upcoming Conférences Jacques Monod on Developmental Biology, May 18-22, 2026 cjm.sb-roscoff.fr/en/conferenc...
@lionlchristiaen.bsky.social and I have an exciting program of speakers and slots for selected short talks, etc.
@lionlchristiaen.bsky.social and I have an exciting program of speakers and slots for selected short talks, etc.
October 30, 2025 at 5:19 AM
So looking forward to this. Please sign up!!
Reposted by François Leulier
🪰 folks! Despite Harvard lawsuit outcome, FlyBase NIH grant was not released. FlyBase now runs on the public, like NPR, PBS etc. If we don't step up, it can go away! Donations site on flybase.org homepage. Note: it links to IU stock center, but its for FlyBase, see instructions. pls give+share! 2/2
FlyBase Homepage
FlyBase: a database for drosophila genetics and molecular biology
flybase.org
October 29, 2025 at 12:31 PM
🪰 folks! Despite Harvard lawsuit outcome, FlyBase NIH grant was not released. FlyBase now runs on the public, like NPR, PBS etc. If we don't step up, it can go away! Donations site on flybase.org homepage. Note: it links to IU stock center, but its for FlyBase, see instructions. pls give+share! 2/2
Reposted by François Leulier
#RP_INRAE De nouvelles pistes de recherche dans la lutte contre les insectes ravageurs avec la découverte de structures membranaires en réseau construites par des bactéries symbiotiques du charançon pour mieux se nourrir.
Étude co-pilotée avec @insa-lyon.fr
➡️ url.inrae.fr/4qLzH1g
Étude co-pilotée avec @insa-lyon.fr
➡️ url.inrae.fr/4qLzH1g
October 29, 2025 at 2:21 PM
#RP_INRAE De nouvelles pistes de recherche dans la lutte contre les insectes ravageurs avec la découverte de structures membranaires en réseau construites par des bactéries symbiotiques du charançon pour mieux se nourrir.
Étude co-pilotée avec @insa-lyon.fr
➡️ url.inrae.fr/4qLzH1g
Étude co-pilotée avec @insa-lyon.fr
➡️ url.inrae.fr/4qLzH1g
Reposted by François Leulier
We are thrilled to announce the inaugural Metabolism in Development & Physiology virtual seminar, a new series connecting researchers across all stages & disciplines in metabolism!
🗓 13 Nov 2025, 16:00 CET
🎙 Alexander Aulehla (EMBL Heidelberg), &
🎙 Christopher Bell (Uni of Oxford)
See you there!
🗓 13 Nov 2025, 16:00 CET
🎙 Alexander Aulehla (EMBL Heidelberg), &
🎙 Christopher Bell (Uni of Oxford)
See you there!
October 28, 2025 at 4:13 PM
We are thrilled to announce the inaugural Metabolism in Development & Physiology virtual seminar, a new series connecting researchers across all stages & disciplines in metabolism!
🗓 13 Nov 2025, 16:00 CET
🎙 Alexander Aulehla (EMBL Heidelberg), &
🎙 Christopher Bell (Uni of Oxford)
See you there!
🗓 13 Nov 2025, 16:00 CET
🎙 Alexander Aulehla (EMBL Heidelberg), &
🎙 Christopher Bell (Uni of Oxford)
See you there!
Reposted by François Leulier
We selected the laziest mouse at each round to inoculate the next batch of germfree mice: over rounds of selection and passaging, behavior shifted without changes to the mouse genome: rdcu.be/eM3rO
🦠🧫
🦠🧫
Selection and transmission of the gut microbiome alone can shift mammalian behavior
Nature Communications - Here, the authors present evidence that the gut microbiome alone, without changes in the host genome, can shape how animals respond to selection, identifying a bacterium and...
rdcu.be
October 28, 2025 at 7:51 AM
We selected the laziest mouse at each round to inoculate the next batch of germfree mice: over rounds of selection and passaging, behavior shifted without changes to the mouse genome: rdcu.be/eM3rO
🦠🧫
🦠🧫
Reposted by François Leulier
"En France aussi, la liberté académique subit des attaques politiques depuis plusieurs années, notamment avec l’émergence de groupes d’intérêt (...)"
www.lemonde.fr/sciences/art...
www.lemonde.fr/sciences/art...
Budget 2026 : « La taxation des expérimentations animales mettrait en péril la recherche en France »
TRIBUNE. Dans une tribune au « Monde », des représentants de sociétés savantes, de fondations, d’associations et de réseaux scientifiques mettent en garde contre le dépôt d’amendements au projet de lo...
www.lemonde.fr
October 28, 2025 at 5:30 PM
"En France aussi, la liberté académique subit des attaques politiques depuis plusieurs années, notamment avec l’émergence de groupes d’intérêt (...)"
www.lemonde.fr/sciences/art...
www.lemonde.fr/sciences/art...
