Jeffrey van Haren
@jeffreyharen.bsky.social
Cell biologist, Assistant professor @ Erasmus MC, Optical Imaging Centre (OIC). Postdoc alumnus @ UCSF. Interested in cytoskeleton dynamics, neuronal growth cones, live cell microscopy, optogenetics. Opinions are my own.
Reposted by Jeffrey van Haren
It mourns not for its own fate, but for that of the world and all its beauty, flitting through the cosmos, blown into the void like a light blue wildflower trampled by the night's frost.
November 6, 2025 at 4:59 PM
It mourns not for its own fate, but for that of the world and all its beauty, flitting through the cosmos, blown into the void like a light blue wildflower trampled by the night's frost.
Reposted by Jeffrey van Haren
In the spirit 👻 of Freaky Friday 🎃, here is a beautiful yet eery video of zebrafish retina development showing horizontal cells (🔵) finding their way out of the crowded amacrine (🟠) layer to settle beneath the photoreceptors. Happy #Halloween!
🎥: PhD student Rae Wong from the @nordenlab.bsky.social
🎥: PhD student Rae Wong from the @nordenlab.bsky.social
October 31, 2025 at 2:29 PM
In the spirit 👻 of Freaky Friday 🎃, here is a beautiful yet eery video of zebrafish retina development showing horizontal cells (🔵) finding their way out of the crowded amacrine (🟠) layer to settle beneath the photoreceptors. Happy #Halloween!
🎥: PhD student Rae Wong from the @nordenlab.bsky.social
🎥: PhD student Rae Wong from the @nordenlab.bsky.social
Reposted by Jeffrey van Haren
Reposted by Jeffrey van Haren
During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost!
apply.interfolio.com/174756
apply.interfolio.com/174756
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
October 14, 2025 at 5:35 PM
During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost!
apply.interfolio.com/174756
apply.interfolio.com/174756
Reposted by Jeffrey van Haren
We hire!
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...
October 14, 2025 at 1:50 PM
We hire!
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...
Reposted by Jeffrey van Haren
I found these immune cells just finished mitosis but their midbody is still yet to be resolved. How cool? If you zoom in to the midbody, you can see its classical shape just like in the textbooks. I love these little details.
October 14, 2025 at 10:56 AM
I found these immune cells just finished mitosis but their midbody is still yet to be resolved. How cool? If you zoom in to the midbody, you can see its classical shape just like in the textbooks. I love these little details.
Reposted by Jeffrey van Haren
The future of High-Content Imaging has arrived.
-> Ultra-fast 3D imaging of multi-well plates at high resolution using an air objective!
See previous posts and the new miOPM preprint for details: doi.org/10.1101/2025...
-> Ultra-fast 3D imaging of multi-well plates at high resolution using an air objective!
See previous posts and the new miOPM preprint for details: doi.org/10.1101/2025...
October 13, 2025 at 12:44 AM
The future of High-Content Imaging has arrived.
-> Ultra-fast 3D imaging of multi-well plates at high resolution using an air objective!
See previous posts and the new miOPM preprint for details: doi.org/10.1101/2025...
-> Ultra-fast 3D imaging of multi-well plates at high resolution using an air objective!
See previous posts and the new miOPM preprint for details: doi.org/10.1101/2025...
Reposted by Jeffrey van Haren
Playing around with how to represent volume in #Snouty light sheet data. Here is a dividing hiPSC with endogenously tagged histone in all three orthogonal projections. Bluer is further away. If anything, it distracts from politics.
October 8, 2025 at 7:57 PM
Playing around with how to represent volume in #Snouty light sheet data. Here is a dividing hiPSC with endogenously tagged histone in all three orthogonal projections. Bluer is further away. If anything, it distracts from politics.
Reposted by Jeffrey van Haren
🍀🔬
MSL10 is a high-sensitivity mechanosensor in the tactile sense of the Venus flytrap @natcomms.nature.com from Toyota lab.
www.nature.com/articles/s41...
MSL10 is a high-sensitivity mechanosensor in the tactile sense of the Venus flytrap @natcomms.nature.com from Toyota lab.
www.nature.com/articles/s41...
October 1, 2025 at 2:57 PM
🍀🔬
MSL10 is a high-sensitivity mechanosensor in the tactile sense of the Venus flytrap @natcomms.nature.com from Toyota lab.
www.nature.com/articles/s41...
MSL10 is a high-sensitivity mechanosensor in the tactile sense of the Venus flytrap @natcomms.nature.com from Toyota lab.
www.nature.com/articles/s41...
