Our study with @stadtfeldlab.bsky.social on the dual mechanism by which EHMT2 is repressing totipotency-associated vs lineage-specific loci is now out @emboreports.org. See thread by @cmuyehara.bsky.social who led the study with K Chatterjee. Full article here link.springer.com/article/10.1...
December 14, 2025 at 8:15 PM
Our study with @stadtfeldlab.bsky.social on the dual mechanism by which EHMT2 is repressing totipotency-associated vs lineage-specific loci is now out @emboreports.org. See thread by @cmuyehara.bsky.social who led the study with K Chatterjee. Full article here link.springer.com/article/10.1...
Very excited to announce that our collaborative study with @efapostolou29.bsky.social on the transcriptional mechanisms distinguishing totipotent and pluripotent cells has been published (link.springer.com/article/10.1...). #totipotency #ZGA #stemcells #epigenetics #chromatin
December 12, 2025 at 2:45 PM
Very excited to announce that our collaborative study with @efapostolou29.bsky.social on the transcriptional mechanisms distinguishing totipotent and pluripotent cells has been published (link.springer.com/article/10.1...). #totipotency #ZGA #stemcells #epigenetics #chromatin
In this OA commentary, co-EIC Kang Chong explores a new study that reports a #developmental route to #plant totipotency, offering promising strategies to improve regeneration efficiency in difficult-to-transform #crops.
doi.org/10.1111/jipb...
@wileylifesci.bsky.social #PlantScience #OpenAccess
doi.org/10.1111/jipb...
@wileylifesci.bsky.social #PlantScience #OpenAccess
Rewiring the stomatal lineage: A novel developmental pathway to plant totipotency
This commentary highlights a study revealing that stomatal lineage precursor cells can be reprogrammed into somatic embryos through a LEC2–SPCH–YUC auxin regulatory circuit. This study uncovers a dev....
doi.org
December 12, 2025 at 5:35 PM
In this OA commentary, co-EIC Kang Chong explores a new study that reports a #developmental route to #plant totipotency, offering promising strategies to improve regeneration efficiency in difficult-to-transform #crops.
doi.org/10.1111/jipb...
@wileylifesci.bsky.social #PlantScience #OpenAccess
doi.org/10.1111/jipb...
@wileylifesci.bsky.social #PlantScience #OpenAccess
Epigenetics Update - N6-methyladenosine on L1PA governs the trans-silencing of LTRs and restrains totipotency in naive human embryonic stem cells bit.ly/4quXN05
#Epigenetics #StemCells #ESCs #Totipotency
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Discover the breakthrough at epigenometech.com
#Epigenetics #StemCells #ESCs #Totipotency
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Discover the breakthrough at epigenometech.com
November 3, 2025 at 12:33 PM
Epigenetics Update - N6-methyladenosine on L1PA governs the trans-silencing of LTRs and restrains totipotency in naive human embryonic stem cells bit.ly/4quXN05
#Epigenetics #StemCells #ESCs #Totipotency
---
Discover the breakthrough at epigenometech.com
#Epigenetics #StemCells #ESCs #Totipotency
---
Discover the breakthrough at epigenometech.com
6/ Applying these insights to stem cell differentiation, we show that manipulating P-body assembly or specific microRNA activity can direct pluripotent stem cells toward totipotency or the germ-cell lineage.
October 28, 2025 at 4:02 PM
6/ Applying these insights to stem cell differentiation, we show that manipulating P-body assembly or specific microRNA activity can direct pluripotent stem cells toward totipotency or the germ-cell lineage.
My commentary published in Current Biology! “Plant regeneration: Breaking the silence of totipotency by reprogramming a stomatal precursor cell” Full text available →
authors.elsevier.com/a/1lzT-3QW8S...
authors.elsevier.com/a/1lzT-3QW8S...
October 26, 2025 at 5:40 PM
My commentary published in Current Biology! “Plant regeneration: Breaking the silence of totipotency by reprogramming a stomatal precursor cell” Full text available →
authors.elsevier.com/a/1lzT-3QW8S...
authors.elsevier.com/a/1lzT-3QW8S...
It was a branch on a tree. I stripped the Bark from this spot and rubbed rooting hormone on it. Then wrapped it with wet Sphagnum moss and plastic and foil.
