Amoyel lab
@amoyellab.bsky.social
Stem cell biology and all things fly testis
Pinned
Amoyel lab
@amoyellab.bsky.social
· Jul 25
Somatic cells compartmentalise their metabolism to sustain germ cell survival
To ensure success in reproduction, organisms dedicate substantial resources to supporting the germline. In testes, somatic gonadal cells form a barrier that isolates germ cells from circulating nutrie...
www.biorxiv.org
🆕🧪‼️
New lab preprint!
We study how germ cells (the cells that give rise to gametes, in this case sperm) are supported by somatic (non-germ) cells of the gonad. This matters for our understanding of reproduction - without germ cell development, animals are sterile.
www.biorxiv.org/content/10.1...
New lab preprint!
We study how germ cells (the cells that give rise to gametes, in this case sperm) are supported by somatic (non-germ) cells of the gonad. This matters for our understanding of reproduction - without germ cell development, animals are sterile.
www.biorxiv.org/content/10.1...
Reposted by Amoyel lab
New PhD opportunity studying oocyte biology. Excited about this new direction in the lab.
The ageing nucleus in the mammalian oocyte with Dr Suzanne Madgwick @suzannemadgwick.bsky.social www.findaphd.com/phds/project...
MRC DiMeN Doctoral Training Partnership: The ageing nucleus in the mammalian oocyte at Newcastle University on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: The ageing nucleus in the mammalian oocyte at Newcastle University, listed on FindAPhD.com
www.findaphd.com
November 4, 2025 at 3:48 PM
New PhD opportunity studying oocyte biology. Excited about this new direction in the lab.
Reposted by Amoyel lab
🔜Only one week to go 🎉! Looking forward to hosting the inaugural talks of our “Metabolism in Development & Physiology” seminar series. Join us by registering here: forms.gle/Y8QzucogKKrZ...
We’re excited for our very first “Metabolism in Development & Physiology” seminar next week!
🗓 13 Nov 2025, 16:00 CET
🎙 Alexander Aulehla (EMBL Heidelberg)
🎙 Christopher Bell (Uni of Oxford)
Register here to join the the talks: forms.gle/Y8QzucogKKrZ...
🗓 13 Nov 2025, 16:00 CET
🎙 Alexander Aulehla (EMBL Heidelberg)
🎙 Christopher Bell (Uni of Oxford)
Register here to join the the talks: forms.gle/Y8QzucogKKrZ...
November 3, 2025 at 2:18 PM
🔜Only one week to go 🎉! Looking forward to hosting the inaugural talks of our “Metabolism in Development & Physiology” seminar series. Join us by registering here: forms.gle/Y8QzucogKKrZ...
Please sign up for the mailing list here to get the Zoom link:
forms.gle/Y8QzucogKKrZ...
forms.gle/Y8QzucogKKrZ...
Check out the new online seminar series for the developmental metabolism community @devmetphys.bsky.social. Born out of #EMBODevMet, it brings together researchers from across the field.
👉 don’t miss the inaugural event on Nov 13 subscribe now!
#DevBio #Metabolism #ScienceCommunity
👉 don’t miss the inaugural event on Nov 13 subscribe now!
#DevBio #Metabolism #ScienceCommunity
We are thrilled to announce the inaugural Metabolism in Development & Physiology virtual seminar, a new series connecting researchers across all stages & disciplines in metabolism!
🗓 13 Nov 2025, 16:00 CET
🎙 Alexander Aulehla (EMBL Heidelberg), &
🎙 Christopher Bell (Uni of Oxford)
See you there!
🗓 13 Nov 2025, 16:00 CET
🎙 Alexander Aulehla (EMBL Heidelberg), &
🎙 Christopher Bell (Uni of Oxford)
See you there!
October 29, 2025 at 3:01 PM
Please sign up for the mailing list here to get the Zoom link:
forms.gle/Y8QzucogKKrZ...
forms.gle/Y8QzucogKKrZ...
Join us for a new zoom series on metabolism and development. This will be a monthly feature with PIs and trainees presenting.
