Anh Hoang Le, PhD 🏳️🌈
@anhhle2702.bsky.social
Sir Henry Wellcome fellow studying macrophage migration and mechanobiology @UCL. BSc Biochemistry @Bristol. PhD Cancer Biology @CRUK Scotland Institute. 🏴
Cell lover by day, takeaway lover by night.
https://hoanganhle2602.wixsite.com/cellsandtheirwonders
Cell lover by day, takeaway lover by night.
https://hoanganhle2602.wixsite.com/cellsandtheirwonders
Pinned
My first post will be of course my proudest thing I've ever achieved. My cover image for @jcellbiol.bsky.social. It remains something I'm forever grateful and proud of.
Today I did my annual lecture on Critical Thinking to first year Biochemistry students. We had about 15 mins standing outside the lecture theater waiting for the previous one to finish. I asked a group of students if they were here for the Critical thinking lecture. And one of them immediately...
November 17, 2025 at 8:40 PM
Today I did my annual lecture on Critical Thinking to first year Biochemistry students. We had about 15 mins standing outside the lecture theater waiting for the previous one to finish. I asked a group of students if they were here for the Critical thinking lecture. And one of them immediately...
Reposted by Anh Hoang Le, PhD 🏳️🌈
I guess it never gets old...bc we love #CellMigration
ATP has many roles: energy currency, hydrotrope, and *danger signal*
Immune cells are faster after ATP exposure, F-actin (cyan) goes to the rear for nitro boost!
www.science.org/doi/full/10....
@focalplane.bsky.social #fluorescencefriday 🧪🔬
ATP has many roles: energy currency, hydrotrope, and *danger signal*
Immune cells are faster after ATP exposure, F-actin (cyan) goes to the rear for nitro boost!
www.science.org/doi/full/10....
@focalplane.bsky.social #fluorescencefriday 🧪🔬
November 14, 2025 at 8:38 PM
I guess it never gets old...bc we love #CellMigration
ATP has many roles: energy currency, hydrotrope, and *danger signal*
Immune cells are faster after ATP exposure, F-actin (cyan) goes to the rear for nitro boost!
www.science.org/doi/full/10....
@focalplane.bsky.social #fluorescencefriday 🧪🔬
ATP has many roles: energy currency, hydrotrope, and *danger signal*
Immune cells are faster after ATP exposure, F-actin (cyan) goes to the rear for nitro boost!
www.science.org/doi/full/10....
@focalplane.bsky.social #fluorescencefriday 🧪🔬
Reposted by Anh Hoang Le, PhD 🏳️🌈
Rudolfo Karl, Elvira Mass, Dagmar Wachten @wachtenlab.bsky.social and colleagues discover that renal tissue-resident macrophages promote cystogenesis in early polycystic kidney disease.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
November 14, 2025 at 2:14 PM
Rudolfo Karl, Elvira Mass, Dagmar Wachten @wachtenlab.bsky.social and colleagues discover that renal tissue-resident macrophages promote cystogenesis in early polycystic kidney disease.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
Reposted by Anh Hoang Le, PhD 🏳️🌈
We are very happy to share our new PrePrint: Myosin VI orchestrates estrogen-driven gene expression in breast
cancer cells. www.biorxiv.org/content/10.1...
We characterise how Myosin VI is a key regulator of the Estrogen Receptor. Perturbation of Myosin VI impedes ER functionality.
cancer cells. www.biorxiv.org/content/10.1...
We characterise how Myosin VI is a key regulator of the Estrogen Receptor. Perturbation of Myosin VI impedes ER functionality.
November 14, 2025 at 9:33 AM
We are very happy to share our new PrePrint: Myosin VI orchestrates estrogen-driven gene expression in breast
cancer cells. www.biorxiv.org/content/10.1...
We characterise how Myosin VI is a key regulator of the Estrogen Receptor. Perturbation of Myosin VI impedes ER functionality.
cancer cells. www.biorxiv.org/content/10.1...
We characterise how Myosin VI is a key regulator of the Estrogen Receptor. Perturbation of Myosin VI impedes ER functionality.
Reposted by Anh Hoang Le, PhD 🏳️🌈
Call for papers: Chilean Developmental Biology: at Home and Around the World - Cells & Development.
