Adriano Bolondi
@adrianobolondi.bsky.social
Researcher @crg.eu, previous MeissnerLab @molgen.mpg.de. Interested in how cells and genes make embryos. #EMBO & #MSCA fellow
Reposted by Adriano Bolondi
🧬 We are excited to announce the
INTERNATIONAL DUTCH EMBRYO MODEL MEETING 2026
— Engineering the Origins of Life
📅 7–8 May 2026
📍 Utrecht, The Netherlands
Register & submit abstracts:
www.oncodeinstitute.nl/internationa...
INTERNATIONAL DUTCH EMBRYO MODEL MEETING 2026
— Engineering the Origins of Life
📅 7–8 May 2026
📍 Utrecht, The Netherlands
Register & submit abstracts:
www.oncodeinstitute.nl/internationa...
February 13, 2026 at 9:47 AM
🧬 We are excited to announce the
INTERNATIONAL DUTCH EMBRYO MODEL MEETING 2026
— Engineering the Origins of Life
📅 7–8 May 2026
📍 Utrecht, The Netherlands
Register & submit abstracts:
www.oncodeinstitute.nl/internationa...
INTERNATIONAL DUTCH EMBRYO MODEL MEETING 2026
— Engineering the Origins of Life
📅 7–8 May 2026
📍 Utrecht, The Netherlands
Register & submit abstracts:
www.oncodeinstitute.nl/internationa...
Reposted by Adriano Bolondi
Once your 3D sample is reconstructed, you can rotate, take virtual sections in any orientation, project gene expression through depth, link 3D space with UMAP, and compute spatial differential expression on the reconstructed volume to find region-enriched genes.
February 6, 2026 at 2:14 PM
Once your 3D sample is reconstructed, you can rotate, take virtual sections in any orientation, project gene expression through depth, link 3D space with UMAP, and compute spatial differential expression on the reconstructed volume to find region-enriched genes.
Reposted by Adriano Bolondi
To turn spatial data into a 3D object, check our protocol (open source, napari plug-in). @guignardlab.bsky.social @adrianobolondi.bsky.social @ibdm.bsky.social
For example, if you have spatial RNA-seq as sections, you can align them automatically to analyse directly in 3D.
bio-protocol.org/e5607
For example, if you have spatial RNA-seq as sections, you can align them automatically to analyse directly in 3D.
bio-protocol.org/e5607
February 6, 2026 at 2:13 PM
To turn spatial data into a 3D object, check our protocol (open source, napari plug-in). @guignardlab.bsky.social @adrianobolondi.bsky.social @ibdm.bsky.social
For example, if you have spatial RNA-seq as sections, you can align them automatically to analyse directly in 3D.
bio-protocol.org/e5607
For example, if you have spatial RNA-seq as sections, you can align them automatically to analyse directly in 3D.
bio-protocol.org/e5607
Reposted by Adriano Bolondi
We're recruiting a #devbio Postdoctoral Fellow to explore the hTLS system! If you know any fab PhD students finishing, or candidates wanting to get their hands on #SCBEM embryo models, do get them to apply! 🌟https://www.crick.ac.uk/careers-study/vacancies/2026-02-03-postdoctoral-fellow-moris-lab
February 5, 2026 at 6:28 PM
Reposted by Adriano Bolondi
EMBL scientists Jamie Hackett and Robert Prevedel have been awarded ERC Proof of Concept grants to support the translation of innovative ideas into tangible therapeutic and imaging tools.
www.embl.org/news/awards-...
@erc.europa.eu @jamiehackett.bsky.social
www.embl.org/news/awards-...
@erc.europa.eu @jamiehackett.bsky.social
January 27, 2026 at 12:24 PM
EMBL scientists Jamie Hackett and Robert Prevedel have been awarded ERC Proof of Concept grants to support the translation of innovative ideas into tangible therapeutic and imaging tools.
www.embl.org/news/awards-...
@erc.europa.eu @jamiehackett.bsky.social
www.embl.org/news/awards-...
