Dhanur Prakash Iyer
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dhanuriyer.bsky.social
Dhanur Prakash Iyer
@dhanuriyer.bsky.social
62 followers 200 following 4 posts
PhD@Bulut Karslioglu lab, Berlin. Postdoctoral researcher in Ruprecht lab at the CRG, Barcelona, and University of Innsbruck .
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Reposted by Dhanur Prakash Iyer
zebrafishrock.bsky.social
Finally! A working protocol for the RT sperm storage 🐟

Working link: bio-protocol.org/en/bpdetail?...
bio-protocol.bsky.social Bio-protocol @bio-protocol.bsky.social · 4d
Room-Temperature Storage of Zebrafish and Medaka Sperm Using Lactic Acid-Stabilized L-15 Medium:https://bio-protocol.org/en/bpdetail?id=5534&type=0&source=Bluesky
December 19, 2025 at 6:50 AM
Reposted by Dhanur Prakash Iyer
neurogut.bsky.social
Textbooks said neurons don’t burn fatty acids for energy🤔. Our study delivers the first in vivo demonstration that fatty acid oxidation in defined memory neurons fuels memory formation.

Closing chapter of my PhD 🥳, out today in Nature Metabolism💥 @natmetabolism.nature.com
Neuronal fatty acid oxidation fuels memory after intensive learning in Drosophila - Nature Metabolism
Neurons are shown to use fatty acid β-oxidation as a fuel source for memory formation upon intensive learning in Drosophila, challenging the view that neurons are unable to use fatty acids for energy ...
www.nature.com
December 10, 2025 at 11:13 AM
Reposted by Dhanur Prakash Iyer
amartinezarias.bsky.social
Enjoying a visit @DBT_inStem & @ncbsbangalore.bsky.social
Beautiful campus, great Science, amazing students
Thank you @InamdarManeesha for the opportunity and @kvijayraghavan.bsky.social for a stimulating conversation
December 11, 2025 at 7:05 AM
Reposted by Dhanur Prakash Iyer
matthias-krause.bsky.social
Exciting new findings: Wnt-receptor endocytosis is required for canonical Wnt activation, yet uptake mechanisms has been controversial. We resolve this by showing that Wnt3a triggers rapid Clathrin- and Fast Endophilin-Mediated LRP6 endocytosis at low concentrations sufficient for Wnt activation.
The Actin regulator Mena promotes Wnt signalosome endocytosis and Wnt signalling
Wnt signaling controls embryonic development and tissue maintenance. Endocytosis of Wnt-receptors is required for signalling, yet uptake mechanisms remain poorly understood. Here, we identify the acti...
www.biorxiv.org
November 27, 2025 at 9:51 AM
Reposted by Dhanur Prakash Iyer
amoyellab.bsky.social
Join us for a new zoom series on metabolism and development. This will be a monthly feature with PIs and trainees presenting.
Sign up here (forms.gle/Y8QzucogKKrZ...) to get the Zoom link and join the mailing list.
October 28, 2025 at 6:05 PM
Reposted by Dhanur Prakash Iyer
niethammerlab.bsky.social
After some limbo, paper #1 finally accepted (i.p.). Watch out for a comprehensively updated version of pubmed.ncbi.nlm.nih.gov/39711539/.
coming soon. My gratitude to the reviewers for their thoughtful suggestions and critical but fair review. Kudos to Joe and Zaza for all the hard work!
October 3, 2025 at 7:35 PM
Reposted by Dhanur Prakash Iyer
mrsantos.bsky.social
(2/4) We discovered that Nodal/Smad2 signaling, a branch of the TGF-β pathway, is essential to sustain this paused state in embryonic stem cells and embryos. www.biorxiv.org/content/10.1...
Nodal/Smad2 signaling sustains developmental pausing by repressing Pparg-mediated lipid metabolism
Cells and organisms can enter transient dormant states to survive unfavorable conditions during development, physiological adult contexts, and disease. One paradigmatic case of dormancy is diapause, w...
www.biorxiv.org
October 9, 2025 at 8:08 PM
Reposted by Dhanur Prakash Iyer
kongjuzhu.bsky.social
Fantastic work from Xi and Qi-long! Chicken ES cells will take classic chicken embryology to a new level.
October 10, 2025 at 6:15 AM
Reposted by Dhanur Prakash Iyer
dev-journal.bsky.social
In preprints: gastruloids get (a)head

