Compartmentalized inflammation is a key driver of multiple sclerosis (MS) progression, but the mechanisms sustaining its persistence remain unclear. A…

Degeneration of myelinating oligodendrocytes and the resulting breakdown of the myelin sheath are key drivers of neurodegeneration and disability across numerous central nervous system pathologies. Thus, a compelling strategy to preserve neuronal function is to promote endogenous myelin repair by oligodendrocyte precursor cells (OPCs). Extracellular vesicles (EVs) secreted by pro-regenerative microglia have been shown to enhance OPC maturation and remyelination across different experimental m...

Sheehan et al. have characterized the circadian translatomes of astrocytes and microglia in the mouse cortex in the context of amyloid pathology or aging, revealing cell- and disease-specific reprogra...

The developmental dynamics of distinct cell types across brain regions remain poorly understood. Here authors generate DevAtlas, a high-resolution developmental 3D atlas, mapping region and cell type-...

Microglia are resident immune cells of the central nervous system (CNS) that dynamically adapt to their microenvironment to achieve multiple housekeeping roles. While ex vivo and in vitro models are i...

A first-of-its-kind whole genome map from researchers at Recursion with partners Roche and Genentech offers a new approach to exploring novel targets and pathways for a wide range of neurological dise...