Sign up here (forms.gle/Y8QzucogKKrZ...) to get the Zoom link and join the mailing list.
Sign up here (forms.gle/Y8QzucogKKrZ...) to get the Zoom link and join the mailing list.
October 28, 2025 at 6:05 PM
Join us for a new zoom series on metabolism and development. This will be a monthly feature with PIs and trainees presenting.
Sign up here (forms.gle/Y8QzucogKKrZ...) to get the Zoom link and join the mailing list.
Sign up here (forms.gle/Y8QzucogKKrZ...) to get the Zoom link and join the mailing list.
Thanks for writing this - all of us in development need to hear this!
I wrote something on developmental biology and disability and put it up on the node last night:
thenode.biologists.com/developmenta...
I've been nervous to share because some of it veers a bit personal but they are thoughts that won't stay quiet. Would love to know what people think about it!
thenode.biologists.com/developmenta...
I've been nervous to share because some of it veers a bit personal but they are thoughts that won't stay quiet. Would love to know what people think about it!
Developmental Biology and Disability - the Node
Hopeful monsters. Morphospace. Mutation. Natural variation. Mutagenesis screens. Polymorphism. Deformity. Phenotype. Disease. Adaptation. Anomaly.
thenode.biologists.com
September 30, 2025 at 1:57 PM
Thanks for writing this - all of us in development need to hear this!
Interested in morphogens and how they can robustly specifiy different cell types with single-cell resolution?
Check out this preprint combining experiments and modelling by our colleagues and partners in crime @ucl-cdb.bsky.social:
www.biorxiv.org/content/10.1...
Check out this preprint combining experiments and modelling by our colleagues and partners in crime @ucl-cdb.bsky.social:
www.biorxiv.org/content/10.1...
Morphogen and juxtacrine signalling dynamically integrate to specify cell fates with single-cell resolution
Morphogen gradients guide tissue patterning but do not act in isolation. How they integrate with other signalling modalities, like juxtacrine signalling, and how these integrations influence pattern r...
www.biorxiv.org
September 25, 2025 at 2:27 PM
Interested in morphogens and how they can robustly specifiy different cell types with single-cell resolution?
Check out this preprint combining experiments and modelling by our colleagues and partners in crime @ucl-cdb.bsky.social:
www.biorxiv.org/content/10.1...
Check out this preprint combining experiments and modelling by our colleagues and partners in crime @ucl-cdb.bsky.social:
www.biorxiv.org/content/10.1...
Fantastic meeting! Thanks @events.embl.org for hosting, @embo.org for funding this and to organisers and all attendees for thought-provoking and exciting science!
✨ That's a wrap on #EMBODevMet after four inspiring days of cutting-edge science, new ideas, and reconnections.
👏 A huge thanks to all participants, speakers, and organisers who made this event so special.
We can't wait to welcome you back to another EMBL event 👉 embl.org/events
👏 A huge thanks to all participants, speakers, and organisers who made this event so special.
We can't wait to welcome you back to another EMBL event 👉 embl.org/events
September 13, 2025 at 3:24 PM
Fantastic meeting! Thanks @events.embl.org for hosting, @embo.org for funding this and to organisers and all attendees for thought-provoking and exciting science!
Looking forward to this! Great chance to catch up with everyone and all the amazing Drosophila research going on!
Abstract submission is now closed but you can still register to #EDRC2025 until the meeting starts! Looking forward to seeing you all in Alicante!
September 13, 2025 at 3:22 PM
Looking forward to this! Great chance to catch up with everyone and all the amazing Drosophila research going on!
Reposted by Amoyel lab
So excited to share this preprint from the Rosin lab in collaboration with the Hawley lab and @eelcotromer.bsky.social on moth spermatogenesis! We investigate the meiotic errors that occur during the formation of apyrene sperm (that have no DNA) in silkworms!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Programmed meiotic errors facilitate dichotomous sperm production in the silkworm, Bombyx mori
The goal of meiosis is typically to produce haploid gametes (eggs or sperm). Failure to do so is catastrophic for fertility and offspring health. However, Lepidopteran (moths and butterflies) males pr...
www.biorxiv.org
August 4, 2025 at 10:38 AM
So excited to share this preprint from the Rosin lab in collaboration with the Hawley lab and @eelcotromer.bsky.social on moth spermatogenesis! We investigate the meiotic errors that occur during the formation of apyrene sperm (that have no DNA) in silkworms!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Lovely work by @martinestermann.bsky.social and colleagues from the Capel lab! Together with our recent work (www.biorxiv.org/content/10.1...), this really makes a strong case that lactate is crucial to supporting male germ cells in vivo - from flies to mammals.
