Pablo J. Sáez
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pjsaez.bsky.social
Pablo J. Sáez
@pjsaez.bsky.social
1.6K followers 470 following 240 posts
Husband - Dad of 2 - Scientist 🇨🇱 Chilean expat.
I love to study how cells walk & talk.
PI of the @cellcommlab.bsky.social
#CellMigration #CellComm #calciumsignaling #organelles 🧪🔬
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pjsaez.bsky.social
Pablo J. Sáez @pjsaez.bsky.social · Jan 9
#FluorescenceFriday

Proud of our the last paper @cellcommlab.bsky.social & 1st one of @jboixcampos.bsky.social

We continue to study #CellMigration & how cells decide where to go: ↖️↗️⬇️?

(movie of the actin #cytoskeleton)

Full www.science.org/doi/10.1126/...
@focalplane.bsky.social @science.org 🧪🔬
Reposted by Pablo J. Sáez
ceciborassi.bsky.social
We are happy to announce the start of the MechanoBioTalks – Mechanics, Materials and Living Matter an initiative organized by GreenTE young researchers. The aim of the webinars is to bring together researchers interested in biomechanics, biophysics and biology.
Register here: green-te.nl/activities/
Activities - GreenTE
Activities Webinars ”MechanoBioTalks – Mechanics, Materials and Living Matter” is a webinar series supported by the GreenTE consortium and organized […]
green-te.nl
January 22, 2026 at 9:29 AM
Reposted by Pablo J. Sáez
drmichaelway.bsky.social
2nd postdoc job alert in the Crick Institute in London. Project will examine the role of motors & the cytoskeleton (actin, septins and microtubules) during vaccinia virus egress using biochemical, structural & cellular approaches + live cell imaging. spread the word.
crick.ac.uk/WayPostdoc20...
Postdoctoral Fellow - Cellular signalling and cytoskeletal function lab
crick.ac.uk
February 6, 2026 at 8:29 AM
Reposted by Pablo J. Sáez
aaandmoore.bsky.social
Not something you see in textbooks very often: tripolar mitosis.
February 7, 2026 at 8:00 AM
Reposted by Pablo J. Sáez
focalplane.bsky.social
Our #preprint list is up on FocalPlane. This list focusses on the latest tools in bioimage analysis.
Let us know if you have any recommendations to add to our list.
focalplane.biologists.com/2026/02/06/m...
Microscopy preprints: bioimage analysis - FocalPlane
Microscopy preprints: bioimage analysis - News
focalplane.biologists.com
February 6, 2026 at 2:56 PM
Reposted by Pablo J. Sáez
mag2art.bsky.social
"The microtubule GTP-tubulin cap size is modulated during cell division" is now available on @biorxivpreprint! This video by Anna Cassidy shows the tips of growing microtubules (EB1) and DNA (histone 2B) during metaphase. #Cellbiology
www.biorxiv.org/content/10.6...
February 4, 2026 at 5:20 PM
Reposted by Pablo J. Sáez
focalplane.bsky.social
The next @bioimagingna.bsky.social @canadabioimaging.bsky.social Nanoscopy (previously STED) User Group meeting is on 12 February from 12 pm ET. The group welcomes researchers at all levels for an open discussion on nanoscopy methods.
focalplane.biologists.com/2026/02/02/b...
BINA STED User Group, February 12, 12 PM ET - FocalPlane
BINA STED User Group, February 12, 12 PM ET -
focalplane.biologists.com
February 3, 2026 at 4:46 PM
Reposted by Pablo J. Sáez
jcellsci.bsky.social
After 15 years as Editor-in-chief (EiC), Michael Way @drmichaelway.bsky.social will be stepping down at the end of 2026 & we are seeking feedback from the cell biology community as part of the consultation process for appointing a new EiC.
We'd love to hear from you: www.surveymonkey.com/r/GZCC9F9
Fill out our community survey to help shape the future of JCS Journal of Cell Science logo Line drawing of a group of people with speech bubbles above their heads
February 3, 2026 at 1:36 PM
Reposted by Pablo J. Sáez
pjsaez.bsky.social
#FluorescenceFriday

