Anh Hoang Le, PhD 🏳️🌈
@anhhle2702.bsky.social
Sir Henry Wellcome fellow studying macrophage migration and mechanobiology @UCL. BSc Biochemistry @Bristol. PhD Cancer Biology @CRUK Scotland Institute. 🏴
Cell lover by day, takeaway lover by night.
https://hoanganhle2602.wixsite.com/cellsandtheirwonders
Cell lover by day, takeaway lover by night.
https://hoanganhle2602.wixsite.com/cellsandtheirwonders
I found these immune cells just finished mitosis but their midbody is still yet to be resolved. How cool? If you zoom in to the midbody, you can see its classical shape just like in the textbooks. I love these little details.
October 14, 2025 at 10:56 AM
I found these immune cells just finished mitosis but their midbody is still yet to be resolved. How cool? If you zoom in to the midbody, you can see its classical shape just like in the textbooks. I love these little details.
And we got a tree as well! A Wild cherry (Prunus avium) 🌸 So cool! Thank you to @biologists.bsky.social and @seemagrewal.bsky.social for the opportunity.
forest.biologists.com/landscape/?i...
forest.biologists.com/landscape/?i...
October 2, 2025 at 3:43 PM
And we got a tree as well! A Wild cherry (Prunus avium) 🌸 So cool! Thank you to @biologists.bsky.social and @seemagrewal.bsky.social for the opportunity.
forest.biologists.com/landscape/?i...
forest.biologists.com/landscape/?i...
YO, what's up with all these almost-witchcraft techniques?? In this paper, they develop a way to freeze cells so quickly that it preserves Calcium waves midway!! WHAT??? HELLO??? So now you can do 3D reconstruction of calcium waves with just a normal confocal. www.nature.com/articles/s41...
August 26, 2025 at 9:11 PM
YO, what's up with all these almost-witchcraft techniques?? In this paper, they develop a way to freeze cells so quickly that it preserves Calcium waves midway!! WHAT??? HELLO??? So now you can do 3D reconstruction of calcium waves with just a normal confocal. www.nature.com/articles/s41...
I was looking through my old microscopy videos, and found this perfect shot of a macropinosome forming through the collapse of an actin-driven membrane ruffle (cyan). Immediately, CRYI-A (orange) is recruited to the vesicle to finish the job. Still in awe with this process after all those years!
July 31, 2025 at 11:19 PM
I was looking through my old microscopy videos, and found this perfect shot of a macropinosome forming through the collapse of an actin-driven membrane ruffle (cyan). Immediately, CRYI-A (orange) is recruited to the vesicle to finish the job. Still in awe with this process after all those years!
It's one of those experiments where you don't really know if it's worth doing it but you're also curious to know what happens if you do it.
I adapted another Optogenetic tool in 🐸 that allows one to change the migration direction of immune cells. It works beautifully, but is it useful for me, Idk 😅
I adapted another Optogenetic tool in 🐸 that allows one to change the migration direction of immune cells. It works beautifully, but is it useful for me, Idk 😅
July 19, 2025 at 6:44 PM
It's one of those experiments where you don't really know if it's worth doing it but you're also curious to know what happens if you do it.
I adapted another Optogenetic tool in 🐸 that allows one to change the migration direction of immune cells. It works beautifully, but is it useful for me, Idk 😅
I adapted another Optogenetic tool in 🐸 that allows one to change the migration direction of immune cells. It works beautifully, but is it useful for me, Idk 😅
Haha what is my BSCB image Drops of Colours doing on an @embo.org tote bag? The original image was inspired by Andy Warhol's Marilyn Monroe pop art so the black and white doesn't quite do it justice, but it was still a pleasant surprise! 🥰
May 22, 2025 at 1:49 PM
Haha what is my BSCB image Drops of Colours doing on an @embo.org tote bag? The original image was inspired by Andy Warhol's Marilyn Monroe pop art so the black and white doesn't quite do it justice, but it was still a pleasant surprise! 🥰
2/We discussed in details 3 major examples demonstrating the importance of cellular tissue as the substrate for other cells to migrate on: the Drosophila egg chamber, the Xenopus neural crest, and the lateral line in zebrafish. I'm also very proud of these figures too.
May 20, 2025 at 11:55 AM
2/We discussed in details 3 major examples demonstrating the importance of cellular tissue as the substrate for other cells to migrate on: the Drosophila egg chamber, the Xenopus neural crest, and the lateral line in zebrafish. I'm also very proud of these figures too.
1/I'm excited to share my review with CSHL exploring the concept of neighbouring cells as substrate to guide the collective migration of other cells. We tend to focus on cell-matrix interactions, but forget that within tissue, cell-cell interactions exist.
cshperspectives.cshlp.org/content/earl...
cshperspectives.cshlp.org/content/earl...
May 20, 2025 at 11:55 AM
1/I'm excited to share my review with CSHL exploring the concept of neighbouring cells as substrate to guide the collective migration of other cells. We tend to focus on cell-matrix interactions, but forget that within tissue, cell-cell interactions exist.
cshperspectives.cshlp.org/content/earl...
cshperspectives.cshlp.org/content/earl...
