Hanieh Falahati
@haniehfalahati.bsky.social
A broken Jack-In-The-Box. @De Camilli lab @Yale. Formerly @Wieschaus lab @Princeton
Pinned
Our paper is out just in time for #EM_Monday! It is about a specialized neuron-specific ER, called the spine apparatus, which is found close to synapses and has a very peculiar shape. If you think neurons are special, the spine apparatus is their🦄 horn! But how does it form?!
doi.org/10.1016/j.cu...
doi.org/10.1016/j.cu...
People I can’t recommend this enough! He is one of the most knowledgeable people I know, a great mentor AND a wonderful person
The Hanna lab is looking for an enthusiastic Research Technologist to join the team! 😊
You’ll help lead projects focused on organelle health & resilience to establish momentum in the lab. 🔬🥽
Job description and details can be found here: psu.wd1.myworkdayjobs.com/PSU_Staff/jo...
You’ll help lead projects focused on organelle health & resilience to establish momentum in the lab. 🔬🥽
Job description and details can be found here: psu.wd1.myworkdayjobs.com/PSU_Staff/jo...
Research Technologist
APPLICATION INSTRUCTIONS: CURRENT PENN STATE EMPLOYEE (faculty, staff, technical service, or student), please login to Workday to complete the internal application process. Please do not apply here, a...
psu.wd1.myworkdayjobs.com
October 23, 2025 at 1:03 PM
People I can’t recommend this enough! He is one of the most knowledgeable people I know, a great mentor AND a wonderful person
Reposted by Hanieh Falahati
One for the Apicomplexa peeps:
ever wonder how does the IMC grow so fast during progeny formation? Where do all the lipids come from? In our latest work on malaria RBC stages we implicate this monster protein (~6000 residues!) and ER contact sites.
Happy+proud to share and keen to hear thoughts!
ever wonder how does the IMC grow so fast during progeny formation? Where do all the lipids come from? In our latest work on malaria RBC stages we implicate this monster protein (~6000 residues!) and ER contact sites.
Happy+proud to share and keen to hear thoughts!
July 26, 2025 at 5:16 PM
One for the Apicomplexa peeps:
ever wonder how does the IMC grow so fast during progeny formation? Where do all the lipids come from? In our latest work on malaria RBC stages we implicate this monster protein (~6000 residues!) and ER contact sites.
Happy+proud to share and keen to hear thoughts!
ever wonder how does the IMC grow so fast during progeny formation? Where do all the lipids come from? In our latest work on malaria RBC stages we implicate this monster protein (~6000 residues!) and ER contact sites.
Happy+proud to share and keen to hear thoughts!
Reposted by Hanieh Falahati
The Hanna lab opens this coming January in the Dept of Biochemistry and Molecular Biology at Penn State Uni! Follow us as we uncover the mechanisms that respond to lysosome damage
May 28, 2025 at 1:26 PM
The Hanna lab opens this coming January in the Dept of Biochemistry and Molecular Biology at Penn State Uni! Follow us as we uncover the mechanisms that respond to lysosome damage
Reposted by Hanieh Falahati
A very special first post on Bluesky: I’m excited to share that I’ll be starting my lab at Penn State this coming January in the Dept of Biochemistry & Molecular Biology! I’ll be hiring at all levels soon. Check out updates, thoughts, and positions on the lab account: @hanna-lab.bsky.social
May 28, 2025 at 1:25 PM
A very special first post on Bluesky: I’m excited to share that I’ll be starting my lab at Penn State this coming January in the Dept of Biochemistry & Molecular Biology! I’ll be hiring at all levels soon. Check out updates, thoughts, and positions on the lab account: @hanna-lab.bsky.social
Reposted by Hanieh Falahati
Mo and Hans's work here is truly a landmark in dense structural imaging, but the proof of the pudding is in the eating. Do yourself a favor and check out the Neuroglancer links and get an early glimpse at a technique I'm confident we'll see more and more over the next few years.
Light-microscopy-based connectomic reconstruction of mammalian brain tissue - Nature
A technique called LICONN (light-microscopy-based connectomics) allows mapping of brain tissue at synapse level and simultaneous measurement of molecular information, thus enabling quantification of c...
www.nature.com
May 10, 2025 at 2:26 AM
Mo and Hans's work here is truly a landmark in dense structural imaging, but the proof of the pudding is in the eating. Do yourself a favor and check out the Neuroglancer links and get an early glimpse at a technique I'm confident we'll see more and more over the next few years.
Earlier this month I had the honor of interviewing Dr. Zoncu @robzonculab.bsky.social during his visit to Yale. It was so inspiring- and also fun! Here is a link: medicine.yale.edu/cellbio/news...
