Tuuli Lappalainen
@tuuliel.bsky.social
Professor at KTH, NY Genome Center, SciLifeLab, working on functional genomics and human genetics.
Reposted by Tuuli Lappalainen
type for books used to be set using little metal letters built into words in racks and then inked and pressed on to paper. If you had stock phrases you wanted to reuse a lot you could make a cast of them called a ‘stereotype’. The sound of them *clicking* into place, in French, is ‘cliché’
Man, everything is so bleak, anyone got a fun fact or little bit of trivia they want to share
November 21, 2025 at 10:17 AM
type for books used to be set using little metal letters built into words in racks and then inked and pressed on to paper. If you had stock phrases you wanted to reuse a lot you could make a cast of them called a ‘stereotype’. The sound of them *clicking* into place, in French, is ‘cliché’
Reposted by Tuuli Lappalainen
📢 Our Dept. of Systems Biology at Columbia University has an open tenure-track Assistant Professor position in the broad area of quantitative biology. Come join our awesome department in NYC! Please circulate.
apply.interfolio.com/177622
Suggested deadline: 12/15/2025.
@columbiasysbio.bsky.social
apply.interfolio.com/177622
Suggested deadline: 12/15/2025.
@columbiasysbio.bsky.social
November 15, 2025 at 4:02 AM
📢 Our Dept. of Systems Biology at Columbia University has an open tenure-track Assistant Professor position in the broad area of quantitative biology. Come join our awesome department in NYC! Please circulate.
apply.interfolio.com/177622
Suggested deadline: 12/15/2025.
@columbiasysbio.bsky.social
apply.interfolio.com/177622
Suggested deadline: 12/15/2025.
@columbiasysbio.bsky.social
Reposted by Tuuli Lappalainen
Well, it's a little clearer now why billionaires are so invested in technology that produces better written emails.
November 12, 2025 at 10:23 PM
Well, it's a little clearer now why billionaires are so invested in technology that produces better written emails.
Reposted by Tuuli Lappalainen
If guaranteeing essentials sounds radical, it speaks to how far we have drifted from democracy‘s core promises. Markets will not beat back the far right. An antifascist economics might. Mamdani provides a playbook for democrats around the world.
My latest
My latest
Zohran Mamdani shows how Democrats can defeat authoritarians like Trump | Isabella Weber
Democrats have two choices: fight to make life affordable again for ordinary people or watch voters embrace authoritarians
www.theguardian.com
November 7, 2025 at 1:02 PM
If guaranteeing essentials sounds radical, it speaks to how far we have drifted from democracy‘s core promises. Markets will not beat back the far right. An antifascist economics might. Mamdani provides a playbook for democrats around the world.
My latest
My latest
Reposted by Tuuli Lappalainen
Come and join us here in Cambridge! Applications open for a new faculty position, for a researcher in computational and/or theoretical biology, based jointly in Genetics and Mathematics. Happy to answer questions about research, teaching and working here.
www.cam.ac.uk/jobs/faculty...
www.cam.ac.uk/jobs/faculty...
Faculty Position in Computational Biology
Applications are invited for an Assistant/ Associate Professorship in Computational Biology to commence on 1 April 2026 or shortly thereafter. This is a joint post between the Department of Applied
www.cam.ac.uk
November 11, 2025 at 9:05 PM
Come and join us here in Cambridge! Applications open for a new faculty position, for a researcher in computational and/or theoretical biology, based jointly in Genetics and Mathematics. Happy to answer questions about research, teaching and working here.
www.cam.ac.uk/jobs/faculty...
www.cam.ac.uk/jobs/faculty...
Reposted by Tuuli Lappalainen
Chuck Schumer Helps Pull Democrats Back From Brink Of Courage
November 10, 2025 at 5:02 AM
Chuck Schumer Helps Pull Democrats Back From Brink Of Courage
Reposted by Tuuli Lappalainen
Reposted by Tuuli Lappalainen
This perfectly encapsulates how I feel living in the US. The republican party is an insane death cult, the democratic party is 3 corporations in a trench coat, and the "socialists" are just the completely normal left-wing capitalists you'd find in any of 2 dozen European nations.
Europeans recognize Zohran Mamdani’s supposedly radical policies as ‘normal’
Critics of New York City’s mayor-elect have said his pledges of free bus service and universal childcare are unrealistic, but in Europe it’s a given
www.theguardian.com
November 8, 2025 at 5:18 AM
This perfectly encapsulates how I feel living in the US. The republican party is an insane death cult, the democratic party is 3 corporations in a trench coat, and the "socialists" are just the completely normal left-wing capitalists you'd find in any of 2 dozen European nations.