If you're a Chile-based scientist and Chilean researcher working abroad, please consider submit to us for this special issue.
‼️Submission deadline: 30 June 2026
www.sciencedirect.com/special-issu...
If you're a Chile-based scientist and Chilean researcher working abroad, please consider submit to us for this special issue.
‼️Submission deadline: 30 June 2026
www.sciencedirect.com/special-issu...
November 14, 2025 at 5:31 PM
Call for papers: Chilean Developmental Biology: at Home and Around the World - Cells & Development.
If you're a Chile-based scientist and Chilean researcher working abroad, please consider submit to us for this special issue.
‼️Submission deadline: 30 June 2026
www.sciencedirect.com/special-issu...
If you're a Chile-based scientist and Chilean researcher working abroad, please consider submit to us for this special issue.
‼️Submission deadline: 30 June 2026
www.sciencedirect.com/special-issu...
Reposted by Anh Hoang Le, PhD 🏳️🌈
This week's #FluorescenceFriday, we'll be treated with one of the classical models of #devbio, the neural crest cells. Here is a beautiful video of neural crest cells with GFP-tagged focal adhesion kinase (🔵) and LifeAct-RFP (🟣) migrating on a Fibronectin matrix.
📹: Adam Shellard
📹: Adam Shellard
November 14, 2025 at 5:45 PM
This week's #FluorescenceFriday, we'll be treated with one of the classical models of #devbio, the neural crest cells. Here is a beautiful video of neural crest cells with GFP-tagged focal adhesion kinase (🔵) and LifeAct-RFP (🟣) migrating on a Fibronectin matrix.
📹: Adam Shellard
📹: Adam Shellard
Reposted by Anh Hoang Le, PhD 🏳️🌈
Researchers at the Crick have discovered that mice lacking a specific gene responsible for cell structure lose intestinal balance and experience systemic inflammation, mirroring a lethal condition seen in humans.
www.crick.ac.uk/news/2025-11...
www.crick.ac.uk/news/2025-11...
How weakness in cell structure affects the host-microbiome relationship
Mice lacking a gene responsible for cell structure lose intestinal balance and experience systemic inflammation, mirroring a lethal condition seen in humans.
www.crick.ac.uk
November 13, 2025 at 7:56 PM
Researchers at the Crick have discovered that mice lacking a specific gene responsible for cell structure lose intestinal balance and experience systemic inflammation, mirroring a lethal condition seen in humans.
www.crick.ac.uk/news/2025-11...
www.crick.ac.uk/news/2025-11...
Reposted by Anh Hoang Le, PhD 🏳️🌈
We finally made it over here ! And excited to share our new paper on mechanical forces regulating stem cell plasticity in colorectal cancer, involving force transduction via mechanosensitive calcium channels! www.cell.com/cell-reports...
Mechanosensitive calcium channels and integrins coordinate the reprogramming of colorectal cancer cells into a fetal-like state
van der Net et al. show that mechanical interactions with the stromal component collagen
I trigger reprogramming of colorectal cancer cells into a fetal-like state, through
mechanosensitive integrins ...
www.cell.com
November 7, 2025 at 4:33 PM
We finally made it over here ! And excited to share our new paper on mechanical forces regulating stem cell plasticity in colorectal cancer, involving force transduction via mechanosensitive calcium channels! www.cell.com/cell-reports...
Reposted by Anh Hoang Le, PhD 🏳️🌈
"His secret weapons were an unquenchable curiosity and continuing hands-on experimentation at the bench with his beautiful frog embryos and oocytes".
A thoughtful tribute to the life of Sir John Gurdon by Edward M. De Robertis that we really recommend everyone to read.
doi.org/10.1016/j.cd...
A thoughtful tribute to the life of Sir John Gurdon by Edward M. De Robertis that we really recommend everyone to read.
doi.org/10.1016/j.cd...
November 7, 2025 at 9:12 PM
"His secret weapons were an unquenchable curiosity and continuing hands-on experimentation at the bench with his beautiful frog embryos and oocytes".
A thoughtful tribute to the life of Sir John Gurdon by Edward M. De Robertis that we really recommend everyone to read.
doi.org/10.1016/j.cd...
