Andrés Guillén Samander
@aguillensamander.bsky.social
🇵🇪 EMBO Postdoctoral Fellow @BNITM in Hamburg studying interorganelle communication in Malaria parasites
Reposted by Andrés Guillén Samander
The Hanna lab is looking for an enthusiastic Research Technologist to join the team! 😊
You’ll help lead projects focused on organelle health & resilience to establish momentum in the lab. 🔬🥽
Job description and details can be found here: psu.wd1.myworkdayjobs.com/PSU_Staff/jo...
You’ll help lead projects focused on organelle health & resilience to establish momentum in the lab. 🔬🥽
Job description and details can be found here: psu.wd1.myworkdayjobs.com/PSU_Staff/jo...
Research Technologist
APPLICATION INSTRUCTIONS: CURRENT PENN STATE EMPLOYEE (faculty, staff, technical service, or student), please login to Workday to complete the internal application process. Please do not apply here, a...
psu.wd1.myworkdayjobs.com
October 22, 2025 at 7:09 PM
The Hanna lab is looking for an enthusiastic Research Technologist to join the team! 😊
You’ll help lead projects focused on organelle health & resilience to establish momentum in the lab. 🔬🥽
Job description and details can be found here: psu.wd1.myworkdayjobs.com/PSU_Staff/jo...
You’ll help lead projects focused on organelle health & resilience to establish momentum in the lab. 🔬🥽
Job description and details can be found here: psu.wd1.myworkdayjobs.com/PSU_Staff/jo...
Reposted by Andrés Guillén Samander
The outer membrane of Gram-negative bacteria blocks many antibiotics. Our latest work reveals that L-type pyocins bypass this barrier by inactivating the BAM complex, killing Pseudomonas aeruginosa without entering the cell, providing a new blueprint for beating antibiotic resistance.
A Protein Antibiotic Inhibits the BAM Complex to Kill Without Cell Entry
Many antibiotics are ineffective against Gram-negative pathogens such as Pseudomonas aeruginosa because they cannot penetrate the bacterial outer membrane. Here, we show that protein antibiotics calle...
www.biorxiv.org
September 20, 2025 at 9:29 AM
The outer membrane of Gram-negative bacteria blocks many antibiotics. Our latest work reveals that L-type pyocins bypass this barrier by inactivating the BAM complex, killing Pseudomonas aeruginosa without entering the cell, providing a new blueprint for beating antibiotic resistance.
Reposted by Andrés Guillén Samander
New paper alert! I’m very excited to share our paper published in @embojournal.org! @pdc-lab.bsky.social @yaleneuro.bsky.social
Bridge-like lipid transfer protein 3A (BLTP3A) participates in endomembrane repair as an effector of #ATG8 conjugation to single membranes (CASM) - helping repair or minimize #lysosome damage
@mike-hanna.bsky.social et al, @pdc-lab.bsky.social
www.embopress.org/doi/full/10....
@mike-hanna.bsky.social et al, @pdc-lab.bsky.social
www.embopress.org/doi/full/10....
September 12, 2025 at 2:04 PM
New paper alert! I’m very excited to share our paper published in @embojournal.org! @pdc-lab.bsky.social @yaleneuro.bsky.social
Reposted by Andrés Guillén Samander
Rodriguez Salazar, @caglaeroglu.bsky.social et al. @dukehealth.bsky.social show that Drp1-mediated mitochondrial fission is necessary for peripheral #astrocyte process formation. Loss of Drp1 induces astrocyte reactivity & disrupts cortical astrocyte organization rupress.org/jcb/article/...
September 3, 2025 at 6:30 PM
Rodriguez Salazar, @caglaeroglu.bsky.social et al. @dukehealth.bsky.social show that Drp1-mediated mitochondrial fission is necessary for peripheral #astrocyte process formation. Loss of Drp1 induces astrocyte reactivity & disrupts cortical astrocyte organization rupress.org/jcb/article/...
Reposted by Andrés Guillén Samander
@anbangdai.bsky.social et al. @pdc-lab.bsky.social report the localization of BLTP2 in different human cell types & reveal binding partners that mediate its tethering to the PM & to PM-connected structures including certain #endosomes & #macropinosomes undergoing fusion rupress.org/jcb/article/...
September 3, 2025 at 4:15 PM
@anbangdai.bsky.social et al. @pdc-lab.bsky.social report the localization of BLTP2 in different human cell types & reveal binding partners that mediate its tethering to the PM & to PM-connected structures including certain #endosomes & #macropinosomes undergoing fusion rupress.org/jcb/article/...
Reposted by Andrés Guillén Samander
New preprint: In situ Architecture of #Plasmodesmata.
