BrunetLab
@brunetlab.bsky.social
Aging lab @Stanford. Our interests include mechanisms of aging, brain aging and rejuvenation, neural stem cell aging, genetics of lifespan and suspended animation in killifish
Pinned
BrunetLab
@brunetlab.bsky.social
· Dec 18
Spatial transcriptomic clocks reveal cell proximity effects in brain ageing
Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...
rdcu.be
Thrilled to see this paper out!! 🧪
Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!
Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!
rdcu.be/d33uQ 🧵
Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!
Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!
rdcu.be/d33uQ 🧵
Reposted by BrunetLab
I'm just delighted to announce our new preprint on genome-scale perturb-seq in CD4+ T cells. We learned both general lessons about the power of perturb-seq, and specific lessons about T cell biology.
Led by amazing postdocs Emma Dann and Ronghui Zhu, with my wonderful collaborator Alex Marson.
Led by amazing postdocs Emma Dann and Ronghui Zhu, with my wonderful collaborator Alex Marson.
Together with @ronghuizhu.bsky.social, we are thrilled to present our new perturb-seq study of 22M primary CD4+ T cells, across donors and timepoints – the result of a decade-long collaboration between the Marson @marsonlab.bsky.social and Pritchard @jkpritch.bsky.social labs 🧵 tinyurl.com/gwt2025
Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traits
Gene regulatory networks encode the fundamental logic of cellular functions, but systematic network mapping remains challenging, especially in cell states relevant to human biology and disease. Here, ...
tinyurl.com
January 5, 2026 at 7:27 PM
I'm just delighted to announce our new preprint on genome-scale perturb-seq in CD4+ T cells. We learned both general lessons about the power of perturb-seq, and specific lessons about T cell biology.
Led by amazing postdocs Emma Dann and Ronghui Zhu, with my wonderful collaborator Alex Marson.
Led by amazing postdocs Emma Dann and Ronghui Zhu, with my wonderful collaborator Alex Marson.
Reposted by BrunetLab
We have had a lot of requests for the protocol for single-nucleus RNA-seq of adult C. elegans neurons that our lab developed - I hope that you find this helpful! 🧪 #Celegans www.sciencedirect.com/science/arti...
Protocol for single-nucleus RNA sequencing of adult C. elegans neurons
Single-nucleus sequencing, specifically, remains the gold standard for characterizing difficult-to-dissociate cell types, such as neurons in complex b…
www.sciencedirect.com
December 19, 2025 at 4:28 PM
We have had a lot of requests for the protocol for single-nucleus RNA-seq of adult C. elegans neurons that our lab developed - I hope that you find this helpful! 🧪 #Celegans www.sciencedirect.com/science/arti...
Reposted by BrunetLab
New paper alert!!...🤩 Led by @blogeman.bsky.social, we identify how cell type-specific hormonal responses in the hypothalamus tunes parenting behavior in males and females 🐭🧠🍼. Highlights in thread 👇 1/6
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Cell Type-Specific Hormonal Signaling Configures Hypothalamic Circuits for Parenting
Parenting behavior emerges from hormonally sensitive circuits, but how distinct circuit components are affected by, and contribute to, sex and state dependent changes in infant caregiving remains uncl...
www.biorxiv.org
December 13, 2025 at 2:03 PM
New paper alert!!...🤩 Led by @blogeman.bsky.social, we identify how cell type-specific hormonal responses in the hypothalamus tunes parenting behavior in males and females 🐭🧠🍼. Highlights in thread 👇 1/6
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by BrunetLab
Remarkable energy at the inaugural @cshlnews.bsky.social conference on Assembloids and complex cell–cell interactions across tissues and systems
A wonderful series of talks so far highlighting advances & discoveries being made with these self-organizing systems and a few common themes are emerging
A wonderful series of talks so far highlighting advances & discoveries being made with these self-organizing systems and a few common themes are emerging
December 10, 2025 at 8:50 PM
Remarkable energy at the inaugural @cshlnews.bsky.social conference on Assembloids and complex cell–cell interactions across tissues and systems
A wonderful series of talks so far highlighting advances & discoveries being made with these self-organizing systems and a few common themes are emerging
A wonderful series of talks so far highlighting advances & discoveries being made with these self-organizing systems and a few common themes are emerging
Reposted by BrunetLab
Our latest collaboration with @jkpritch.bsky.social – led by joint post-doc Mineto Ota – is in @nature.com today: www.nature.com/articles/s41...
December 10, 2025 at 10:57 PM
Our latest collaboration with @jkpritch.bsky.social – led by joint post-doc Mineto Ota – is in @nature.com today: www.nature.com/articles/s41...
