Olivier Neyrolles
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oneyrolles.bsky.social
Olivier Neyrolles
@oneyrolles.bsky.social
Director of https://www.ipbs.fr Toulouse ๐Ÿ‡ซ๐Ÿ‡ท๐Ÿ‡ช๐Ÿ‡บ

Microbe-host enthusiast tackling TB and beyond | Passionate #SciComm advocate | #MicroSky #TBSky #CNRS | He/Him | Views mine
Pinned
๐Ÿšจ ๐๐ž๐ฐ ๐ฉ๐ซ๐ž๐ฉ๐ซ๐ข๐ง๐ญ ๐Ÿ๐ซ๐จ๐ฆ ๐จ๐ฎ๐ซ ๐ฅ๐š๐›, ๐š๐ง๐ ๐š ๐Ÿ๐ข๐ซ๐ฌ๐ญ ๐ข๐ง ๐ญ๐ก๐ž ๐“๐ ๐Ÿ๐ข๐ž๐ฅ๐! ๐Ÿšจ

Weโ€™re thrilled to share our new study revealing how the chromatin regulator SP140 preserves protective T cell immunity during #tuberculosis infection by restraining harmful type I IFN responses.

๐Ÿ“– ๐—ฅ๐—ฒ๐—ฎ๐—ฑ ๐˜๐—ต๐—ฒ ๐—ฝ๐—ฟ๐—ฒ๐—ฝ๐—ฟ๐—ถ๐—ป๐˜: shorturl.at/r5jd9
So inspiring to see the next generation of researchers in action. Their science gets clearer and more impactful every year.

Watching Max Caouaille and Aizat Abdul at #TBVAC was genuinely moving. Great science, great storytelling, huge passion.

The future of research is in very good hands. ๐Ÿ‘
January 29, 2026 at 6:02 PM
Reposted by Olivier Neyrolles
The Barber lab is looking to hire post-docs to work on #tuberculosis #immunology using murine and NHP models. BSL3 experience not required. Check out our lab in the NIH intramural program in Bethesda MD!
January 15, 2026 at 12:15 PM
Reposted by Olivier Neyrolles
A great meeting ahead for host and pathogen aficionados! Keynote speakers: Florence Niedergang (Cochin) and Raphael Valdivia (Duke)- plenty of opportunities for early career researchers to present their work and a very collegial and supportive network. Belfast here we go! Please repost.
SAVE THE DATE!

The 2026 UK CellularMicrobiologyNetwork meeting will be held 22nd - 23rd of June at @wwiem-qub.bsky.social in Belfast.

Researchers from the UK and beyond are invited to share exciting work on the mechanisms of host-pathogen interactions.

Follow us to stay tuned! www.ukcellmicro.org
January 12, 2026 at 6:34 PM
January 13, 2026 at 6:20 AM
These findings open new avenues for targeting monocyte mobilization in inflammatory diseases, infections, and autoimmune disorders like lupus.
๐Ÿ™Œ Huge thanks to the team, and our collaborators! Supported by @agencerecherche.bsky.social, @frm-officiel.bsky.social, and Bettencourt Schueller Foundation.
January 13, 2026 at 6:20 AM
...
๐Ÿ”น NCAM1 is the main polysialic acid carrier in inflammatory monocytes, and its loss phenocopies ST8SIA4 deficiency.
๐Ÿ”น Polysialylation regulates CCR2 surface distribution, cytoskeleton, and chemokine binding, revealing a new mechanism controlling immune cell trafficking.
January 13, 2026 at 6:20 AM
Key findings include:
๐Ÿ”น Human ๐‘†๐‘‡8๐‘†๐ผ๐ด4 variants are associated with lower monocyte and lymphocyte counts and higher SLE risk.
๐Ÿ”น ST8SIA4 deficiency causes monocytopenia in mice by impairing CCR2-dependent monocyte exit from bone marrow.
...
January 13, 2026 at 6:20 AM
Inflammatory monocytes are critical for fighting infections (like tuberculosis) and regulating inflammation. We found that the enzyme ST8SIA4, through polysialylation, controls their egress from the bone marrow via the CCR2 receptor, both at steady state and during ๐‘€. ๐‘ก๐‘ข๐‘๐‘’๐‘Ÿ๐‘๐‘ข๐‘™๐‘œ๐‘ ๐‘–๐‘  infection.
January 13, 2026 at 6:20 AM
๐Ÿฅณ ๐„๐ฑ๐œ๐ข๐ญ๐ž๐ ๐ญ๐จ ๐ฌ๐ก๐š๐ซ๐ž ๐จ๐ฎ๐ซ ๐ฅ๐š๐ญ๐ž๐ฌ๐ญ ๐ฐ๐จ๐ซ๐ค ๐ฌ๐ก๐จ๐ฐ๐ข๐ง๐  ๐ก๐จ๐ฐ ๐ฉ๐จ๐ฅ๐ฒ๐ฌ๐ข๐š๐ฅ๐ฒ๐ฅ๐š๐ญ๐ข๐จ๐ง, ๐š ๐ซ๐š๐ซ๐ž ๐ฉ๐ซ๐จ๐ญ๐ž๐ข๐ง ๐ฆ๐จ๐๐ข๐Ÿ๐ข๐œ๐š๐ญ๐ข๐จ๐ง, ๐ซ๐ž๐ ๐ฎ๐ฅ๐š๐ญ๐ž๐ฌ ๐ข๐ง๐Ÿ๐ฅ๐š๐ฆ๐ฆ๐š๐ญ๐จ๐ซ๐ฒ ๐ฆ๐จ๐ง๐จ๐œ๐ฒ๐ญ๐ž ๐ฆ๐จ๐›๐ข๐ฅ๐ข๐ณ๐š๐ญ๐ข๐จ๐ง ๐Ÿ๐ซ๐จ๐ฆ ๐ญ๐ก๐ž ๐›๐จ๐ง๐ž ๐ฆ๐š๐ซ๐ซ๐จ๐ฐ.

