Our results in #Drosophila illustrate that enterokines can regulate IGF signalling, beyond insulin release per se. An evolutionarily conserved or convergent strategy in regulating developmental plasticity in animals?
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This work expands the concept of decretins, first proposed by Seung K. Kim al. in the context of sugar metabolism regulation in adults, to include developmental pace control
www.cell.com/cell-metabol...
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We establish that Limostatin acts as a « decretin » (in opposition to the famous incretin, such as GLP-1), ie decreasing circulating levels of Insulin-like peptides, enabling juveniles to adapt developmental pace and preserve viability while nutrients are scarce
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We found Limostatin induced in a handful of enteroendocrine cells ONLY when nutrient shortage is sensed
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Limostatin is a nutrient-sensitive enterokine coordinating developmental plasticity through inter-organ signalling
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🪰 folks! Despite Harvard lawsuit outcome, FlyBase NIH grant was not released. FlyBase now runs on the public, like NPR, PBS etc. If we don't step up, it can go away! Donations site on flybase.org homepage. Note: it links to IU stock center, but its for FlyBase, see instructions. pls give+share! 2/2