A thoughtful tribute to the life of Sir John Gurdon by Edward M. De Robertis that we really recommend everyone to read.
doi.org/10.1016/j.cd...
Reposted by Anh Hoang Le, PhD 🏳️🌈
Sir John Gurdon was also the president of the @isdb.bsky.social from 1989-1992. He also facilitated or influenced the establishment of the @bsdb.bsky.social, @lasdb.bsky.social, many institutes, and generations of scientists, and worked with @biologists.bsky.social for decades. You will be missed.
"His secret weapons were an unquenchable curiosity and continuing hands-on experimentation at the bench with his beautiful frog embryos and oocytes".
A thoughtful tribute to the life of Sir John Gurdon by Edward M. De Robertis that we really recommend everyone to read.
doi.org/10.1016/j.cd...
A thoughtful tribute to the life of Sir John Gurdon by Edward M. De Robertis that we really recommend everyone to read.
doi.org/10.1016/j.cd...
November 7, 2025 at 9:23 PM
Sir John Gurdon was also the president of the @isdb.bsky.social from 1989-1992. He also facilitated or influenced the establishment of the @bsdb.bsky.social, @lasdb.bsky.social, many institutes, and generations of scientists, and worked with @biologists.bsky.social for decades. You will be missed.
Reposted by Anh Hoang Le, PhD 🏳️🌈
Please repost - Multiple PhDs available
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
November 5, 2025 at 9:18 AM
Please repost - Multiple PhDs available
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Reposted by Anh Hoang Le, PhD 🏳️🌈
I'm thrilled to finally share my PhD work on understanding how Ca2+ signals regulate the protruding front of the cell. It’s been an incredible journey working alongside all the collaborators.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A TRPV4–dependent calcium signaling axis governs lamellipodial actin architecture to promote cell migration
Cell migration is crucial for development and tissue homeostasis, while its dysregulation leads to severe pathologies. Cell migration is driven by the extension of actin–based lamellipodia protrusions...
www.biorxiv.org
March 30, 2025 at 12:44 PM
I'm thrilled to finally share my PhD work on understanding how Ca2+ signals regulate the protruding front of the cell. It’s been an incredible journey working alongside all the collaborators.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Anh Hoang Le, PhD 🏳️🌈
Register for the Dynamic Cell VI conference, Reading, UK, April 2026! This conference focusses on all aspects of cell dynamics, co-organised by @bscb-official.bsky.social and @biochemsoc.bsky.social with @royalmicrosoc.bsky.social and the Chinese Society for Cell Biology.
bit.ly/Dynamic-Cell-VI
bit.ly/Dynamic-Cell-VI
October 10, 2025 at 2:24 PM
Register for the Dynamic Cell VI conference, Reading, UK, April 2026! This conference focusses on all aspects of cell dynamics, co-organised by @bscb-official.bsky.social and @biochemsoc.bsky.social with @royalmicrosoc.bsky.social and the Chinese Society for Cell Biology.
bit.ly/Dynamic-Cell-VI
bit.ly/Dynamic-Cell-VI
Reposted by Anh Hoang Le, PhD 🏳️🌈
Please Repost!
Tobi Zach and I have an MRC DiMeN PhD position available! Come join us!
www.findaphd.com/phds/project...
Tobi Zach and I have an MRC DiMeN PhD position available! Come join us!
www.findaphd.com/phds/project...
MRC DiMeN Doctoral Training Partnership: Stopping premature ageing: Investigating the role of actomyosin mediated nuclear force feedback in cell homeostasis at University of Liverpool on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Stopping premature ageing: Investigating the role of actomyosin mediated nuclear force feedback in cell homeostasis at University of Liverpool, l...
www.findaphd.com
November 2, 2025 at 11:13 AM
Please Repost!
Tobi Zach and I have an MRC DiMeN PhD position available! Come join us!
www.findaphd.com/phds/project...
Tobi Zach and I have an MRC DiMeN PhD position available! Come join us!
www.findaphd.com/phds/project...
Reposted by Anh Hoang Le, PhD 🏳️🌈
Can't believe it — my first‑author paper is out and my image graces the cover of @dev-journal.bsky.social 🎉
Here, we reveal how early developmental programs shape and maintain #zebrafish gill architecture throughout life
🔗 journals.biologists.com/dev/issue/15...
