Lorena Benedetti
@lorenabenedetti.bsky.social
Neuroscientist and cell biologist dedicated to unraveling how organelles adapt their structure and function to sustain neuronal signaling and metabolism. Postdoc in the JLS lab @ HHMI Janelia
Pinned
I am super excited to share our article addressing a longstanding question in neurobiology: how Ca²⁺ signaling cascades initiated at dendritic spines operate at a distance. Check it out here: authors.elsevier.com/sd/article/S... @cp-cell.bsky.social.
Excited that our paper was featured! It was exciting to bring together advanced imaging and physiology to uncover this hidden layer of communication in brain cells.
New blog post, where I review some recent interesting papers on the role of cell organelles for neuronal calcium signaling: gcamp6f.com/2025/08/11/i...
Featuring work by @lorenabenedetti.bsky.social, O'Hare et al. and Lin et al.!
Featuring work by @lorenabenedetti.bsky.social, O'Hare et al. and Lin et al.!
Interesting papers on the role of cell organelles in neuronal dendrites for calcium signaling
Researchers utilize calcium imaging to track neuronal activity in the brain, highlighting the role of calcium as a signaling molecule. Recent studies investigate intracellular calcium dynamics, par…
gcamp6f.com
October 3, 2025 at 5:41 PM
Excited that our paper was featured! It was exciting to bring together advanced imaging and physiology to uncover this hidden layer of communication in brain cells.
Thrilled to see our paper highlighted in @ptrrupprecht.bsky.social blog post!
The ER helps carry Ca2+ signals not just within dendrites but also across tiny spines, the main sites of synaptic input. This means that spines can be connected through the ER.
gcamp6f.com/2025/08/11/i...
The ER helps carry Ca2+ signals not just within dendrites but also across tiny spines, the main sites of synaptic input. This means that spines can be connected through the ER.
gcamp6f.com/2025/08/11/i...
Interesting papers on the role of cell organelles in neuronal dendrites for calcium signaling
Researchers utilize calcium imaging to track neuronal activity in the brain, highlighting the role of calcium as a signaling molecule. Recent studies investigate intracellular calcium dynamics, par…
gcamp6f.com
October 3, 2025 at 5:38 PM
Thrilled to see our paper highlighted in @ptrrupprecht.bsky.social blog post!
The ER helps carry Ca2+ signals not just within dendrites but also across tiny spines, the main sites of synaptic input. This means that spines can be connected through the ER.
gcamp6f.com/2025/08/11/i...
The ER helps carry Ca2+ signals not just within dendrites but also across tiny spines, the main sites of synaptic input. This means that spines can be connected through the ER.
gcamp6f.com/2025/08/11/i...
Extremely honored and humbled to be part of the 2025 Leading Edge Court. Grateful for the opportunity to join this inspiring community of scientists pushing the boundaries of discovery. Looking forward to learning, connecting, and growing together! 🌟
#LeadingEdge2025 #WomenInScience #hhmi #janelia
#LeadingEdge2025 #WomenInScience #hhmi #janelia
We are thrilled to announce the 2025 Leading Edge Fellows! 40 outstanding postdoctoral fellows doing pioneering research in a wide range of biological and biomedical disciplines.
Learn more about these exceptional scientists:
www.leadingedgesymposium.org/fellows
Learn more about these exceptional scientists:
www.leadingedgesymposium.org/fellows
May 30, 2025 at 2:25 PM
Extremely honored and humbled to be part of the 2025 Leading Edge Court. Grateful for the opportunity to join this inspiring community of scientists pushing the boundaries of discovery. Looking forward to learning, connecting, and growing together! 🌟
#LeadingEdge2025 #WomenInScience #hhmi #janelia
#LeadingEdge2025 #WomenInScience #hhmi #janelia
Cool new #optogenetic tool developed to disassemble intermediate filaments 🤩
Happy to officially introduce FilaBuster - a strategy for rapid, light-mediated intermediate filament disassembly. Compatible with multiple IF types, modular in design, and precise enough to induce localized filament disassembly in live cells.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
April 24, 2025 at 1:08 AM
Cool new #optogenetic tool developed to disassemble intermediate filaments 🤩
Reposted by Lorena Benedetti
What started as a brief chat with @buvansr.bsky.social and @vgelfand.bsky.social at the 2023 CellBio meeting @ascbiology.bsky.social has grown into our published collaborative work on single vimentin IF dynamics and organization in cells. Love when stuff like that happens.