@erc.europa.eu @jamiehackett.bsky.social
Reposted by Adriano Bolondi
We wrote a protocol article detailing induction of dormancy in stem cells, embryos, and blastoids. We hope that it is useful to the community. As usual fun to work with @nicolasrivron.bsky.social, Heidar and Dhanur.
January 26, 2026 at 6:55 PM
We wrote a protocol article detailing induction of dormancy in stem cells, embryos, and blastoids. We hope that it is useful to the community. As usual fun to work with @nicolasrivron.bsky.social, Heidar and Dhanur.
Reposted by Adriano Bolondi
Lovely little pre-Christmas present to see this out @natcellbio.nature.com! Some 🔥 new results in here since the biorvix incl (1) a new RARE-GFP reporter ✳️🙌, (2) additional NMP quantification 🔢, (3) no neural tube patterning on RA inhibition 🙅 etc. Enjoy! 😍 www.nature.com/articles/s41...
Modelling co-development between the somites and neural tube in human trunk-like structures - Nature Cell Biology
Makwana, Tilley et al. generate human stem cell-based trunk-like structures approximating Carnegie stage 13–14 of development. They use them to model and study the development of the thoracic and lumbar trunk.
www.nature.com
December 16, 2025 at 10:04 AM
Lovely little pre-Christmas present to see this out @natcellbio.nature.com! Some 🔥 new results in here since the biorvix incl (1) a new RARE-GFP reporter ✳️🙌, (2) additional NMP quantification 🔢, (3) no neural tube patterning on RA inhibition 🙅 etc. Enjoy! 😍 www.nature.com/articles/s41...
Reposted by Adriano Bolondi
🎉 Our deconstructed, stem-cell–based approach to studying signaling centers and limb-development cell types is out! 🥳 So nice to see it in its final form after the preprint— and huge thanks to the community for all the enthusiasm and interest since then!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Specialized signaling centers direct cell fate and spatial organization in a mesodermal organoid model
Stem cell–derived mesodermal organoids reveal how signaling centers guide cell fate and tissue organization.
www.science.org
December 2, 2025 at 9:15 AM
🎉 Our deconstructed, stem-cell–based approach to studying signaling centers and limb-development cell types is out! 🥳 So nice to see it in its final form after the preprint— and huge thanks to the community for all the enthusiasm and interest since then!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Adriano Bolondi
Outstanding PhD fellowship call OPEN for excellent students.
lacaixafoundation.org/en/doctoral-...
This is for students incoming from outside Spain. And it is VERY well supported (ie at European levels).
If you’re interested in doing a PhD in our lab @irbbarcelona.org, reach out!!!!
lacaixafoundation.org/en/doctoral-...
This is for students incoming from outside Spain. And it is VERY well supported (ie at European levels).
If you’re interested in doing a PhD in our lab @irbbarcelona.org, reach out!!!!
Doctoral INPhINIT fellowships - Incoming Call 2026
We grant 30 fellowships for researchers of any nationality who wish to pursue a doctorate in a STEM discipline at research centres of excellence in Spain or Portugal.
www.google.com
November 26, 2025 at 7:43 AM
Outstanding PhD fellowship call OPEN for excellent students.
lacaixafoundation.org/en/doctoral-...
This is for students incoming from outside Spain. And it is VERY well supported (ie at European levels).
If you’re interested in doing a PhD in our lab @irbbarcelona.org, reach out!!!!
lacaixafoundation.org/en/doctoral-...
This is for students incoming from outside Spain. And it is VERY well supported (ie at European levels).
If you’re interested in doing a PhD in our lab @irbbarcelona.org, reach out!!!!