« … Un Français consomme en moyenne plus de 10 000 animaux au cours de sa vie alors qu’il en utilise indirectement seulement 2,5 en moyenne pour la recherche scientifique et biomédicale … »
Les extrêmes mettent en danger notre démocratie mais aussi la science et la santé. J’ai cosigné une tribune publiée dans Le Monde aujourd’hui pour dénoncer les amendements LFI/RN visant à taxer l’expérimentation animale car ils constituent une menace pour la recherche et les découvertes médicales 🔬
Budget 2026 : « La taxation des expérimentations animales mettrait en péril la recherche en France »
TRIBUNE. Dans une tribune au « Monde », des représentants de sociétés savantes, de fondations, d’associations et de réseaux scientifiques mettent en garde contre le dépôt d’amendements au projet de lo...
www.lemonde.fr
October 28, 2025 at 5:58 PM
« … Un Français consomme en moyenne plus de 10 000 animaux au cours de sa vie alors qu’il en utilise indirectement seulement 2,5 en moyenne pour la recherche scientifique et biomédicale … »
Reposted by François Leulier
Les extrêmes mettent en danger notre démocratie mais aussi la science et la santé. J’ai cosigné une tribune publiée dans Le Monde aujourd’hui pour dénoncer les amendements LFI/RN visant à taxer l’expérimentation animale car ils constituent une menace pour la recherche et les découvertes médicales 🔬
Budget 2026 : « La taxation des expérimentations animales mettrait en péril la recherche en France »
TRIBUNE. Dans une tribune au « Monde », des représentants de sociétés savantes, de fondations, d’associations et de réseaux scientifiques mettent en garde contre le dépôt d’amendements au projet de lo...
www.lemonde.fr
October 28, 2025 at 5:55 PM
Les extrêmes mettent en danger notre démocratie mais aussi la science et la santé. J’ai cosigné une tribune publiée dans Le Monde aujourd’hui pour dénoncer les amendements LFI/RN visant à taxer l’expérimentation animale car ils constituent une menace pour la recherche et les découvertes médicales 🔬
Reposted by François Leulier
Bizarre that our 2020 #Drosophila #AMP review already feels out of date.
Thanks to #AnnualReviews to cover the many updates in the field and present a much more complete picture of the diversity, mechanisms, topics, of fly immunity re: host defence peptides.
www.annualreviews.org/content/jour...
Thanks to #AnnualReviews to cover the many updates in the field and present a much more complete picture of the diversity, mechanisms, topics, of fly immunity re: host defence peptides.
www.annualreviews.org/content/jour...
October 24, 2025 at 12:05 PM
Bizarre that our 2020 #Drosophila #AMP review already feels out of date.
Thanks to #AnnualReviews to cover the many updates in the field and present a much more complete picture of the diversity, mechanisms, topics, of fly immunity re: host defence peptides.
www.annualreviews.org/content/jour...
Thanks to #AnnualReviews to cover the many updates in the field and present a much more complete picture of the diversity, mechanisms, topics, of fly immunity re: host defence peptides.
www.annualreviews.org/content/jour...
The regrowth of Fly labs in Gif continues, great to read!!! 👏
I'm thrilled to announce that I’m opening my own research team in the Department of Genome Biology at I2BC @i2bcparissaclay.bsky.social ! #ATIP-Avenir
Very excited to start this new adventure! www.i2bc.paris-saclay.fr/equipe-intra...
Very excited to start this new adventure! www.i2bc.paris-saclay.fr/equipe-intra...
Equipe Courret – Institute for Integrative Biology of the Cell
www.i2bc.paris-saclay.fr
October 25, 2025 at 5:24 AM
The regrowth of Fly labs in Gif continues, great to read!!! 👏
Reposted by François Leulier
On mange des OGM tous les jours depuis plusieurs décennies (les plantes obtenues par mutagénèse chimique ou radiative) et ça ne pose aucun problème
Il est temps que les institutions européennes défendent l'intérêt général et le droit des consommateurs à savoir ce qu'ils mangent et à choisir librement. #NGT #NouveauxOGM
October 24, 2025 at 8:32 PM
On mange des OGM tous les jours depuis plusieurs décennies (les plantes obtenues par mutagénèse chimique ou radiative) et ça ne pose aucun problème
Reposted by François Leulier
Learn more about recent advances in anaerobic #microbiology at EMBO Practical Course "Breathless Microbes: Life With No Oxygen" in Nijmegen, Netherlands, 6–10 July 2026. 🧪
Deadline: 15 April 2026
meetings.embo.org/event/26-bre...
#EMBObreathless #EMBOevents #MicroSky #biotechnology #biochemistry
Deadline: 15 April 2026
meetings.embo.org/event/26-bre...
#EMBObreathless #EMBOevents #MicroSky #biotechnology #biochemistry
Breathless Microbes: Life With No Oxygen
Recent advances in anaerobic microbiology have driven significant progress in biotechnology, environmental microbiology, and biochemistry. Anaerobes play key roles in sustainable biotechnological pro…
meetings.embo.org
October 25, 2025 at 4:32 AM
Learn more about recent advances in anaerobic #microbiology at EMBO Practical Course "Breathless Microbes: Life With No Oxygen" in Nijmegen, Netherlands, 6–10 July 2026. 🧪
Deadline: 15 April 2026
meetings.embo.org/event/26-bre...
#EMBObreathless #EMBOevents #MicroSky #biotechnology #biochemistry
Deadline: 15 April 2026
meetings.embo.org/event/26-bre...
#EMBObreathless #EMBOevents #MicroSky #biotechnology #biochemistry