8 weeks later and this root ball filled the plastic wrap. Cut it off and plant.
Totipotency is a helluva thing!
8 weeks later and this root ball filled the plastic wrap. Cut it off and plant.
Totipotency is a helluva thing!
June 29, 2025 at 3:16 PM
It was a branch on a tree. I stripped the Bark from this spot and rubbed rooting hormone on it. Then wrapped it with wet Sphagnum moss and plastic and foil.
8 weeks later and this root ball filled the plastic wrap. Cut it off and plant.
Totipotency is a helluva thing!
8 weeks later and this root ball filled the plastic wrap. Cut it off and plant.
Totipotency is a helluva thing!
Germ cells' totipotency relies on assembling germ granules: RNA-protein complexes key during oocyte to gamete stages. PMID:38890558, Nat Rev Genet 2024, @NatureRevGenet https://doi.org/10.1038/s41576-024-00744-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
How germ granules promote germ cell fate | Nature Reviews Genetics
Germ cells are the only cells in the body capable of giving rise to a new organism, and this totipotency hinges on their ability to assemble membraneless germ granules. These specialized RNA and protein complexes are hallmarks of germ cells throughout their life cycle: as embryonic germ granules in late oocytes and zygotes, Balbiani bodies in immature oocytes, and nuage in maturing gametes. Decades of developmental, genetic and biochemical studies have identified protein and RNA constituents unique to germ granules and have implicated these in germ cell identity, genome integrity and gamete differentiation. Now, emerging research is defining germ granules as biomolecular condensates that achieve high molecular concentrations by phase separation, and it is assigning distinct roles to germ granules during different stages of germline development. This organization of the germ cell cytoplasm into cellular subcompartments seems to be critical not only for the flawless continuity throu
doi.org
April 13, 2025 at 11:10 AM
Germ cells' totipotency relies on assembling germ granules: RNA-protein complexes key during oocyte to gamete stages. PMID:38890558, Nat Rev Genet 2024, @NatureRevGenet https://doi.org/10.1038/s41576-024-00744-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Totipotency and high plasticity in an embryo with a stereotyped, invariant cleavage program https://www.biorxiv.org/content/10.1101/2025.02.12.637942v1
February 13, 2025 at 6:31 PM
Totipotency and high plasticity in an embryo with a stereotyped, invariant cleavage program https://www.biorxiv.org/content/10.1101/2025.02.12.637942v1
This review elucidates the expression dynamics of key #TransposableElements, particularly LINE-1, throughout preimplantation development and their contribution to the regulation of developmental progression and #totipotency. #medsky
#OpenAccess: www.sciencedirect.co...
#OpenAccess: www.sciencedirect.co...
February 12, 2025 at 1:30 PM
This review elucidates the expression dynamics of key #TransposableElements, particularly LINE-1, throughout preimplantation development and their contribution to the regulation of developmental progression and #totipotency. #medsky
#OpenAccess: www.sciencedirect.co...
#OpenAccess: www.sciencedirect.co...
Most downloaded article!
This review elucidates the expression dynamics of key #TransposableElements, particularly LINE-1, throughout preimplantation development and their contribution to the regulation of developmental progression and #totipotency. #medsky
www.sciencedirect.co...
This review elucidates the expression dynamics of key #TransposableElements, particularly LINE-1, throughout preimplantation development and their contribution to the regulation of developmental progression and #totipotency. #medsky
www.sciencedirect.co...
June 8, 2025 at 5:30 PM
Most downloaded article!
This review elucidates the expression dynamics of key #TransposableElements, particularly LINE-1, throughout preimplantation development and their contribution to the regulation of developmental progression and #totipotency. #medsky
www.sciencedirect.co...
This review elucidates the expression dynamics of key #TransposableElements, particularly LINE-1, throughout preimplantation development and their contribution to the regulation of developmental progression and #totipotency. #medsky
www.sciencedirect.co...
Now online!
This review explores the origin and evolution of #retrotransposons, focusing on how long interspersed element-1 & #EndogenousRetroviruses regulate pre-implantation development and contribute to cellular #totipotency. #medsky
#OpenAccess:
This review explores the origin and evolution of #retrotransposons, focusing on how long interspersed element-1 & #EndogenousRetroviruses regulate pre-implantation development and contribute to cellular #totipotency. #medsky
#OpenAccess:
www.sciencedirect.com
July 25, 2025 at 5:18 AM
Now online!
