Ollie Inge
@oliveringe.bsky.social
Postdoctoral Fellow - Morris Lab @ Brigham and Women’s / Harvard Medical School. Prev. PhD @santoslab at The Francis Crick Institute. Single-cell dynamics, signalling and fate specification during development.
Pinned
Ollie Inge
@oliveringe.bsky.social
· Sep 9
Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation
Inge et al. show that human endoderm originates from two converging developmental
routes with distinct dynamics and efficiencies yet similar developmental potential.
Combinatorial activin and BMP4 sig...
www.cell.com
1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...
Reposted by Ollie Inge
Thrilled to share my main postdoc work with @jamesbriscoe.bsky.social
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding
The formation of neural circuits depends on the precise spatial and temporal organisation of neuronal populations during development. In the vertebrate spinal cord, progenitors are patterned into mole...
www.biorxiv.org
October 26, 2025 at 5:15 PM
Thrilled to share my main postdoc work with @jamesbriscoe.bsky.social
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
Reposted by Ollie Inge
We had a blast tonight at the ‘Curious about the Crick’ event showcasing the science in our lab. Lots of enthusiasm and so many interesting questions. Was awesome to share this with my wonderful lab from brainstorming to communicating the science we love. Thank you to @crick.ac.uk for having us
October 21, 2025 at 9:44 PM
We had a blast tonight at the ‘Curious about the Crick’ event showcasing the science in our lab. Lots of enthusiasm and so many interesting questions. Was awesome to share this with my wonderful lab from brainstorming to communicating the science we love. Thank you to @crick.ac.uk for having us
Reposted by Ollie Inge
The Crick PhD program is open and there are amazing projects including our lab's. I couldn't recommend enough joining the program: brilliant community and excellent training and mentorship.
Specific project with us will be decided based on your interests.
Apply here www.crick.ac.uk/careers-stud...
Specific project with us will be decided based on your interests.
Apply here www.crick.ac.uk/careers-stud...
October 17, 2025 at 5:36 PM
The Crick PhD program is open and there are amazing projects including our lab's. I couldn't recommend enough joining the program: brilliant community and excellent training and mentorship.
Specific project with us will be decided based on your interests.
Apply here www.crick.ac.uk/careers-stud...
Specific project with us will be decided based on your interests.
Apply here www.crick.ac.uk/careers-stud...
Reposted by Ollie Inge
Very saddened to hear of John Gurdon’s passing. I’ve been lucky enough to interact with him at multiple points through my career - from undergrad lectures, through his position as former Chair of @biologists.bsky.social’s Board of Directors, and as an author at @dev-journal.bsky.social.
Nobel Laureate Professor Sir John Gurdon dies aged 92
It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.
www.cam.ac.uk
October 7, 2025 at 5:40 PM
Very saddened to hear of John Gurdon’s passing. I’ve been lucky enough to interact with him at multiple points through my career - from undergrad lectures, through his position as former Chair of @biologists.bsky.social’s Board of Directors, and as an author at @dev-journal.bsky.social.
Reposted by Ollie Inge
Just over one week until this opportunity closes!
If you’re an ambitious computational scientist looking for a Postdoc position, apply now
If you’re an ambitious computational scientist looking for a Postdoc position, apply now
@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer.
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
www.imperial.ac.uk
October 7, 2025 at 7:56 AM
Just over one week until this opportunity closes!
If you’re an ambitious computational scientist looking for a Postdoc position, apply now
If you’re an ambitious computational scientist looking for a Postdoc position, apply now
Reposted by Ollie Inge
🚀 Excited to share scPortrait! Led by Sophia Mädler & Niklas Schmacke w/ the Mann lab — a new @scverse tool for standardized single-cell image data. Enables ML-ready extraction, >1B cell processing, cross-omics, & cancer macrophage insights.
🔗 www.biorxiv.org/content/10.1...
🔗 www.biorxiv.org/content/10.1...
September 28, 2025 at 5:50 PM
🚀 Excited to share scPortrait! Led by Sophia Mädler & Niklas Schmacke w/ the Mann lab — a new @scverse tool for standardized single-cell image data. Enables ML-ready extraction, >1B cell processing, cross-omics, & cancer macrophage insights.
🔗 www.biorxiv.org/content/10.1...
🔗 www.biorxiv.org/content/10.1...
Reposted by Ollie Inge
Farewell dinner for @oliveringe.bsky.social with our wonderful Santos lab family. Ollie was our 1st Crick PhD student! Lots to celebrate and many fun memories. We are so grateful to have had Ollie in the lab and cannot wait to see what’s next for him in the Morris lab at Harvard! Best of luck,Ollie!