Reposted by Jeffrey van Haren
Giotto Suite provides a comprehensive, flexible and scalable platform for technology-agnostic spatial omics analysis using R. @rndries.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Giotto Suite: a multiscale and technology-agnostic spatial multiomics analysis ecosystem - Nature Methods
Giotto Suite provides a comprehensive, flexible and scalable platform for technology-agnostic spatial omics analysis using R.
www.nature.com
October 3, 2025 at 12:44 PM
Giotto Suite provides a comprehensive, flexible and scalable platform for technology-agnostic spatial omics analysis using R. @rndries.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Jeffrey van Haren
SCHEPHERD--the bioelectric cell herding platform built for YOU. Single cells, monolayers, organoids--this herds them all + new tricks. Plz try it-- we will *give* you parts! Teaser here of a steering a single cell. GS Yubin Lin's lifeblood with J. Yodh on piano; Celeste R. and Paul K. Thread 1/N
September 17, 2025 at 5:20 PM
SCHEPHERD--the bioelectric cell herding platform built for YOU. Single cells, monolayers, organoids--this herds them all + new tricks. Plz try it-- we will *give* you parts! Teaser here of a steering a single cell. GS Yubin Lin's lifeblood with J. Yodh on piano; Celeste R. and Paul K. Thread 1/N
Reposted by Jeffrey van Haren
My group at Science has been running a big campaign to engineer new channelrhodopsins.
Excited to share the first results from it today: a suite of highly sensitive new opsins.
We call them "WAChRs".
Everyday indoor office lighting is enough to activate them pretty strongly.
Excited to share the first results from it today: a suite of highly sensitive new opsins.
We call them "WAChRs".
Everyday indoor office lighting is enough to activate them pretty strongly.
September 18, 2025 at 2:06 PM
My group at Science has been running a big campaign to engineer new channelrhodopsins.
Excited to share the first results from it today: a suite of highly sensitive new opsins.
We call them "WAChRs".
Everyday indoor office lighting is enough to activate them pretty strongly.
Excited to share the first results from it today: a suite of highly sensitive new opsins.
We call them "WAChRs".
Everyday indoor office lighting is enough to activate them pretty strongly.
Reposted by Jeffrey van Haren
A bit delayed, but excited to still share our latest paper, showing that intercellular forces transduced by E-cadherin activate EGFR-ERK signaling in epithelia by inducing EGFR ligand shedding! Mechanical and biochemical signals can act together within a single, linear cascade! tinyurl.com/mr9mj9j2
E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand shedding
Epithelial stretching promotes the release of EGF receptor ligands that stimulate ERK activation.
tinyurl.com
September 13, 2025 at 6:05 PM
A bit delayed, but excited to still share our latest paper, showing that intercellular forces transduced by E-cadherin activate EGFR-ERK signaling in epithelia by inducing EGFR ligand shedding! Mechanical and biochemical signals can act together within a single, linear cascade! tinyurl.com/mr9mj9j2
Reposted by Jeffrey van Haren
Ant reproduction is getting weirder and weirder. Here’s the latest: queens of a Mediterranean harvester ant mate with males from a different species and then lay eggs that clonally inherit those males’ genome. I.e., they lay eggs that develop into a different species. 🤯
The discovery of an unusual reproductive system for one ant species solves a long-standing puzzle
go.nature.com/47mxGkM
go.nature.com/47mxGkM
Ant queens produce sons of two distinct species
The discovery of an unusual reproductive system for one ant species solves a long-standing puzzle about a missing population of another ant species.
go.nature.com
September 5, 2025 at 10:07 PM
Ant reproduction is getting weirder and weirder. Here’s the latest: queens of a Mediterranean harvester ant mate with males from a different species and then lay eggs that clonally inherit those males’ genome. I.e., they lay eggs that develop into a different species. 🤯
Reposted by Jeffrey van Haren
I’ve already highlighted this landmark #lipidtime paper by @nadlerlab.bsky.social & colleagues, but ICYMI, do read André’s thread — this study is a huge leap forward in understanding the logic of intracellular lipid flux & is a phenomenal example of #chembio probes 🤝 quantitative imaging 🤝 modeling!
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 31, 2025 at 5:35 PM
I’ve already highlighted this landmark #lipidtime paper by @nadlerlab.bsky.social & colleagues, but ICYMI, do read André’s thread — this study is a huge leap forward in understanding the logic of intracellular lipid flux & is a phenomenal example of #chembio probes 🤝 quantitative imaging 🤝 modeling!
Nice! A song about one of my favorite fluorescent proteins! mStayGold!
August 30, 2025 at 11:23 AM
Nice! A song about one of my favorite fluorescent proteins! mStayGold!
Reposted by Jeffrey van Haren
It's reassuring to know that letting your beverages dry out in your workplace coffee mugs and turning them into disgusting gobs of sticky goo is an ancient and time-honored practice.
www.smithsonianmag.com/smart-news/s...
www.smithsonianmag.com/smart-news/s...
Scientists Found Sticky Goo Inside a 2,500-Year-Old Jar. Seventy Years Later, They Finally Know What It Is
By studying the mysterious substance's chemical makeup, scientists determined the pot was once full of honey
www.smithsonianmag.com
August 3, 2025 at 7:32 PM
It's reassuring to know that letting your beverages dry out in your workplace coffee mugs and turning them into disgusting gobs of sticky goo is an ancient and time-honored practice.
www.smithsonianmag.com/smart-news/s...
www.smithsonianmag.com/smart-news/s...
