Fresh batch of Hot Plasmids here! Find new tools for:
🧠 Neural cell-surface proteomics
🔋 Nerve-to-cancer mitochondrial transfer @greletlab.bsky.social
🔬 Red calcium biosensors @massecklab.bsky.social & @piatkevich.bsky.social
✂️ CRISPRa-AAV for adipocytes @nadavahituv.bsky.social
& more!
🧠 Neural cell-surface proteomics
🔋 Nerve-to-cancer mitochondrial transfer @greletlab.bsky.social
🔬 Red calcium biosensors @massecklab.bsky.social & @piatkevich.bsky.social
✂️ CRISPRa-AAV for adipocytes @nadavahituv.bsky.social
& more!
November 11, 2025 at 3:00 PM
Fresh batch of Hot Plasmids here! Find new tools for:
🧠 Neural cell-surface proteomics
🔋 Nerve-to-cancer mitochondrial transfer @greletlab.bsky.social
🔬 Red calcium biosensors @massecklab.bsky.social & @piatkevich.bsky.social
✂️ CRISPRa-AAV for adipocytes @nadavahituv.bsky.social
& more!
🧠 Neural cell-surface proteomics
🔋 Nerve-to-cancer mitochondrial transfer @greletlab.bsky.social
🔬 Red calcium biosensors @massecklab.bsky.social & @piatkevich.bsky.social
✂️ CRISPRa-AAV for adipocytes @nadavahituv.bsky.social
& more!
Seipin-adipogenin controls lipid storage in fat cells: A protein complex promotes the expansion of lipid droplets during the formation of mature adipocytes @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
November 6, 2025 at 10:59 PM
Seipin-adipogenin controls lipid storage in fat cells: A protein complex promotes the expansion of lipid droplets during the formation of mature adipocytes @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
#NatMetabPicks | In @cp-cellmetabolism.bsky.social led by @dominiquelangin.bsky.social ( @inserm.fr )
Hormone-sensitive lipase localizes to the nucleus in adipocytes and regulates adipose tissue homeostasis independently of its cytosolic function.
🧪
www.cell.com/cell-metabol...
Hormone-sensitive lipase localizes to the nucleus in adipocytes and regulates adipose tissue homeostasis independently of its cytosolic function.
🧪
www.cell.com/cell-metabol...
Nuclear hormone-sensitive lipase regulates adipose tissue mass and adipocyte metabolism
Dufau, Recazens, et al. identified the neutral lipase HSL in the nucleus of adipocytes,
where it modulates gene expression. The trafficking of HSL between the nucleus and
the cytosol is under the cont...
www.cell.com
November 3, 2025 at 3:40 PM
#NatMetabPicks | In @cp-cellmetabolism.bsky.social led by @dominiquelangin.bsky.social ( @inserm.fr )
Hormone-sensitive lipase localizes to the nucleus in adipocytes and regulates adipose tissue homeostasis independently of its cytosolic function.
🧪
www.cell.com/cell-metabol...
Hormone-sensitive lipase localizes to the nucleus in adipocytes and regulates adipose tissue homeostasis independently of its cytosolic function.
🧪
www.cell.com/cell-metabol...
Looking for a PhD position in Chemical Biology, exploring a novel lipid signaling pathway in adipocytes?
Join our lab and combine chemical and genetic tools to uncover new molecular mechanisms and therapeutic targets for metabolic disease.
Apply via link below!
#Lipids #ChemicalBiology #Metabolism
Join our lab and combine chemical and genetic tools to uncover new molecular mechanisms and therapeutic targets for metabolic disease.
Apply via link below!
#Lipids #ChemicalBiology #Metabolism
October 20, 2025 at 4:19 PM
Looking for a PhD position in Chemical Biology, exploring a novel lipid signaling pathway in adipocytes?
Join our lab and combine chemical and genetic tools to uncover new molecular mechanisms and therapeutic targets for metabolic disease.
Apply via link below!
#Lipids #ChemicalBiology #Metabolism
Join our lab and combine chemical and genetic tools to uncover new molecular mechanisms and therapeutic targets for metabolic disease.
Apply via link below!
#Lipids #ChemicalBiology #Metabolism
For #FluorescenceFriday, α-spectrin (red) and lipid droplets (green) are shown in adipocytes 🔬 #Microscopy #CellBiology
October 10, 2025 at 6:37 PM
For #FluorescenceFriday, α-spectrin (red) and lipid droplets (green) are shown in adipocytes 🔬 #Microscopy #CellBiology
PROFOLUS: Researchers headed by Nadav Ahituv wondered what would happen if normal cells are given the ability to outcompete cancer cells for nutrients. This curiously drew their attention to adipocytes or fat cells.
