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sfmpathogenesis.bsky.social
SFM Microbial Pathogenesis
@sfmpathogenesis.bsky.social
540 followers 710 following 85 posts
Community of researchers interested in understanding the molecular & cellular mechanisms that pathogens use to colonize their hosts. #microbiology #infection
Section of the French Society for Microbiology
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sfmpathogenesis.bsky.social
SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · Nov 14
🚨 Save the date!
The Annual Congress of the French Society for Microbiology is heading to Lyon, Oct 7-9, 2026!
An unmissable event for all microbe lovers.

More information coming soon
#SFM2026 #Microbiology #MicroSky
@sfmicrobiologie.bsky.social
Reposted by SFM Microbial Pathogenesis
natcomms.nature.com
#Microbiology

The anti-tuberculosis drug bedaquiline targets the mycobacterial ATP synthase, but how that leads to bacterial death is unclear

Here the authors clarify how bedaquiline works

@jnblab.bsky.social @morwan.me
#TBSky #antibiotics #AMR

http://dlvr.it/TQjZ0W
Cartoon representing the mycobacterial oxidative phosphorylation system, including cytochromes, NDH-2, and ATP synthase. Taken from Figure 1 of the article.
February 2, 2026 at 5:07 PM
sfmpathogenesis.bsky.social
New from @cascaleslab.bsky.social: A new weapon in the T6SS arsenal. Jonas Desjardins et al. uncover a new family of T6SS toxins that target competitors’ metabolic core, defining a novel NAD(P)⁺ glycohydrolase family, Tne5.

📖 shorturl.at/3QhkS

#MicroSky
January 28, 2026 at 2:59 PM
sfmpathogenesis.bsky.social
New research from @pasteur.fr reveals how 𝐿𝑒𝑔𝑖𝑜𝑛𝑒𝑙𝑙𝑎 uses LpDot1 to methylate SFPQ, disrupting paraspeckles & rewiring host splicing, dampening immune genes like NF-κB2 & CD45 for survival.

✍️ @cbuch.bsky.social, @mrolando.bsky.social & coll.
📖 Read the preprint: shorturl.at/kFh8z
#MicroSky
January 14, 2026 at 9:16 AM
sfmpathogenesis.bsky.social
New study uncovers mitochondrial DNA G-quadruplexes as druggable targets in Plasmodium falciparum, with RHPS4 showing strong activity against resistant #malaria parasites.

✍️ Mariam Salim & coll. @ipbstoulouse.bsky.social @lcc-cnrs.bsky.social
📖 shorturl.at/wlVit
#InfectiousDiseases #DrugDiscovery
January 9, 2026 at 5:05 AM
sfmpathogenesis.bsky.social
New research shows cannabidiol inhibits HIV-1 infection across key mucosal immune cells via TRPV1 activation and CGRP signaling, blocking early transmission events.
A promising avenue for future #HIV prevention.

✍️ CC Barbosa Bomfim & coll. @institutcochin.bsky.social
📖 shorturl.at/Fdz7g
#Microsky
© NIBSC / SCIENCE PHOTO LIBRARY
January 9, 2026 at 4:59 AM
sfmpathogenesis.bsky.social
New study reveals a high-resolution genetic map of how E. coli adapts to the gut, showing diet- and inflammation-dependent metabolism, niche shifts, and unexpected roles for mobile genetic elements.

✍️ @amandinemaire.bsky.social & coll.
📖 shorturl.at/DYSTv

#Microbiome #Pathogenesis #Microsky
January 6, 2026 at 4:55 AM
sfmpathogenesis.bsky.social
Epstein-Barr virus protein EBNA-1 targets the nucleolus in G1/S phase, cuts rRNA synthesis by 50%, and triggers oxidative stress, all via EBP2. A new viral survival strategy?

✍️ M. Chabi, N. Jourdan & coll. @ibps.bsky.social
📖 shorturl.at/uReKo

#Virology #CancerResearch
January 4, 2026 at 8:49 AM
sfmpathogenesis.bsky.social
New study reveals how Pseudomonas aeruginosa delivers the T6SS phospholipase Tle1 and avoids self-intoxication. Structural and experimental data identify Tli1a as the key immunity protein.

