@canaztekin.bsky.social
Group Leader @mpi-bio-fml.bsky.social/Branco Weiss Fellow. Studying how to regrow limbs! Alum: @EPFL ELISIR / @Cambridge_Uni @GurdonInstitute
EN/TR
EN/TR
Pinned
🚨Why can’t mammals regenerate legs or arms like frog tadpoles or salamanders?
Our preprint tackles (part of) this BIG question with surprising findings about oxygen sensing
🔗 www.biorxiv.org/content/10.1...
Happy New Year, everyone! 🎉
🐭 vs 🐸 #evodevo #regenerative #cellbio 🧵👇
Our preprint tackles (part of) this BIG question with surprising findings about oxygen sensing
🔗 www.biorxiv.org/content/10.1...
Happy New Year, everyone! 🎉
🐭 vs 🐸 #evodevo #regenerative #cellbio 🧵👇
Reposted
A study from the new "Insect Sex Determination and Development research group" is featured on the front of PNAS, uncovering a conserved genetic switch for sex determination, stable across 150 million years of evolution. Read the full press release:
tinyurl.com/bdzebvdf
tinyurl.com/bdzebvdf
January 21, 2026 at 7:27 AM
A study from the new "Insect Sex Determination and Development research group" is featured on the front of PNAS, uncovering a conserved genetic switch for sex determination, stable across 150 million years of evolution. Read the full press release:
tinyurl.com/bdzebvdf
tinyurl.com/bdzebvdf
Reposted
Paper alert: Our study led by @evapillai.bsky.social and @sudimukherjee.bsky.social showing that mechanical properties of the #brain actively shape the molecular landscape during development and #axonpathfinding is finally out! www.nature.com/articles/s41... @pdncambridge.bsky.social @fau.de @MPZPM
Long-range chemical signalling in vivo is regulated by mechanical signals - Nature Materials
Tissue stiffness mediated by Piezo1 is shown to regulate the expression of diffusive guidance cues in the developing Xenopus laevis brain, revealing a crosstalk between mechanical signals and long-ran...
www.nature.com
January 19, 2026 at 4:39 PM
Paper alert: Our study led by @evapillai.bsky.social and @sudimukherjee.bsky.social showing that mechanical properties of the #brain actively shape the molecular landscape during development and #axonpathfinding is finally out! www.nature.com/articles/s41... @pdncambridge.bsky.social @fau.de @MPZPM
Reposted
Start your independent as an ELISIR fellow right after your PhD, in one of the most terrific places in Europe !
January 14, 2026 at 1:13 PM
Start your independent as an ELISIR fellow right after your PhD, in one of the most terrific places in Europe !
Reposted
Interested in doing an interdisciplinary PhD to elucidate signalling centres that orchestrates limb regeneration? Come to work with the amazing @canaztekin.bsky.social and myself!!
🚨We are recruiting two PhD students 🚨
1) Quantitative & dynamic analysis of limb-regenerative signaling centers w/ @osvaldo-chara.bsky.social 📶🧮💻
🔗https://www.phd.tuebingen.mpg.de/80704/Quantitative-and-dynamic-analysis-of-limb-regenerative-signaling-center-interactions
1) Quantitative & dynamic analysis of limb-regenerative signaling centers w/ @osvaldo-chara.bsky.social 📶🧮💻
🔗https://www.phd.tuebingen.mpg.de/80704/Quantitative-and-dynamic-analysis-of-limb-regenerative-signaling-center-interactions
December 17, 2025 at 8:40 AM
Interested in doing an interdisciplinary PhD to elucidate signalling centres that orchestrates limb regeneration? Come to work with the amazing @canaztekin.bsky.social and myself!!