Glycogen metabolism in mouse embryonic Sertoli cells sustains the germ line through the lactate shuttle https://www.biorxiv.org/content/10.1101/2025.07.23.666216v1
July 27, 2025 at 11:30 AM
Lovely work by @martinestermann.bsky.social and colleagues from the Capel lab! Together with our recent work (www.biorxiv.org/content/10.1...), this really makes a strong case that lactate is crucial to supporting male germ cells in vivo - from flies to mammals.
🆕🧪‼️
New lab preprint!
We study how germ cells (the cells that give rise to gametes, in this case sperm) are supported by somatic (non-germ) cells of the gonad. This matters for our understanding of reproduction - without germ cell development, animals are sterile.
www.biorxiv.org/content/10.1...
New lab preprint!
We study how germ cells (the cells that give rise to gametes, in this case sperm) are supported by somatic (non-germ) cells of the gonad. This matters for our understanding of reproduction - without germ cell development, animals are sterile.
www.biorxiv.org/content/10.1...
Somatic cells compartmentalise their metabolism to sustain germ cell survival
To ensure success in reproduction, organisms dedicate substantial resources to supporting the germline. In testes, somatic gonadal cells form a barrier that isolates germ cells from circulating nutrie...
www.biorxiv.org
July 25, 2025 at 11:20 AM
🆕🧪‼️
New lab preprint!
We study how germ cells (the cells that give rise to gametes, in this case sperm) are supported by somatic (non-germ) cells of the gonad. This matters for our understanding of reproduction - without germ cell development, animals are sterile.
www.biorxiv.org/content/10.1...
New lab preprint!
We study how germ cells (the cells that give rise to gametes, in this case sperm) are supported by somatic (non-germ) cells of the gonad. This matters for our understanding of reproduction - without germ cell development, animals are sterile.
www.biorxiv.org/content/10.1...
Reposted by Amoyel lab
Somatic cells compartmentalise their metabolism to sustain germ cell survival https://www.biorxiv.org/content/10.1101/2025.07.22.666113v1
July 22, 2025 at 8:31 PM
Somatic cells compartmentalise their metabolism to sustain germ cell survival https://www.biorxiv.org/content/10.1101/2025.07.22.666113v1
Essential reading! How often do we really need to change plastic pipette tips?
We've been washing and reusing tips in our lab too, led by Inês Baldaia who really led on making sure that tip washing doesn't interfere with data.
We've been washing and reusing tips in our lab too, led by Inês Baldaia who really led on making sure that tip washing doesn't interfere with data.
Load gels? Use #zebrafish 🐟? Want to do more sustainable research w/out compromising science? We-G Gestri, K Turner, G Powell @stevewilsonlab.bsky.social-made these protocols. Yes, we use these in our @science.org+@nature.com papers.
www.protocols.io/view/re-usin...
www.protocols.io/view/washing...
www.protocols.io/view/re-usin...
www.protocols.io/view/washing...
Re-using pipette tips for gel loading
Gel loading tips can be reused for most applications; there’s REALLY no need to throw them away after a single use. In
our labs, we routinely reuse tips when loading gels, onl...
www.protocols.io
July 23, 2025 at 1:38 PM
Essential reading! How often do we really need to change plastic pipette tips?
We've been washing and reusing tips in our lab too, led by Inês Baldaia who really led on making sure that tip washing doesn't interfere with data.
We've been washing and reusing tips in our lab too, led by Inês Baldaia who really led on making sure that tip washing doesn't interfere with data.
Imagine a world without Flybase... Let's all help out if we can!
