Max Gutierrez
@maxgg.bsky.social
Cell Biologist 🇦🇷&🇬🇧 at The Crick in London
Reposted by Max Gutierrez
Last couple of days to vote for your favourite 'Featured image' from 2025 ❤️🔬!
focalplane.biologists.com/2025/12/19/v...
focalplane.biologists.com/2025/12/19/v...
December 29, 2025 at 11:23 AM
Last couple of days to vote for your favourite 'Featured image' from 2025 ❤️🔬!
focalplane.biologists.com/2025/12/19/v...
focalplane.biologists.com/2025/12/19/v...
Pre-Christmas vibes at @crick.ac.uk 🎄
December 22, 2025 at 9:39 PM
Pre-Christmas vibes at @crick.ac.uk 🎄
Reposted by Max Gutierrez
‘Why solutions to antimicrobial resistance are urgently needed‘ sergemostowylab.bsky.social & I had the opportunity to write an editorial for @dmmjournal.bsky.social ‘s collection celebrating 100 years of @biologists.bsky.social you can read it here: journals.biologists.com/dmm/article/...
Why solutions to antimicrobial resistance are urgently needed
Summary: This Editorial discusses the growing global problem of antimicrobial resistance, and new and emerging opportunities for developing real-world solutions, involving both basic science and clini...
journals.biologists.com
December 19, 2025 at 11:46 AM
‘Why solutions to antimicrobial resistance are urgently needed‘ sergemostowylab.bsky.social & I had the opportunity to write an editorial for @dmmjournal.bsky.social ‘s collection celebrating 100 years of @biologists.bsky.social you can read it here: journals.biologists.com/dmm/article/...
Reposted by Max Gutierrez
We’re excited to share our latest study that reshapes our understanding of Mycobacterium tuberculosis (Mtb) lipid composition, with major implications for drug discovery, immunity, and vaccine development.
www.nature.com/articles/s41...
A thread.
www.nature.com/articles/s41...
A thread.
Mycobacterium tuberculosis overcomes phosphate starvation by extensively remodelling its lipidome with phosphorus-free lipids - Nature Communications
Here, the authors show that Mycobacterium tuberculosis manipulates lipid metabolism to overcome host restriction, by remodelling its lipidome and utilising host lipids as an alternative phosphate sour...
www.nature.com
December 22, 2025 at 1:11 PM
We’re excited to share our latest study that reshapes our understanding of Mycobacterium tuberculosis (Mtb) lipid composition, with major implications for drug discovery, immunity, and vaccine development.
www.nature.com/articles/s41...
A thread.
www.nature.com/articles/s41...
A thread.
Reposted by Max Gutierrez
Of course I like all the papers that we publish, but this is actually a very cool story, a great example of 'bush mechanics' in mycobacteria.
A new role for lipoproteins LpqZ and FecB in orchestrating mycobacterial cell envelope biogenesis | mBio journals.asm.org/doi/10.1128/...
A new role for lipoproteins LpqZ and FecB in orchestrating mycobacterial cell envelope biogenesis | mBio journals.asm.org/doi/10.1128/...
A new role for lipoproteins LpqZ and FecB in orchestrating mycobacterial cell envelope biogenesis | mBio
Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains the world’s deadliest bacterial infection, in part because the bacterium’s
unique cell envelope makes it highly resistant to antibioti...
journals.asm.org
December 13, 2025 at 8:28 AM
Of course I like all the papers that we publish, but this is actually a very cool story, a great example of 'bush mechanics' in mycobacteria.
A new role for lipoproteins LpqZ and FecB in orchestrating mycobacterial cell envelope biogenesis | mBio journals.asm.org/doi/10.1128/...
A new role for lipoproteins LpqZ and FecB in orchestrating mycobacterial cell envelope biogenesis | mBio journals.asm.org/doi/10.1128/...
Academia is just a job. And you need 29.95 quid to find out why...
December 11, 2025 at 7:45 AM
Academia is just a job. And you need 29.95 quid to find out why...