September 26, 2025 at 11:59 AM
Farewell dinner for @oliveringe.bsky.social with our wonderful Santos lab family. Ollie was our 1st Crick PhD student! Lots to celebrate and many fun memories. We are so grateful to have had Ollie in the lab and cannot wait to see what’s next for him in the Morris lab at Harvard! Best of luck,Ollie!
Reposted by Ollie Inge
@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer.
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
www.imperial.ac.uk
September 18, 2025 at 8:02 PM
@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer.
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Reposted by Ollie Inge
Genes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...
HDAC3 prevents enhancer hyperactivation to enable developmental transitions
Dynamic gene regulation requires precise cooperation between transcription factors and chromatin modifiers at regulatory elements to achieve not only activation or repression, but also appropriate tra...
www.biorxiv.org
September 18, 2025 at 9:55 AM
Genes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...
Reposted by Ollie Inge
It was fun to look back over a decade of 'From Stem Cells to Human Development' meetings at @dev-journal.bsky.social. This is one of the projects I most enjoyed during my time at the journal - and I really hope we helped to catalyse and support a community... journals.biologists.com/dev/article/...
From stem cells to human development: supporting a growing field
In 2014, Development organised the first of The Company of Biologists’ Journal Meetings: ‘From Stem Cells to Human Development’. Conceived to help bring together the developmental biology and stem cel...
journals.biologists.com
September 17, 2025 at 9:31 AM
It was fun to look back over a decade of 'From Stem Cells to Human Development' meetings at @dev-journal.bsky.social. This is one of the projects I most enjoyed during my time at the journal - and I really hope we helped to catalyse and support a community... journals.biologists.com/dev/article/...
Reposted by Ollie Inge
Fresh from the press💥 We asked what happens when you evolve gene regulatory networks computationally at scale. Do general principles of GRN evolution jump out? Is the process predictable? Read on to find out @prxlife.bsky.social @crick.ac.uk @ucl-ipls.bsky.social 👉 journals.aps.org/prxlife/abst...
Gene Network Organization, Mutation, and Selection Collectively Drive Developmental Pattern Evolvability and Predictability
The historical order in which mutations appear during evolution determine the evolutionary trajectory of gene regulatory networks and influence how developmental patterns change and diversify over tim...
journals.aps.org
September 16, 2025 at 7:46 PM
Fresh from the press💥 We asked what happens when you evolve gene regulatory networks computationally at scale. Do general principles of GRN evolution jump out? Is the process predictable? Read on to find out @prxlife.bsky.social @crick.ac.uk @ucl-ipls.bsky.social 👉 journals.aps.org/prxlife/abst...
Reposted by Ollie Inge
This is Mirjam, Santos Lab’ PhD student presenting her work at the EMBL meeting on Developmental Metabolism 🫶. Conference was incredible and Mirjam had an amazing time!
September 15, 2025 at 4:09 PM
This is Mirjam, Santos Lab’ PhD student presenting her work at the EMBL meeting on Developmental Metabolism 🫶. Conference was incredible and Mirjam had an amazing time!
1/3 After 6+ years at @crick.ac.uk I split my last cells and hung up my lab coat! Thank you to the brilliant community from fellow PhDs/Postdocs, LOAs, STPs, academic training team and to all past/present @santoslab.bsky.social members. My Crick journey would not have been the same without you all!
September 13, 2025 at 11:35 AM
1/3 After 6+ years at @crick.ac.uk I split my last cells and hung up my lab coat! Thank you to the brilliant community from fellow PhDs/Postdocs, LOAs, STPs, academic training team and to all past/present @santoslab.bsky.social members. My Crick journey would not have been the same without you all!
Reposted by Ollie Inge
Drs. @dbenzinger.bsky.social and @jamesbriscoe.bsky.social at the @crick.ac.uk established an #optogenetic system for the precise spatiotemporal control in vitro of Sonic hedgehog morphogen production. 🦔
📄 - https://bit.ly/3Vxf0rf
🎙️ - https://bit.ly/3JWWpT9
📄 - https://bit.ly/3Vxf0rf
🎙️ - https://bit.ly/3JWWpT9
September 10, 2025 at 9:56 PM
Drs. @dbenzinger.bsky.social and @jamesbriscoe.bsky.social at the @crick.ac.uk established an #optogenetic system for the precise spatiotemporal control in vitro of Sonic hedgehog morphogen production. 🦔
📄 - https://bit.ly/3Vxf0rf
🎙️ - https://bit.ly/3JWWpT9
📄 - https://bit.ly/3Vxf0rf
🎙️ - https://bit.ly/3JWWpT9
Reposted by Ollie Inge
Researchers have found that early embryonic cells start to specialise via converging developmental paths, rather than following linear trajectories as was previously believed.
www.crick.ac.uk/news/2025-09...
www.crick.ac.uk/news/2025-09...
