@stadtfeldlab.bsky.social
Stem cell biologist intrigued by the developmental functions of epigenome regulators and how they can go awry. Father of two beautiful kids. Former Tour de France contender (in his dreams). Opinions expressed here are my own.
https://www.stadtfeldlab.com
https://www.stadtfeldlab.com
Reposted
new Lai lab paper @natsmb.nature.com! Dicer is specifically mutated in cancer, but we don't fully understand its molecular/reg impacts. with @danweihuangfu.bsky.social, we characterized the first knockin Dicer hotspot in hESCs, and found unexpected defects in miRNA biogenesis! 🧬 1/4
rdcu.be/eOc0q
rdcu.be/eOc0q
Human DICER1 hotspot mutation induces both loss and gain of miRNA function
Nature Structural & Molecular Biology - Jee et al. study a cancer hotspot allele of DICER1 that disrupts RNaseIIIb activity. Beyond ablating 5p hairpin cleavage, 3p passenger strands are...
rdcu.be
November 10, 2025 at 4:43 PM
new Lai lab paper @natsmb.nature.com! Dicer is specifically mutated in cancer, but we don't fully understand its molecular/reg impacts. with @danweihuangfu.bsky.social, we characterized the first knockin Dicer hotspot in hESCs, and found unexpected defects in miRNA biogenesis! 🧬 1/4
rdcu.be/eOc0q
rdcu.be/eOc0q
Reposted
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
November 10, 2025 at 11:11 AM
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
Reposted
Don't miss the chance to attend the annual virtual meeting on the advances in Nuclear Topology and 3D chromatin Architecture in Cancer organized by @janeskok @iannisaifantis1 @artsinyc and Melnick. The registration is FREE (see barcode) and the speaker lineup SPECTACULAR.
November 5, 2025 at 3:06 PM
Don't miss the chance to attend the annual virtual meeting on the advances in Nuclear Topology and 3D chromatin Architecture in Cancer organized by @janeskok @iannisaifantis1 @artsinyc and Melnick. The registration is FREE (see barcode) and the speaker lineup SPECTACULAR.
Very insightful study by @distefanolab.bsky.social and @brumbaugh-lab.bsky.social labs, revealing RNA sequestration as a mechanism to restrict and direct cellular plasticity.
1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology
Stem cell differentiation is controlled by manipulating RNA condensates.
www.nature.com
October 28, 2025 at 4:37 PM
Very insightful study by @distefanolab.bsky.social and @brumbaugh-lab.bsky.social labs, revealing RNA sequestration as a mechanism to restrict and direct cellular plasticity.
Reposted
For over 20 years, the mouse model organism has helped scientists uncover the biology behind human health and disease.
But the mouse reference genomes still have missing pieces.
The first collection of telomere-to-telomere mouse genomes are now available for two key mouse strains.
🧬💻
But the mouse reference genomes still have missing pieces.
The first collection of telomere-to-telomere mouse genomes are now available for two key mouse strains.
🧬💻
October 27, 2025 at 11:51 AM
For over 20 years, the mouse model organism has helped scientists uncover the biology behind human health and disease.
But the mouse reference genomes still have missing pieces.
The first collection of telomere-to-telomere mouse genomes are now available for two key mouse strains.
🧬💻
But the mouse reference genomes still have missing pieces.
The first collection of telomere-to-telomere mouse genomes are now available for two key mouse strains.
🧬💻
Really impressive study on spinal cord development by @giulia-boezio.bsky.social and @jamesbriscoe.bsky.social. #neurodevelopment
Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding https://www.biorxiv.org/content/10.1101/2025.10.24.684328v1
October 24, 2025 at 5:23 PM
Really impressive study on spinal cord development by @giulia-boezio.bsky.social and @jamesbriscoe.bsky.social. #neurodevelopment
Reposted
Happy to see some of the work I’ve done during my PhD officially published! Check it out!
Happy to share the final version of this work out in ACS CS. Inspired by ‘binding-focused’ chemoproteomic methods, we developed a ‘function-focused’ strategy to agnostically identify degradable proteins.
This was a big team effort led by
@inesforrest.bsky.social
and in collaboration with AbbVie.
This was a big team effort led by
@inesforrest.bsky.social
and in collaboration with AbbVie.
Proteome-Wide Discovery of Degradable Proteins Using Bifunctional Molecules
Targeted protein degradation (TPD) is an emergent therapeutic strategy with the potential to circumvent challenges associated with targets unamenable to conventional pharmacological inhibition. Among ...
pubs.acs.org
October 22, 2025 at 10:10 PM
Happy to see some of the work I’ve done during my PhD officially published! Check it out!
Reposted
Reposted
Honored to be named the Laura and Isaac Perlmutter Endowed Chair in Biochemistry at NYU Grossman School of Medicine. Grateful to my mentors, lab members, and the NYU community—and most of all, to my amazing family for their constant support!