Renganathan, Moor, @vgelfand.bsky.social et al. use single-particle tracking to show that #vimentin intermediate filaments display active movement throughout the cell, with individual filaments within a bundle moving independently rupress.org/jcb/article/...
#Cytoskeleton #Microscopy
#Cytoskeleton #Microscopy
March 10, 2025 at 6:39 PM
What started as a brief chat with @buvansr.bsky.social and @vgelfand.bsky.social at the 2023 CellBio meeting @ascbiology.bsky.social has grown into our published collaborative work on single vimentin IF dynamics and organization in cells. Love when stuff like that happens.
Reposted by Lorena Benedetti
Do you LOVE organelles??
Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social!
Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy
🧵1/N
Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social!
Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy
🧵1/N
February 27, 2025 at 8:13 PM
Do you LOVE organelles??
Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social!
Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy
🧵1/N
Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social!
Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy
🧵1/N
Reposted by Lorena Benedetti
🔬 Researchers from the Shroff Lab & collaborators have developed a new method to simultaneously image the 3D orientation & position of biomolecules, giving scientists a new view into how structures are arranged inside cells.
🔗 www.janelia.org/news/new-ima...
🔗 www.janelia.org/news/new-ima...
February 24, 2025 at 4:01 PM
🔬 Researchers from the Shroff Lab & collaborators have developed a new method to simultaneously image the 3D orientation & position of biomolecules, giving scientists a new view into how structures are arranged inside cells.
🔗 www.janelia.org/news/new-ima...
🔗 www.janelia.org/news/new-ima...
New insights into the mysterious spine apparatus from the super talented @haniehfalahati.bsky.social
Our paper is out just in time for #EM_Monday! It is about a specialized neuron-specific ER, called the spine apparatus, which is found close to synapses and has a very peculiar shape. If you think neurons are special, the spine apparatus is their🦄 horn! But how does it form?!
doi.org/10.1016/j.cu...
doi.org/10.1016/j.cu...
February 10, 2025 at 12:43 PM
New insights into the mysterious spine apparatus from the super talented @haniehfalahati.bsky.social
Reposted by Lorena Benedetti
💪New research led by @lorenabenedetti.bsky.social in the Lippincott-Schwartz Lab shows that subcellular structures similar to those that propagate signals that make muscles contract also transmit signals in the brain that may facilitate learning & memory 🧠
🔗 https://hhmi.news/4jMHbNY
🔗 https://hhmi.news/4jMHbNY
February 7, 2025 at 6:58 PM
💪New research led by @lorenabenedetti.bsky.social in the Lippincott-Schwartz Lab shows that subcellular structures similar to those that propagate signals that make muscles contract also transmit signals in the brain that may facilitate learning & memory 🧠
🔗 https://hhmi.news/4jMHbNY
🔗 https://hhmi.news/4jMHbNY
Reposted by Lorena Benedetti
This #FluorescenceFriday video shows 89 volumes from the #HHMIJanelia FlyLight Split-GAL4 collection: premotor and related neurons from the #Drosophila fruit fly's equivalent of a spinal cord. I gave a high-level description of the video to neuVid, which drove rendering by VVD Viewer.
January 3, 2025 at 9:59 AM
This #FluorescenceFriday video shows 89 volumes from the #HHMIJanelia FlyLight Split-GAL4 collection: premotor and related neurons from the #Drosophila fruit fly's equivalent of a spinal cord. I gave a high-level description of the video to neuVid, which drove rendering by VVD Viewer.
Check out the stunning movie by @xianglejerry.bsky.social from @wumin-lab.bsky.social, the winner of the 2024 ASCB Video Contest! Traveling waves of FBP17-EGFP at the cortex of immune mast cells #ASCB2024 @ascbiology.bsky.social
December 27, 2024 at 7:45 PM
Check out the stunning movie by @xianglejerry.bsky.social from @wumin-lab.bsky.social, the winner of the 2024 ASCB Video Contest! Traveling waves of FBP17-EGFP at the cortex of immune mast cells #ASCB2024 @ascbiology.bsky.social
Reposted by Lorena Benedetti
This video was fun. I matched the #Neuroscience segmentations shown first (from the #HHMIJanelia FlyEM team) to the #CellBiology segmentations shown later (from Alyson Petruncio, @herrsaalfeld.bsky.social and the CellMap team). I described the animation with neuVid and rendered it with #Blender.
