Olga Anczukow
@olgaanczukow.bsky.social
RNA splicing, Cancer, Aging, and Rare Diseases | Associate Professor The Jackson Laboratory https://www.anczukowlab.com
Join us at this exciting Workshop on #LongReads with keynotes from @aphillippy.bsky.social @mydennis.bsky.social
co-organized by @christinebeck.bsky.social and Mark Adams @jacksonlab.bsky.social Register www.jax.org/longread
#RNA #genomics #bioinformatics #cancer #medicine #evolution #neuroscience
co-organized by @christinebeck.bsky.social and Mark Adams @jacksonlab.bsky.social Register www.jax.org/longread
#RNA #genomics #bioinformatics #cancer #medicine #evolution #neuroscience
Long-Read Sequencing Workshop
The program will involve sessions on Genome Evolution, Genome Regulation, Transcriptomics, Rare Diseases, Common Diseases, and Viral and Microbial Genomes. Committed speakers include Adam Phillipy (NH...
www.jax.org
November 14, 2025 at 7:57 PM
Join us at this exciting Workshop on #LongReads with keynotes from @aphillippy.bsky.social @mydennis.bsky.social
co-organized by @christinebeck.bsky.social and Mark Adams @jacksonlab.bsky.social Register www.jax.org/longread
#RNA #genomics #bioinformatics #cancer #medicine #evolution #neuroscience
co-organized by @christinebeck.bsky.social and Mark Adams @jacksonlab.bsky.social Register www.jax.org/longread
#RNA #genomics #bioinformatics #cancer #medicine #evolution #neuroscience
Reposted by Olga Anczukow
How does @pacbio.bsky.social long-read RNA-Seq help explain response difference through RNA splicing regulation in immunotherapy? Check out the Dec webinar with @olgaanczukow.bsky.social and Ryan Englander and I! www.the-scientist.com/long-read-rn...
Long-Read RNA Sequencing Reveals a Regulatory Role for Splicing in Immunotherapy Responses
Olga Anczukow and Ryan Englander discuss how transcriptome splicing affects immune system function in lung cancer.
www.the-scientist.com
November 6, 2025 at 9:35 PM
How does @pacbio.bsky.social long-read RNA-Seq help explain response difference through RNA splicing regulation in immunotherapy? Check out the Dec webinar with @olgaanczukow.bsky.social and Ryan Englander and I! www.the-scientist.com/long-read-rn...
Reposted by Olga Anczukow
Really happy to share a link to our work showing that anti-progestin therapy could help prevent breast cancer before menopause.
Published today in Nature, the study suggests this could be a new way to stop breast cancer before it starts: urldefense.com/v3/__https:/...
Brilliant team science
Published today in Nature, the study suggests this could be a new way to stop breast cancer before it starts: urldefense.com/v3/__https:/...
Brilliant team science
Anti-progestin therapy targets hallmarks of breast cancer risk
Nature - Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing...
urldefense.com
November 5, 2025 at 9:07 PM
Really happy to share a link to our work showing that anti-progestin therapy could help prevent breast cancer before menopause.
Published today in Nature, the study suggests this could be a new way to stop breast cancer before it starts: urldefense.com/v3/__https:/...
Brilliant team science
Published today in Nature, the study suggests this could be a new way to stop breast cancer before it starts: urldefense.com/v3/__https:/...
Brilliant team science
Reposted by Olga Anczukow
Cell populations in human breast cancers are molecularly and biologically distinct with age
"how age affects cells in the breast tumor microenvironment or how they contribute to age-related pathology."
www.nature.com/articles/s43...
"how age affects cells in the breast tumor microenvironment or how they contribute to age-related pathology."
www.nature.com/articles/s43...
Cell populations in human breast cancers are molecularly and biologically distinct with age - Nature Aging
Parsons and colleagues characterize age-associated changes in the tumor microenvironment of triple-negative and estrogen receptor-positive breast cancer using computational analysis of transcriptomic ...
www.nature.com
November 5, 2025 at 10:40 AM
Cell populations in human breast cancers are molecularly and biologically distinct with age
"how age affects cells in the breast tumor microenvironment or how they contribute to age-related pathology."
www.nature.com/articles/s43...