October 17, 2025 at 4:03 PM
Honored to be named the Laura and Isaac Perlmutter Endowed Chair in Biochemistry at NYU Grossman School of Medicine. Grateful to my mentors, lab members, and the NYU community—and most of all, to my amazing family for their constant support!
Reposted
“It actually doesn’t take much to be considered a difficult woman. That’s why there are so many of us.”
― Jane Goodall
💙 RIP to a real one. My childhood hero
― Jane Goodall
💙 RIP to a real one. My childhood hero
October 2, 2025 at 2:56 AM
“It actually doesn’t take much to be considered a difficult woman. That’s why there are so many of us.”
― Jane Goodall
💙 RIP to a real one. My childhood hero
― Jane Goodall
💙 RIP to a real one. My childhood hero
Reposted
We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22.
biochem.weill.cornell.edu/join-our-fac...
biochem.weill.cornell.edu/join-our-fac...
Join our Faculty | Department of Biochemistry & Biophysics
Call for applications:We invite applications for a tenure-track Assistant Professor position in the newly established Department of Biochemistry and Biophysics. We are conducting an open search for ou...
biochem.weill.cornell.edu
September 29, 2025 at 7:58 PM
We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22.
biochem.weill.cornell.edu/join-our-fac...
biochem.weill.cornell.edu/join-our-fac...
Reposted
👇👇👇
🚨For chromatin, epigenetics and non-coding RNA lovers: only two more weeks left to apply!
Check out our lab page and if interested don't hesitate to apply 3d-chrom.iit.it
Research Technician
app.ncoreplat.com/jobposition/...
Senior Researcher-Technologist
app.ncoreplat.com/jobposition/...
Check out our lab page and if interested don't hesitate to apply 3d-chrom.iit.it
Research Technician
app.ncoreplat.com/jobposition/...
Senior Researcher-Technologist
app.ncoreplat.com/jobposition/...
September 29, 2025 at 5:28 PM
👇👇👇
Reposted
Some proteins are primarily regulated by one mechanism: RNA abundance, translation, or clearance.
The regulation of most proteins is dominated by different regulatory mechanisms across cell types.
Gratifyingly, this complex regulation defines simple rules ⬇️
www.biorxiv.org/content/10.1...
The regulation of most proteins is dominated by different regulatory mechanisms across cell types.
Gratifyingly, this complex regulation defines simple rules ⬇️
www.biorxiv.org/content/10.1...
September 22, 2025 at 10:54 AM
Some proteins are primarily regulated by one mechanism: RNA abundance, translation, or clearance.
The regulation of most proteins is dominated by different regulatory mechanisms across cell types.
Gratifyingly, this complex regulation defines simple rules ⬇️
www.biorxiv.org/content/10.1...
The regulation of most proteins is dominated by different regulatory mechanisms across cell types.
Gratifyingly, this complex regulation defines simple rules ⬇️
www.biorxiv.org/content/10.1...
Reposted
alert to all H1B holders, please share: Trump just banned H-1B employees from reentering US unless employer pays $100,000 "fee". Proclamation applies to both new H-1B entrants and current H-1B employees who are abroad. set to take effect tmrw sun sept 21. please return if you can. i am so sorry. 😢
September 20, 2025 at 1:13 PM
alert to all H1B holders, please share: Trump just banned H-1B employees from reentering US unless employer pays $100,000 "fee". Proclamation applies to both new H-1B entrants and current H-1B employees who are abroad. set to take effect tmrw sun sept 21. please return if you can. i am so sorry. 😢
Reposted
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene
Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...
www.science.org
September 18, 2025 at 6:59 PM
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted
Congrats Maria! very well deserved... @mskcancercenter.bsky.social @mskeducation.bsky.social
Maria Jasin, whose fundamental research on repair of damaged DNA in cells has transformed our understanding of cancers linked to inherited gene mutations, has been selected as the 2025 recipient of the Pearl Meister Greengard Prize. Congratulations! #WomenInScience
Developmental biologist Maria Jasin wins the 2025 Pearl Meister Greengard Prize - News
Maria Jasin, whose fundamental research on repair of damaged DNA in cells has transformed our understanding of cancers linked to inherited gene mutations, has been selected as the 2025 recipient of the Pearl Meister Greengard Prize. Awarded annually by ...
www.rockefeller.edu
September 17, 2025 at 2:29 PM
Congrats Maria! very well deserved... @mskcancercenter.bsky.social @mskeducation.bsky.social
Very interesting pre-print by @moritz-negwer.mstdn.science.ap.brid.gy and @naelnadifkasri-lab.bsky.social using a new clearing technology to capture the abundance of specific neuron populations in a mouse model of ASD. #autism #neurodevelopment #Kleefstra
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Whole-brain clearing reveals region- and cell type-specific imbalances in inhibitory neurons in a mouse model for Kleefstra Syndrome
GABAergic inhibition is essential for balanced brain function and is frequently disrupted in neurodevelopmental disorders such as autism spectrum disorder (ASD). The inhibition is generated by a diver...
www.biorxiv.org
September 17, 2025 at 12:47 PM
Very interesting pre-print by @moritz-negwer.mstdn.science.ap.brid.gy and @naelnadifkasri-lab.bsky.social using a new clearing technology to capture the abundance of specific neuron populations in a mouse model of ASD. #autism #neurodevelopment #Kleefstra
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Beautiful study, beautiful creatures.