This review explores the origin and evolution of #retrotransposons, focusing on how long interspersed element-1 & #EndogenousRetroviruses regulate pre-implantation development and contribute to cellular #totipotency. #medsky
#OpenAccess:
This review explores the origin and evolution of #retrotransposons, focusing on how long interspersed element-1 & #EndogenousRetroviruses regulate pre-implantation development and contribute to cellular #totipotency. #medsky
#OpenAccess:
Totipotency is the ability of a cell to give rise to all cell types, both embryonic & extraembryonic. But how do we test this in human cells? Check out Box 2: Experimental Criteria to Evaluate Human Totipotency in our recent review: pubmed.ncbi.nlm.nih.gov/39366361/
November 25, 2024 at 11:57 PM
Totipotency is the ability of a cell to give rise to all cell types, both embryonic & extraembryonic. But how do we test this in human cells? Check out Box 2: Experimental Criteria to Evaluate Human Totipotency in our recent review: pubmed.ncbi.nlm.nih.gov/39366361/
3/5 This metastable cell population provides a valuable tool for future investigations into both the transcriptional and post-transcriptional barriers to totipotency, as well as the molecular mechanisms underlying this state.
December 13, 2024 at 8:20 PM
3/5 This metastable cell population provides a valuable tool for future investigations into both the transcriptional and post-transcriptional barriers to totipotency, as well as the molecular mechanisms underlying this state.
CRISPRa-mediated disentanglement of the Dux-MERVL axis in the 2C-like state, totipotency and cell death
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
CRISPRa-mediated disentanglement of the Dux-MERVL axis in the 2C-like state, totipotency and cell death
Transposable elements (TEs) provide sequences that are powerful cis-regulatory drivers of gene expression programmes. This is particularly apparent during early development when many TEs become de-rep...
www.biorxiv.org
December 5, 2024 at 7:55 PM
CRISPRa-mediated disentanglement of the Dux-MERVL axis in the 2C-like state, totipotency and cell death
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Regeneration of Little IceAge bryophytes emerging from a polar glacier w/ implications of totipotency in extreme env
http://m.pnas.org/content/early/2013/05/22/1304199110.abstract
http://m.pnas.org/content/early/2013/05/22/1304199110.abstract
January 21, 2025 at 7:24 PM
Regeneration of Little IceAge bryophytes emerging from a polar glacier w/ implications of totipotency in extreme env
http://m.pnas.org/content/early/2013/05/22/1304199110.abstract
http://m.pnas.org/content/early/2013/05/22/1304199110.abstract
New online: Addendum: Retinoic acid signaling is critical during the totipotency window in early mammalian development
Addendum: Retinoic acid signaling is critical during the totipotency window in early mammalian development
Nature Structural & Molecular Biology, Published online: 02 September 2025; doi:10.1038/s41594-025-01661-yAddendum: Retinoic acid signaling is critical during the totipotency window in early mammalian development
go.nature.com
September 2, 2025 at 11:58 AM
New online: Addendum: Retinoic acid signaling is critical during the totipotency window in early mammalian development
LEUTX and OTX2 orchestrate totipotency-to-pluripotency transitions and heterogeneity in pEPSCs
LEUTX and OTX2 orchestrate totipotency-to-pluripotency transitions and heterogeneity in pEPSCs
Porcine expanded pluripotent stem cells (pEPSCs) display unique transcriptional heterogeneity, spanning totipotent-like to primed pluripotency-like states, mirroring early- to post-implantation transitions. By identifying OTX2 and LEUTX as key regulators of developmental potential, this study links the molecular control of pEPSCs to insights into mammalian embryogenesis, advancing agricultural and biomedical applications.
dlvr.it
October 15, 2025 at 12:36 PM
LEUTX and OTX2 orchestrate totipotency-to-pluripotency transitions and heterogeneity in pEPSCs
Completely agree. Pluripotency is basically = totipotency but without ability to form extra-embryonic tissues. They are definitely looking at multipotency here.