Reposted by Adriano Bolondi
popEVE is out in Nature Genetics! 🎉
We built a proteome-wide model that combines cross-species and human population variation to rank missense variants by disease severity and help diagnose rare genetic disorders.
rdcu.be/eRu7K
We built a proteome-wide model that combines cross-species and human population variation to rank missense variants by disease severity and help diagnose rare genetic disorders.
rdcu.be/eRu7K
Proteome-wide model for human disease genetics
Nature Genetics - popEVE is a proteome-wide deep generative model to identify and predict pathogenicity of missense mutations causing genetic disorders.
rdcu.be
November 24, 2025 at 1:35 PM
popEVE is out in Nature Genetics! 🎉
We built a proteome-wide model that combines cross-species and human population variation to rank missense variants by disease severity and help diagnose rare genetic disorders.
rdcu.be/eRu7K
We built a proteome-wide model that combines cross-species and human population variation to rank missense variants by disease severity and help diagnose rare genetic disorders.
rdcu.be/eRu7K
Happy to see Atsuhiro Taguchi's work on genes involved in liver zonation published in Dev @cellpress.bsky.social. Kudos to all authors at @molgen.mpg.de #MeissnerLab #HniszLab. Grateful for the opportunity to help!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Single-cell activation screen identifies hepatic maturation regulators with zonal resolution
The maturation of lineage-committed embryonic hepatocytes requires both the timed activation of metabolic gene regulatory networks (GRNs) and silencin…
www.sciencedirect.com
November 21, 2025 at 10:45 AM
Happy to see Atsuhiro Taguchi's work on genes involved in liver zonation published in Dev @cellpress.bsky.social. Kudos to all authors at @molgen.mpg.de #MeissnerLab #HniszLab. Grateful for the opportunity to help!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Adriano Bolondi
check out my journal club on the seminal discovery of local translation in neurons (Kang & Schuman. 1996), and more recently, its activity in neocortex neurodevelopment (Pilaz...Silver. 2023).
cheers to the @erin-schuman.bsky.social & @debbysilver.bsky.social labs!
www.nature.com/articles/s41...
cheers to the @erin-schuman.bsky.social & @debbysilver.bsky.social labs!
www.nature.com/articles/s41...
The on-site, on-demand, neuronal gene machine - Nature Reviews Neuroscience
In this Journal Club, Matthew Kraushar discusses a study published in 1996 that found a role for local protein translation in hippocampal synaptic plasticity.
www.nature.com
November 18, 2025 at 6:35 PM
check out my journal club on the seminal discovery of local translation in neurons (Kang & Schuman. 1996), and more recently, its activity in neocortex neurodevelopment (Pilaz...Silver. 2023).
cheers to the @erin-schuman.bsky.social & @debbysilver.bsky.social labs!
www.nature.com/articles/s41...
cheers to the @erin-schuman.bsky.social & @debbysilver.bsky.social labs!
www.nature.com/articles/s41...
Reposted by Adriano Bolondi
Happy to present the final version of our Cadherin and gastruloid manuscript, online at @cp-cellreports.bsky.social.
www.cell.com/cell-reports...
Initially in BiorXiv (www.biorxiv.org/content/10.1...) 1/12
www.cell.com/cell-reports...
Initially in BiorXiv (www.biorxiv.org/content/10.1...) 1/12
Cadherins modulate the self-organizing potential of pseudo-embryos
Gastruloids derived from ES cells mimic embryonic patterning through robust self-organization.
Mayran et al. uncover that this competence depends on a cadherin switch regulated
by Snai1-driven E-cadhe...
www.cell.com
November 17, 2025 at 10:37 AM
Happy to present the final version of our Cadherin and gastruloid manuscript, online at @cp-cellreports.bsky.social.
www.cell.com/cell-reports...
Initially in BiorXiv (www.biorxiv.org/content/10.1...) 1/12
www.cell.com/cell-reports...
Initially in BiorXiv (www.biorxiv.org/content/10.1...) 1/12
Reposted by Adriano Bolondi
"His secret weapons were an unquenchable curiosity and continuing hands-on experimentation at the bench with his beautiful frog embryos and oocytes".
A thoughtful tribute to the life of Sir John Gurdon by Edward M. De Robertis that we really recommend everyone to read.
doi.org/10.1016/j.cd...