Jost, Schweizer et al. @ Cuello lab found that a mutation linked to aortic aneurysmas led to distorted actin #cytoskeleton in VSMCs #mechanobiology

New collab @cellcommlab.bsky.social by @jboixcampos.bsky.social🔥

Full www.sciencedirect.com/science/arti...
#microscopy #cell 🧪🔬
January 16, 2026 at 9:43 PM
Reposted by Pablo J. Sáez
jcellsci.bsky.social
JCS snapshot - Tracking coordinated cellular dynamics in time-lapse microscopy with ARCOS.px

@macdobry.bsky.social presents the key findings from their recent JCS paper with @bgraedel.bsky.social and colleagues @olivierpertz.bsky.social.

journals.biologists.com/jcs/article/...
January 29, 2026 at 2:24 PM
Reposted by Pablo J. Sáez
jcb.org
#Addendum to 1970 paper, “CYTOPLASMIC FILAMENTS OF AMOEBA PROTEUS: I. The Role of Filaments in Consistency Changes and Movement,” includes eight video sequences originally recorded on 16-mm films. No technology was available at the time to include this data. 🎞️ rupress.org/jcb/article/...

#Actin
January 29, 2026 at 3:45 PM
pjsaez.bsky.social
Very hot from the press !

Almost every topic we work in:
#IonChannels #Leukocytes #CalciumSignaling

T cell response depends on target-cell stifness to drive Piezo1- Orai1 membrane channels activation, softening of tumours prevents this response.

Full www.science.org/doi/10.1126/... @science.org
T cell polarization and NFAT activation are stiffness dependent and differentially regulated by the channels PIEZO1 and ORAI1
Target stiffness influences T cell polarization and gene expression through distinct Ca2+ channels.
www.science.org
January 27, 2026 at 8:17 PM
Reposted by Pablo J. Sáez
guijacquemet.bsky.social
🚨 We are hiring TWO postdocs to join the Cell Migration Lab (cellmig.org) 🇫🇮 as part of the new Centre of Excellence in Immune–Endothelial Interfaces (IMMENs).
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶
CELL MIGRATION LAB
We study cell migration in health and disease
cellmig.org
January 21, 2026 at 7:57 AM
Reposted by Pablo J. Sáez
bpodaily.bsky.social
Skin cell volume regulates their terminal differentiation

📷 Sebastiaan Zijl et al @kingscollegelondon.bsky.social
in @jcellsci.bsky.social
➡️ bpod.org.uk/archive/2026... with Lux Fatimathas
January 15, 2026 at 9:53 AM
Reposted by Pablo J. Sáez
sanchezlab.bsky.social
Interested in cell-cell communication and microscopy? We are searching for a motivated postdoctoral researcher to join Münster! Please Apply! @uni-muenster.de
January 19, 2026 at 4:54 PM
Reposted by Pablo J. Sáez
focalplane.bsky.social
Following on from her beautiful featured image post on FocalPlane, Christina Daly @christinaadaly.bsky.social shares her top tips for imaging cytonemes.
@labogden.bsky.social.
focalplane.biologists.com/2026/01/19/c...
Cytoneme Imaging Tips and Tricks - FocalPlane
Cytoneme Imaging Tips and Tricks - How to
focalplane.biologists.com
January 19, 2026 at 1:30 PM
pjsaez.bsky.social
#FluorescenceFriday

Jost, Schweizer et al. @ Cuello lab found that a mutation linked to aortic aneurysmas led to distorted actin #cytoskeleton in VSMCs #mechanobiology

New collab @cellcommlab.bsky.social by @jboixcampos.bsky.social🔥

Full www.sciencedirect.com/science/arti...
#microscopy #cell 🧪🔬
January 16, 2026 at 9:43 PM
Reposted by Pablo J. Sáez
jcellsci.bsky.social
Issue 24 is complete

Marking the end of @biologists.bsky.social 100-year anniversary celebrations, our cover features members of the JCS community, including some researchers from our ‘First Person’ & ‘Cell Scientists to Watch’ interviews.