March 21, 2025 at 11:28 AM
Completely agree. Pluripotency is basically = totipotency but without ability to form extra-embryonic tissues. They are definitely looking at multipotency here.
Just stumbled on autobiographical sketch by Ingo Potrykus
From the Concept of Totipotency to Biofortified Cereals
<a href="http://www.annualreviews.org/doi/abs/10.1146/annurev-arplant-043014-114734" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">http://www.annualreviews.org/doi/abs/10.1146/annurev-arplant-043014-114734
From the Concept of Totipotency to Biofortified Cereals
<a href="http://www.annualreviews.org/doi/abs/10.1146/annurev-arplant-043014-114734" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">http://www.annualreviews.org/doi/abs/10.1146/annurev-arplant-043014-114734
June 17, 2015 at 5:59 PM
Just stumbled on autobiographical sketch by Ingo Potrykus
From the Concept of Totipotency to Biofortified Cereals
<a href="http://www.annualreviews.org/doi/abs/10.1146/annurev-arplant-043014-114734" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">http://www.annualreviews.org/doi/abs/10.1146/annurev-arplant-043014-114734
From the Concept of Totipotency to Biofortified Cereals
<a href="http://www.annualreviews.org/doi/abs/10.1146/annurev-arplant-043014-114734" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">http://www.annualreviews.org/doi/abs/10.1146/annurev-arplant-043014-114734
I have a magical girl RPG ive been working on for years where the top level stats are "Vim, Pulchritude, Imagination, and Totipotency"
August 26, 2024 at 3:34 PM
I have a magical girl RPG ive been working on for years where the top level stats are "Vim, Pulchritude, Imagination, and Totipotency"
Plant Science Research Weekly -- How do plants attain totipotency? Reprogramming somatic cells into embryos (Cell) (Summary by Katarina Kurtović, katarinakurtovic.bsky.social) buff.ly/jsBXzYu
#PlantaePSRW
#PlantaePSRW
katarinakurtovic.bsky.social
October 31, 2025 at 2:15 PM
Plant Science Research Weekly -- How do plants attain totipotency? Reprogramming somatic cells into embryos (Cell) (Summary by Katarina Kurtović, katarinakurtovic.bsky.social) buff.ly/jsBXzYu
#PlantaePSRW
#PlantaePSRW
We previously found that NR5A2 targets cell-type specific (putative) enhancers between 2-cell embryos (totipotency) and ESCs (pluripotency). We hypothesized that NR5A2 may cooperate with other TFs to control distinct transcriptional networks during totipotency-to-pluripotency transition. (3/n)
February 20, 2025 at 7:43 AM
We previously found that NR5A2 targets cell-type specific (putative) enhancers between 2-cell embryos (totipotency) and ESCs (pluripotency). We hypothesized that NR5A2 may cooperate with other TFs to control distinct transcriptional networks during totipotency-to-pluripotency transition. (3/n)
Exciting🌱! Reprogramming stomatal precursor cells to totipotency -- Cooperation of LEC2 with SPEECHLESS induces auxin biosynthesis genes, inciting a bifurcation of stomatal differentiation trajectory into a new, somatic embryo founder cell state.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration
In Arabidopsis, transcriptional factors LEC2 and SPCH enhance local auxin biosynthesis,
establishing a transcriptional framework that enables differentiated single somatic
epidermal cells to regain to...
www.cell.com
September 23, 2025 at 3:40 AM
Exciting🌱! Reprogramming stomatal precursor cells to totipotency -- Cooperation of LEC2 with SPEECHLESS induces auxin biosynthesis genes, inciting a bifurcation of stomatal differentiation trajectory into a new, somatic embryo founder cell state.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Weekly #stemcell & regenerative reads: FDA approves peptide therapy for Barth Syndrome, other rare disease news, induced totipotency, more ipscell.com/2025/11/week... #stemcells
Weekly reads: FDA approves peptide therapy for Barth, other rare disease news, induced totipotency - The Niche
Professor discusses the week's regenerative news including FDA approves peptide therapy for Barth, mammoth RNA, & induced totipotency.
ipscell.com
November 23, 2025 at 3:05 PM
Weekly #stemcell & regenerative reads: FDA approves peptide therapy for Barth Syndrome, other rare disease news, induced totipotency, more ipscell.com/2025/11/week... #stemcells