Hydra body axis balance: a fight between two transcription factors
This Research Highlight showcases the work from Jaroslav Ferenc, Marylène Bonvin, Panagiotis Papasaikas, Jacqueline Ferralli, Clara Nuninger and Charisios D. Tsiairis:
journals.biologists.com/dev/article/...
This Research Highlight showcases the work from Jaroslav Ferenc, Marylène Bonvin, Panagiotis Papasaikas, Jacqueline Ferralli, Clara Nuninger and Charisios D. Tsiairis:
journals.biologists.com/dev/article/...
September 16, 2025 at 10:35 AM
Beautiful study, beautiful creatures.
Reposted
1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...
Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation
Inge et al. show that human endoderm originates from two converging developmental
routes with distinct dynamics and efficiencies yet similar developmental potential.
Combinatorial activin and BMP4 sig...
www.cell.com
September 9, 2025 at 8:01 PM
1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...
Reposted
We’re pleased to exclusively announce the longlist for the 2025 National Book Awards for Young People’s Literature. See it here.
The 2025 National Book Awards Longlist
Through Friday, The New Yorker presents the longlists for Young People’s Literature, Translated Literature, Poetry, Fiction, and Nonfiction.
www.newyorker.com
September 9, 2025 at 12:24 PM
We’re pleased to exclusively announce the longlist for the 2025 National Book Awards for Young People’s Literature. See it here.
Just read this paper by @tesarlab.bsky.social lab and collaborators on the role of SOX6 in oligodendrocytes and found it highly insightful and stimulating. www.cell.com/cell/fulltex... #development #transcription #enhancers
Transient gene melting governs the timing of oligodendrocyte maturation
Oligodendrocyte maturation is governed by an SOX6-dependent gene-melted chromatin
state at multiple immaturity loci. Reducing SOX6 accelerates maturation, offering
a potential strategy to regenerate m...
www.cell.com
September 9, 2025 at 10:39 AM
Just read this paper by @tesarlab.bsky.social lab and collaborators on the role of SOX6 in oligodendrocytes and found it highly insightful and stimulating. www.cell.com/cell/fulltex... #development #transcription #enhancers
Reposted
🚨🚨🚨 Please repost
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...
September 8, 2025 at 3:15 PM
🚨🚨🚨 Please repost
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...
Reposted
🧵 An open letter to the US Open and USTA:
Trump will attend the #USOpen as a guest of ROLEX. Yesterday, Trump declared 'WAR' on Chicago. The USTA has called for media censorship of dissent against Trump today.
I played NCAA tennis many years ago and still play. Today I resign my #USTA membership.
Trump will attend the #USOpen as a guest of ROLEX. Yesterday, Trump declared 'WAR' on Chicago. The USTA has called for media censorship of dissent against Trump today.
I played NCAA tennis many years ago and still play. Today I resign my #USTA membership.
September 7, 2025 at 4:53 PM
Reposted
Super proud of Njoud and her PhD thesis work.
Here she demonstrates that mitochondrial dysfunction is one of the earliest defects in DRPLA-patient derived neurons. Furthermore, neurodegeneration and ROS accumulation can be rescued with phenylbutyrate treatment.
www.biorxiv.org/content/10.1...
Here she demonstrates that mitochondrial dysfunction is one of the earliest defects in DRPLA-patient derived neurons. Furthermore, neurodegeneration and ROS accumulation can be rescued with phenylbutyrate treatment.
www.biorxiv.org/content/10.1...
Mitochondrial dysfunction precedes neurodegeneration in DRPLA patient-derived neurons, and phenylbutyrate improves survival.
Dentatorubral-pallidoluysian atrophy (DRPLA) is a progressive autosomal-dominant neurodegenerative disorder caused by a CAG repeat expansion in the ATN1 gene, which encodes the transcriptional corepre...
www.biorxiv.org
September 7, 2025 at 5:06 PM
Super proud of Njoud and her PhD thesis work.
Here she demonstrates that mitochondrial dysfunction is one of the earliest defects in DRPLA-patient derived neurons. Furthermore, neurodegeneration and ROS accumulation can be rescued with phenylbutyrate treatment.
www.biorxiv.org/content/10.1...
Here she demonstrates that mitochondrial dysfunction is one of the earliest defects in DRPLA-patient derived neurons. Furthermore, neurodegeneration and ROS accumulation can be rescued with phenylbutyrate treatment.
www.biorxiv.org/content/10.1...