Reposted by Tuuli Lappalainen
There are two complementary views of scientific advance: the "heroes" view, individual geniuses driving unique one-of-a-kind advances, and the "multiple discovery" or zeitgeist view, that the time is ripe for a discovery, and the details of who makes it first, where, and how are, well, details.(1/3)
November 8, 2025 at 9:23 AM
There are two complementary views of scientific advance: the "heroes" view, individual geniuses driving unique one-of-a-kind advances, and the "multiple discovery" or zeitgeist view, that the time is ripe for a discovery, and the details of who makes it first, where, and how are, well, details.(1/3)
Reposted by Tuuli Lappalainen
JOB POSTING: Director, National Human Genome Research Institute hr.nih.gov/careers/open...
hr.nih.gov
November 7, 2025 at 3:57 PM
JOB POSTING: Director, National Human Genome Research Institute hr.nih.gov/careers/open...
Reposted by Tuuli Lappalainen
How do GWAS and rare variant burden tests rank gene signals?
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
Specificity, length and luck drive gene rankings in association studies - Nature
Genetic association tests prioritize candidate genes based on different criteria.
www.nature.com
November 7, 2025 at 12:05 AM
How do GWAS and rare variant burden tests rank gene signals?
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
Reposted by Tuuli Lappalainen
New 🧬✂️ pre-print! We show that paired prime editing can efficiently generate large deletions — even >1 Mb — with high precision and at scale. We use this to perform the first pooled prime deletion screen across the human genome.
🔗 biorxiv.org/content/10.1...
A short thread (by Juliane Weller)👇
🔗 biorxiv.org/content/10.1...
A short thread (by Juliane Weller)👇
Generating long deletions across the genome with pooled paired prime editing screens
Engineered deletions are a powerful probe for studying genome architecture, function, and regulation. Yet, the lack of effective methods to create them in large numbers and at multi-kilobase scale has...
biorxiv.org
November 5, 2025 at 2:17 PM
New 🧬✂️ pre-print! We show that paired prime editing can efficiently generate large deletions — even >1 Mb — with high precision and at scale. We use this to perform the first pooled prime deletion screen across the human genome.
🔗 biorxiv.org/content/10.1...
A short thread (by Juliane Weller)👇
🔗 biorxiv.org/content/10.1...
A short thread (by Juliane Weller)👇
Nyt kun New Yorkin uusi pormestari kiinnostaa Suomessakin, ajattelin (10+ vuotta kaupungissa asuneena) korjata mediassa pyöriviä virheitä ja väärinkäsityksiä. Kun paikallista kontekstia ei tunneta, niin analyysit ja ihan faktatkin menevät välillä vinoon.
November 5, 2025 at 9:18 AM
Nyt kun New Yorkin uusi pormestari kiinnostaa Suomessakin, ajattelin (10+ vuotta kaupungissa asuneena) korjata mediassa pyöriviä virheitä ja väärinkäsityksiä. Kun paikallista kontekstia ei tunneta, niin analyysit ja ihan faktatkin menevät välillä vinoon.
Reposted by Tuuli Lappalainen
New study of 800K+ genomes from gnomAD reveals most “pathogenic” variants in healthy people aren’t truly disease-tolerant. They are explained by annotation errors, mosaicism, or compensatory variants. 🧬
A big step for precision medicine!
www.nature.com/articles/s41...
A big step for precision medicine!
www.nature.com/articles/s41...
Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database - Nature Communications
Here the authors provide an explanation for 95% of examined predicted loss of function variants found in disease-associated haploinsufficient genes in the Genome Aggregation Database (gnomAD),…
www.nature.com
November 4, 2025 at 3:06 PM
New study of 800K+ genomes from gnomAD reveals most “pathogenic” variants in healthy people aren’t truly disease-tolerant. They are explained by annotation errors, mosaicism, or compensatory variants. 🧬
A big step for precision medicine!
www.nature.com/articles/s41...
A big step for precision medicine!
www.nature.com/articles/s41...
Reposted by Tuuli Lappalainen
Academics in Assyria in the 7th c BC complain that admin is preventing them from doing research and teaching
November 3, 2025 at 10:04 AM
Academics in Assyria in the 7th c BC complain that admin is preventing them from doing research and teaching
Reposted by Tuuli Lappalainen
Applications for MCSA are up 64%! 50% now come from outside the EU. Trump effect?