A thoughtful tribute to the life of Sir John Gurdon by Edward M. De Robertis that we really recommend everyone to read.
doi.org/10.1016/j.cd...
November 7, 2025 at 9:12 PM
"His secret weapons were an unquenchable curiosity and continuing hands-on experimentation at the bench with his beautiful frog embryos and oocytes".
A thoughtful tribute to the life of Sir John Gurdon by Edward M. De Robertis that we really recommend everyone to read.
doi.org/10.1016/j.cd...
A thoughtful tribute to the life of Sir John Gurdon by Edward M. De Robertis that we really recommend everyone to read.
doi.org/10.1016/j.cd...
Reposted by Adriano Bolondi
@campaslab.bsky.social @jesseveenvliet.bsky.social labs use #gastruloids to explore axial extension in mammalian embryos
www.biorxiv.org/content/10.1...
They find novel mechanisms involving and interplay of proliferation and mechanical constraining.
#NotInTheGenes #CellsRUs
www.biorxiv.org/content/10.1...
They find novel mechanisms involving and interplay of proliferation and mechanical constraining.
#NotInTheGenes #CellsRUs
November 6, 2025 at 6:40 AM
@campaslab.bsky.social @jesseveenvliet.bsky.social labs use #gastruloids to explore axial extension in mammalian embryos
www.biorxiv.org/content/10.1...
They find novel mechanisms involving and interplay of proliferation and mechanical constraining.
#NotInTheGenes #CellsRUs
www.biorxiv.org/content/10.1...
They find novel mechanisms involving and interplay of proliferation and mechanical constraining.
#NotInTheGenes #CellsRUs
Reposted by Adriano Bolondi
Really excited to present the results of a fantastic collaboration with Jesse Veenvliet @jesseveenvliet.bsky.social @mpi-cbg.de @poldresden.bsky.social 🤩
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
October 28, 2025 at 8:25 AM
Really excited to present the results of a fantastic collaboration with Jesse Veenvliet @jesseveenvliet.bsky.social @mpi-cbg.de @poldresden.bsky.social 🤩
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
Reposted by Adriano Bolondi
Oh wow - pre-made templates :) - EB
I am happy to present our latest research at the ISSCR 2026 Annual Meeting, taking place in Montréal, Canada on 8-11 July 2026. #ISSCR2026 invt.io/1bxb7uh48oo @isscr.org
I am happy to present our latest research at the ISSCR 2026 Annual Meeting, taking place in Montréal, Canada on 8-11 July 2026. #ISSCR2026 invt.io/1bxb7uh48oo @isscr.org
I'm speaking at ISSCR 2026 Annual Meeting, join me
Register now
invt.io
October 27, 2025 at 8:15 PM
Oh wow - pre-made templates :) - EB
I am happy to present our latest research at the ISSCR 2026 Annual Meeting, taking place in Montréal, Canada on 8-11 July 2026. #ISSCR2026 invt.io/1bxb7uh48oo @isscr.org
I am happy to present our latest research at the ISSCR 2026 Annual Meeting, taking place in Montréal, Canada on 8-11 July 2026. #ISSCR2026 invt.io/1bxb7uh48oo @isscr.org
Reposted by Adriano Bolondi
Wouldn’t it be cool to leverage the throughput of single-cell data to study splicing regulation even when we lack exon resolution? 😀
Here’s the peer-reviewed version of our paper on how we can measure changes in splicing factor activity in virtually any single-cell dataset: doi.org/10.1093/nar/...
Here’s the peer-reviewed version of our paper on how we can measure changes in splicing factor activity in virtually any single-cell dataset: doi.org/10.1093/nar/...
Using single-cell perturbation screens to decode the regulatory architecture of splicing factor programs
Abstract. Splicing factors shape the isoform pool of most transcribed genes, playing a critical role in cellular physiology. Their dysregulation is a hallm
doi.org
October 25, 2025 at 2:16 PM
Wouldn’t it be cool to leverage the throughput of single-cell data to study splicing regulation even when we lack exon resolution? 😀
Here’s the peer-reviewed version of our paper on how we can measure changes in splicing factor activity in virtually any single-cell dataset: doi.org/10.1093/nar/...