Wilhelmus A. Brouwer @wesselbrouwer.bsky.social and
Luca Braccioli @bracciolilab.bsky.social discuss the #preprint by Balaskas et al. "An advanced head-to-tail mouse embryo model with hypoxia-mediated neural patterning”

journals.biologists.com/dev/article/...
In Preprints: A new preprint curation initiative from Development
October 6, 2025 at 5:44 PM
Reposted by Dhanur Prakash Iyer
molgen.mpg.de
In our “Meet the first author” interview series, we take a look behind the scenes of science. This time we spoke with Francesca Rossi, first author of a recent collaborative paper in Nucleic Acids Research from the Kinkley Lab.

👉 Read the interview here: www.molgen.mpg.de/2025-09-22-m...
October 6, 2025 at 8:59 AM
Reposted by Dhanur Prakash Iyer
akankshi.bsky.social
Our latest preprint! Into morphogenesis, Yap, ECM, signaling, vertex models, feedbacks/robustness? There is something here for everyone. We discovered a positive feedback loop that extends inner ear canals, and a built-in mechanism that shuts it down when morphogenesis is done. tinyurl.com/464wsjhd
September 26, 2025 at 12:55 PM
Reposted by Dhanur Prakash Iyer
stefanschoenfelder.bsky.social
This paper uncovers that HERVK LTR5Hs, a hominoid-specific retrovirus, act as epiblast enhancers with a crucial function in human pre-implantation development - stunning!
doi.org/10.1038/s415...
A human-specific regulatory mechanism revealed in a pre-implantation model - Nature
Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.
doi.org
October 4, 2025 at 10:51 PM
Reposted by Dhanur Prakash Iyer
adrianobolondi.bsky.social
🚨JOB ALERT🚨

FRIENDS PLEASE SPREAD and RT

We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.

See below 2 calls👇
October 2, 2025 at 11:00 AM
Reposted by Dhanur Prakash Iyer
sarawickstrom.bsky.social
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
www.nature.com
September 29, 2025 at 4:45 PM
Reposted by Dhanur Prakash Iyer
juliabatki.bsky.social
I am excited to announce that we are looking for a Lab Manager @fmiscience.bsky.social in Basel. If you want to be part of a growing team investigating development and tissue formation, and are enthusiastic about helping set up a new lab, please check out the role:

www.fmi.ch/education-ca...
September 14, 2025 at 11:46 AM
Reposted by Dhanur Prakash Iyer
nadlerlab.bsky.social
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
August 21, 2025 at 5:19 AM
Reposted by Dhanur Prakash Iyer
slefkopoulos.bsky.social
Anyone here interested in #metabolism in #devbio ?
We recently published a Review article by Jin Zhang & co discussing the relationship between metabolism and #embryogenesis. Enjoy the read! :D
👉https://rdcu.be/eADIT
www.nature.com/articles/s41...
Metabolic regulation of key developmental events during mammalian embryogenesis - Nature Cell Biology
This Review discusses the intricate relationship between metabolism and embryogenesis, highlighting the orchestration of key developmental processes by metabolites and signalling molecules that provid...
www.nature.com
August 13, 2025 at 9:08 PM
Reposted by Dhanur Prakash Iyer
cecad.bsky.social
What happens when #mitochondria fail in high-energy tissues? Cells adjust their metabolism and alter the mechanics of the nucleus! Read more on the discovery by Dr. Harshita Kaul from the Trifunovic Lab in Nature Metabolism.