#FluorescenceFriday #LifelongDevSI
Here, we reveal how early developmental programs shape and maintain #zebrafish gill architecture throughout life
🔗 journals.biologists.com/dev/issue/15...
#FluorescenceFriday #LifelongDevSI
October 31, 2025 at 10:55 AM
Can't believe it — my first‑author paper is out and my image graces the cover of @dev-journal.bsky.social 🎉
Here, we reveal how early developmental programs shape and maintain #zebrafish gill architecture throughout life
🔗 journals.biologists.com/dev/issue/15...
#FluorescenceFriday #LifelongDevSI
Here, we reveal how early developmental programs shape and maintain #zebrafish gill architecture throughout life
🔗 journals.biologists.com/dev/issue/15...
#FluorescenceFriday #LifelongDevSI
Reposted by Anh Hoang Le, PhD 🏳️🌈
In the spirit 👻 of Freaky Friday 🎃, here is a beautiful yet eery video of zebrafish retina development showing horizontal cells (🔵) finding their way out of the crowded amacrine (🟠) layer to settle beneath the photoreceptors. Happy #Halloween!
🎥: PhD student Rae Wong from the @nordenlab.bsky.social
🎥: PhD student Rae Wong from the @nordenlab.bsky.social
October 31, 2025 at 2:29 PM
In the spirit 👻 of Freaky Friday 🎃, here is a beautiful yet eery video of zebrafish retina development showing horizontal cells (🔵) finding their way out of the crowded amacrine (🟠) layer to settle beneath the photoreceptors. Happy #Halloween!
🎥: PhD student Rae Wong from the @nordenlab.bsky.social
🎥: PhD student Rae Wong from the @nordenlab.bsky.social
Reposted by Anh Hoang Le, PhD 🏳️🌈
The ECM is no longer in the back seat when it comes to development. Check out our special issue "Dynamics of the extracellular matrix in development, cell physiology and disease" with 8 selected articles to learn more: A 🧵 www.sciencedirect.com/special-issu...
Cells & Development | Dynamics of the extracellular matrix in development, cell physiology and disease. | ScienceDirect.com by Elsevier
Extracellular matrices (ECMs) are everywhere in our body– from the sheet-like basement membranes that line epithelia and other tissues - to the loose stromal arrays of mesenchyme - to the rigid struct...
www.sciencedirect.com
October 30, 2025 at 5:48 PM
The ECM is no longer in the back seat when it comes to development. Check out our special issue "Dynamics of the extracellular matrix in development, cell physiology and disease" with 8 selected articles to learn more: A 🧵 www.sciencedirect.com/special-issu...
Reposted by Anh Hoang Le, PhD 🏳️🌈
Stop by at the two lab posters at the @dgz.bsky.social Meeting in Heidelberg!
Esther will present Mikhail’s work on asymmetric furrow ingression and Sophia on a novel signaling pathway that positions the cleavage furrow at the right place.
Esther will present Mikhail’s work on asymmetric furrow ingression and Sophia on a novel signaling pathway that positions the cleavage furrow at the right place.
October 26, 2025 at 8:46 AM
Stop by at the two lab posters at the @dgz.bsky.social Meeting in Heidelberg!
Esther will present Mikhail’s work on asymmetric furrow ingression and Sophia on a novel signaling pathway that positions the cleavage furrow at the right place.
Esther will present Mikhail’s work on asymmetric furrow ingression and Sophia on a novel signaling pathway that positions the cleavage furrow at the right place.
Reposted by Anh Hoang Le, PhD 🏳️🌈
Cell-cell junction proteins like ZO-1 not only play a critical role in the mechanical interaction between cells, but also participate in the biochemical signalling to coordinate the cell sheet. Check out this review on collective cell migration here to learn more: doi.org/10.1016/j.cd...
October 24, 2025 at 11:32 PM
Cell-cell junction proteins like ZO-1 not only play a critical role in the mechanical interaction between cells, but also participate in the biochemical signalling to coordinate the cell sheet. Check out this review on collective cell migration here to learn more: doi.org/10.1016/j.cd...