Converging development: how cell paths unite in the embryo
By tracking the fate of individual embryonic stem cells, researchers have found that endoderm cells – early embryonic cells that give rise to tissues such as the gut and lungs – originate from multipl...
www.crick.ac.uk
September 10, 2025 at 9:29 AM
Researchers have found that early embryonic cells start to specialise via converging developmental paths, rather than following linear trajectories as was previously believed.
www.crick.ac.uk/news/2025-09...
www.crick.ac.uk/news/2025-09...
1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...
Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation
Inge et al. show that human endoderm originates from two converging developmental
routes with distinct dynamics and efficiencies yet similar developmental potential.
Combinatorial activin and BMP4 sig...
www.cell.com
September 9, 2025 at 8:01 PM
1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...
Reposted by Ollie Inge
Latest on Waddington Landscapes: Computational methods to fit dynamical landscapes directly to single cell data
Applied to neural tube patterning shows morphogen-signalling landscapes can be linearly interpolated
Connects interpretable landscape models with data
www.biorxiv.org/content/10.1...
Applied to neural tube patterning shows morphogen-signalling landscapes can be linearly interpolated
Connects interpretable landscape models with data
www.biorxiv.org/content/10.1...
Reconstructing Waddington's Landscape from Data
The development of a zygote into a functional organism requires that this single progenitor cell gives rise to numerous distinct cell types. Attempts to exhaustively tabulate the interactions within d...
www.biorxiv.org
August 14, 2025 at 7:53 AM
Latest on Waddington Landscapes: Computational methods to fit dynamical landscapes directly to single cell data
Applied to neural tube patterning shows morphogen-signalling landscapes can be linearly interpolated
Connects interpretable landscape models with data
www.biorxiv.org/content/10.1...
Applied to neural tube patterning shows morphogen-signalling landscapes can be linearly interpolated
Connects interpretable landscape models with data
www.biorxiv.org/content/10.1...
Reposted by Ollie Inge
Thrilled to bits to see our latest work online in Dev Cell! 🥳
We wanted to know how cells build functional organs with precision🫀🫁📏 Here we show how coupling of cell shape and organ function fine tunes the form and contractile power of the developing #zebrafish heart 1/n
tinyurl.com/cell-stretch
We wanted to know how cells build functional organs with precision🫀🫁📏 Here we show how coupling of cell shape and organ function fine tunes the form and contractile power of the developing #zebrafish heart 1/n
tinyurl.com/cell-stretch
Mechanochemical coupling of cell shape and organ function optimizes heart size and contractile efficiency in zebrafish
Andrews et al. demonstrate that multiscale feedback between mechanical and chemical
cues builds a functional heart to support zebrafish embryonic life. Cell recruitment
and organ-scale forces drive tr...
tinyurl.com
August 6, 2025 at 2:53 PM
Thrilled to bits to see our latest work online in Dev Cell! 🥳
We wanted to know how cells build functional organs with precision🫀🫁📏 Here we show how coupling of cell shape and organ function fine tunes the form and contractile power of the developing #zebrafish heart 1/n
tinyurl.com/cell-stretch
We wanted to know how cells build functional organs with precision🫀🫁📏 Here we show how coupling of cell shape and organ function fine tunes the form and contractile power of the developing #zebrafish heart 1/n
tinyurl.com/cell-stretch
Reposted by Ollie Inge
So happy to finally see this work published! We reveal that an in vitro system mimics specification of extra-embryonic mesoderm into the visceral yolk-sac and allantois, and use this model alongside in vivo experiments to study the role of Eomes and T in these tissues. Big thanks to all co-authors 🥳
Collaborative science is just so much fun! From our brilliant collaboration with Liz Robertson from @dunnschool.bsky.social; embryology, single cell omics and computational biology deliver new insights into the intricacies of blood and endothelial development. www.sciencedirect.com/science/arti...
June 24, 2025 at 5:45 PM
So happy to finally see this work published! We reveal that an in vitro system mimics specification of extra-embryonic mesoderm into the visceral yolk-sac and allantois, and use this model alongside in vivo experiments to study the role of Eomes and T in these tissues. Big thanks to all co-authors 🥳
Reposted by Ollie Inge
New work with Saunders & Charras labs
Physical boundaries guide cell fate decisions during human trunk development
Reaction Diffusion model shows how geometry shapes biology with TBXT expression forming consistent domains regardless of colony size & shape
www.biorxiv.org/content/10.1...
Physical boundaries guide cell fate decisions during human trunk development
Reaction Diffusion model shows how geometry shapes biology with TBXT expression forming consistent domains regardless of colony size & shape
www.biorxiv.org/content/10.1...
Boundary constraints can determine pattern emergence
The robust patterning of cell fates during embryonic development requires precise coordination of signalling gradients within defined spatial constraints. Using a geometrically confined in vitro syste...
www.biorxiv.org
July 23, 2025 at 5:37 AM
New work with Saunders & Charras labs
Physical boundaries guide cell fate decisions during human trunk development
Reaction Diffusion model shows how geometry shapes biology with TBXT expression forming consistent domains regardless of colony size & shape
www.biorxiv.org/content/10.1...
Physical boundaries guide cell fate decisions during human trunk development
Reaction Diffusion model shows how geometry shapes biology with TBXT expression forming consistent domains regardless of colony size & shape
www.biorxiv.org/content/10.1...
Reposted by Ollie Inge
New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes?
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Global inhibition of deadenylation stabilizes the transcriptome in mitotic cells
In the presence of cell division errors, mammalian cells can pause in mitosis for tens of hours with little to no transcription, while still requiring continued translation for viability. These unique...
www.biorxiv.org
July 23, 2025 at 10:57 AM
New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes?
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Ollie Inge
Amazing work by Afnan @stochastalive.bsky.social and our lab satellite colleagues @crick.ac.uk, comparing human vs mouse forebrain signalling centres & progenitor diversity in nascent embryonic telencephalon. Outcome of exploration soon on bioRxiv.
@kingsioppn.bsky.social @devneuro.bsky.social
@kingsioppn.bsky.social @devneuro.bsky.social
A look at the developing human embryonic forebrain in 3D!
Post-doc @stochastalive.bsky.social shares this week's image showing a dorsal view of the human embryonic forebrain at Carnegie Stage 16 (~6 weeks post conception). Major regions marked by FOXG1, WNT8B, PAX6, and SHH are displayed.
Post-doc @stochastalive.bsky.social shares this week's image showing a dorsal view of the human embryonic forebrain at Carnegie Stage 16 (~6 weeks post conception). Major regions marked by FOXG1, WNT8B, PAX6, and SHH are displayed.
June 11, 2025 at 7:28 PM
Amazing work by Afnan @stochastalive.bsky.social and our lab satellite colleagues @crick.ac.uk, comparing human vs mouse forebrain signalling centres & progenitor diversity in nascent embryonic telencephalon. Outcome of exploration soon on bioRxiv.
@kingsioppn.bsky.social @devneuro.bsky.social
@kingsioppn.bsky.social @devneuro.bsky.social
Was so lovely to be part of this work with @borzogharibi.bsky.social @santoslab.bsky.social ! Read below to learn more about this cool new model of extra-embryonic development.
Now online! Post-gastrulation amnioids as a stem cell-derived model of human extra-embryonic development
Post-gastrulation amnioids as a stem cell-derived model of human extra-embryonic development
An embryonic stem cell-based 3D model that accurately recapitulates the size, morphology, and functional features of the human amnion at 4 weeks, termed the post-gastrulation amnioid (PGA), is developed. The model’s reproducibility and scalability make it ideal for studying amniogenesis and for clinical applications that use human amniotic sac membranes.
dlvr.it
May 15, 2025 at 4:27 PM
Was so lovely to be part of this work with @borzogharibi.bsky.social @santoslab.bsky.social ! Read below to learn more about this cool new model of extra-embryonic development.
Reposted by Ollie Inge
Now online! Post-gastrulation amnioids as a stem cell-derived model of human extra-embryonic development
Post-gastrulation amnioids as a stem cell-derived model of human extra-embryonic development
An embryonic stem cell-based 3D model that accurately recapitulates the size, morphology, and functional features of the human amnion at 4 weeks, termed the post-gastrulation amnioid (PGA), is developed. The model’s reproducibility and scalability make it ideal for studying amniogenesis and for clinical applications that use human amniotic sac membranes.
dlvr.it
May 15, 2025 at 2:59 PM
Now online! Post-gastrulation amnioids as a stem cell-derived model of human extra-embryonic development