The European Research market just got a hell of a lot more crowded.
EU should turn on the tap
marie-sklodowska-curie-actions.ec.europa.eu/news/msca-po...
The European Research market just got a hell of a lot more crowded.
EU should turn on the tap
marie-sklodowska-curie-actions.ec.europa.eu/news/msca-po...
MSCA Postdoctoral Fellowships 2025 receives record number of 17,058 proposals
This year’s annual MSCA Postdoctoral Fellowships call has attracted considerable interest from the research community with 17,058 proposals submitted.
marie-sklodowska-curie-actions.ec.europa.eu
October 22, 2025 at 2:11 PM
Applications for MCSA are up 64%! 50% now come from outside the EU. Trump effect?
The European Research market just got a hell of a lot more crowded.
EU should turn on the tap
marie-sklodowska-curie-actions.ec.europa.eu/news/msca-po...
The European Research market just got a hell of a lot more crowded.
EU should turn on the tap
marie-sklodowska-curie-actions.ec.europa.eu/news/msca-po...
Reposted by Tuuli Lappalainen
Struggling to imagine the chutzpah it takes to say that someone "doesn't understand New York culture" because they're an immigrant.
So here's Andrew Cuomo reacting to Maria Bartiromo wondering if Mamdani will "change the look of New York" and have Muslim women "completely covered up," telling her that Mamdani "doesn't understand New York culture" because he has "dual citizenship" and "he's a citizen of Uganda."
October 29, 2025 at 4:23 PM
Struggling to imagine the chutzpah it takes to say that someone "doesn't understand New York culture" because they're an immigrant.
Reposted by Tuuli Lappalainen
Amazing job opportunity at the @institutimagine.bsky.social, Head of the Genomics Platform.
I am adding an English translation of the opportunity, but fluency in French is a (reasonable) requirement for the position. Application link below.
www.welcometothejungle.com/fr/companies...
I am adding an English translation of the opportunity, but fluency in French is a (reasonable) requirement for the position. Application link below.
www.welcometothejungle.com/fr/companies...
October 23, 2025 at 7:14 PM
Amazing job opportunity at the @institutimagine.bsky.social, Head of the Genomics Platform.
I am adding an English translation of the opportunity, but fluency in French is a (reasonable) requirement for the position. Application link below.
www.welcometothejungle.com/fr/companies...
I am adding an English translation of the opportunity, but fluency in French is a (reasonable) requirement for the position. Application link below.
www.welcometothejungle.com/fr/companies...
Reposted by Tuuli Lappalainen
US PhD admissions shrink as fears over Trump’s cuts take hold. [In some cases, to zero.] Story by @alexwitze.bsky.social www.nature.com/articles/d41...
US PhD admissions shrink as fears over Trump’s cuts take hold
Some doctoral programmes are admitting no students at all amid uncertainty about federal science funding.
www.nature.com
October 22, 2025 at 4:49 PM
US PhD admissions shrink as fears over Trump’s cuts take hold. [In some cases, to zero.] Story by @alexwitze.bsky.social www.nature.com/articles/d41...
Reposted by Tuuli Lappalainen
absolute workhorse of a reaction image from over 100 years ago
October 20, 2025 at 7:36 AM
absolute workhorse of a reaction image from over 100 years ago
Reposted by Tuuli Lappalainen
Esim. tässä todetaan, että juuri näin #velkajarru
toimi Saksassa. Eikä vain siirtymän vaan kaikkiin sijoituksiin.
Pääomakanta on kohta rikkaiden maiden heikoimpia.
Velkajarru oli "probably the worst fiscal rule by any government anywhere" ja "fiscal doomsday machine."
swiftpress.com/book/kaput/
toimi Saksassa. Eikä vain siirtymän vaan kaikkiin sijoituksiin.
Pääomakanta on kohta rikkaiden maiden heikoimpia.
Velkajarru oli "probably the worst fiscal rule by any government anywhere" ja "fiscal doomsday machine."
swiftpress.com/book/kaput/
Kaput | Swift Press
‘Compelling’ Guardian ‘Eloquent and comprehensive’ Financial Times ‘Excellent’ The Telegraph ‘Astonishing’ The Times ‘An eye-opener’ Gavin Esler Until recently, Germany appeared to be a paragon of eco...
swiftpress.com
October 20, 2025 at 1:37 PM
Esim. tässä todetaan, että juuri näin #velkajarru
toimi Saksassa. Eikä vain siirtymän vaan kaikkiin sijoituksiin.