Reposted by BrunetLab
I am thrilled to share our latest work led by @zurisullivan.bsky.social in collaboration with @moffittlab.bsky.social ! We find that the brain encodes distinct, pathogen-specific sickness states across behavior, physiology, neural activity, and gene expression 1/6
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
www.biorxiv.org
December 9, 2025 at 12:05 PM
I am thrilled to share our latest work led by @zurisullivan.bsky.social in collaboration with @moffittlab.bsky.social ! We find that the brain encodes distinct, pathogen-specific sickness states across behavior, physiology, neural activity, and gene expression 1/6
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by BrunetLab
S-adenosylmethionine synthases (SAMS) have distinct roles in #StressResponse & #mitochondrial metabolism in #Celegans. @akw-lab.bsky.social &co show that SAMS-1 supports broad metabolic functions (e.g. PC synthesis), while SAMS-4 aids protein transmethylation @plosbiology.org 🧪 plos.io/4rvQvtt
December 3, 2025 at 9:10 AM
S-adenosylmethionine synthases (SAMS) have distinct roles in #StressResponse & #mitochondrial metabolism in #Celegans. @akw-lab.bsky.social &co show that SAMS-1 supports broad metabolic functions (e.g. PC synthesis), while SAMS-4 aids protein transmethylation @plosbiology.org 🧪 plos.io/4rvQvtt
Interested in neural stem cells and neurogenesis throughout lifespan?
Exciting meeting in 2026 in Switzerland!!
neuro-unige.ch/news/csf-mee...
Exciting meeting in 2026 in Switzerland!!
neuro-unige.ch/news/csf-mee...
Conference: Neurogenesis from development to adulthood in health and disease
The adult brain consists of billions of neurons that show an unimaginable complexity in their structural diversity and functional connectivity allowing for a plethora of brain functions. Notably…
neuro-unige.ch
December 2, 2025 at 6:54 PM
Interested in neural stem cells and neurogenesis throughout lifespan?
Exciting meeting in 2026 in Switzerland!!
neuro-unige.ch/news/csf-mee...
Exciting meeting in 2026 in Switzerland!!
neuro-unige.ch/news/csf-mee...
Reposted by BrunetLab
Here is a copy of last year's Twitter thread explaining our preprint - jump to (21) for the new stuff 👀
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
November 27, 2025 at 9:59 PM
Here is a copy of last year's Twitter thread explaining our preprint - jump to (21) for the new stuff 👀
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
Reposted by BrunetLab
Excellent commentary on transgenerational inheritance and the importance of rigor and reproducibility.
Subtitled: when a colleague drags and tries to throw you under the bus because they couldn't follow protocols
@ctmurphy1.bsky.social
Subtitled: when a colleague drags and tries to throw you under the bus because they couldn't follow protocols
@ctmurphy1.bsky.social
I wrote this insight for eLife. A friend said, "Why would you want to step on that rake?". Well, I guess that's just who I am. Enjoy. elifesciences.org/articles/109...
Transgenerational Epigenetic Inheritance: Twists and turns in the story of learned avoidance
Evidence that learned avoidance of a pathogenic bacterium can be transmitted to future generations in C. elegans is growing.
elifesciences.org
November 11, 2025 at 11:44 PM
Excellent commentary on transgenerational inheritance and the importance of rigor and reproducibility.
Subtitled: when a colleague drags and tries to throw you under the bus because they couldn't follow protocols
@ctmurphy1.bsky.social
Subtitled: when a colleague drags and tries to throw you under the bus because they couldn't follow protocols
@ctmurphy1.bsky.social
Reposted by BrunetLab
Love this Insight by @steeltownworms.bsky.social on a series of @elife.bsky.social papers on what it takes to reproduce a phenomenon of transgenerationally transmitted learned pathogen avoidance in C. elegans. Thank you, Lesley!
elifesciences.org/articles/109...
elifesciences.org/articles/109...
November 11, 2025 at 7:41 PM
Love this Insight by @steeltownworms.bsky.social on a series of @elife.bsky.social papers on what it takes to reproduce a phenomenon of transgenerationally transmitted learned pathogen avoidance in C. elegans. Thank you, Lesley!
elifesciences.org/articles/109...
elifesciences.org/articles/109...
Cool neurogenesis meeting in the Swiss Alps!!
'Neurogenesis from development to adulthood in health and disease'
To submit an application: asconameeting@unige.ch
'Neurogenesis from development to adulthood in health and disease'
To submit an application: asconameeting@unige.ch
November 11, 2025 at 4:30 PM
Cool neurogenesis meeting in the Swiss Alps!!
