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sfmpathogenesis.bsky.social
SFM Microbial Pathogenesis
@sfmpathogenesis.bsky.social
520 followers 700 following 67 posts
Community of researchers interested in understanding the molecular & cellular mechanisms that pathogens use to colonize their hosts. #microbiology #infection
Section of the French Society for Microbiology
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sfmpathogenesis.bsky.social
Excessive Ca²⁺ signaling fuels inflammation in a zebrafish model of #cysticfibrosis, and verapamil, an FDA-approved Ca²⁺ channel blocker, restores balance & limits inflammation, new study reveals. A promising repurposing opportunity for CF therapy!
📖 shorturl.at/Fxg9F
✍️ @sarahdja.bsky.social & coll.
October 15, 2025 at 6:09 AM
sfmpathogenesis.bsky.social
Phages are not always fast-evolving chaos machines. In an oyster farm, Vibrio phages stayed genetically identical for 4 yrs, showing surprising viral stability shaped by nested ecology & mobile genetic elements.

✍️ @fredoleroux.bsky.social @epcrocha.bsky.social & coll.
📖 shorturl.at/Nq8G1
#MicroSky
October 13, 2025 at 3:37 AM
sfmpathogenesis.bsky.social
tRNA-modification mutants in mycobacteria boost antibiotic recalcitrance by activating WhiB7 & coupling alanine metabolism to ribosome rescue and survival, new study reveals.

✍️ @jvaubourgeix.bsky.social & coll.
📖 shorturl.at/86JTs

#MicroSky #AMR #RNAsky
@imperialcollegeldn.bsky.social @inserm.fr
October 13, 2025 at 3:29 AM
sfmpathogenesis.bsky.social
Staphylococcus aureus EVs are more than cargo carriers, they’re immune modulators. New work on MRSA N315 EVs reveals selective uptake, RNA release, and activation of TLR and NOD2 signaling.

✍️ Julia Papail, Eric Guédon & coll.
@inrae-bzhndie.bsky.social
📖 shorturl.at/EuXh0
#MicroSky #Staphylococcus
October 10, 2025 at 4:09 AM
sfmpathogenesis.bsky.social
New study suggests fetal brain vulnerability to Oropouche virus (OROV) in early pregnancy: Epidemic-related strain infects human neural progenitors & brain organoids, causing proliferation arrest, apoptosis & loss of brain architecture.
#Virology
✍️ Alexandra Albert & coll.
📖 shorturl.at/nhO8F
October 3, 2025 at 5:34 AM
sfmpathogenesis.bsky.social
New study shows pyrazinamide kills TB by acidifying bacterial cytosol — not via PanD/CoA depletion. A long-standing debate settled, paving the way for smarter PZA-like drugs. #MicroSky

✍️ J. Laudouze, Y. Antonenko, @alexandregouzy.bsky.social, @pierresantucci.bsky.social & coll.
📖 shorturl.at/tuz6Q
Revisited model of PZA/HPOA efficacy, supporting a pH-dependent mechanism of weak acid permeation and cytosolic acidification as main mechanism of bactericidal activity. In this model, the authors propose that the presence of glycerol potentiates PZA/HPOA efficacy by generating acidic intermediates that lower IBpH. Accordingly, β-alanine and pantothenate might mitigate this effect by acting as buffering molecules that alleviate acidosis. Finally, PanD enzymatic activity consumes protons which in turn increases IBpH. Therefore, in this model PanD minimally contributes to PZA tolerance and cannot be considered as the primary target of the drug.
September 29, 2025 at 4:08 AM
sfmpathogenesis.bsky.social
Mycobacterium tuberculosis forms nitrate-induced intracytoplasmic membranes (MIMs) that rewire metabolism & dampen inflammation during infection, uncovering a new layer of bacterial adaptation!
✍️ @camimille.bsky.social @enningalab.bsky.social @pasteur.fr
📖 shorturl.at/9kbDM
September 19, 2025 at 7:42 AM
sfmpathogenesis.bsky.social
Streptococcus pneumoniae can induce competence via the ClpX/ClpP protease through the RipA toxin, which stresses replication and activates comCDE. Metabolically active but dying cells release CSP, spreading competence to neighbors.
#MicroSky
✍️ @polardlab.bsky.social & coll.
📖 shorturl.at/E9ael
September 4, 2025 at 5:50 AM
sfmpathogenesis.bsky.social
Listeria monocytogenes doesn’t just rush to the cytosol. It can replicate in permeated epithelial phagosomes lacking cathepsin D, where LLO sustains growth, PlcB drives escape, and the PrfA program is primed.
✍️ @alicelebreton.bsky.social & coll. @ibensens.bsky.social
📖 shorturl.at/1bFph
September 4, 2025 at 5:44 AM
sfmpathogenesis.bsky.social
#Dengue virus slips infection-boosting RNAs into mosquito saliva by hitching a ride in EVs, a study finds. The viral RNA hooks onto a mosquito protein, AeSyntenin, to get packaged and released.
#MicroSky #Virology