✍️ @del-leica99-98.bsky.social & coll.
📖 shorturl.at/hRHg2

#MiscoSky #TypeVISecretion #Pseudomonas
January 4, 2026 at 8:23 AM
Reposted by SFM Microbial Pathogenesis
shigellameeting.bsky.social
Come and visit me in Paris! #Shigella2026 - travel bursaries deadline tomorrow. Submit your abstracts at www.shigella2026.conferences-pasteur.org/home
shigellameeting.bsky.social The Shigella Meeting @shigellameeting.bsky.social · Sep 18
Come and join us in Paris 2026 to talk all about Shigella!
December 15, 2025 at 8:36 PM
Reposted by SFM Microbial Pathogenesis
dukasju.bsky.social
We propose immuno-centric view of secreted polymorphic toxin diversification and involvement of novel XPC systems in this process! Fantastic work of @jmartinkus.bsky.social with lab of @cascaleslab.bsky.social !
www.cell.com/current-biol...
Poly-immunity arrays associated with Rhs toxins confer wide protection against competitors
Martinkus et al. show that Photorhabdus and Xenorhabdus species encode arrays of immunity genes whose protein products neutralize toxins secreted by competitors. These arrays, often linked to Xer pass...
www.cell.com
December 15, 2025 at 5:45 PM
Reposted by SFM Microbial Pathogenesis
pasteur.fr
🔬 Call to create junior research groups at the Institut Pasteur

Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies

📅 Deadline: Feb 9, 2026
👥 2-12 years post-PhD

Apply now 📝 research.pasteur.fr/en/call/crea...

#JobOpportunity #Research
Creation of new junior research groups at the Institut Pasteur - Call for applications 2026 - Research
The Institut Pasteur is launching an international call to recruit new junior research group leaders leveraging cutting-edge transdisciplinary approaches to exploring infectious diseases, host-microbe...
research.pasteur.fr
December 8, 2025 at 8:53 AM
sfmpathogenesis.bsky.social
🧬 A new “Life Identification Number (LIN)” system aims to modernize bacterial classification with a clearer, more stable hierarchy. A step forward for genomic taxonomy!
📖 shorturl.at/vkQuS
✍️ @sylvainbrisse.bsky.social & coll.

@pasteur.fr @ox.ac.uk @monashuniversity.bsky.social @lshtm.bsky.social
November 30, 2025 at 8:20 AM
sfmpathogenesis.bsky.social
👏👏👏 Bravo @hakimi.bsky.social on winning the 2025 @inserm.fr Research Prize and the @fondationdefrance.bsky.social Allianz Prize!

Hakimi's team is cracking #Toxoplasma's secrets, and developing innovative therapies to block transmission.

@academiesciences.bsky.social
©Inserm/François Guénet
November 29, 2025 at 6:51 AM
sfmpathogenesis.bsky.social
Scientists can now visually track full-length #HIV genomes hiding inside cells, in real time.
This new imaging technique reveals where silent viral reservoirs form, offering a powerful path toward curative strategies.
#HIVresearch #CureHIV

📖 shorturl.at/ZN6hC
✍️ F. Di Nunzio & coll. @pasteur.fr
November 27, 2025 at 4:55 AM
sfmpathogenesis.bsky.social
Infections don’t enter the body in one big burst, they trickle in over time, new study reveals. This changes how we understand disease and could help us spot early warning signs sooner!

📖 shorturl.at/RxxXo
✍️ @nemopeeters.bsky.social & coll.

@lipme-toulouse.bsky.social
#MicroSky #PlantScience
November 22, 2025 at 3:17 PM
sfmpathogenesis.bsky.social
Viral coinfections aren’t additive, order matters. Flu often blocks COVID via strong IFN responses, RSV can boost later flu, and each pairing triggers unique cell programs. Timing shapes outcomes for care and modeling.
📖 shorturl.at/KH8cf
✍️ @olivierterrier.bsky.social & coll. @ciri-lyon.bsky.social
November 19, 2025 at 9:19 AM
sfmpathogenesis.bsky.social
Two M. tuberculosis RelE toxins don’t cut mRNA, they slice 16S rRNA itself, shutting down translation in a totally unexpected way, new study reveals.
A big leap in understanding TB’s survival tricks and new angles for therapies.