"how age affects cells in the breast tumor microenvironment or how they contribute to age-related pathology."
www.nature.com/articles/s43...
Reposted by Olga Anczukow
KATMAP infers splicing factor activity and regulatory targets from knockdown data - @daspliceisright.bsky.social go.nature.com/47ycrMJ
KATMAP infers splicing factor activity and regulatory targets from knockdown data - Nature Biotechnology
A biophysical model uses knockdown or overexpression data to infer splicing factor activity.
go.nature.com
November 4, 2025 at 3:13 PM
KATMAP infers splicing factor activity and regulatory targets from knockdown data - @daspliceisright.bsky.social go.nature.com/47ycrMJ
Cold induced #RNA binding protein linked with longevity and DNA repair
The remarkably long lifespan of bowhead whales could be due to an increased ability to repair DNA mutations, according to research in Nature. go.nature.com/4hzvDN7 🌏 🧪
November 4, 2025 at 7:35 AM
Cold induced #RNA binding protein linked with longevity and DNA repair
Reposted by Olga Anczukow
CRISPR activation restores expression of a haploinsufficient neuronal sodium channel, rescuing neuronal deficits associated with multiple neurodevelopmental disorders. #NBThighlight www.nature.com/articles/s41...
CRISPR activation for SCN2A-related neurodevelopmental disorders - Nature
Using SCN2A haploinsufficiency as a proof-of-concept, upregulation of the existing functional gene copy through CRISPR activation was able to rescue neurological-associated phenotypes in Scn2a haploin...
www.nature.com
September 18, 2025 at 11:33 AM
CRISPR activation restores expression of a haploinsufficient neuronal sodium channel, rescuing neuronal deficits associated with multiple neurodevelopmental disorders. #NBThighlight www.nature.com/articles/s41...
Reposted by Olga Anczukow
This week's issue of #ScienceTranslationalMedicine has arrived!
New mRNA vaccines generate self-assembling nanoparticles to enhance immunity, dual-targeting "decoys" prevent metastasis and potentiate immunotherapy against melanoma in mice, and more. https://scim.ag/4n6wrKC
New mRNA vaccines generate self-assembling nanoparticles to enhance immunity, dual-targeting "decoys" prevent metastasis and potentiate immunotherapy against melanoma in mice, and more. https://scim.ag/4n6wrKC
October 15, 2025 at 9:25 PM
This week's issue of #ScienceTranslationalMedicine has arrived!
New mRNA vaccines generate self-assembling nanoparticles to enhance immunity, dual-targeting "decoys" prevent metastasis and potentiate immunotherapy against melanoma in mice, and more. https://scim.ag/4n6wrKC
New mRNA vaccines generate self-assembling nanoparticles to enhance immunity, dual-targeting "decoys" prevent metastasis and potentiate immunotherapy against melanoma in mice, and more. https://scim.ag/4n6wrKC
Reposted by Olga Anczukow
Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...
Somatic mutation and selection at population scale - Nature
A new version of nanorate DNA sequencing, with an error rate lower than five errors per billion base pairs and compatible with whole-exome and targeted capture, enables epidemiological-scale studies of somatic mutation and selection and the generation of high-resolution selection maps across coding and non-coding sites for many genes.
www.nature.com
October 8, 2025 at 4:31 PM
Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...
Reposted by Olga Anczukow
Cambridge researchers show that whole genome sequencing for breast cancer patients is likely to identify unique genetic features that could guide treatment or help match patients to clinical trials - which could benefit over 15,000 women a year.
🔗 crukcambridgecentre.org.uk/news/researc...
🔗 crukcambridgecentre.org.uk/news/researc...
October 8, 2025 at 9:16 AM
Cambridge researchers show that whole genome sequencing for breast cancer patients is likely to identify unique genetic features that could guide treatment or help match patients to clinical trials - which could benefit over 15,000 women a year.