December 21, 2024 at 9:58 AM
This video was fun. I matched the #Neuroscience segmentations shown first (from the #HHMIJanelia FlyEM team) to the #CellBiology segmentations shown later (from Alyson Petruncio, @herrsaalfeld.bsky.social and the CellMap team). I described the animation with neuVid and rendered it with #Blender.
Reposted by Lorena Benedetti
Congratulations to @lorenabenedetti.bsky.social and colleagues @jls_lab.bsky.social for this beautiful work revealing the role for periodic ER-PM junctions in propagating long range Ca²⁺ signaling along dendrites.
I am super excited to share our article addressing a longstanding question in neurobiology: how Ca²⁺ signaling cascades initiated at dendritic spines operate at a distance. Check it out here: authors.elsevier.com/sd/article/S... @cp-cell.bsky.social.
December 21, 2024 at 4:05 PM
Congratulations to @lorenabenedetti.bsky.social and colleagues @jls_lab.bsky.social for this beautiful work revealing the role for periodic ER-PM junctions in propagating long range Ca²⁺ signaling along dendrites.
Reposted by Lorena Benedetti
I was amazed to see this beautiful work at @hhmijanelia.bsky.social a few months ago - happy to see it out! The ER as an integral actor of neurotransmission 🤯
I am super excited to share our article addressing a longstanding question in neurobiology: how Ca²⁺ signaling cascades initiated at dendritic spines operate at a distance. Check it out here: authors.elsevier.com/sd/article/S... @cp-cell.bsky.social.
December 21, 2024 at 3:27 PM
I was amazed to see this beautiful work at @hhmijanelia.bsky.social a few months ago - happy to see it out! The ER as an integral actor of neurotransmission 🤯
Reposted by Lorena Benedetti
First heard of this at the cell biology of the neuron #GRC. It was such a great study with beautifully executed experiments. Congrats to everyone involved!
I am super excited to share our article addressing a longstanding question in neurobiology: how Ca²⁺ signaling cascades initiated at dendritic spines operate at a distance. Check it out here: authors.elsevier.com/sd/article/S... @cp-cell.bsky.social.
December 21, 2024 at 3:05 PM
First heard of this at the cell biology of the neuron #GRC. It was such a great study with beautifully executed experiments. Congrats to everyone involved!
Reposted by Lorena Benedetti
Very cool work on ER/PM junctions in neurons and how they regulate VGCCs. #neuroskyence
I am super excited to share our article addressing a longstanding question in neurobiology: how Ca²⁺ signaling cascades initiated at dendritic spines operate at a distance. Check it out here: authors.elsevier.com/sd/article/S... @cp-cell.bsky.social.
December 21, 2024 at 2:55 PM
Very cool work on ER/PM junctions in neurons and how they regulate VGCCs. #neuroskyence
I am super excited to share our article addressing a longstanding question in neurobiology: how Ca²⁺ signaling cascades initiated at dendritic spines operate at a distance. Check it out here: authors.elsevier.com/sd/article/S... @cp-cell.bsky.social.
December 20, 2024 at 9:13 PM
I am super excited to share our article addressing a longstanding question in neurobiology: how Ca²⁺ signaling cascades initiated at dendritic spines operate at a distance. Check it out here: authors.elsevier.com/sd/article/S... @cp-cell.bsky.social.
Reposted by Lorena Benedetti
Learn about the periodic ER organization along neurites in insects and vertebrates and its potential role in long-range Ca2+ signal integration
www.sciencedirect.com/science/arti...
by the fabulous @lorenabenedetti.bsky.social and friends.
www.sciencedirect.com/science/arti...
by the fabulous @lorenabenedetti.bsky.social and friends.