🚨We are recruiting two PhD students 🚨
1) Quantitative & dynamic analysis of limb-regenerative signaling centers w/ @osvaldo-chara.bsky.social 📶🧮💻
🔗https://www.phd.tuebingen.mpg.de/80704/Quantitative-and-dynamic-analysis-of-limb-regenerative-signaling-center-interactions
1) Quantitative & dynamic analysis of limb-regenerative signaling centers w/ @osvaldo-chara.bsky.social 📶🧮💻
🔗https://www.phd.tuebingen.mpg.de/80704/Quantitative-and-dynamic-analysis-of-limb-regenerative-signaling-center-interactions
December 17, 2025 at 7:53 AM
🚨We are recruiting two PhD students 🚨
1) Quantitative & dynamic analysis of limb-regenerative signaling centers w/ @osvaldo-chara.bsky.social 📶🧮💻
🔗https://www.phd.tuebingen.mpg.de/80704/Quantitative-and-dynamic-analysis-of-limb-regenerative-signaling-center-interactions
1) Quantitative & dynamic analysis of limb-regenerative signaling centers w/ @osvaldo-chara.bsky.social 📶🧮💻
🔗https://www.phd.tuebingen.mpg.de/80704/Quantitative-and-dynamic-analysis-of-limb-regenerative-signaling-center-interactions
Reposted
New paper from our lab and @friedrich-group.bsky.social !! Insights into morphogen gradient scaling to regenerate a limb at the appropriate size. #axolotl, #limbregeneration
Axolotl can regrow lost limbs, matching their body size. How? Our new theory-experiment paper in @pnas.org proposes how oppositely oriented morphogen gradients scaling with animal size promote proportional growth. Great collaboration with @tatianasg.bsky.social @cmcb-tud.bsky.social
November 28, 2025 at 1:19 PM
New paper from our lab and @friedrich-group.bsky.social !! Insights into morphogen gradient scaling to regenerate a limb at the appropriate size. #axolotl, #limbregeneration
Reposted
🎉 Our deconstructed, stem-cell–based approach to studying signaling centers and limb-development cell types is out! 🥳 So nice to see it in its final form after the preprint— and huge thanks to the community for all the enthusiasm and interest since then!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Specialized signaling centers direct cell fate and spatial organization in a mesodermal organoid model
Stem cell–derived mesodermal organoids reveal how signaling centers guide cell fate and tissue organization.
www.science.org
December 2, 2025 at 9:15 AM
🎉 Our deconstructed, stem-cell–based approach to studying signaling centers and limb-development cell types is out! 🥳 So nice to see it in its final form after the preprint— and huge thanks to the community for all the enthusiasm and interest since then!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
🎉 Our deconstructed, stem-cell–based approach to studying signaling centers and limb-development cell types is out! 🥳 So nice to see it in its final form after the preprint— and huge thanks to the community for all the enthusiasm and interest since then!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Specialized signaling centers direct cell fate and spatial organization in a mesodermal organoid model
Stem cell–derived mesodermal organoids reveal how signaling centers guide cell fate and tissue organization.
www.science.org
December 2, 2025 at 9:15 AM
🎉 Our deconstructed, stem-cell–based approach to studying signaling centers and limb-development cell types is out! 🥳 So nice to see it in its final form after the preprint— and huge thanks to the community for all the enthusiasm and interest since then!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted
Happy to present the final version of our Cadherin and gastruloid manuscript, online at @cp-cellreports.bsky.social.
www.cell.com/cell-reports...
Initially in BiorXiv (www.biorxiv.org/content/10.1...) 1/12
www.cell.com/cell-reports...
Initially in BiorXiv (www.biorxiv.org/content/10.1...) 1/12
Cadherins modulate the self-organizing potential of pseudo-embryos
Gastruloids derived from ES cells mimic embryonic patterning through robust self-organization.
Mayran et al. uncover that this competence depends on a cadherin switch regulated
by Snai1-driven E-cadhe...
www.cell.com
November 17, 2025 at 10:37 AM
Happy to present the final version of our Cadherin and gastruloid manuscript, online at @cp-cellreports.bsky.social.
www.cell.com/cell-reports...
Initially in BiorXiv (www.biorxiv.org/content/10.1...) 1/12
www.cell.com/cell-reports...
Initially in BiorXiv (www.biorxiv.org/content/10.1...) 1/12
Reposted
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
November 6, 2025 at 2:49 PM
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
🔬 Limb regeneration depends on regenerative signaling center cells — but how do these cells influence others to proliferate, migrate, or differentiate?
We’re recruiting PhD or Postdoc candidates to explore this with our collaborator @osvaldo-chara.bsky.social !
We’re recruiting PhD or Postdoc candidates to explore this with our collaborator @osvaldo-chara.bsky.social !
October 21, 2025 at 6:56 AM
🔬 Limb regeneration depends on regenerative signaling center cells — but how do these cells influence others to proliferate, migrate, or differentiate?
We’re recruiting PhD or Postdoc candidates to explore this with our collaborator @osvaldo-chara.bsky.social !