โœ๏ธ Aurรฉlien Boyancรฉ, Nelly Gilles, @yoannrombouts.bsky.social & coll. @ipbstoulouse.bsky.social

๐Ÿ“– shorturl.at/IDwza

๐Ÿ‘‡ A short thread...
January 13, 2026 at 6:20 AM
Nothing like a good meal with an even better team.
Hereโ€™s to a bright, productive 2026! ๐Ÿคฉ

@mcaouaille.bsky.social @saurabhchugh09.bsky.social @vogeleerp.bsky.social @yoannrombouts.bsky.social & more!
January 8, 2026 at 5:27 PM
Reposted by Olivier Neyrolles
Two pieces of fun news:

1. We've launched a new website for our lab: www.brysonlab.org

2. With some new funding, we are recruiting for new postdocs and graduate students. The projects build upon our previous studies of antigen presentation and phagosome biology and go into new exciting dimensions!
The Bryson Lab | Vaccine Development & Research at MIT
Developing effective accessible vaccines to end tuberculosis worldwide. Combining immunoengineering, molecular microbiology & systems biology at MIT.
www.brysonlab.org
December 18, 2025 at 6:29 PM
Reposted by Olivier Neyrolles
๐Ÿšจ We are excited to announce that @virginiestevenin.bsky.social has been awarded a starting grant from the @frm-officiel.bsky.social to establish her research team at IPBS and study the nutrition of pathogenic bacteria inside human host cells.
More info: shorturl.at/U6zSa

#MicroSky #Salmonella
December 18, 2025 at 4:48 AM
A big thank-you to @sheetalgandotra.bsky.social & @vivekrao.bsky.social and everyone at CSIR-IGIB for their warm welcome! ๐Ÿ˜Š
What a wonderful day with incredibly friendly hosts and such brilliant, motivated students!
๐Ÿ‡ซ๐Ÿ‡ท๐Ÿ‡ฎ๐Ÿ‡ณ Long live Franco-Indian cooperation!
December 12, 2025 at 4:20 PM
Huge congratulations to the entire team and to @mcaouaille.bsky.social for this outstanding PhD thesis work; an ambitious, beautifully executed study that pushes both TB immunology and intravital imaging into entirely new territory.

#Tuberculosis #ImmunoSky #MicroSky #Microscopy
December 11, 2025 at 6:07 AM
Combined with spectral cytometry and single-cell RNA-seq, these findings reveal how IFN-Iโ€“driven pathology creates physical and molecular barriers that undermine adaptive immunity, and how targeting this axis may reopen the path for effective T cellโ€“mediated control of TB.
December 11, 2025 at 6:07 AM
๐—จ๐˜€๐—ถ๐—ป๐—ด ๐˜๐—ต๐—ถ๐˜€ ๐—ฎ๐—ฝ๐—ฝ๐—ฟ๐—ผ๐—ฎ๐—ฐ๐—ต, ๐˜„๐—ฒ ๐—ณ๐—ผ๐˜‚๐—ป๐—ฑ ๐˜๐—ต๐—ฎ๐˜:
โ€ข Without SP140, excess IFN-I traps CD8โบ and CD4โบ T cells and prevents their movement in lesions.
โ€ข The few T cells that enter become almost immobile.
โ€ข Blocking IFNAR fully restores T cell motility and surveillance.
December 11, 2025 at 6:07 AM
๐Ÿ”ฌ ๐—™๐—ถ๐—ฟ๐˜€๐˜-๐—ฒ๐˜ƒ๐—ฒ๐—ฟ ๐—ถ๐—ป๐˜๐—ฟ๐—ฎ๐˜ƒ๐—ถ๐˜๐—ฎ๐—น ๐—น๐˜‚๐—ป๐—ด ๐—บ๐—ถ๐—ฐ๐—ฟ๐—ผ๐˜€๐—ฐ๐—ผ๐—ฝ๐˜† ๐—ถ๐—ป ๐—ง๐—• allowed us to watch T cells in real time inside infected lesions, an unprecedented view made possible by the work of Emma Lefranรงais, Lรฉa Fromont & colleagues. Preprint here: shorturl.at/gm20H
December 11, 2025 at 6:07 AM
๐Ÿšจ ๐๐ž๐ฐ ๐ฉ๐ซ๐ž๐ฉ๐ซ๐ข๐ง๐ญ ๐Ÿ๐ซ๐จ๐ฆ ๐จ๐ฎ๐ซ ๐ฅ๐š๐›, ๐š๐ง๐ ๐š ๐Ÿ๐ข๐ซ๐ฌ๐ญ ๐ข๐ง ๐ญ๐ก๐ž ๐“๐ ๐Ÿ๐ข๐ž๐ฅ๐! ๐Ÿšจ

Weโ€™re thrilled to share our new study revealing how the chromatin regulator SP140 preserves protective T cell immunity during #tuberculosis infection by restraining harmful type I IFN responses.