Pääomakanta on kohta rikkaiden maiden heikoimpia.
Velkajarru oli "probably the worst fiscal rule by any government anywhere" ja "fiscal doomsday machine."
swiftpress.com/book/kaput/
toimi Saksassa. Eikä vain siirtymän vaan kaikkiin sijoituksiin.
Pääomakanta on kohta rikkaiden maiden heikoimpia.
Velkajarru oli "probably the worst fiscal rule by any government anywhere" ja "fiscal doomsday machine."
swiftpress.com/book/kaput/
Pelottaa ja säälittää #velkajarru -Suomen tulevaisuus, mutta on pakko onnitella Kokoomusta mestarillisesta pelistä. Kokoomuslainen leikkauspolitiikka, hyvinvointivaltion kurjistaminen ja vihreän siirtymän investointien tukahduttaminen on nyt saatu politiikan peruslinjaksi vuosikymmenten ajaksi. 1/
October 14, 2025 at 3:46 PM
Pelottaa ja säälittää #velkajarru -Suomen tulevaisuus, mutta on pakko onnitella Kokoomusta mestarillisesta pelistä. Kokoomuslainen leikkauspolitiikka, hyvinvointivaltion kurjistaminen ja vihreän siirtymän investointien tukahduttaminen on nyt saatu politiikan peruslinjaksi vuosikymmenten ajaksi. 1/
Reminder of our postdoc position! Happy to meet at #ASHG25 this week to discuss.
We're hiring! My team at @nygenome.org is looking for a statistical genetics postdoc to decipher functional architecture of complex diseases from cutting-edge CRISPR+scRNA-seq data, with @nevillesanjana.bsky.social lab. Happy to meet at #ASHG25, apply here
jobs.silkroad.com/NYGenome/Car...
jobs.silkroad.com/NYGenome/Car...
Postdoctoral Research Associate, Lappalainen & Sanjana Labs - 101 Avenue of the Americas, 7th Floor, New York, New York - New York Genome Center
Find a career with New York Genome Center
jobs.silkroad.com
October 14, 2025 at 2:39 PM
Reminder of our postdoc position! Happy to meet at #ASHG25 this week to discuss.
Reposted by Tuuli Lappalainen
Just in time for #ASHG2025, a new FinnGen public data release is live!
This release features the first clinical laboratory value association results. Analyses cover 383 lab measurements (OMOPIDs) with data from ≥1,000 participants each.
Access the results here: www.finngen.fi/en/access_re...
This release features the first clinical laboratory value association results. Analyses cover 383 lab measurements (OMOPIDs) with data from ≥1,000 participants each.
Access the results here: www.finngen.fi/en/access_re...
October 14, 2025 at 2:17 PM
Just in time for #ASHG2025, a new FinnGen public data release is live!
This release features the first clinical laboratory value association results. Analyses cover 383 lab measurements (OMOPIDs) with data from ≥1,000 participants each.
Access the results here: www.finngen.fi/en/access_re...
This release features the first clinical laboratory value association results. Analyses cover 383 lab measurements (OMOPIDs) with data from ≥1,000 participants each.
Access the results here: www.finngen.fi/en/access_re...
Reposted by Tuuli Lappalainen
Mutta miksi noin järjettömän paljon EU-sääntöjä tiukempi tavoite? Miksi se pitää teidän hyväksyä?
Ja jos tästä aiotaan lukita laki, jonka kaataminen vaatii enemmän kuin yksinkertaisen enemmistön, niin eikö se pitäisi säätää perustuslain säätämisjärjestyksessä?
Vallankaappaushan tämä on.
Ja jos tästä aiotaan lukita laki, jonka kaataminen vaatii enemmän kuin yksinkertaisen enemmistön, niin eikö se pitäisi säätää perustuslain säätämisjärjestyksessä?
Vallankaappaushan tämä on.
October 14, 2025 at 6:54 AM
Mutta miksi noin järjettömän paljon EU-sääntöjä tiukempi tavoite? Miksi se pitää teidän hyväksyä?
Ja jos tästä aiotaan lukita laki, jonka kaataminen vaatii enemmän kuin yksinkertaisen enemmistön, niin eikö se pitäisi säätää perustuslain säätämisjärjestyksessä?
Vallankaappaushan tämä on.
Ja jos tästä aiotaan lukita laki, jonka kaataminen vaatii enemmän kuin yksinkertaisen enemmistön, niin eikö se pitäisi säätää perustuslain säätämisjärjestyksessä?
Vallankaappaushan tämä on.