'Neurogenesis from development to adulthood in health and disease'
To submit an application: asconameeting@unige.ch
'Neurogenesis from development to adulthood in health and disease'
To submit an application: asconameeting@unige.ch
Reposted by BrunetLab
Science brings us new miracles every day. Update from a mother whose son was the first patient dosed with Grace Science's gene therapy for NGly1 deficiency (GS-100). Video can be seen on YouTube. #glycotime
www.youtube.com/watch?v=tdNn...
www.youtube.com/watch?v=tdNn...
www.youtube.com
October 31, 2025 at 4:24 PM
Science brings us new miracles every day. Update from a mother whose son was the first patient dosed with Grace Science's gene therapy for NGly1 deficiency (GS-100). Video can be seen on YouTube. #glycotime
www.youtube.com/watch?v=tdNn...
www.youtube.com/watch?v=tdNn...
Reposted by BrunetLab
Nice cover of our work linking SRGAP2/SYNGAP1 synaptic neoteny and ID/ASD with @blibep.bsky.social @benvermaercke.bsky.social @franckp.bsky.social @boninlab.bsky.social @cecilecharrier.bsky.social www.thetransmitter.org/spectrum/pro...
Protein tug-of-war controls pace of synaptic development, sets human brains apart
Human-specific duplicates of SRGAP2 prolong cortical development by manipulating SYNGAP, an autism-linked protein that slows synaptic growth.
www.thetransmitter.org
October 26, 2025 at 3:40 PM
Nice cover of our work linking SRGAP2/SYNGAP1 synaptic neoteny and ID/ASD with @blibep.bsky.social @benvermaercke.bsky.social @franckp.bsky.social @boninlab.bsky.social @cecilecharrier.bsky.social www.thetransmitter.org/spectrum/pro...
Reposted by BrunetLab
Thank you Alzforum for featuring our new preprint identifying regulators of disease states of #microglia.
Project led by Amanda McQuade, computation by Reet Mishra, collaboration with the Nunez and De Jager labs.
Alzforum
www.alzforum.org/news/researc...
Preprint
www.biorxiv.org/content/10.1...
Project led by Amanda McQuade, computation by Reet Mishra, collaboration with the Nunez and De Jager labs.
Alzforum
www.alzforum.org/news/researc...
Preprint
www.biorxiv.org/content/10.1...
October 22, 2025 at 6:28 PM
Thank you Alzforum for featuring our new preprint identifying regulators of disease states of #microglia.
Project led by Amanda McQuade, computation by Reet Mishra, collaboration with the Nunez and De Jager labs.
Alzforum
www.alzforum.org/news/researc...
Preprint
www.biorxiv.org/content/10.1...
Project led by Amanda McQuade, computation by Reet Mishra, collaboration with the Nunez and De Jager labs.
Alzforum
www.alzforum.org/news/researc...
Preprint
www.biorxiv.org/content/10.1...
Reposted by BrunetLab
For obvious reasons, I've become fascinated with retrotransposons. So we ( @alexwhiteley.bsky.social and I) wrote an article now out in Neuron @cellpress.bsky.social on how we think retrotransposons influence brain function and health! kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
October 20, 2025 at 8:00 PM
For obvious reasons, I've become fascinated with retrotransposons. So we ( @alexwhiteley.bsky.social and I) wrote an article now out in Neuron @cellpress.bsky.social on how we think retrotransposons influence brain function and health! kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
Reposted by BrunetLab
During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost!
apply.interfolio.com/174756
apply.interfolio.com/174756
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
October 14, 2025 at 5:35 PM
During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost!
apply.interfolio.com/174756
apply.interfolio.com/174756
Reposted by BrunetLab
I'm very excited to announce that UNC Biology has 6 faculty positions open this year! The first is for an Asst Professor who studies organismal resilience using an integrative approach 1/n
unc.peopleadmin.com/postings/307...
unc.peopleadmin.com/postings/307...
October 12, 2025 at 2:20 PM
I'm very excited to announce that UNC Biology has 6 faculty positions open this year! The first is for an Asst Professor who studies organismal resilience using an integrative approach 1/n
unc.peopleadmin.com/postings/307...
unc.peopleadmin.com/postings/307...
Reposted by BrunetLab
✨ It's happening again! 🚀 Registration for Stem Cells in Neuroscience 2026 has officially opened! 🧠 Don't miss your chance to attend this exciting event with great keynote speakers, thought-provoking workshops and ample networking opportunities 👉🏼 www.stemcelltuebingen.com #neuroscience #stemcells
October 2, 2025 at 3:43 PM
✨ It's happening again! 🚀 Registration for Stem Cells in Neuroscience 2026 has officially opened! 🧠 Don't miss your chance to attend this exciting event with great keynote speakers, thought-provoking workshops and ample networking opportunities 👉🏼 www.stemcelltuebingen.com #neuroscience #stemcells
Reposted by BrunetLab
It should be great!