Thanks Guillaume. The idea is simple like this. F1 is time 1, F2 is time 2. The cell turns. Angle alpha is what I want. When it turns again F3, the angle is between F1 and F3. The cell may or may not move but this is not important.
April 26, 2025 at 9:13 AM
Thanks Guillaume. The idea is simple like this. F1 is time 1, F2 is time 2. The cell turns. Angle alpha is what I want. When it turns again F3, the angle is between F1 and F3. The cell may or may not move but this is not important.
The angle alpha between F1 and F2 is what I want to measure.
April 25, 2025 at 10:11 PM
The angle alpha between F1 and F2 is what I want to measure.
I want to measure this angle alpha between the two vectors F1 and F2 based on where is the cell pointing to.
April 25, 2025 at 10:11 PM
I want to measure this angle alpha between the two vectors F1 and F2 based on where is the cell pointing to.
I found these 2 giant 🐸 embryos (left hand side). They are about 2 times larger than the normal embryos (right hand side). Why are they so big?? #question #developmentalbiology #devbio
April 16, 2025 at 2:28 PM
I found these 2 giant 🐸 embryos (left hand side). They are about 2 times larger than the normal embryos (right hand side). Why are they so big?? #question #developmentalbiology #devbio
I think I finally got the right dose for the Optogenetic tool. Embryos are happy. Cells are happy. Localisation looks good. Science takes so much time, but when it works, it always makes me want to do more (until it doesn't and then I want to die). #FluorescenceFriday
March 21, 2025 at 9:02 PM
I think I finally got the right dose for the Optogenetic tool. Embryos are happy. Cells are happy. Localisation looks good. Science takes so much time, but when it works, it always makes me want to do more (until it doesn't and then I want to die). #FluorescenceFriday
So happy I finally made the ILID-SspB Optogenetic system work in 🐸. Though not perfect and need some optimisations, it worked. Got the constructs from @joachimgoedhart.bsky.social and made it into a frog expression system. Here is the Opto-PH-Rho in action. It's real, guys!! #FluorescenceFriday
March 14, 2025 at 3:49 PM
So happy I finally made the ILID-SspB Optogenetic system work in 🐸. Though not perfect and need some optimisations, it worked. Got the constructs from @joachimgoedhart.bsky.social and made it into a frog expression system. Here is the Opto-PH-Rho in action. It's real, guys!! #FluorescenceFriday
Excited to join the Immune cell interactions workshop tomorrow. This will be my very first immunology conference. I've known of the work of many people here but I'm not an immunologist. I've always been fascinated by immune cells that I decided to focus my postdoc on it. I hope to learn a lot!
February 22, 2025 at 12:40 PM
Excited to join the Immune cell interactions workshop tomorrow. This will be my very first immunology conference. I've known of the work of many people here but I'm not an immunologist. I've always been fascinated by immune cells that I decided to focus my postdoc on it. I hope to learn a lot!
How did I only just realise that the vials with the red streak are Kanamycin resistant and the ones that don't have the mark are Ampicilin resistant? @addgene.bsky.social Can you confirm? 😱😱 I always go on the website to check for the resistant selection.
February 11, 2025 at 5:04 PM
How did I only just realise that the vials with the red streak are Kanamycin resistant and the ones that don't have the mark are Ampicilin resistant? @addgene.bsky.social Can you confirm? 😱😱 I always go on the website to check for the resistant selection.
This past year has been chaotic. Lots of down and not many ups. But hey, science game is a perseverance game! And I'm still here so see you next year, biatch 👋👋👋
December 18, 2024 at 2:07 PM
This past year has been chaotic. Lots of down and not many ups. But hey, science game is a perseverance game! And I'm still here so see you next year, biatch 👋👋👋
The vector field of this spreading tissue looks just like the sun during a coronal mass ejection event #MicroscopyMonday
December 2, 2024 at 6:28 PM
The vector field of this spreading tissue looks just like the sun during a coronal mass ejection event #MicroscopyMonday
Sorry, but after updating my Mac to this new Sequoia system, there have been a lot of weird and inconvenient changes to my laptop. One is this dangerously close "Erase Disk..." button right beneath the "Eject disk..." button??? Umm, HELLO??? What could possibly go wrong here????
November 27, 2024 at 8:23 PM
Sorry, but after updating my Mac to this new Sequoia system, there have been a lot of weird and inconvenient changes to my laptop. One is this dangerously close "Erase Disk..." button right beneath the "Eject disk..." button??? Umm, HELLO??? What could possibly go wrong here????
My first post will be of course my proudest thing I've ever achieved. My cover image for @jcellbiol.bsky.social. It remains something I'm forever grateful and proud of.
November 9, 2024 at 7:02 PM
My first post will be of course my proudest thing I've ever achieved. My cover image for @jcellbiol.bsky.social. It remains something I'm forever grateful and proud of.