✍️ @julienpompon.bsky.social & coll.
@ird-fr.bsky.social
📖 shorturl.at/lxUyw
August 14, 2025 at 3:37 AM
sfmpathogenesis.bsky.social
New study reveals a CD38-like ADP-ribosyl cyclase toxin delivered by T6SS that depletes NAD+ in both bacterial and eukaryotic cells.
A striking case of structural mimicry, cross-immunity, and widespread deployment in microbial warfare.
✍️‪ @jmartinkus.bsky.social & coll.
📖 shorturl.at/b5LSB
#MicroSky
July 25, 2025 at 4:26 AM
sfmpathogenesis.bsky.social
A new study delivers the most comprehensive phylogenomic analysis of Spirochaetes to date, revealing their deep evolutionary roots and shedding light on the loss of spiral morphology and host adaptation.
✍️ @microbiomol.bsky.social and coll. @pasteur.fr
📖 shorturl.at/UxAWu
#MicroSky
July 7, 2025 at 5:20 AM
sfmpathogenesis.bsky.social
E. coli and P. aeruginosa need the Hsp90 chaperone to produce key virulence factors colibactin & pyoverdine, study reveals. Hsp90 stabilizes megasynthases behind complex metabolite biosynthesis. New angles on infection control & biotech tools!
📖 shorturl.at/n1Pu6
✍️ Fratacci, Chaouche & coll. #IMM
July 3, 2025 at 5:06 AM
sfmpathogenesis.bsky.social
New insights into Shigella flexneri pathogenesis: the VapBC TA system is activated during intracellular infection, coordinating stress adaptation, T3SS-mediated virulence, and immune evasion, new study reveals.

✍️ E. Saifi & coll. @inem-necker.bsky.social @pasteur.fr
📖 shorturl.at/26d33
#MicroSky
July 1, 2025 at 4:21 AM
sfmpathogenesis.bsky.social
A new path in the fight against AMR!
Using B cells from CF patients, researchers isolated human mAbs targeting the T3SS of P. aeruginosa. Structural & functional data reveal distinct neutralization modes, blocking virulence without antibiotics! #MicroSky
✍️ ‪JM Desveaux @ coll.
📖 shorturl.at/2hixd
June 26, 2025 at 4:41 AM
sfmpathogenesis.bsky.social
A prophage-encoded single-stranded DNA-binding protein (SSBP) from S. aureus attenuates bacterial virulence and enhances macrophage activation via IL-6, new study reveals. SSBP boosts immune clearance and shows therapeutic potential. #MicroSky #Phage
✍️ Ahmad-Mansour & coll.
📖 shorturl.at/6yqFx
June 17, 2025 at 4:06 AM
sfmpathogenesis.bsky.social
Dynamic excision of the F13 hlb-converting prophage in Staph. aureus is critical for full virulence, new study reveals. Loss of F13 restores β-hemolysin expression and enhances pathogenicity, while locking the prophage impairs infection. #MicroSky
✍️ O. Poupel & coll @pasteur.fr
📖 shorturl.at/F1W3t
June 13, 2025 at 10:00 AM
sfmpathogenesis.bsky.social
Uropathogenic E. coli uses a novel two-gene system, DanRI, to outsmart neutrophils by blocking NETs and ROS. Induced by host nucleosomes, DanRI boosts bacterial survival & persistence. A new twist in immune evasion!
✍️ @doracerina.bsky.social & coll.
📖 shorturl.at/cAj05
#MicroSky
June 12, 2025 at 11:38 AM
sfmpathogenesis.bsky.social
Nearly half of bacteria carry mobile, accessory PDF enzymes that can resist actinonin, new study reveals. Resistance to PDF-targeting antibiotics is already encoded and poised to spread.
#AMR #MicroSky
✍️ @morgan-lamberioux.bsky.social and coll.
@pasteur.fr
📖 shorturl.at/WTBVx
June 10, 2025 at 3:41 AM
sfmpathogenesis.bsky.social
New study reshapes our view of sleeping sickness: #Trypanosoma brucei persists in fatty skin tissues and uses host-derived glycerol to get transmission-ready, even when blood levels are low.
#SleepingSickness #ScienceNews #Parasites
✍️F. Bringaud & coll.
📖https://shorturl.at/LGGxk
May 28, 2025 at 4:35 AM
sfmpathogenesis.bsky.social
Antibiotics disrupt gut microbes, but what about their viruses?
A new study finds that gut phages crash, bloom, and bounce back after antibiotics, helping restore microbial balance via kill-the-winner dynamics.
✍️ @eugenpfeifer.bsky.social & coll.
📖 shorturl.at/AtafX
#MicroSky #AMR
May 27, 2025 at 4:25 AM
sfmpathogenesis.bsky.social
New study reveals that Salmonella can replicate inside macrophages even without its T3SSs, if the nutrient conditions are right! Metabolic heterogeneity of host cells is a game-changer in bacterial replication dynamics. #MicroSky

✍️ @pescoll.bsky.social and coll. @pasteur.fr

📖 shorturl.at/a9a06
May 17, 2025 at 6:41 AM
sfmpathogenesis.bsky.social
Why did Omicron dominate the #COVID19 waves?
New study reveals: Faster replication in human nasal tissue, Disruption of motile cilia & Stealthy evasion of innate immune defenses

Omicron wasn’t just fast, it was sneaky!

✍️ @lisachakrabarti.bsky.social and coll. @pasteur.fr

shorturl.at/ByGOh
May 7, 2025 at 5:14 AM
sfmpathogenesis.bsky.social
New study reveals how segmented filamentous bacteria attach to the gut lining: a unique tip structure on their intracellular offspring is key! Cryo-EM shows a novel S-layer transition at the tip, critical for immune-boosting host interaction. #Microsky
📖 shorturl.at/gXueL
✍️ P. Schnupf and coll.
April 11, 2025 at 1:37 PM
sfmpathogenesis.bsky.social
New study reveals how NCOA7-AS helps block flu virus entry by teaming up with V-ATPase and SNX5/6. Key mutations break this defense, offering new insight into how cells fight infection.
✍️ M. Arnaud-Arnould, @arebendenne.bsky.social, @mickael-blaise.bsky.social, C. Goujon & coll.
📖 shorturl.at/q2uYb
April 3, 2025 at 3:45 AM