Explore our ToC: journals.biologists.com/jcs/issue/13...
JCS cover: Marking the end of The Company of Biologists' 100-year anniversary, the final journal cover of 2025 features members of our community, including our academic and guest Editors, our FocalPlane Advisory Board, some of the ‘First Person’ and ‘Cell Scientists to Watch’ scientists featured this year, and our in-house team of administrators and editors at our editorial office in Cambridge.
January 6, 2026 at 10:49 AM
pjsaez.bsky.social
#FluorescenceFriday

Proud of our the last paper @cellcommlab.bsky.social & 1st one of @jboixcampos.bsky.social

We continue to study #CellMigration & how cells decide where to go: ↖️↗️⬇️?

(movie of the actin #cytoskeleton)

Full www.science.org/doi/10.1126/...
@focalplane.bsky.social @science.org 🧪🔬
January 9, 2026 at 4:23 PM
Reposted by Pablo J. Sáez
jboixcampos.bsky.social
Our work is finally published in @science.org Advances! 🎉

My very first paper, and what a journey it's been 🙂‍↕️

Huge thanks to the whole team, and especially to @pjsaez.bsky.social for believing in me. It turned out way better than I could've ever dreamt ✨

📄 science.org/doi/10.1126/sciadv.ads2734
January 7, 2026 at 1:09 PM
Reposted by Pablo J. Sáez
focalplane.bsky.social
👁️I spy our Scientific Advisory Board members on the @jcellsci.bsky.social cover.
FocalPlane is a youngster at 5 years old, but we're looking forward to continuing our development in 2026 with the help of the #microscopy and #cellbio communities.
jcellsci.bsky.social Journal of Cell Science @jcellsci.bsky.social · Jan 6
Issue 24 is complete

Marking the end of @biologists.bsky.social 100-year anniversary celebrations, our cover features members of the JCS community, including some researchers from our ‘First Person’ & ‘Cell Scientists to Watch’ interviews.

Explore our ToC: journals.biologists.com/jcs/issue/13...
JCS cover: Marking the end of The Company of Biologists' 100-year anniversary, the final journal cover of 2025 features members of our community, including our academic and guest Editors, our FocalPlane Advisory Board, some of the ‘First Person’ and ‘Cell Scientists to Watch’ scientists featured this year, and our in-house team of administrators and editors at our editorial office in Cambridge.
January 7, 2026 at 10:00 AM
Reposted by Pablo J. Sáez
jencwaters.bsky.social
🔬 🖥️ Applications are open for the CSHL course Quantitative Imaging: From Acquisition to Analysis (April 6–21, 2026)!

An intensive, hands-on course covering advanced fluorescence microscopy and quantitative image analysis using open-source tools.

🗓️ Apply online by Jan 30, 2026
Quantitative Imaging: From Acquisition to Analysis
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
meetings.cshl.edu
January 6, 2026 at 7:18 PM
pjsaez.bsky.social
#HappyNewYear !
Let's start 2026 with a @cellcommlab.bsky.social paper

How many branches is OK during #CellMigration?
It depends on the #cell: for ex. immune cells are just fine.

In collab. w. #NirGov @hfspo.bsky.social

Full www.science.org/doi/10.1126/...
@focalplane.bsky.social @science.org 🧪🔬
January 1, 2026 at 8:59 PM
Reposted by Pablo J. Sáez
focalplane.bsky.social
Our final #preprint list of 2025 is now up on FocalPlane!

In this post, we focus on recent (and recently updated) preprints in bioimage analysis. Let us know if you have any recommendations of preprints that we have missed.
focalplane.biologists.com/2025/12/29/m...
Microscopy preprints: bioimage analysis - FocalPlane
Microscopy preprints: bioimage analysis - News
focalplane.biologists.com
December 29, 2025 at 5:53 PM
Reposted by Pablo J. Sáez
artologica.net
Just making sure that 2025 is definitely over
14th century painting of St. Margaret of Antioch attacking a devil woman in a virid dress hitting a demon with a hammer
January 1, 2026 at 4:43 AM
Reposted by Pablo J. Sáez
vitoryang.bsky.social
RhoGAP15B RNAi collapses leader protrusions, while RhoGAP15B OE stabilises and extends them, underscoring tight control protrusion dynamics.
December 31, 2025 at 2:32 PM