Here’s the peer-reviewed version of our paper on how we can measure changes in splicing factor activity in virtually any single-cell dataset: doi.org/10.1093/nar/...
Reposted by Adriano Bolondi
Fully-funded 4-year PhD Opportunities available at the @crick.ac.uk , including a project in our lab on human #embryomodels Feel free to share with anyone interested, and apply through the online portal before 5th November! 👏
www.crick.ac.uk/careers-stud...
www.crick.ac.uk/careers-stud...
Moris Lab | Investigating human trunk development using stem cell-based embryo models
www.crick.ac.uk
October 6, 2025 at 12:03 PM
Fully-funded 4-year PhD Opportunities available at the @crick.ac.uk , including a project in our lab on human #embryomodels Feel free to share with anyone interested, and apply through the online portal before 5th November! 👏
www.crick.ac.uk/careers-stud...
www.crick.ac.uk/careers-stud...
Reposted by Adriano Bolondi
Two positions available (start Jan/Feb 2026):
- Research Assistant: surl.li/atndnv
- Master Student: surl.li/kgwrni
Deadline: Nov 1st
Please reach out to me (adriano.bolondi@crg.es) if you want to join us in sunny Barcelona!☀️
- Research Assistant: surl.li/atndnv
- Master Student: surl.li/kgwrni
Deadline: Nov 1st
Please reach out to me (adriano.bolondi@crg.es) if you want to join us in sunny Barcelona!☀️
October 2, 2025 at 11:00 AM
Two positions available (start Jan/Feb 2026):
- Research Assistant: surl.li/atndnv
- Master Student: surl.li/kgwrni
Deadline: Nov 1st
Please reach out to me (adriano.bolondi@crg.es) if you want to join us in sunny Barcelona!☀️
- Research Assistant: surl.li/atndnv
- Master Student: surl.li/kgwrni
Deadline: Nov 1st
Please reach out to me (adriano.bolondi@crg.es) if you want to join us in sunny Barcelona!☀️
Reposted by Adriano Bolondi
🚨JOB ALERT🚨
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
October 2, 2025 at 11:00 AM
🚨JOB ALERT🚨
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
Reposted by Adriano Bolondi
yo scientists awesome opportunity! ⬇️🔥
🚨JOB ALERT🚨
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
October 2, 2025 at 11:39 AM
yo scientists awesome opportunity! ⬇️🔥
Reposted by Adriano Bolondi
I think everybody knows but Adri is awesome!
🚨JOB ALERT🚨
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
October 2, 2025 at 12:34 PM
I think everybody knows but Adri is awesome!
🚨JOB ALERT🚨
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
October 2, 2025 at 11:00 AM
🚨JOB ALERT🚨
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
Reposted by Adriano Bolondi
Stay Connected with VGZT Season 7 🌍
From Oct 2025–July 2026, join our online seminar series featuring cutting-edge developmental biology across diverse model organisms. Hear from senior PhD students, postdocs, and PIs as they share their latest discoveries with a global audience.
From Oct 2025–July 2026, join our online seminar series featuring cutting-edge developmental biology across diverse model organisms. Hear from senior PhD students, postdocs, and PIs as they share their latest discoveries with a global audience.
September 25, 2025 at 8:59 AM
Stay Connected with VGZT Season 7 🌍
From Oct 2025–July 2026, join our online seminar series featuring cutting-edge developmental biology across diverse model organisms. Hear from senior PhD students, postdocs, and PIs as they share their latest discoveries with a global audience.
From Oct 2025–July 2026, join our online seminar series featuring cutting-edge developmental biology across diverse model organisms. Hear from senior PhD students, postdocs, and PIs as they share their latest discoveries with a global audience.