➡️ uni.koeln/QZURH

#CellStress #NatureMetabolism @unicologne.bsky.social
Beyond classic stress signalling: how mitochondrial stress softens the cell nucleus and alters cellular identity
A University of Cologne research team has discovered that cells in high-energy-demanding tissues respond to mitochondrial dysfunction in a surprising way. Instead of shutting down, cells adjust their ...
uni.koeln
August 1, 2025 at 12:22 PM
Reposted by Dhanur Prakash Iyer
gautamdey.bsky.social
1 month to abstract deadline for the first cell biology of the nucleus meeting at @embl.org in many years - organised by the stellar @luskinglab.bsky.social @sarawickstrom.bsky.social Tom Quail & Simone Koehler

Tons of open slots, invited and selected speakers all get 20 mins ❤️

#EESNucleus
July 23, 2025 at 10:49 AM
Reposted by Dhanur Prakash Iyer
abbybuch.bsky.social
The nuclear lamina strengthens the nucleus and organizes the genome. So what happens when you acutely degrade it in living cells? Not what we thought! (1/n)
www.molbiolcell.org/doi/10.1091/...
Lamin B1 and LAP2β resist cytoskeletal force to maintain lamin A/C meshwork organization and preserve nuclear integrity | Molecular Biology of the Cell
The nuclear lamins are extremely long-lived proteins in most cell types. As a consequence, lamin function cannot be effectively dissected with temporal precision using standard knock-down approaches. ...
www.molbiolcell.org
July 21, 2025 at 5:46 PM
Reposted by Dhanur Prakash Iyer
felixmendu.bsky.social
Announcing a new @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology" that we are organizing with Michael Krieg and Verena Ruprecht at @icfo.eu (Barcelona) on 16-20 February, 2026. Please, repost and spread the word! 🙏 #EMBOmechanobio

meetings.embo.org/event/26-org...
Intracellular mechanics and organelle mechanobiology
Mechanobiology is an interdisciplinary field that emerges at the cross-section of biology, physics and engineering. It aims to understand how living cells, tissues and animals sense and respond to me…
meetings.embo.org
July 4, 2025 at 3:50 PM
Reposted by Dhanur Prakash Iyer
bulutkarslioglu.bsky.social
⚠️ I am really excited to share the work of Anastasios Balaskas, an excellent PhD candidate in the lab, with the wider world. Tasos made a significant advance: generating a stem cell-based embryo model that contains both posterior and anterior neural tissues of the late-stage gastrulating embryo.
June 23, 2025 at 7:51 AM
Reposted by Dhanur Prakash Iyer
stowersinstitute.bsky.social
Meet Vignesh Babu, Scientist in Custom Protein Resources in this #RoadToResearch Q&A!

"Working at the Stowers Institute has provided me with a wealth of new knowledge about the diverse array of research organisms and the fascinating proteins they possess."

Read more: bit.ly/40eqRNA
Road to Research: Q&A with Vignesh Babu, Scientist in Custom Protein…
"Working at the Stowers Institute has provided me with a wealth of new knowledge about the diverse array of research organisms and the fascinating…
bit.ly
June 20, 2025 at 12:25 PM
Reposted by Dhanur Prakash Iyer
How do dormant cells keep their proteostasis in check?
@gzaffagnini.bsky.social & our PhD student Stephanie Rosswag take a deep dive in our featured review @cp-trendsbiochem.bsky.social
Don’t miss it! - EB
www.sciencedirect.com/science/arti...
Proteostasis in cellular dormancy: lessons from yeast to oocytes
Cellular dormancy is characterized by a prolonged, reversible cell cycle arrest and absence of growth. Dormancy allows organisms to endure unfavorable…
www.sciencedirect.com
June 11, 2025 at 12:31 PM
Reposted by Dhanur Prakash Iyer
amartinezarias.bsky.social
Very important @nicolettapetridou.bsky.social‬ report #mechanochemical signalling control fate transitions www.biorxiv.org/content/10.1... w/ wide/significant implications. Perhaps the clearest indication so far of HOW #NotInTheGenes cell interactions mechanical pattern gene expression
#MustRead
June 8, 2025 at 8:03 AM