📖 shorturl.at/Z8MVX
✍️ @genevauxpierre.bsky.social & coll.
#MicroSky
November 18, 2025 at 8:56 AM
sfmpathogenesis.bsky.social
🚨 MONTHLY ANTIBIOTOLERANCE WEBINAR SERIES 2025-2026
Friday Nov 14, 3 PM
Invited speakers: Sophie Helaine & Audrey Menegaz Proenca
More info and registration here 👉 www.sfm-microbiologie.org/evenement/mo...
#Microbiology #Microsky
MONTHLY ANTIBIOTOLERANCE WEBINAR SERIES - Société Française de Microbiologie
www.sfm-microbiologie.org
November 14, 2025 at 9:53 AM
sfmpathogenesis.bsky.social
🚨 Save the date!
The Annual Congress of the French Society for Microbiology is heading to Lyon, Oct 7-9, 2026!
An unmissable event for all microbe lovers.

More information coming soon
#SFM2026 #Microbiology #MicroSky
@sfmicrobiologie.bsky.social
November 14, 2025 at 9:49 AM
sfmpathogenesis.bsky.social
In flies and worms, more pathogenic viruses caused greater aging acceleration, and the effect lingered even after clearance, new study reveals.
#Aging #Infection #MicroSky #Virology
📖 shorturl.at/OeYVp
✍️ @rubengonzalez.bsky.social @castellosanjuan.bsky.social
@salehlabparis.bsky.social @pasteur.fr
November 14, 2025 at 6:32 AM
Reposted by SFM Microbial Pathogenesis
ipbstoulouse.bsky.social
Exciting #postdoc opportunity in KL Ung's group!
Understanding the molecular mechanisms of cell wall remodeling in pathogens

Learn more: shorturl.at/gPuFV
Deadline: January 15, 2026
Contact: recruit@ipbs.fr
#Protein #Biochemistry #StructuralBiology #Biophysics #CryoEM
November 4, 2025 at 5:34 AM
sfmpathogenesis.bsky.social
Excessive Ca²⁺ signaling fuels inflammation in a zebrafish model of #cysticfibrosis, and verapamil, an FDA-approved Ca²⁺ channel blocker, restores balance & limits inflammation, new study reveals. A promising repurposing opportunity for CF therapy!
📖 shorturl.at/Fxg9F
✍️ @sarahdja.bsky.social & coll.
October 15, 2025 at 6:09 AM
sfmpathogenesis.bsky.social
Phages are not always fast-evolving chaos machines. In an oyster farm, Vibrio phages stayed genetically identical for 4 yrs, showing surprising viral stability shaped by nested ecology & mobile genetic elements.

✍️ @fredoleroux.bsky.social @epcrocha.bsky.social & coll.
📖 shorturl.at/Nq8G1
#MicroSky
October 13, 2025 at 3:37 AM
sfmpathogenesis.bsky.social
tRNA-modification mutants in mycobacteria boost antibiotic recalcitrance by activating WhiB7 & coupling alanine metabolism to ribosome rescue and survival, new study reveals.

✍️ @jvaubourgeix.bsky.social & coll.
📖 shorturl.at/86JTs

#MicroSky #AMR #RNAsky
@imperialcollegeldn.bsky.social @inserm.fr
October 13, 2025 at 3:29 AM
sfmpathogenesis.bsky.social
Staphylococcus aureus EVs are more than cargo carriers, they’re immune modulators. New work on MRSA N315 EVs reveals selective uptake, RNA release, and activation of TLR and NOD2 signaling.

✍️ Julia Papail, Eric Guédon & coll.
@inrae-bzhndie.bsky.social
📖 shorturl.at/EuXh0
#MicroSky #Staphylococcus
October 10, 2025 at 4:09 AM