We’re recruiting PhD or Postdoc candidates to explore this with our collaborator @osvaldo-chara.bsky.social !
Reposted
Delighted that Ziqi Dong's PhD paper is out for all to read! Hypoxia is fundamental to normal development, and fascinating! Thanks to all of our co-authors including @jamesnathanlab.bsky.social @jellevda.bsky.social authors.elsevier.com/sd/article/S...
October 11, 2025 at 8:22 AM
Delighted that Ziqi Dong's PhD paper is out for all to read! Hypoxia is fundamental to normal development, and fascinating! Thanks to all of our co-authors including @jamesnathanlab.bsky.social @jellevda.bsky.social authors.elsevier.com/sd/article/S...
Reposted
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
October 16, 2025 at 6:23 AM
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted
I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
Induction of menstruation in mice reveals the regulation of menstrual shedding
During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...
www.biorxiv.org
October 10, 2025 at 12:50 PM
I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
Reposted
🚨JOB ALERT🚨
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
October 2, 2025 at 11:00 AM
🚨JOB ALERT🚨
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
Reposted
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
www.nature.com
September 29, 2025 at 4:45 PM
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Reposted
Are you interested on how regenerating tissues transit between stages? Am sharing here our work showing that during #Xenopus tail regeneration, tissue stiffening activates a Piezo1-Yap1 mechanosensitive cascade to allow wounded epithelia to transit into regenerative states!
September 23, 2025 at 7:39 PM
Are you interested on how regenerating tissues transit between stages? Am sharing here our work showing that during #Xenopus tail regeneration, tissue stiffening activates a Piezo1-Yap1 mechanosensitive cascade to allow wounded epithelia to transit into regenerative states!
Reposted
📢 Institut Jacques Monod Seminars
📅 Oct. 7th
📍 Institut Jacques Monod
Invited by the @stemdevevo.bsky.social Lab , @canaztekin.bsky.social will present an Institut Jacques Monod seminar on the theme « Signaling centers of appendage regeneration: from single cells to species »
➡️ buff.ly/Nvw4YZn
📅 Oct. 7th
📍 Institut Jacques Monod
Invited by the @stemdevevo.bsky.social Lab , @canaztekin.bsky.social will present an Institut Jacques Monod seminar on the theme « Signaling centers of appendage regeneration: from single cells to species »
➡️ buff.ly/Nvw4YZn
September 23, 2025 at 8:01 AM
📢 Institut Jacques Monod Seminars
📅 Oct. 7th
📍 Institut Jacques Monod
Invited by the @stemdevevo.bsky.social Lab , @canaztekin.bsky.social will present an Institut Jacques Monod seminar on the theme « Signaling centers of appendage regeneration: from single cells to species »
➡️ buff.ly/Nvw4YZn
📅 Oct. 7th
📍 Institut Jacques Monod
Invited by the @stemdevevo.bsky.social Lab , @canaztekin.bsky.social will present an Institut Jacques Monod seminar on the theme « Signaling centers of appendage regeneration: from single cells to species »
➡️ buff.ly/Nvw4YZn
Reposted
🧵1/14 Preprint thread! Can we predict a cell’s fate based on its dynamics? 🔮 Our new study unveils a framework for watching development unfold in real-time, revealing how a cell's shape and movement encode info about its future fate. 🔬📄 Preprint: tinyurl.com/4shf8v4x
September 22, 2025 at 9:37 AM
🧵1/14 Preprint thread! Can we predict a cell’s fate based on its dynamics? 🔮 Our new study unveils a framework for watching development unfold in real-time, revealing how a cell's shape and movement encode info about its future fate. 🔬📄 Preprint: tinyurl.com/4shf8v4x
George, our very first postdoc (super brave!), has been central to so many projects. Had a hugely risky project that paved the way for his regeneration work. Proud to share it here again
#PostdocAppreciationWeek 🐸 vs 🐭 👇
🔗 www.biorxiv.org/content/10.1...
#PostdocAppreciationWeek 🐸 vs 🐭 👇
🔗 www.biorxiv.org/content/10.1...
September 18, 2025 at 1:39 PM
George, our very first postdoc (super brave!), has been central to so many projects. Had a hugely risky project that paved the way for his regeneration work. Proud to share it here again
#PostdocAppreciationWeek 🐸 vs 🐭 👇
🔗 www.biorxiv.org/content/10.1...