Engineering Fat Cells Against Cancer Cells - Profolus
A proposed cancer treatment called Adipose Manipulation Transplantation involves engineering fat cells to fight against cancer cells.
www.profolus.com
October 10, 2025 at 4:30 PM
PROFOLUS: Researchers headed by Nadav Ahituv wondered what would happen if normal cells are given the ability to outcompete cancer cells for nutrients. This curiously drew their attention to adipocytes or fat cells.
More lovely Promethion-powered science from @vonMeyennlab & colleagues @ethzurich - an obesogenic memory in 🐭 adipocytes, based on stable epigenetic changes, may prime them to load up on fat, thus contributing to the problematic ‘yo-yo’ effect often seen with dieting! www.nature.com/articles/s41...
Adipose tissue retains an epigenetic memory of obesity after weight loss - Nature
Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially contributes to th...
www.nature.com
November 20, 2024 at 6:39 PM
More lovely Promethion-powered science from @vonMeyennlab & colleagues @ethzurich - an obesogenic memory in 🐭 adipocytes, based on stable epigenetic changes, may prime them to load up on fat, thus contributing to the problematic ‘yo-yo’ effect often seen with dieting! www.nature.com/articles/s41...
#WeekendRead! #NoTimeToDie! Wang, Min, Wang &co show @cp-cellmetabolism.bsky.social that ferroptosis in adipocytes leads to hif1a degradation & activates a program that protects from adipose tissue expansion, steatosis, & insulin resistance! www.cell.com/cell-metabol...
Adipocyte-derived ferroptotic signaling mitigates obesity
Wang et al. show that a ferroptosis signature is compromised in adipose tissues of humans and mice with obesity. By constraining HIF1α availability, ferroptotic signaling in adipocytes reduces lipid accumulation and increases thermogenesis via a c-Myc-Pgc1β axis, and thus, targeting this pathway may prevent or treat obesity and metabolic disorders.
www.cell.com
December 28, 2024 at 4:20 PM
#WeekendRead! #NoTimeToDie! Wang, Min, Wang &co show @cp-cellmetabolism.bsky.social that ferroptosis in adipocytes leads to hif1a degradation & activates a program that protects from adipose tissue expansion, steatosis, & insulin resistance! www.cell.com/cell-metabol...
Ultimately, our findings suggest that larger adipocytes constitute a distinct cell population within mammary adipose tissue and increase lipid transfer to invading cancer cells. As a result, we propose that adipocyte size could serve as a prognostic biomarker for breast cancer patients. 5/5
April 7, 2025 at 6:46 PM
Ultimately, our findings suggest that larger adipocytes constitute a distinct cell population within mammary adipose tissue and increase lipid transfer to invading cancer cells. As a result, we propose that adipocyte size could serve as a prognostic biomarker for breast cancer patients. 5/5
#Imidacloprid, a #neonicotinoid insecticide, potentiates #adipogenesis in 3T3-L1 adipocytes [J Agric Food Chem. 2013] <a href="http://www.ncbi.nlm.nih.gov/pubmed/23215241" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">http://www.ncbi.nlm.nih.gov/pubmed/23215241
Imidacloprid, a neonicotinoid insecticide, potentiates adipogenesis in 3T3-L1 adipocytes - PubMed
There is emerging evidence that organochlorine and organophosphorus insecticide exposure may be linked to excessive weight gain and symptoms of diabetes. However, there is a lack of knowledge for other types of insecticides with potential influence on obesity and diabetes. Thus, the purpose of this …
www.ncbi.nlm.nih.gov
November 8, 2024 at 7:00 PM
#Imidacloprid, a #neonicotinoid insecticide, potentiates #adipogenesis in 3T3-L1 adipocytes [J Agric Food Chem. 2013] <a href="http://www.ncbi.nlm.nih.gov/pubmed/23215241" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">http://www.ncbi.nlm.nih.gov/pubmed/23215241
Our latest issue is now online! Features articles on #adipose, #immune checkpoint inhibitors, #diabetes, #achondroplasia and more -> www.nature.com/nrendo/ #EndoSky
April 14, 2025 at 10:20 AM
Our latest issue is now online! Features articles on #adipose, #immune checkpoint inhibitors, #diabetes, #achondroplasia and more -> www.nature.com/nrendo/ #EndoSky
New molecular insights into the mechanisms linking adipocytes metabolism and behaviour suggesting that inhibition of GDF15–GFRAL signalling might reduce acute anxiety @naturemetabolism.bsky.social
www.nature.com/articles/s42...
www.nature.com/articles/s42...