Reposted by Max Gutierrez
📢 Early-Career TB Researchers: Submit short talk abstracts & scholarship apps by Nov. 24! Join us Mar 23-26, 2026 in Cape Town for cutting-edge TB & global health. 🎥Highlights: youtu.be/YcKVeGWqXSM
Submit: keysym.us/KSTB26
@maxgg.bsky.social @breealdridge.bsky.social #KSTB26 #tuberculosis #TB
Submit: keysym.us/KSTB26
@maxgg.bsky.social @breealdridge.bsky.social #KSTB26 #tuberculosis #TB
Tuberculosis Meeting Promo
YouTube video by KeystoneSymposia
youtu.be
November 21, 2025 at 10:01 PM
📢 Early-Career TB Researchers: Submit short talk abstracts & scholarship apps by Nov. 24! Join us Mar 23-26, 2026 in Cape Town for cutting-edge TB & global health. 🎥Highlights: youtu.be/YcKVeGWqXSM
Submit: keysym.us/KSTB26
@maxgg.bsky.social @breealdridge.bsky.social #KSTB26 #tuberculosis #TB
Submit: keysym.us/KSTB26
@maxgg.bsky.social @breealdridge.bsky.social #KSTB26 #tuberculosis #TB
In the era of chatGPT, Claude, Grok, DeepSeek, Perplexity etc and finding an email in outlook using keywords is literally impossible….
November 21, 2025 at 8:08 PM
In the era of chatGPT, Claude, Grok, DeepSeek, Perplexity etc and finding an email in outlook using keywords is literally impossible….
👇👇Last days to submit your abstract to be considered for a short talk! Deadline 24 November!https://www.keystonesymposia.org/conferences/conference-listing/meeting/travel/c42026
Tuberculosis: Understanding the Disease Across Scales | Keystone Symposia
Join us at the Keystone Symposia on Tuberculosis: Understanding the Disease Across Scales, March 2026, in Cape Town, with field leaders!
www.keystonesymposia.org
November 19, 2025 at 8:48 PM
👇👇Last days to submit your abstract to be considered for a short talk! Deadline 24 November!https://www.keystonesymposia.org/conferences/conference-listing/meeting/travel/c42026
...Students will need to develop sufficient expertise to identify when AI systems produce plausible but incorrect outputs — which poses a dilemma because this requires the very skills that AI is starting to replace...
www.nature.com/articles/d41...
www.nature.com/articles/d41...
PhD training needs a reboot in an AI world
As machines get better at data analysis and writing tasks, doctoral training must evolve to make the most of artificial-intelligence outputs.
www.nature.com
November 9, 2025 at 9:54 PM
...Students will need to develop sufficient expertise to identify when AI systems produce plausible but incorrect outputs — which poses a dilemma because this requires the very skills that AI is starting to replace...
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Max Gutierrez
Proud to share a preprint of our paper on how bridge-like lipid transport protein VPS13C senses lysosomal membrane tension in anticipation of membrane lesions to initiate net ER-to-lysosome lipid transfer for efficient lysosomal repair www.biorxiv.org/content/10.1...
VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair
Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach,...
www.biorxiv.org
October 25, 2025 at 1:11 PM
Proud to share a preprint of our paper on how bridge-like lipid transport protein VPS13C senses lysosomal membrane tension in anticipation of membrane lesions to initiate net ER-to-lysosome lipid transfer for efficient lysosomal repair www.biorxiv.org/content/10.1...
Reposted by Max Gutierrez
Crick group leaders work across disciplines, supported by core funding and mentoring to build ambitious, curiosity-driven research.
Apply now to join us ➡️ www.crick.ac.uk/careers-stud...
Apply now to join us ➡️ www.crick.ac.uk/careers-stud...
October 27, 2025 at 2:07 PM
Crick group leaders work across disciplines, supported by core funding and mentoring to build ambitious, curiosity-driven research.
Apply now to join us ➡️ www.crick.ac.uk/careers-stud...
Apply now to join us ➡️ www.crick.ac.uk/careers-stud...
Reposted by Max Gutierrez
🚨 We’re hiring a postdoc! 🚨
Interested in lysosomes, Parkinson’s disease, cell biology, microscopy — or all of the above? Come work with us at the Bonet-Ponce Lab!
Reach out directly: luis.bonetponce@osumc.edu
Learn more: bonetponcelab.com
Let’s chat!