We currently have a call for support that has gone out to European labs, to support FlyBase-UK. We are asking our colleagues from labs in the US and other countries to wait for a similar call to them that will go out in the near future, to support the US sites. We thank you for your patience.
URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯
Any lab using @flybase.bsky.social please donate using the link in post below.
This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
Any lab using @flybase.bsky.social please donate using the link in post below.
This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
June 5, 2025 at 9:41 AM
Imagine a world without Flybase... Let's all help out if we can!
Last week to submit abstracts! Looking forward to #EDRC2025 and amazing #Drosophila research in Alicante!
@fly-eds.bsky.social @fly-jedi.bsky.social
@fly-eds.bsky.social @fly-jedi.bsky.social
Do you have some cool results to present to the #Drosophila community at #EDRC2025 ? Please do not forget that abstract submissions are opened until the 28th of May edrc2025alicante.com/abstracts/
May 19, 2025 at 4:35 PM
Last week to submit abstracts! Looking forward to #EDRC2025 and amazing #Drosophila research in Alicante!
@fly-eds.bsky.social @fly-jedi.bsky.social
@fly-eds.bsky.social @fly-jedi.bsky.social
Reposted by Amoyel lab
Remember that early bird registration closes on the 15th of May and abstract deadline is the 28th of May. Book early for the best prices and a chance to present your work at #EDRC2025
We are excited to announce the opening of registrations for the upcoming #EDRC2025 conference (25th-28th September 2025) in Alicante to showcase the latest advances in #Drosophila biology and technology edrc2025alicante.com
EDRC 2025 Alicante
edrc2025alicante.com
April 29, 2025 at 4:15 PM
Remember that early bird registration closes on the 15th of May and abstract deadline is the 28th of May. Book early for the best prices and a chance to present your work at #EDRC2025
Thanks @dev-journal.bsky.social for featuring our paper - led by Rodrigo Garcia and Linus Schumacher in Edinburgh. So much exciting #germcell biology at the #GRC meeting!
Focus on gametogenesis
Our Reviews Editor, Laura Hankins, will be attending the GRC on Germinal Stem Cell Biology in Barcelona this week. To complement the meeting, we have put together a collection of review-type and Research Articles on this topic: journals.biologists.com/collection/2...
Our Reviews Editor, Laura Hankins, will be attending the GRC on Germinal Stem Cell Biology in Barcelona this week. To complement the meeting, we have put together a collection of review-type and Research Articles on this topic: journals.biologists.com/collection/2...
April 29, 2025 at 9:26 AM
Thanks @dev-journal.bsky.social for featuring our paper - led by Rodrigo Garcia and Linus Schumacher in Edinburgh. So much exciting #germcell biology at the #GRC meeting!
Calling all fly researchers! Submit your abstracts before 28 May! Looking forward to seeing all the great #drosophila research going on at #EDRC2025 in Spain
@edrc2025.bsky.social @fly-jedi.bsky.social @fly-eds.bsky.social
@edrc2025.bsky.social @fly-jedi.bsky.social @fly-eds.bsky.social
Abstract submission is now open for #EDRC2025 ! Don’t forget to submit yours! edrc2025alicante.com/abstracts/
April 26, 2025 at 12:20 PM
Calling all fly researchers! Submit your abstracts before 28 May! Looking forward to seeing all the great #drosophila research going on at #EDRC2025 in Spain
@edrc2025.bsky.social @fly-jedi.bsky.social @fly-eds.bsky.social
@edrc2025.bsky.social @fly-jedi.bsky.social @fly-eds.bsky.social
Been looking forward to reading this since Amelie presented her poster at the #CSHL #germcells meeting!
Modular regulation of the stem cell transcriptome defines self-renewal, differentiation, and dedifferentiation https://www.biorxiv.org/content/10.1101/2025.04.10.648217v1
April 14, 2025 at 1:01 PM
Been looking forward to reading this since Amelie presented her poster at the #CSHL #germcells meeting!