Periodic ER-plasma membrane junctions support long-range Ca2+ signal integration in dendrites
Neuronal dendrites must relay synaptic inputs over long distances, but the mechanisms by which activity-evoked intracellular signals propagate over ma…
www.sciencedirect.com
December 20, 2024 at 7:43 PM
Learn about the periodic ER organization along neurites in insects and vertebrates and its potential role in long-range Ca2+ signal integration
www.sciencedirect.com/science/arti...
by the fabulous @lorenabenedetti.bsky.social and friends.
www.sciencedirect.com/science/arti...
by the fabulous @lorenabenedetti.bsky.social and friends.
Reposted by Lorena Benedetti
It was such a pleasure to host you both at our #CellBio2024 #SciArt Show & Reception! Thank you for making this event so special, and for bringing your creativity and enthusiasm to our community 😍
Turning #science into art, one masterpiece at a time! 🎨🔬
Check out some incredible
#sciart from last night's Science Art show at #CellBio2024 featuring the work of Institute members @snowotarski.bsky.social and Mol Mir! @beatascienceart.bsky.social
Check out some incredible
#sciart from last night's Science Art show at #CellBio2024 featuring the work of Institute members @snowotarski.bsky.social and Mol Mir! @beatascienceart.bsky.social
December 19, 2024 at 1:09 AM
It was such a pleasure to host you both at our #CellBio2024 #SciArt Show & Reception! Thank you for making this event so special, and for bringing your creativity and enthusiasm to our community 😍
Reposted by Lorena Benedetti
Really bummed to have missed ASCB this year due to some last-minute circumstances, but excited that our manuscript describing an IF disassembly tool will (hopefully) be posted soon. Here's a movie of vimentin color-coded by orientation.
December 18, 2024 at 5:40 AM
Really bummed to have missed ASCB this year due to some last-minute circumstances, but excited that our manuscript describing an IF disassembly tool will (hopefully) be posted soon. Here's a movie of vimentin color-coded by orientation.
Reposted by Lorena Benedetti
ASCB President Sandra Murray with our 2024 Mentoring Keynote, Sonya Neal, Associate Professor, HHMI Freeman Hrabowski Scholar, UC San Diego, HHMI #CellBio2024
December 14, 2024 at 4:28 PM
ASCB President Sandra Murray with our 2024 Mentoring Keynote, Sonya Neal, Associate Professor, HHMI Freeman Hrabowski Scholar, UC San Diego, HHMI #CellBio2024
Reposted by Lorena Benedetti
Hullooooo Cell Biology friends. If you're heading to #CellBio2024 in (hopefully!) sunny San Diego this year, then come and check out our session on 'ER structure and function across cell types' Room28C- Dec18th 09:00am! See you there! **Please RT** 🥳
November 19, 2024 at 8:22 PM
Hullooooo Cell Biology friends. If you're heading to #CellBio2024 in (hopefully!) sunny San Diego this year, then come and check out our session on 'ER structure and function across cell types' Room28C- Dec18th 09:00am! See you there! **Please RT** 🥳
Reposted by Lorena Benedetti
🚨For the lucky colleagues attending #CellBio2024 in San Diego, check out our session on 'ER structure and function across cell types' Room28C- Dec18th 09:00am! A fantastic lineup covering the latest across the field.
See you there! **Please RT** 🥳
t.co/6eq3cyGlVZ
November 26, 2024 at 6:06 PM
🚨For the lucky colleagues attending #CellBio2024 in San Diego, check out our session on 'ER structure and function across cell types' Room28C- Dec18th 09:00am! A fantastic lineup covering the latest across the field.
See you there! **Please RT** 🥳
t.co/6eq3cyGlVZ
Reposted by Lorena Benedetti
#CellBio2024, the joint meeting of ASCB and EMBO, will take place December 14-18, 2024, in San Diego, California. Join us to connect with scientists, present your research, and explore the latest advancements in cell biology science and technology.
www.ascb.org/cellbio2024/
www.ascb.org/cellbio2024/
November 27, 2024 at 2:43 PM
#CellBio2024, the joint meeting of ASCB and EMBO, will take place December 14-18, 2024, in San Diego, California. Join us to connect with scientists, present your research, and explore the latest advancements in cell biology science and technology.
www.ascb.org/cellbio2024/
www.ascb.org/cellbio2024/
Reposted by Lorena Benedetti
Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..
December 4, 2024 at 4:05 PM
Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..