Reposted by Jeffrey van Haren
Beyond Static Screens: A High-Throughput Pooled Imaging CRISPR Platform for Dynamic Phenotype Discovery by Kees Jalink and team: www.biorxiv.org/content/10.1...
July 14, 2025 at 7:35 AM
Beyond Static Screens: A High-Throughput Pooled Imaging CRISPR Platform for Dynamic Phenotype Discovery by Kees Jalink and team: www.biorxiv.org/content/10.1...
Reposted by Jeffrey van Haren
Biggest real problem Europe has is that after a certain career age, it’s Advanced or bust for many people. And there’s VERY few ERC advanced grants (way lower number than R01s). This creates a huge problem for recruitment, especially from outside, which is supposedly what they’re trying to improve.
July 13, 2025 at 9:58 AM
Biggest real problem Europe has is that after a certain career age, it’s Advanced or bust for many people. And there’s VERY few ERC advanced grants (way lower number than R01s). This creates a huge problem for recruitment, especially from outside, which is supposedly what they’re trying to improve.
Reposted by Jeffrey van Haren
Cool idea that stems from integrating learnings from animal behaviorists with leading edge vaccine technology 👏
Clever innovation to reduce/prevent spread of rabies to livestock via vampire bats. Researchers adapted an oral vaccine that prevents viral shedding of rabies to a gel formulation and applied to just a few bats then monitored how the bat grooming enabled the gel to be spread across bat colony…🧪
July 9, 2025 at 3:24 PM
Cool idea that stems from integrating learnings from animal behaviorists with leading edge vaccine technology 👏
Reposted by Jeffrey van Haren
Production has started for a new #Snoutscope objective, AMS-AGY v3. It has significantly larger FOV and some other tweaks from v1 and v2. Currently accepting pre-orders. The price will need to increase modestly after deliveries start late October.
July 9, 2025 at 8:00 PM
Production has started for a new #Snoutscope objective, AMS-AGY v3. It has significantly larger FOV and some other tweaks from v1 and v2. Currently accepting pre-orders. The price will need to increase modestly after deliveries start late October.
Reposted by Jeffrey van Haren
Attempts by law enforcement & governments to subvert end-to-end encryption are ongoing. The European Commission will spend a year thinking about their new "Roadmap for law enforcement access to data" & they are (genuinely) asking for people to join an expert group to help: berthub.eu/articles/pos...
Possible End to End to End Encryption: Come Help - Bert Hubert
tl;dr: The European Commission is honestly asking for experts to advise them on ways to institute “effective and lawful access to data for law enforcement”. If you are an expert, I urge you to apply t...
berthub.eu
July 5, 2025 at 11:43 AM
Attempts by law enforcement & governments to subvert end-to-end encryption are ongoing. The European Commission will spend a year thinking about their new "Roadmap for law enforcement access to data" & they are (genuinely) asking for people to join an expert group to help: berthub.eu/articles/pos...
Reposted by Jeffrey van Haren
Speak up to prevent a major loss for the field. CASP, which helped shaping structural biology including AlphaFold is on the verge of shutting down. NIH funding has lapsed, UC Davis support ends and the core team is being let go. Painfully shortsighted.
Exclusive: Famed protein structure competition nears end as NIH grant money runs out
Agency silent on funding renewal for contest that inspired creation of AIs that predicted how proteins would fold
www.science.org
July 4, 2025 at 12:07 PM
Speak up to prevent a major loss for the field. CASP, which helped shaping structural biology including AlphaFold is on the verge of shutting down. NIH funding has lapsed, UC Davis support ends and the core team is being let go. Painfully shortsighted.
Reposted by Jeffrey van Haren
Anyone know of service providers who can do shallow shotgun sequencing for 1000s of samples at a low cost per sample? We want to use shotgun sequencing to screen 1000s of samples so we want the cost per sample to be as low as possible and do not need that much data per sample (~100 Mb or so).
June 30, 2025 at 8:58 PM
Anyone know of service providers who can do shallow shotgun sequencing for 1000s of samples at a low cost per sample? We want to use shotgun sequencing to screen 1000s of samples so we want the cost per sample to be as low as possible and do not need that much data per sample (~100 Mb or so).
Reposted by Jeffrey van Haren
Episode 8 - CellProfiler does a lot, but could it do EVEN MORE? Hop on in to let @erinweisbart.bsky.social tell you all about CellProfiler plugins - where to find them, how to use them, and how they can add the Power Of Deep Learning to your local copy of CellProfiler!
June 23, 2025 at 1:44 PM
Episode 8 - CellProfiler does a lot, but could it do EVEN MORE? Hop on in to let @erinweisbart.bsky.social tell you all about CellProfiler plugins - where to find them, how to use them, and how they can add the Power Of Deep Learning to your local copy of CellProfiler!