Dhanur Prakash Iyer
@dhanuriyer.bsky.social
PhD@Bulut Karslioglu lab, Berlin. Postdoctoral researcher in Ruprecht lab at the CRG, Barcelona, and University of Innsbruck .
Reposted by Dhanur Prakash Iyer
(2/4) We discovered that Nodal/Smad2 signaling, a branch of the TGF-β pathway, is essential to sustain this paused state in embryonic stem cells and embryos. www.biorxiv.org/content/10.1...
Nodal/Smad2 signaling sustains developmental pausing by repressing Pparg-mediated lipid metabolism
Cells and organisms can enter transient dormant states to survive unfavorable conditions during development, physiological adult contexts, and disease. One paradigmatic case of dormancy is diapause, w...
www.biorxiv.org
October 9, 2025 at 8:08 PM
(2/4) We discovered that Nodal/Smad2 signaling, a branch of the TGF-β pathway, is essential to sustain this paused state in embryonic stem cells and embryos. www.biorxiv.org/content/10.1...
Reposted by Dhanur Prakash Iyer
This paper uncovers that HERVK LTR5Hs, a hominoid-specific retrovirus, act as epiblast enhancers with a crucial function in human pre-implantation development - stunning!
doi.org/10.1038/s415...
doi.org/10.1038/s415...
A human-specific regulatory mechanism revealed in a pre-implantation model - Nature
Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.
doi.org
October 4, 2025 at 10:51 PM
This paper uncovers that HERVK LTR5Hs, a hominoid-specific retrovirus, act as epiblast enhancers with a crucial function in human pre-implantation development - stunning!
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Congrats, Julia. Very happy for you. All the very best.
August 25, 2025 at 6:20 PM
Congrats, Julia. Very happy for you. All the very best.