Reposted by Anh Hoang Le, PhD 🏳️🌈
🧠Talk about having guts! 💪Embryonic mouse intestines stained for ❤️💚 nerves and 💙 endothelial cells, forming the early circuits that keep things moving (literally!) 🔬 Image by Nathan Burns. #FluorescenceFriday #DevBio
October 17, 2025 at 9:07 PM
🧠Talk about having guts! 💪Embryonic mouse intestines stained for ❤️💚 nerves and 💙 endothelial cells, forming the early circuits that keep things moving (literally!) 🔬 Image by Nathan Burns. #FluorescenceFriday #DevBio
Reposted by Anh Hoang Le, PhD 🏳️🌈
How do endodermal cells behave during gastrulation? In this paper, the authors found that a gradient of BMP regulates mesoderm and endoderm convergent extension. Endoderm cells also use the mesoderm and Cxcr4a signalling to guide their movement. The imaging is beautiful!
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
October 17, 2025 at 6:27 PM
How do endodermal cells behave during gastrulation? In this paper, the authors found that a gradient of BMP regulates mesoderm and endoderm convergent extension. Endoderm cells also use the mesoderm and Cxcr4a signalling to guide their movement. The imaging is beautiful!
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
Reposted by Anh Hoang Le, PhD 🏳️🌈
Working on the cell biology of the nucleus? We're still accepting submissions for our special issue on this topic!
Find out more at:
journals.biologists.com/jcs/pages/nu...
#cellbiology #nucleus #notforprofit #freetopublish
Find out more at:
journals.biologists.com/jcs/pages/nu...
#cellbiology #nucleus #notforprofit #freetopublish
October 17, 2025 at 10:32 AM
Working on the cell biology of the nucleus? We're still accepting submissions for our special issue on this topic!
Find out more at:
journals.biologists.com/jcs/pages/nu...
#cellbiology #nucleus #notforprofit #freetopublish
Find out more at:
journals.biologists.com/jcs/pages/nu...
#cellbiology #nucleus #notforprofit #freetopublish
Reposted by Anh Hoang Le, PhD 🏳️🌈
We're still accepting submissions for our next special issue:
Cell Biology of the Nucleus
Guest edited by @abbybuch.bsky.social and Megan King @luskinglab.bsky.social.
Submission deadline: 3 November
journals.biologists.com/jcs/pages/nu...
#cellbiology #nucleus #notforprofit #freetopublish
Cell Biology of the Nucleus
Guest edited by @abbybuch.bsky.social and Megan King @luskinglab.bsky.social.
Submission deadline: 3 November
journals.biologists.com/jcs/pages/nu...
#cellbiology #nucleus #notforprofit #freetopublish
September 30, 2025 at 9:26 AM
We're still accepting submissions for our next special issue:
Cell Biology of the Nucleus
Guest edited by @abbybuch.bsky.social and Megan King @luskinglab.bsky.social.
Submission deadline: 3 November
journals.biologists.com/jcs/pages/nu...
#cellbiology #nucleus #notforprofit #freetopublish
Cell Biology of the Nucleus
Guest edited by @abbybuch.bsky.social and Megan King @luskinglab.bsky.social.
Submission deadline: 3 November
journals.biologists.com/jcs/pages/nu...
#cellbiology #nucleus #notforprofit #freetopublish
I found these immune cells just finished mitosis but their midbody is still yet to be resolved. How cool? If you zoom in to the midbody, you can see its classical shape just like in the textbooks. I love these little details.
October 14, 2025 at 10:56 AM
I found these immune cells just finished mitosis but their midbody is still yet to be resolved. How cool? If you zoom in to the midbody, you can see its classical shape just like in the textbooks. I love these little details.
Reposted by Anh Hoang Le, PhD 🏳️🌈
A new review from the @mayorlab.bsky.social on the chemical and physical cues regulating neural crest cells migration is out. Check it out!
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...
Neural Crest Migration Orchestrated by Molecular and Mechanical Signals
The neural crest is a highly migratory multipotent cell population traveling large distances in the vertebrate embryo. Neural crest cells migrate collectively in subpopulations, ranging in size from s...
www.annualreviews.org
October 13, 2025 at 8:15 PM
A new review from the @mayorlab.bsky.social on the chemical and physical cues regulating neural crest cells migration is out. Check it out!
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...