Using #cryoET, #AlphaFold & proteomics, we uncover the native organization of plant intercellular nanopores.
🔗 doi.org/10.1101/2025...
🧪🧵1/n
#teamtomo #PlantScience #Physcomitrium #Arabidopsis #cryoEM
Using #cryoET, #AlphaFold & proteomics, we uncover the native organization of plant intercellular nanopores.
🔗 doi.org/10.1101/2025...
🧪🧵1/n
#teamtomo #PlantScience #Physcomitrium #Arabidopsis #cryoEM
July 26, 2025 at 3:38 PM
New preprint: In situ Architecture of #Plasmodesmata.
Using #cryoET, #AlphaFold & proteomics, we uncover the native organization of plant intercellular nanopores.
🔗 doi.org/10.1101/2025...
🧪🧵1/n
#teamtomo #PlantScience #Physcomitrium #Arabidopsis #cryoEM
Using #cryoET, #AlphaFold & proteomics, we uncover the native organization of plant intercellular nanopores.
🔗 doi.org/10.1101/2025...
🧪🧵1/n
#teamtomo #PlantScience #Physcomitrium #Arabidopsis #cryoEM
One for the Apicomplexa peeps:
ever wonder how does the IMC grow so fast during progeny formation? Where do all the lipids come from? In our latest work on malaria RBC stages we implicate this monster protein (~6000 residues!) and ER contact sites.
Happy+proud to share and keen to hear thoughts!
ever wonder how does the IMC grow so fast during progeny formation? Where do all the lipids come from? In our latest work on malaria RBC stages we implicate this monster protein (~6000 residues!) and ER contact sites.
Happy+proud to share and keen to hear thoughts!
July 26, 2025 at 5:16 PM
One for the Apicomplexa peeps:
ever wonder how does the IMC grow so fast during progeny formation? Where do all the lipids come from? In our latest work on malaria RBC stages we implicate this monster protein (~6000 residues!) and ER contact sites.
Happy+proud to share and keen to hear thoughts!
ever wonder how does the IMC grow so fast during progeny formation? Where do all the lipids come from? In our latest work on malaria RBC stages we implicate this monster protein (~6000 residues!) and ER contact sites.
Happy+proud to share and keen to hear thoughts!
Reposted by Andrés Guillén Samander
"The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage" out now in Nature Cell Biology
rdcu.be/ehbaL
rdcu.be/ehbaL
The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage
Nature Cell Biology - Wang et al. show the recruitment of the lipid channel protein VPS13C and formation of VPS13C-dependent contacts between endoplasmic reticulum and lysosomes after lysosomal...
rdcu.be
April 10, 2025 at 2:17 PM
"The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage" out now in Nature Cell Biology
rdcu.be/ehbaL
rdcu.be/ehbaL
Reposted by Andrés Guillén Samander
📢 The Preliminary Programme for the 2nd WiM Online Conference is out 🥳 🎉
The Early Bird Registration closes Feb 14 2025, 23.59 UTC (50 USD). Fee waivers are available for LMICs & you can also buy fee waivers or donate. Register and apply/donate: womeninmalaria.es/wim-conferen... 💙💛 Please share!
The Early Bird Registration closes Feb 14 2025, 23.59 UTC (50 USD). Fee waivers are available for LMICs & you can also buy fee waivers or donate. Register and apply/donate: womeninmalaria.es/wim-conferen... 💙💛 Please share!
January 27, 2025 at 7:26 PM
📢 The Preliminary Programme for the 2nd WiM Online Conference is out 🥳 🎉
The Early Bird Registration closes Feb 14 2025, 23.59 UTC (50 USD). Fee waivers are available for LMICs & you can also buy fee waivers or donate. Register and apply/donate: womeninmalaria.es/wim-conferen... 💙💛 Please share!
The Early Bird Registration closes Feb 14 2025, 23.59 UTC (50 USD). Fee waivers are available for LMICs & you can also buy fee waivers or donate. Register and apply/donate: womeninmalaria.es/wim-conferen... 💙💛 Please share!
Reposted by Andrés Guillén Samander
Our paper is out just in time for #EM_Monday! It is about a specialized neuron-specific ER, called the spine apparatus, which is found close to synapses and has a very peculiar shape. If you think neurons are special, the spine apparatus is their🦄 horn! But how does it form?!
doi.org/10.1016/j.cu...
doi.org/10.1016/j.cu...
December 2, 2024 at 5:52 PM
Our paper is out just in time for #EM_Monday! It is about a specialized neuron-specific ER, called the spine apparatus, which is found close to synapses and has a very peculiar shape. If you think neurons are special, the spine apparatus is their🦄 horn! But how does it form?!
doi.org/10.1016/j.cu...
doi.org/10.1016/j.cu...