Learn all things C. elegans #research at the EMBO | The Company of Biologists Workshop "C. elegans Biology: IV LAWM" in Merida, Mexico, 24–28 February 2026.
Registration by 16 January 2026
Abstract submission by 17 October 2025
meetings.embo.org/event/26-worm
#EMBOWorms2026 #EMBOevents 🧪
Registration by 16 January 2026
Abstract submission by 17 October 2025
meetings.embo.org/event/26-worm
#EMBOWorms2026 #EMBOevents 🧪
C. elegans Biology: IV LAWM
This EMBO Workshop on C. elegans Biology is t he IV Latin American Worm Meeting. It will convene in Mérida, Mexico. The overall mission of this meeting is to create an inclusive environment that pro…
meetings.embo.org
September 24, 2025 at 3:07 PM
It should be great!
Interesting in aging, immune function, and organ health?
Join us for a super exciting joint Keystone Symposia in Banff, Canada in March 2026!!
@ericverdin.bsky.social
Join us for a super exciting joint Keystone Symposia in Banff, Canada in March 2026!!
@ericverdin.bsky.social
September 23, 2025 at 8:52 PM
Interesting in aging, immune function, and organ health?
Join us for a super exciting joint Keystone Symposia in Banff, Canada in March 2026!!
@ericverdin.bsky.social
Join us for a super exciting joint Keystone Symposia in Banff, Canada in March 2026!!
@ericverdin.bsky.social
Reposted by BrunetLab
🎉 Congratulations to Needhi Bhalla, UC Santa Cruz (www.bhallalab.com
), named a 2025 #ASCB Fellow! This honor celebrates her outstanding contributions to cell biology, leadership, & service. Fellows will be recognized at #CellBio2025 in Philadelphia this December. #CellBiology
), named a 2025 #ASCB Fellow! This honor celebrates her outstanding contributions to cell biology, leadership, & service. Fellows will be recognized at #CellBio2025 in Philadelphia this December. #CellBiology
September 19, 2025 at 7:37 PM
🎉 Congratulations to Needhi Bhalla, UC Santa Cruz (www.bhallalab.com
), named a 2025 #ASCB Fellow! This honor celebrates her outstanding contributions to cell biology, leadership, & service. Fellows will be recognized at #CellBio2025 in Philadelphia this December. #CellBiology
), named a 2025 #ASCB Fellow! This honor celebrates her outstanding contributions to cell biology, leadership, & service. Fellows will be recognized at #CellBio2025 in Philadelphia this December. #CellBiology
Reposted by BrunetLab
New preprint from our lab!
What can we learn about the properties of gene regulatory elements by CRISPR’ing a random set of accessible sites in human cells?
Find out here: www.biorxiv.org/content/10.1...
👇
1/
What can we learn about the properties of gene regulatory elements by CRISPR’ing a random set of accessible sites in human cells?
Find out here: www.biorxiv.org/content/10.1...
👇
1/
September 19, 2025 at 3:03 AM
New preprint from our lab!
What can we learn about the properties of gene regulatory elements by CRISPR’ing a random set of accessible sites in human cells?
Find out here: www.biorxiv.org/content/10.1...
👇
1/
What can we learn about the properties of gene regulatory elements by CRISPR’ing a random set of accessible sites in human cells?
Find out here: www.biorxiv.org/content/10.1...
👇
1/
Exciting meeting in beautiful Ascona, Switzerland!!
September 17, 2025 at 2:51 PM
Exciting meeting in beautiful Ascona, Switzerland!!
Reposted by BrunetLab
🚨 New from our lab: Here we explored how aging contributes to harmful protein aggregation in diseases like Huntington’s & ALS.
The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch
🧵
www.nature.com/articles/s43...
The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch
🧵
www.nature.com/articles/s43...
The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation - Nature Aging
Aging is a risk factor for neurodegenerative diseases associated with protein aggregation. Here the authors identify age-related hyperactivation of EPS8/RAC signaling in C. elegans as a driver of path...
www.nature.com
September 3, 2025 at 9:19 AM
🚨 New from our lab: Here we explored how aging contributes to harmful protein aggregation in diseases like Huntington’s & ALS.
The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch
🧵
www.nature.com/articles/s43...
The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch
🧵
www.nature.com/articles/s43...