Interested in lysosomes, Parkinson’s disease, cell biology, microscopy — or all of the above? Come work with us at the Bonet-Ponce Lab!
Reach out directly: luis.bonetponce@osumc.edu
Learn more: bonetponcelab.com
Let’s chat!
October 14, 2025 at 5:00 PM
🚨 We’re hiring a postdoc! 🚨
Interested in lysosomes, Parkinson’s disease, cell biology, microscopy — or all of the above? Come work with us at the Bonet-Ponce Lab!
Reach out directly: luis.bonetponce@osumc.edu
Learn more: bonetponcelab.com
Let’s chat!
Interested in lysosomes, Parkinson’s disease, cell biology, microscopy — or all of the above? Come work with us at the Bonet-Ponce Lab!
Reach out directly: luis.bonetponce@osumc.edu
Learn more: bonetponcelab.com
Let’s chat!
Reposted by Max Gutierrez
New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org.
rdcu.be/eKKz1 🇨🇦
rdcu.be/eKKz1 🇨🇦
October 14, 2025 at 11:50 AM
New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org.
rdcu.be/eKKz1 🇨🇦
rdcu.be/eKKz1 🇨🇦
Reposted by Max Gutierrez
WHO reports 1 in 6 bacterial infections worldwide are antibiotic-resistant, with resistance rising sharply since 2018. Gram-negative bacteria like E. coli and K. pneumoniae pose the biggest threat. Action on #AMR surveillance and responsible antibiotic use is needed.
www.who.int/news/item/13...
www.who.int/news/item/13...
WHO warns of widespread resistance to common antibiotics worldwide
One in six laboratory-confirmed bacterial infections causing common infections in people worldwide in 2023 were resistant to antibiotic treatments, according to a new World Health Organization (WHO) r...
www.who.int
October 13, 2025 at 11:09 AM
WHO reports 1 in 6 bacterial infections worldwide are antibiotic-resistant, with resistance rising sharply since 2018. Gram-negative bacteria like E. coli and K. pneumoniae pose the biggest threat. Action on #AMR surveillance and responsible antibiotic use is needed.
www.who.int/news/item/13...
www.who.int/news/item/13...
What an example of courage, resistance and hope. Maria Corina Machado is the winner of the 2025 Nobel Peace Prize. @nobelprize.bsky.social
www.nobelprize.org/prizes/peace...
www.nobelprize.org/prizes/peace...
October 10, 2025 at 8:20 PM
What an example of courage, resistance and hope. Maria Corina Machado is the winner of the 2025 Nobel Peace Prize. @nobelprize.bsky.social
www.nobelprize.org/prizes/peace...
www.nobelprize.org/prizes/peace...
Reposted by Max Gutierrez
We are inviting applications for postdoctoral fellows in immunology of TB at the South African Tuberculosis Vaccine Initiative, University of Cape Town. For more information see the attached ad:
idm.uct.ac.za/media/739223
idm.uct.ac.za/media/739223
October 9, 2025 at 11:28 AM
We are inviting applications for postdoctoral fellows in immunology of TB at the South African Tuberculosis Vaccine Initiative, University of Cape Town. For more information see the attached ad:
idm.uct.ac.za/media/739223
idm.uct.ac.za/media/739223
Reposted by Max Gutierrez
EXCITING NEWS!! We're searching for a new professor colleague at the Biozentrum🇨🇭. Ideal candidates are exploring novel biological questions with structure, biophysics, or high-resolution imaging. 🧪 🧶🧬 🔬
The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩🔬🤓
The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩🔬🤓
September 30, 2025 at 9:52 AM
EXCITING NEWS!! We're searching for a new professor colleague at the Biozentrum🇨🇭. Ideal candidates are exploring novel biological questions with structure, biophysics, or high-resolution imaging. 🧪 🧶🧬 🔬
The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩🔬🤓
The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩🔬🤓
Reposted by Max Gutierrez
Excited to share Wendy Le Mouëllic’s PhD work, now published in @pnas.org!
It reveals that M. tuberculosis depends on inorganic sulfate import to survive inside host cells—fueling essential processes such as redox balance and stress resistance.