#PostdocAppreciationWeek 🐸 vs 🐭 👇
🔗 www.biorxiv.org/content/10.1...
Reposted
Thrilled to share that our Group Leader Prof. Azim Surani, together with Prof. Davor Solter, has been awarded the 2026 Paul Ehrlich & Ludwig Darmstaedter Prize 🎉 for discovering genomic imprinting—a breakthrough that reshaped genetics and launched modern epigenetics.
September 18, 2025 at 1:20 PM
Thrilled to share that our Group Leader Prof. Azim Surani, together with Prof. Davor Solter, has been awarded the 2026 Paul Ehrlich & Ludwig Darmstaedter Prize 🎉 for discovering genomic imprinting—a breakthrough that reshaped genetics and launched modern epigenetics.
Reposted
Out today. 🙏 again to everyone for this wonderful piece of work, in particular to Aurelie @aurhin.bsky.social Chase @chasebolt.bsky.social and Brent @homeobox.bsky.social. 🙏 also to the Harris lab @fish4walking.bsky.social and @neilshubin.bsky.social @biology-unige.bsky.social @college-de-france.fr
September 17, 2025 at 5:30 PM
Out today. 🙏 again to everyone for this wonderful piece of work, in particular to Aurelie @aurhin.bsky.social Chase @chasebolt.bsky.social and Brent @homeobox.bsky.social. 🙏 also to the Harris lab @fish4walking.bsky.social and @neilshubin.bsky.social @biology-unige.bsky.social @college-de-france.fr
🚀 Looking for a Bioinformatician / Data Scientist to join our crew and explore regeneration through single-cell genomics & evolutionary biology! @mpi-bio-fml.bsky.social
📩 Questions? Contact us ✉️
🔗 Apply here: www.mpg.de/25243280/bio...
📩 Questions? Contact us ✉️
🔗 Apply here: www.mpg.de/25243280/bio...
Bioinformatician / Data Scientist (m/f/d)
Bioinformatician / Data scientist position in the Aztekin Lab focusing on Structural Regeneration and support the working group together with the other members
www.mpg.de
September 15, 2025 at 6:58 AM
🚀 Looking for a Bioinformatician / Data Scientist to join our crew and explore regeneration through single-cell genomics & evolutionary biology! @mpi-bio-fml.bsky.social
📩 Questions? Contact us ✉️
🔗 Apply here: www.mpg.de/25243280/bio...
📩 Questions? Contact us ✉️
🔗 Apply here: www.mpg.de/25243280/bio...
Reposted
Excited to share our Review on human PGC development covering the latest in vivo observations & in vitro developments, esp. in the last 5 years. Have a read! journals.biologists.com/dev/article/...
From: @astar-gis.bsky.social @ki.se Warwick University, @gurdoninstitute.bsky.social
From: @astar-gis.bsky.social @ki.se Warwick University, @gurdoninstitute.bsky.social
Emerging principles and models of human primordial germ cell development
Summary: This Review examines recent insights into early human germ cell development and how these regulatory principles guide stem cell-derived models aiming to reconstitute human gametogenesis in vi...
journals.biologists.com
September 12, 2025 at 4:21 PM
Excited to share our Review on human PGC development covering the latest in vivo observations & in vitro developments, esp. in the last 5 years. Have a read! journals.biologists.com/dev/article/...
From: @astar-gis.bsky.social @ki.se Warwick University, @gurdoninstitute.bsky.social
From: @astar-gis.bsky.social @ki.se Warwick University, @gurdoninstitute.bsky.social
Reposted
Excited and very grateful to announce that I have been awarded an ERC Starting Grant by @erc.europa.eu! 🎉 This is a fantastic opportunity to further build my team at the Max Planck Institute of Immunobiology and Epigenetics (@mpi-ie.bsky.social) exploring new grounds in fundamental research:
📣 The ERC Starting Grant call results are out!
Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!
➡️ buff.ly/IsafuFh
#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!
➡️ buff.ly/IsafuFh
#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
September 4, 2025 at 7:19 PM
Excited and very grateful to announce that I have been awarded an ERC Starting Grant by @erc.europa.eu! 🎉 This is a fantastic opportunity to further build my team at the Max Planck Institute of Immunobiology and Epigenetics (@mpi-ie.bsky.social) exploring new grounds in fundamental research: