@stadtfeldlab.bsky.social
Stem cell biologist intrigued by the developmental functions of epigenome regulators and how they can go awry. Father of two beautiful kids. Former Tour de France contender (in his dreams). Opinions expressed here are my own.
https://www.stadtfeldlab.com
https://www.stadtfeldlab.com
Reposted
Particularly excited to announce "In Formation"
👉Vernissage 17h00 Munich *5th of July* @Muffatwerk
1st exhibition of Art&Science work from 4 artists, including annadumitriu.co.uk + @replifate.bsky.social Helen Pynor,Solveig Lill & Pei-Ying Lin
replifate.eu/event/in-for...
😇STAY TUNED 4more info
👉Vernissage 17h00 Munich *5th of July* @Muffatwerk
1st exhibition of Art&Science work from 4 artists, including annadumitriu.co.uk + @replifate.bsky.social Helen Pynor,Solveig Lill & Pei-Ying Lin
replifate.eu/event/in-for...
😇STAY TUNED 4more info
Events for February 2026
We are thrilled to announce In Formation, the first exhibition featuring work from four artist-in-residence projects that bring art into the heart of scientific stem cell and epigenetics research. ...
replifate.eu
February 11, 2026 at 10:10 AM
Particularly excited to announce "In Formation"
👉Vernissage 17h00 Munich *5th of July* @Muffatwerk
1st exhibition of Art&Science work from 4 artists, including annadumitriu.co.uk + @replifate.bsky.social Helen Pynor,Solveig Lill & Pei-Ying Lin
replifate.eu/event/in-for...
😇STAY TUNED 4more info
👉Vernissage 17h00 Munich *5th of July* @Muffatwerk
1st exhibition of Art&Science work from 4 artists, including annadumitriu.co.uk + @replifate.bsky.social Helen Pynor,Solveig Lill & Pei-Ying Lin
replifate.eu/event/in-for...
😇STAY TUNED 4more info
Reposted
Final version of our paper now published.
elifesciences.org/articles/109...
Take homes:
CHD4/NuRD directly limits transcription factor residence times. At active enhancers this keeps them working efficiently. At inactive enhancers it prevents TFs from getting a foothold and causing activation. 1/n
elifesciences.org/articles/109...
Take homes:
CHD4/NuRD directly limits transcription factor residence times. At active enhancers this keeps them working efficiently. At inactive enhancers it prevents TFs from getting a foothold and causing activation. 1/n
The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements
CHD4 directly limits transcription factor binding to chromatin, which prevents activation of silent or cryptic enhancers but facilitates activity of active enhancers.
elifesciences.org
February 4, 2026 at 8:17 AM
Final version of our paper now published.
elifesciences.org/articles/109...
Take homes:
CHD4/NuRD directly limits transcription factor residence times. At active enhancers this keeps them working efficiently. At inactive enhancers it prevents TFs from getting a foothold and causing activation. 1/n
elifesciences.org/articles/109...
Take homes:
CHD4/NuRD directly limits transcription factor residence times. At active enhancers this keeps them working efficiently. At inactive enhancers it prevents TFs from getting a foothold and causing activation. 1/n
An insightful account of the review process at one of the most pre-eminent and influential journals in developmental and stem cell biology, by @jamesbriscoe.bsky.social and fellow @dev-journal.bsky.social editors. #Development #how-to-review #how-to-publish
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
The hard truth about how hard it is to publish in Development
Every researcher knows the anticipation and trepidation that come with submitting a paper to a journal. Years of effort have been distilled into a few thousand words and a handful of figures containin...
journals.biologists.com
January 3, 2026 at 1:42 PM
An insightful account of the review process at one of the most pre-eminent and influential journals in developmental and stem cell biology, by @jamesbriscoe.bsky.social and fellow @dev-journal.bsky.social editors. #Development #how-to-review #how-to-publish
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
Very interesting pre-print from Chris Baker's lab at JAX on the mechanistic link between trans-acting genetic variants and heterochromatin formation in mice. #heterochromatin #epigenetics #variants www.biorxiv.org/content/10.6...
Trans-regulation of heterochromatin underlies genetic variation in 3D genome contacts
Genetic variation drives phenotypic diversity and disease susceptibility. Trans -acting genetic variation coordinates genome-wide chromatin changes, yet the molecular mechanisms underlying this regula...
www.biorxiv.org
December 24, 2025 at 10:12 PM
Very interesting pre-print from Chris Baker's lab at JAX on the mechanistic link between trans-acting genetic variants and heterochromatin formation in mice. #heterochromatin #epigenetics #variants www.biorxiv.org/content/10.6...
Very excited to announce that our collaborative study with @efapostolou29.bsky.social on the transcriptional mechanisms distinguishing totipotent and pluripotent cells has been published (link.springer.com/article/10.1...). #totipotency #ZGA #stemcells #epigenetics #chromatin
December 12, 2025 at 2:45 PM
Very excited to announce that our collaborative study with @efapostolou29.bsky.social on the transcriptional mechanisms distinguishing totipotent and pluripotent cells has been published (link.springer.com/article/10.1...). #totipotency #ZGA #stemcells #epigenetics #chromatin
Interesting and elegant study by Simon Braun's group in Geneva into redundant and unique functions of specific SWI/SNF components during mouse neurodevelopment. www.biorxiv.org/content/10.6... #degrons #neurodevelopment #chromatin
www.biorxiv.org
December 8, 2025 at 11:51 AM
Interesting and elegant study by Simon Braun's group in Geneva into redundant and unique functions of specific SWI/SNF components during mouse neurodevelopment. www.biorxiv.org/content/10.6... #degrons #neurodevelopment #chromatin
Reposted
Very happy to see this published! 🎉🎉🎉 Amazing collaboration with Max Yun and her team @maxyunlab.bsky.social @crtd-tud.bsky.social on Axolotl Thymus regeneration. Thanks also to @claireolingy.bsky.social for coverage, and grateful for December cover #scienceimmunology www.science.org/doi/10.1126/...
Molecular basis for de novo thymus regeneration in a vertebrate, the axolotl
The molecular, cellular, and functional restoration of the axolotl thymus after de novo regeneration is described.
www.science.org
December 5, 2025 at 7:47 PM
Very happy to see this published! 🎉🎉🎉 Amazing collaboration with Max Yun and her team @maxyunlab.bsky.social @crtd-tud.bsky.social on Axolotl Thymus regeneration. Thanks also to @claireolingy.bsky.social for coverage, and grateful for December cover #scienceimmunology www.science.org/doi/10.1126/...
Reposted
Applications are open for @dev-journal.bsky.social 2026 Pathway to Independence (PI) programme, supporting postdocs applying for group leader positions:
Mentoring
Profile raising
Leadership training
Network building
Spread the word...
www.biologists.com/grants/devel...
Mentoring
Profile raising
Leadership training
Network building
Spread the word...
www.biologists.com/grants/devel...
Development's Pathway to Independence Programme
Our grants support and encourage the sharing of knowledge throughout the community by facilitating international collaboration, event attendance and the organisation of scientific meetings, conference...
www.biologists.com
December 3, 2025 at 6:56 AM
Applications are open for @dev-journal.bsky.social 2026 Pathway to Independence (PI) programme, supporting postdocs applying for group leader positions:
Mentoring
Profile raising
Leadership training
Network building
Spread the word...
www.biologists.com/grants/devel...
Mentoring
Profile raising
Leadership training
Network building
Spread the word...
www.biologists.com/grants/devel...
Reposted
new Lai lab paper @natsmb.nature.com! Dicer is specifically mutated in cancer, but we don't fully understand its molecular/reg impacts. with @danweihuangfu.bsky.social, we characterized the first knockin Dicer hotspot in hESCs, and found unexpected defects in miRNA biogenesis! 🧬 1/4
rdcu.be/eOc0q
rdcu.be/eOc0q
Human DICER1 hotspot mutation induces both loss and gain of miRNA function
Nature Structural & Molecular Biology - Jee et al. study a cancer hotspot allele of DICER1 that disrupts RNaseIIIb activity. Beyond ablating 5p hairpin cleavage, 3p passenger strands are...
rdcu.be
November 10, 2025 at 4:43 PM
new Lai lab paper @natsmb.nature.com! Dicer is specifically mutated in cancer, but we don't fully understand its molecular/reg impacts. with @danweihuangfu.bsky.social, we characterized the first knockin Dicer hotspot in hESCs, and found unexpected defects in miRNA biogenesis! 🧬 1/4
rdcu.be/eOc0q
rdcu.be/eOc0q
Reposted
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
November 10, 2025 at 11:11 AM
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
Reposted
Don't miss the chance to attend the annual virtual meeting on the advances in Nuclear Topology and 3D chromatin Architecture in Cancer organized by @janeskok @iannisaifantis1 @artsinyc and Melnick. The registration is FREE (see barcode) and the speaker lineup SPECTACULAR.
November 5, 2025 at 3:06 PM
Don't miss the chance to attend the annual virtual meeting on the advances in Nuclear Topology and 3D chromatin Architecture in Cancer organized by @janeskok @iannisaifantis1 @artsinyc and Melnick. The registration is FREE (see barcode) and the speaker lineup SPECTACULAR.
Very insightful study by @distefanolab.bsky.social and @brumbaugh-lab.bsky.social labs, revealing RNA sequestration as a mechanism to restrict and direct cellular plasticity.
1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology
Stem cell differentiation is controlled by manipulating RNA condensates.
www.nature.com
October 28, 2025 at 4:37 PM
Very insightful study by @distefanolab.bsky.social and @brumbaugh-lab.bsky.social labs, revealing RNA sequestration as a mechanism to restrict and direct cellular plasticity.
Reposted
For over 20 years, the mouse model organism has helped scientists uncover the biology behind human health and disease.
But the mouse reference genomes still have missing pieces.
The first collection of telomere-to-telomere mouse genomes are now available for two key mouse strains.
🧬💻
But the mouse reference genomes still have missing pieces.
The first collection of telomere-to-telomere mouse genomes are now available for two key mouse strains.
🧬💻
October 27, 2025 at 11:51 AM
For over 20 years, the mouse model organism has helped scientists uncover the biology behind human health and disease.
But the mouse reference genomes still have missing pieces.
The first collection of telomere-to-telomere mouse genomes are now available for two key mouse strains.
🧬💻
But the mouse reference genomes still have missing pieces.
The first collection of telomere-to-telomere mouse genomes are now available for two key mouse strains.
🧬💻
Really impressive study on spinal cord development by @giulia-boezio.bsky.social and @jamesbriscoe.bsky.social. #neurodevelopment
Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding https://www.biorxiv.org/content/10.1101/2025.10.24.684328v1
October 24, 2025 at 5:23 PM
Really impressive study on spinal cord development by @giulia-boezio.bsky.social and @jamesbriscoe.bsky.social. #neurodevelopment
Reposted
Happy to see some of the work I’ve done during my PhD officially published! Check it out!
Happy to share the final version of this work out in ACS CS. Inspired by ‘binding-focused’ chemoproteomic methods, we developed a ‘function-focused’ strategy to agnostically identify degradable proteins.
This was a big team effort led by
@inesforrest.bsky.social
and in collaboration with AbbVie.
This was a big team effort led by
@inesforrest.bsky.social
and in collaboration with AbbVie.
Proteome-Wide Discovery of Degradable Proteins Using Bifunctional Molecules
Targeted protein degradation (TPD) is an emergent therapeutic strategy with the potential to circumvent challenges associated with targets unamenable to conventional pharmacological inhibition. Among ...
pubs.acs.org
October 22, 2025 at 10:10 PM
Happy to see some of the work I’ve done during my PhD officially published! Check it out!
Reposted
Reposted
Honored to be named the Laura and Isaac Perlmutter Endowed Chair in Biochemistry at NYU Grossman School of Medicine. Grateful to my mentors, lab members, and the NYU community—and most of all, to my amazing family for their constant support!
October 17, 2025 at 4:03 PM
Honored to be named the Laura and Isaac Perlmutter Endowed Chair in Biochemistry at NYU Grossman School of Medicine. Grateful to my mentors, lab members, and the NYU community—and most of all, to my amazing family for their constant support!
Reposted
“It actually doesn’t take much to be considered a difficult woman. That’s why there are so many of us.”
― Jane Goodall
💙 RIP to a real one. My childhood hero
― Jane Goodall
💙 RIP to a real one. My childhood hero
October 2, 2025 at 2:56 AM
“It actually doesn’t take much to be considered a difficult woman. That’s why there are so many of us.”
― Jane Goodall
💙 RIP to a real one. My childhood hero
― Jane Goodall
💙 RIP to a real one. My childhood hero
Reposted
We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22.
biochem.weill.cornell.edu/join-our-fac...
biochem.weill.cornell.edu/join-our-fac...
Join our Faculty | Department of Biochemistry & Biophysics
Call for applications:We invite applications for a tenure-track Assistant Professor position in the newly established Department of Biochemistry and Biophysics. We are conducting an open search for ou...
biochem.weill.cornell.edu
September 29, 2025 at 7:58 PM
We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22.
biochem.weill.cornell.edu/join-our-fac...
biochem.weill.cornell.edu/join-our-fac...
Reposted
👇👇👇
🚨For chromatin, epigenetics and non-coding RNA lovers: only two more weeks left to apply!
Check out our lab page and if interested don't hesitate to apply 3d-chrom.iit.it
Research Technician
app.ncoreplat.com/jobposition/...
Senior Researcher-Technologist
app.ncoreplat.com/jobposition/...
Check out our lab page and if interested don't hesitate to apply 3d-chrom.iit.it
Research Technician
app.ncoreplat.com/jobposition/...
Senior Researcher-Technologist
app.ncoreplat.com/jobposition/...
September 29, 2025 at 5:28 PM
👇👇👇
Reposted
Some proteins are primarily regulated by one mechanism: RNA abundance, translation, or clearance.
The regulation of most proteins is dominated by different regulatory mechanisms across cell types.
Gratifyingly, this complex regulation defines simple rules ⬇️
www.biorxiv.org/content/10.1...
The regulation of most proteins is dominated by different regulatory mechanisms across cell types.
Gratifyingly, this complex regulation defines simple rules ⬇️
www.biorxiv.org/content/10.1...
September 22, 2025 at 10:54 AM
Some proteins are primarily regulated by one mechanism: RNA abundance, translation, or clearance.
The regulation of most proteins is dominated by different regulatory mechanisms across cell types.
Gratifyingly, this complex regulation defines simple rules ⬇️
www.biorxiv.org/content/10.1...
The regulation of most proteins is dominated by different regulatory mechanisms across cell types.
Gratifyingly, this complex regulation defines simple rules ⬇️
www.biorxiv.org/content/10.1...
Reposted
alert to all H1B holders, please share: Trump just banned H-1B employees from reentering US unless employer pays $100,000 "fee". Proclamation applies to both new H-1B entrants and current H-1B employees who are abroad. set to take effect tmrw sun sept 21. please return if you can. i am so sorry. 😢
September 20, 2025 at 1:13 PM
alert to all H1B holders, please share: Trump just banned H-1B employees from reentering US unless employer pays $100,000 "fee". Proclamation applies to both new H-1B entrants and current H-1B employees who are abroad. set to take effect tmrw sun sept 21. please return if you can. i am so sorry. 😢
Reposted
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene
Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...
www.science.org
September 18, 2025 at 6:59 PM
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted
Congrats Maria! very well deserved... @mskcancercenter.bsky.social @mskeducation.bsky.social
Maria Jasin, whose fundamental research on repair of damaged DNA in cells has transformed our understanding of cancers linked to inherited gene mutations, has been selected as the 2025 recipient of the Pearl Meister Greengard Prize. Congratulations! #WomenInScience
Developmental biologist Maria Jasin wins the 2025 Pearl Meister Greengard Prize - News
Maria Jasin, whose fundamental research on repair of damaged DNA in cells has transformed our understanding of cancers linked to inherited gene mutations, has been selected as the 2025 recipient of the Pearl Meister Greengard Prize. Awarded annually by ...
www.rockefeller.edu
September 17, 2025 at 2:29 PM
Congrats Maria! very well deserved... @mskcancercenter.bsky.social @mskeducation.bsky.social