Meet our Speakers: Dr. Roberto Zoncu
As a scientist, starting from my postdoc and continuing in my own lab, we have helped redefine the role of the lysosome. Historically, it was considered a
medicine.yale.edu
April 19, 2025 at 1:00 AM
Earlier this month I had the honor of interviewing Dr. Zoncu @robzonculab.bsky.social during his visit to Yale. It was so inspiring- and also fun! Here is a link: medicine.yale.edu/cellbio/news...
Reposted by Hanieh Falahati
"The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage" out now in Nature Cell Biology
rdcu.be/ehbaL
rdcu.be/ehbaL
The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage
Nature Cell Biology - Wang et al. show the recruitment of the lipid channel protein VPS13C and formation of VPS13C-dependent contacts between endoplasmic reticulum and lysosomes after lysosomal...
rdcu.be
April 10, 2025 at 2:17 PM
"The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage" out now in Nature Cell Biology
rdcu.be/ehbaL
rdcu.be/ehbaL
Reposted by Hanieh Falahati
It's been done for a while, accepted almost a year ago, but I'm happy to share that my first analysis of the MICrONs cubic mm dataset is online! nature.com/articles/s41...
Inhibitory specificity from a connectomic census of mouse visual cortex - Nature
Using volumetric electron microscopy, the authors map and analyze the structure of cortical inhibition with synaptic resolution across a column of visual cortex.
nature.com
April 9, 2025 at 10:41 PM
It's been done for a while, accepted almost a year ago, but I'm happy to share that my first analysis of the MICrONs cubic mm dataset is online! nature.com/articles/s41...
When the 1st Muslim ban was about to go into effect, I was toward the end of my PhD. I went to Eric’s office in tears to ask if I could still defend my thesis and get a PhD if my legal status was revoked. I was lucky but I am heartbroken that this is actually happening to some students now
April 8, 2025 at 3:17 AM
When the 1st Muslim ban was about to go into effect, I was toward the end of my PhD. I went to Eric’s office in tears to ask if I could still defend my thesis and get a PhD if my legal status was revoked. I was lucky but I am heartbroken that this is actually happening to some students now
Random small reason to be happy: I have got 777 citations today 😄 my favorite number is 7
April 4, 2025 at 12:43 AM
Random small reason to be happy: I have got 777 citations today 😄 my favorite number is 7
Reposted by Hanieh Falahati
Princeton has announced that it is considering selling approximately $320 million of taxable bonds. The bonds are a way for the University to raise short-term funds. The major credit-rating agencies rate University bonds AAA, the highest level of creditworthiness.
Princeton considers issuing bonds same day as federal government pauses grants
The University announced its consideration to sell approximately $320 million of taxable bonds on Tuesday, following a notification from government agencies about the suspension of research grants.
www.dailyprincetonian.com
April 2, 2025 at 12:12 PM
Princeton has announced that it is considering selling approximately $320 million of taxable bonds. The bonds are a way for the University to raise short-term funds. The major credit-rating agencies rate University bonds AAA, the highest level of creditworthiness.
Reposted by Hanieh Falahati
Like the cultural revolution, when anyone smarter than the regime was fired and sent to the countryside. Mao-Tse Trump.
“Dr. Richard Youle, a leading researcher in the field of neurodegenerative disorders…including identifying mechanisms behind Parkinson’s disease” was one of several top scientists PURGED from the NIH today courtesy of Trump/Musk/DOGE.
www.wired.com/story/doctor...
www.wired.com/story/doctor...
Doctor Behind Award-Winning Parkinson’s Research Among Scientists Purged From NIH
Leading scientists at the National Institutes of Health, the US’s leading medical research agency, were swept up Tuesday in the Trump administration’s latest firing blitz.
www.wired.com
April 2, 2025 at 8:04 AM
Like the cultural revolution, when anyone smarter than the regime was fired and sent to the countryside. Mao-Tse Trump.
Reposted by Hanieh Falahati
Worth following @fly-broadcast.bsky.social for new fly papers on PubMed. They deserve a lot more than 50 followers!
@bdsc.bsky.social @flybase.bsky.social @fly-eds.bsky.social @dgrc.bsky.social
@bdsc.bsky.social @flybase.bsky.social @fly-eds.bsky.social @dgrc.bsky.social
PDZD8 promotes autophagy at ER-lysosome membrane contact sites to regulate activity-dependent synaptic growth
#Drosophila
#Drosophila
PDZD8 promotes autophagy at ER-lysosome membrane contact sites to regulate activity-dependent synaptic growth
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
March 31, 2025 at 4:38 PM
Worth following @fly-broadcast.bsky.social for new fly papers on PubMed. They deserve a lot more than 50 followers!
@bdsc.bsky.social @flybase.bsky.social @fly-eds.bsky.social @dgrc.bsky.social
@bdsc.bsky.social @flybase.bsky.social @fly-eds.bsky.social @dgrc.bsky.social
Reposted by Hanieh Falahati
Check out our new review on induced proximity modalities (#TPD and a lot more!) aimed cell surface targets @naturebiotech.bsky.social, spearheaded by postdocs Nick Till and "Rahm" Ramanathan
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Induced proximity at the cell surface - Nature Biotechnology
Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses.
www.nature.com
March 26, 2025 at 2:32 PM
Check out our new review on induced proximity modalities (#TPD and a lot more!) aimed cell surface targets @naturebiotech.bsky.social, spearheaded by postdocs Nick Till and "Rahm" Ramanathan
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Hanieh Falahati
regarding Columbia University, I just learned about this (anonymous) account of negotiations of the Hitler regime in the 1930s with Frankfurt University -- Germany's most prestigious university at the time:
March 24, 2025 at 1:57 PM
regarding Columbia University, I just learned about this (anonymous) account of negotiations of the Hitler regime in the 1930s with Frankfurt University -- Germany's most prestigious university at the time:
In this belated, crazy, #EM_Monday I am posting an image I took showing some organellar communications at a neuronal soma: a mitochondria contacting nuclear envelope, and Golgi going all the way from nuclear envelope to plasma membrane.
March 11, 2025 at 7:15 PM
In this belated, crazy, #EM_Monday I am posting an image I took showing some organellar communications at a neuronal soma: a mitochondria contacting nuclear envelope, and Golgi going all the way from nuclear envelope to plasma membrane.
Reposted by Hanieh Falahati
Honored to be featured this week by @yaleneuro.bsky.social in honor of my Life Sciences Research Foundation @hhmi.org fellowship!
This week’s ✨ #TraineeTuesday ✨ is the incredible Sydney Cason, a postdoc in the De Camilli lab who was recently awarded the Life Sciences Research Foundation Postdoc Fellowship 🏆 for her work exploring lipid transfer in neurons!
Let’s dive into her journey! [1/5]
Let’s dive into her journey! [1/5]
March 11, 2025 at 5:29 PM
Honored to be featured this week by @yaleneuro.bsky.social in honor of my Life Sciences Research Foundation @hhmi.org fellowship!
Reposted by Hanieh Falahati
In a remarkable new paper, Qureshi and Duss use multi-colour single-molecule fluorescence microscopy to directly and simultaneously track transcription, translation & coupling 3/n
www.nature.com/articles/s41...
www.nature.com/articles/s41...
March 1, 2025 at 1:40 PM
In a remarkable new paper, Qureshi and Duss use multi-colour single-molecule fluorescence microscopy to directly and simultaneously track transcription, translation & coupling 3/n
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Hanieh Falahati
Thrilled & honored to be a recipient of a Sloan Fellowship in Chemistry. Thanks for my mentors, colleagues and most importantly my students, for making this possible. #SloanFellow.
🎉Congrats to the 126 early-career scientists who have been awarded a Sloan Research Fellowship this year! These exceptional scholars are drawn from 51 institutions across the US and Canada, and represent the next generation of groundbreaking researchers. sloan.org/fellowships/...
February 18, 2025 at 4:11 PM
Thrilled & honored to be a recipient of a Sloan Fellowship in Chemistry. Thanks for my mentors, colleagues and most importantly my students, for making this possible. #SloanFellow.
And then comes the firing of scientists…
This current freeze of research funds in US reminds me of Iran’s cultural revolution en.m.wikipedia.org/wiki/Cultura...
Cultural Revolution in Iran - Wikipedia
en.m.wikipedia.org
February 17, 2025 at 7:39 PM
And then comes the firing of scientists…
I feel sick to my stomach… what is happening to US science
February 17, 2025 at 7:27 PM
I feel sick to my stomach… what is happening to US science
Reposted by Hanieh Falahati
Everything you always wanted to know about the Axon Initial Segment might be here: authors.elsevier.com/sd/article/S...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
February 13, 2025 at 1:10 PM
Everything you always wanted to know about the Axon Initial Segment might be here: authors.elsevier.com/sd/article/S...
Reposted by Hanieh Falahati
Breaking news: 22 states are suing to block NIH’s cutting of indirect costs.
See our updated story on the Friday night news and its aftermath. scim.ag/4hTJQ6v
See our updated story on the Friday night news and its aftermath. scim.ag/4hTJQ6v
NIH slashes overhead payments for research, sparking outrage and lawsuit
Move to cut indirect cost rate to 15% could cost universities billions of dollars
scim.ag
February 10, 2025 at 6:43 PM
Breaking news: 22 states are suing to block NIH’s cutting of indirect costs.
See our updated story on the Friday night news and its aftermath. scim.ag/4hTJQ6v
See our updated story on the Friday night news and its aftermath. scim.ag/4hTJQ6v