Suzanne Madgwick
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suzannemadgwick.bsky.social
Suzanne Madgwick
@suzannemadgwick.bsky.social
69 followers 130 following 1 posts
Cell cycle regulatory mechanisms in oocyte meiosis...... and finally trying to properly engage with bsky.
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suzannemadgwick.bsky.social
New PhD opportunity studying oocyte biology. Excited about this new direction in the lab.
November 4, 2025 at 3:48 PM
Reposted by Suzanne Madgwick
cgm-newcastle.bsky.social
Very pleased to share 4 exciting new PhD opportunities offered by our Cells, Genes and Molecules Theme in the Faculty of Medical Sciences at Newcastle University. Applications are open until the 4th of December. Please share and see below for project titles and links
November 4, 2025 at 3:37 PM
Reposted by Suzanne Madgwick
wetherall.bsky.social
New paper out = time to actually introduce myself!

I'm Ben, a PDRA in the Egg Lab 🥚 with @suzannemadgwick.bsky.social @ Newcastle University.

I study how oocytes organise chromsomes, developing some cool new tools along the way 🔬 👨‍🔬

Let's talk #fertility, #imaging, and all things science.
The chromosome periphery (Ki67) in a mammalian prophase oocyte.
April 25, 2025 at 1:59 PM
Reposted by Suzanne Madgwick
reviewcommons.org
Separase- the chromosome separation enzyme is differently regulated in meiosis.

Study by Christopher Thomas @ovarylab.bsky.social @suzannemadgwick.bsky.social @newcastleuni.bsky.social

🆕 @reviewcommons.org #preprintpeerreview @biorxivpreprint.bsky.social

➡️ doi.org/10.1101/2025...
May 20, 2025 at 10:46 AM
Reposted by Suzanne Madgwick
ovarylab.bsky.social
A fantastic primer by Martin Anger highlighting our work on separase control in oocytes! 🥚✂️

@suzannemadgwick.bsky.social @wetherall.bsky.social @plosbiology.org
plosbiology.org PLOS Biology @plosbiology.org · Jun 17
Separase plays a key role in cleaving #cohesin complexes during cell division. Martin Anger explores a @plosbiology.org study showing that #separase activity is controled by #cyclin B/CDK1 & securin in #meiosis (and not SGO2, as in mitosis) 🧪 Paper: plos.io/3RAoccz Primer: plos.io/43L91UR
Differences in control of separase activity between meiosis and mitosis. Separase activity in mitosis is controlled by at least three different pathways: a specific protein inhibitor called securin; phosphorylation and binding to Cyclin/CDK1; and the Mad2/SGO2 complex. According to the results of the new study by Wetherall and colleagues [9], the Mad2/SGO2 complex does not play a role in separase control in oocytes.
June 17, 2025 at 10:19 AM