Huge congrats to Wendy & colleagues!
shorturl.at/WbFQC
It reveals that M. tuberculosis depends on inorganic sulfate import to survive inside host cells—fueling essential processes such as redox balance and stress resistance.
Huge congrats to Wendy & colleagues!
shorturl.at/WbFQC
Inorganic sulfate is critical for Mycobacterium tuberculosis lung tissue colonization and redox balance | PNAS
Tuberculosis remains the deadliest infectious disease caused by a single pathogen,
highlighting the urgent need for novel therapies. A deeper under...
www.pnas.org
September 23, 2025 at 3:32 AM
Excited to share Wendy Le Mouëllic’s PhD work, now published in @pnas.org!
It reveals that M. tuberculosis depends on inorganic sulfate import to survive inside host cells—fueling essential processes such as redox balance and stress resistance.
Huge congrats to Wendy & colleagues!
shorturl.at/WbFQC
It reveals that M. tuberculosis depends on inorganic sulfate import to survive inside host cells—fueling essential processes such as redox balance and stress resistance.
Huge congrats to Wendy & colleagues!
shorturl.at/WbFQC
What I would tell my younger self if I could go back in time: enjoy life as in 2025 you will be mostly charging devices, downloading apps and updating software…
September 21, 2025 at 4:10 PM
What I would tell my younger self if I could go back in time: enjoy life as in 2025 you will be mostly charging devices, downloading apps and updating software…
Reposted by Max Gutierrez
🦠 Mycobacteria aren't just tough, they're interior designers! 🦠 Check out our latest #preprint 🚨, led by our PhD student @camimille.bsky.social , where we show that #Mycobacterium tuberculosis builds secret cytoplasmic membranes to adapt its metabolism and sneak past immunity 🤫
Thread coming soon!
Thread coming soon!
Nitrate-responsive Mycobacterial Intracytoplasmic Membranes dampen Inflammation during Mycobacterium tuberculosis Infection https://www.biorxiv.org/content/10.1101/2025.09.17.676823v1
September 18, 2025 at 4:58 PM
🦠 Mycobacteria aren't just tough, they're interior designers! 🦠 Check out our latest #preprint 🚨, led by our PhD student @camimille.bsky.social , where we show that #Mycobacterium tuberculosis builds secret cytoplasmic membranes to adapt its metabolism and sneak past immunity 🤫
Thread coming soon!
Thread coming soon!
Reposted by Max Gutierrez
Watch @maxgg.bsky.social, Group Leader at the Crick, as he explains what happens to cells that are infected with tuberculosis and how his lab is studying our bodies’ response to this infection.
www.youtube.com/watch?v=VWCt...
www.youtube.com/watch?v=VWCt...
Researching the World’s Deadliest Infectious Disease – with Maximiliano Gutierrez
YouTube video by Francis Crick Institute
www.youtube.com
September 10, 2025 at 3:32 PM
Watch @maxgg.bsky.social, Group Leader at the Crick, as he explains what happens to cells that are infected with tuberculosis and how his lab is studying our bodies’ response to this infection.
www.youtube.com/watch?v=VWCt...
www.youtube.com/watch?v=VWCt...
Reposted by Max Gutierrez
Thrilled to share the first story from my postdoc! 🎉 A wonderful experiment + simulations collaboration. In the Drosophila wing, we find that 3D cell shapes affect signalling range and fine-tune developmental patterning www.biorxiv.org/content/10.1... Thread below ⬇️
August 11, 2025 at 1:18 PM
Thrilled to share the first story from my postdoc! 🎉 A wonderful experiment + simulations collaboration. In the Drosophila wing, we find that 3D cell shapes affect signalling range and fine-tune developmental patterning www.biorxiv.org/content/10.1... Thread below ⬇️
A first-in-class cell-wall biosynthesis inhibitor in #TB www.nature.com/articles/s41...
SuFEx-based antitubercular compound irreversibly inhibits Pks13 - Nature
A preclinical covalent compound, CMX410, contains a aryl fluorosulfate warhead that targets the acyltransferase domain of Mtb Pks13, an essential enzyme in cell-wall biosynthesis, making it a pro...
www.nature.com
July 31, 2025 at 6:10 PM
A first-in-class cell-wall biosynthesis inhibitor in #TB www.nature.com/articles/s41...