๐Ÿ“– ๐—ฅ๐—ฒ๐—ฎ๐—ฑ ๐˜๐—ต๐—ฒ ๐—ฝ๐—ฟ๐—ฒ๐—ฝ๐—ฟ๐—ถ๐—ป๐˜: shorturl.at/r5jd9
December 11, 2025 at 6:07 AM
๐—œ๐—ฃ๐—•๐—ฆ ๐—ฟ๐—ฒ๐˜€๐—ฒ๐—ฎ๐—ฟ๐—ฐ๐—ต๐—ฒ๐—ฟ๐˜€ ๐—ถ๐˜€๐—ผ๐—น๐—ฎ๐˜๐—ฒ๐—ฑ ๐—ต๐˜‚๐—บ๐—ฎ๐—ป ๐—ฟ๐—ฒ๐—ด๐˜‚๐—น๐—ฎ๐˜๐—ผ๐—ฟ๐˜† ๐—ฏ๐—ผ๐—ป๐—ฒ ๐—บ๐—ฎ๐—ฟ๐—ฟ๐—ผ๐˜„ ๐—ฎ๐—ฑ๐—ถ๐—ฝ๐—ผ๐—ฐ๐˜†๐˜๐—ฒ๐˜€ ๐—ณ๐—ผ๐—ฟ ๐˜๐—ต๐—ฒ ๐—ณ๐—ถ๐—ฟ๐˜€๐˜ ๐˜๐—ถ๐—บ๐—ฒ!

These anucleate fat cells still metabolize lipids and glucose, support blood cell production, and may shape the bone marrow niche and hematopoiesis.๐Ÿฉธ

๐Ÿ“– shorturl.at/bunUV
#Hematopoiesis #Adipocytes #BoneMarrow
December 5, 2025 at 12:48 PM
Reposted by Olivier Neyrolles
Hey friends. Iโ€™m looking for a postdoc interested in studying host-pathogen interactions and immunology of tuberculosis. Send me some good people! We have a great group here! Email me joanne@pitt.edu. Thanks!
December 4, 2025 at 5:12 PM
Reposted by Olivier Neyrolles
IPBS researchers created LiveLung-TB, a BSL-3 imaging platform that visualizes real-time immune responses in Mtb-infected lungs. They found most CD4 T cells fail to reach infected cells, revealing physical barriers that limit TB immunityโ€”a new window into host-pathogen dynamics! ๐Ÿ”ฌ๐Ÿซ
#Tuberculosis
December 3, 2025 at 5:43 PM
Itโ€™s not! ๐Ÿ˜‚๐Ÿคฆโ€โ™‚๏ธ
November 29, 2025 at 9:09 AM
Reposted by Olivier Neyrolles
#RรฉsultatScientifique ๐Ÿ”Ž | Comment les filaments d'actine s'organisent ร  l'intรฉrieur des cellules et des tissus vivants

๐Ÿ”ฌ @institutfresnel.bsky.social ๐Ÿค @univ-amu.fr @centralemed.bsky.social @cnrs.fr
๐Ÿ“ @cnrs-dr12.bsky.social
Comment les filaments d'actine s'organisent ร  l'intรฉrieur des cellules et des tissus vivants
En utilisant la microscopie de fluorescence rรฉsolue en polarisation, les biologistes et physiciens de l'Institut Fresnel, associรฉs ร  une รฉquipe internat
www.insis.cnrs.fr
November 26, 2025 at 9:58 AM
Reposted by Olivier Neyrolles
Why would Mycobacterium shed its surface right after entering a host cell? Host phagocytes rapidly strip its outer layer, releasing components that alert neighbors and trigger defense responses

Our preprint is out, curious to hear your take! ๐Ÿ‘€
www.biorxiv.org/content/10.1...
November 20, 2025 at 2:29 PM
Reposted by Olivier Neyrolles
๐Ÿ‘‡๐Ÿ‘‡Last days to submit your abstract to be considered for a short talk! Deadline 24 November!https://www.keystonesymposia.org/conferences/conference-listing/meeting/travel/c42026
Tuberculosis: Understanding the Disease Across Scales | Keystone Symposia
Join us at the Keystone Symposia on Tuberculosis: Understanding the Disease Across Scales, March 2026, in Cape Town, with field leaders!
www.keystonesymposia.org
November 19, 2025 at 8:48 PM