GDF15 links adipose tissue lipolysis with anxiety - Nature Metabolism
Anxiety-like behaviour in mice, as a result of psychological stress, is shown to be mediated by GDF15 release in response to adipose tissue lipolysis.
www.nature.com
April 15, 2025 at 9:59 AM
New molecular insights into the mechanisms linking adipocytes metabolism and behaviour suggesting that inhibition of GDF15–GFRAL signalling might reduce acute anxiety @naturemetabolism.bsky.social
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Na/K-ATPase Signaling in Adipocytes Promotes Atherosclerosis https://www.biorxiv.org/content/10.1101/2025.08.18.670994v1
August 20, 2025 at 4:19 AM
Na/K-ATPase Signaling in Adipocytes Promotes Atherosclerosis https://www.biorxiv.org/content/10.1101/2025.08.18.670994v1
You know I once helped on a study that suggested bone marrow cells may contribute to adult adipogenesis - maybe different adipocytes have different inflammatory potential? pubmed.ncbi.nlm.nih.gov/26190649/
Transplanted Bone Marrow-Derived Cells Contribute to Human Adipogenesis - PubMed
Because human white adipocytes display a high turnover throughout adulthood, a continuous supply of precursor cells is required to maintain adipogenesis. Bone marrow (BM)-derived progenitor cells may ...
pubmed.ncbi.nlm.nih.gov
December 7, 2024 at 9:44 AM
You know I once helped on a study that suggested bone marrow cells may contribute to adult adipogenesis - maybe different adipocytes have different inflammatory potential? pubmed.ncbi.nlm.nih.gov/26190649/
🚨Great way to start the week! Delighted to have published this Viewpoint in The FEBS Journal with collaborator Shingo Kajimura, proposing that adipocytes form immune hubs during infection! #Immunosky #AcademicSky
febs.onlinelibrary.wiley.com/doi/full/10....
febs.onlinelibrary.wiley.com/doi/full/10....
FEBS Press
Traditionally, adipocytes have been viewed as energy storage units, which upregulate inflammatory factors in response to obesity. However, emerging evidence demonstrates that adipocytes are highly re....
febs.onlinelibrary.wiley.com
October 21, 2024 at 7:27 PM
🚨Great way to start the week! Delighted to have published this Viewpoint in The FEBS Journal with collaborator Shingo Kajimura, proposing that adipocytes form immune hubs during infection! #Immunosky #AcademicSky
febs.onlinelibrary.wiley.com/doi/full/10....
febs.onlinelibrary.wiley.com/doi/full/10....
twinks have significantly less defense and we know it, and so we're envious of all y'alls and your adipocytes. I do also think that bellies are hawt and create a lot of curves and gradients that are fun to draw.
February 28, 2024 at 4:42 PM
twinks have significantly less defense and we know it, and so we're envious of all y'alls and your adipocytes. I do also think that bellies are hawt and create a lot of curves and gradients that are fun to draw.
Fat cells never forget
We are getting a better understanding of why it is so hard to keep off the pounds. Epigenetics Reminds Adipocytes of their Obese Past After Weight Loss The age-old saying “a moment on the lips, forever on the hips” just got a modern update thanks to an epigenome-based study…
We are getting a better understanding of why it is so hard to keep off the pounds. Epigenetics Reminds Adipocytes of their Obese Past After Weight Loss The age-old saying “a moment on the lips, forever on the hips” just got a modern update thanks to an epigenome-based study…
Fat cells never forget
We are getting a better understanding of why it is so hard to keep off the pounds. Epigenetics Reminds Adipocytes of their Obese Past After Weight Loss The age-old saying “a moment on the lips, forever on the hips” just got a modern update thanks to an epigenome-based study of obesity! New research now describes the existence of epigenetic memory in the adipose tissue of obese individuals that persists after significant weight loss.
amanwithaphd.wordpress.com
December 9, 2024 at 6:58 AM
Fat cells never forget
We are getting a better understanding of why it is so hard to keep off the pounds. Epigenetics Reminds Adipocytes of their Obese Past After Weight Loss The age-old saying “a moment on the lips, forever on the hips” just got a modern update thanks to an epigenome-based study…
We are getting a better understanding of why it is so hard to keep off the pounds. Epigenetics Reminds Adipocytes of their Obese Past After Weight Loss The age-old saying “a moment on the lips, forever on the hips” just got a modern update thanks to an epigenome-based study…
How does epigenetics impact weight loss efforts?
This study uses single-nucleus RNA-seq and a collection of other assays - including CUT&Tag! - to show that adipocytes retain a "memory" of obesity that is linked with rebound weight gain in mice.
www.nature.com/articles/s41...