Reposted by Amoyel lab
Ideally, we'd like authors to cite a recent FlyBase publication. There's a blue box with the text "Citing FlyBase' on our homepage that takes you a page detailing how to cite us wiki.flybase.org/wiki/FlyBase...
FlyBase:Citing FlyBase - FlyBase Wiki
wiki.flybase.org
April 13, 2025 at 6:32 AM
Ideally, we'd like authors to cite a recent FlyBase publication. There's a blue box with the text "Citing FlyBase' on our homepage that takes you a page detailing how to cite us wiki.flybase.org/wiki/FlyBase...
New paper from the lab!
We study how gene expression is controlled post-transcriptionally to determine stem cell fate. plos.io/3Dw1W07
a 🧵:
We study how gene expression is controlled post-transcriptionally to determine stem cell fate. plos.io/3Dw1W07
a 🧵:
Signals from the niche promote distinct modes of translation initiation to control stem cell differentiation and renewal in the Drosophila testis
Transcription is known to tightly regulate gene expression profiles in stem and differentiating cells, but less is known about the role of translational control. This study identifies that signals fro...
plos.io
March 12, 2025 at 3:22 PM
New paper from the lab!
We study how gene expression is controlled post-transcriptionally to determine stem cell fate. plos.io/3Dw1W07
a 🧵:
We study how gene expression is controlled post-transcriptionally to determine stem cell fate. plos.io/3Dw1W07
a 🧵:
Reposted by Amoyel lab
A role for translational control in stem & differentiating cells. @amoyellab.bsky.social &co show that signals from the #StemCell niche induce changes in translational rates (via eIF3d1 phosphorylation) to control stem cell fate in #Drosophila testis 🧪 @plosbiology.org plos.io/3Dw1W07
March 12, 2025 at 9:22 AM
A role for translational control in stem & differentiating cells. @amoyellab.bsky.social &co show that signals from the #StemCell niche induce changes in translational rates (via eIF3d1 phosphorylation) to control stem cell fate in #Drosophila testis 🧪 @plosbiology.org plos.io/3Dw1W07
Love it!
A higher-resolution version of our #TeamTestis #MBoC cover - just in time for #fluorescencefriday 😊🪰🔬🌀.
So grateful that MBoC went with my suggestion! Thank You @ascbiology.bsky.social!
#cellbio #morphogenesis #devbio #ascb
So grateful that MBoC went with my suggestion! Thank You @ascbiology.bsky.social!
#cellbio #morphogenesis #devbio #ascb
January 31, 2025 at 11:21 AM
Love it!
Want to establish your lab in London to study important questions in cell and/or developmental biology?
Our department @ucl-cdb.bsky.social is looking to sponsor independent research Fellows. Details here: bit.ly/4jzae7u and informal enquiries welcome.
Come join us!
Our department @ucl-cdb.bsky.social is looking to sponsor independent research Fellows. Details here: bit.ly/4jzae7u and informal enquiries welcome.
Come join us!
January 28, 2025 at 3:32 PM
Want to establish your lab in London to study important questions in cell and/or developmental biology?
Our department @ucl-cdb.bsky.social is looking to sponsor independent research Fellows. Details here: bit.ly/4jzae7u and informal enquiries welcome.
Come join us!
Our department @ucl-cdb.bsky.social is looking to sponsor independent research Fellows. Details here: bit.ly/4jzae7u and informal enquiries welcome.
Come join us!
This is a big problem! @royalsociety.org many of us would be happy to support efforts to change this and make the UK an attractive place for scientists to come.
‘There is a worldwide shortage of scientists and because it’s a worldwide shortage, there’s worldwide competition,' says our Foreign Secretary Professor Alison Noble, as she warns that the UK's visa process and costs could put off scientists from moving to the UK: www.dailymail.co.uk/news/article...
High visa fees putting skilled scientists and entrepreneurs off the UK
Leading scientists have now called on ministers to review the upfront costs that must be paid by workers in science, technology, engineering and maths fields.
www.dailymail.co.uk
January 24, 2025 at 3:27 PM
This is a big problem! @royalsociety.org many of us would be happy to support efforts to change this and make the UK an attractive place for scientists to come.