This study uses single-nucleus RNA-seq and a collection of other assays - including CUT&Tag! - to show that adipocytes retain a "memory" of obesity that is linked with rebound weight gain in mice.
www.nature.com/articles/s41...
Adipose tissue retains an epigenetic memory of obesity after weight loss - Nature
Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially contributes to th...
www.nature.com
November 20, 2024 at 2:05 PM
How does epigenetics impact weight loss efforts?
This study uses single-nucleus RNA-seq and a collection of other assays - including CUT&Tag! - to show that adipocytes retain a "memory" of obesity that is linked with rebound weight gain in mice.
www.nature.com/articles/s41...
This study uses single-nucleus RNA-seq and a collection of other assays - including CUT&Tag! - to show that adipocytes retain a "memory" of obesity that is linked with rebound weight gain in mice.
www.nature.com/articles/s41...
RRID:SCR_006457 was used by the authors of the Developmental Biology paper "Insulin signaling acts in adult adipocytes via GSK-3β and independently of FOXO to control Drosophila female germline stem cell numbers". Thank you for making your methods matter! #reproducibility #STMpublishing
doi.org
April 11, 2025 at 7:00 AM
RRID:SCR_006457 was used by the authors of the Developmental Biology paper "Insulin signaling acts in adult adipocytes via GSK-3β and independently of FOXO to control Drosophila female germline stem cell numbers". Thank you for making your methods matter! #reproducibility #STMpublishing
Stumbled upon this by accident but it's pretty neat- in mice fed a high fat diet, tirzepatide given intracerebroventricularly is able to induce weight loss- but it seems that it does this by promoting lipolysis and thermogenesis in adipocytes via neural connections to those tissues.
Tirzepatide reduces body weight by increasing fat utilization via the central nervous system‐adipose tissue axis in male mice
Aims Tirzepatide, a dual glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist, demonstrates promise as a potent medication for obesity. However, th...
dom-pubs.onlinelibrary.wiley.com
March 24, 2025 at 11:06 PM
Stumbled upon this by accident but it's pretty neat- in mice fed a high fat diet, tirzepatide given intracerebroventricularly is able to induce weight loss- but it seems that it does this by promoting lipolysis and thermogenesis in adipocytes via neural connections to those tissues.
Lipolytic and Anti-Adipogenic Effect of Capsaicin, Camphor, and Caffeic acid on Human SGBS Adipocytes https://www.biorxiv.org/content/10.1101/2025.05.05.652232v1
May 6, 2025 at 7:31 AM
Lipolytic and Anti-Adipogenic Effect of Capsaicin, Camphor, and Caffeic acid on Human SGBS Adipocytes https://www.biorxiv.org/content/10.1101/2025.05.05.652232v1
We knew that adipocytes have high levels of the PTHrP receptor, PTH1R. We deleted Pth1r in adipose and injected our highly cachectic PTHrP-OE cell line. This not only blocked adipose tissue wasting, but also muscle wasting, suggesting that adipose wasting may fuel muscle wasting in this model
...🧵
...🧵
June 7, 2025 at 5:23 PM
We knew that adipocytes have high levels of the PTHrP receptor, PTH1R. We deleted Pth1r in adipose and injected our highly cachectic PTHrP-OE cell line. This not only blocked adipose tissue wasting, but also muscle wasting, suggesting that adipose wasting may fuel muscle wasting in this model
...🧵
...🧵
What I see more often (sometimes driven by word limits) is people leaving the reader in the dark about what the main player is, thus: "NHE6 is Required for Insulin-Stimulated Glucose Uptake in Adipocytes". This usually happens when authors want to work a bunch of different proteins into the title.
August 5, 2023 at 12:30 PM
What I see more often (sometimes driven by word limits) is people leaving the reader in the dark about what the main player is, thus: "NHE6 is Required for Insulin-Stimulated Glucose Uptake in Adipocytes". This usually happens when authors want to work a bunch of different proteins into the title.
Perilipin membrane association determines Lipid Droplet heterogeneity in differentiating adipocytes https://www.biorxiv.org/content/10.1101/2023.10.30.564726v1
Perilipin membrane association determines Lipid Droplet heterogeneity in differentiating adipocytes https://www.biorxiv.org/content/10.1101/2023.10.30.564726v1
The storage of fat within lipid droplets (LDs) of adipocytes is critical for whole-body health. Acut
www.biorxiv.org
October 31, 2023 at 11:30 PM
Perilipin membrane association determines Lipid Droplet heterogeneity in differentiating adipocytes https://www.biorxiv.org/content/10.1101/2023.10.30.564726v1