🔗 crukcambridgecentre.org.uk/news/researc...
🔗 crukcambridgecentre.org.uk/news/researc...
Reposted by Olga Anczukow
Excited to share our latest work in Neuro-Oncology Advances! 🥳 After comparing several potential therapies, we identified lamotrigine as a promising therapy for NF1 optic glioma, showing both tumor reduction and vision protection. Check out the work of our great team!
Head-to-head preclinical treatment design prioritizes promising therapies for neurofibromatosis type 1 optic glioma clinical translation
AbstractBackground. Authenticated preclinical brain tumor models provide unprecedented opportunities to evaluate next-generation treatments. However, some
academic.oup.com
October 5, 2025 at 11:21 PM
Excited to share our latest work in Neuro-Oncology Advances! 🥳 After comparing several potential therapies, we identified lamotrigine as a promising therapy for NF1 optic glioma, showing both tumor reduction and vision protection. Check out the work of our great team!
Reposted by Olga Anczukow
This is a fascinating paper that particular types of RNA binding proteins with IDRs that target nuclear speckles also can recruit their own RNAs to nuclear speckles as a negative feedback mechanism for condensation the authors call "interstasis" www.nature.com/articles/s41...
Collective homeostasis of condensation-prone proteins via their mRNAs - Nature
The authors discover a homeostatic process termed interstasis, in which an increased concentration of proteins within RNA–protein condensates induces the sequestration of their own mRNAs.
www.nature.com
September 25, 2025 at 8:24 PM
This is a fascinating paper that particular types of RNA binding proteins with IDRs that target nuclear speckles also can recruit their own RNAs to nuclear speckles as a negative feedback mechanism for condensation the authors call "interstasis" www.nature.com/articles/s41...
Reposted by Olga Anczukow
New cures feel sudden, but the seeds were planted decades ago by basic scientists.
Which seeds will turn into cures? Unpredictable looking forward, a straight line looking back. 🧪🧬 🧵
Which seeds will turn into cures? Unpredictable looking forward, a straight line looking back. 🧪🧬 🧵
Huntington's disease successfully treated for first time
One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.
www.bbc.com
September 25, 2025 at 1:39 AM
New cures feel sudden, but the seeds were planted decades ago by basic scientists.
Which seeds will turn into cures? Unpredictable looking forward, a straight line looking back. 🧪🧬 🧵
Which seeds will turn into cures? Unpredictable looking forward, a straight line looking back. 🧪🧬 🧵
Reposted by Olga Anczukow
Very harmonious and inspiring collaboration with Niels Gehring, @volkerboehm.bsky.social and team at Uni Köln, and colleagues at @mdc-berlin.bsky.social . Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome: Molecular Cell www.cell.com/molecular-ce...
Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome
UPF1 depletion inhibits nonsense-mediated mRNA decay (NMD) and stabilizes direct target
transcripts within hours. Boehm et al. use conditional protein degradation and advanced
transcriptomics to map t...
www.cell.com
September 12, 2025 at 7:26 AM
Very harmonious and inspiring collaboration with Niels Gehring, @volkerboehm.bsky.social and team at Uni Köln, and colleagues at @mdc-berlin.bsky.social . Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome: Molecular Cell www.cell.com/molecular-ce...
Reposted by Olga Anczukow
After our study on RNU4-2 and RNU5B-1 published in May (Nava et al, Nature Genetics 2025), I am excited to share our new preprint reporting dominant and recessive variants in RNU2-2 as a frequent cause of developmental and epileptic encephalopathy (DEE).
📄 www.medrxiv.org/content/10.1...
📄 www.medrxiv.org/content/10.1...
Systematic analysis of snRNA genes reveals frequent RNU2-2 variants in dominant and recessive developmental and epileptic encephalopathies
Variants in spliceosomal small nuclear RNA (snRNA) genes RNU4-2 (ReNU syndrome), RNU5B-1 , and RNU2-2 have recently been linked to dominant neurodevelopmental disorders (NDDs), revealing a major, prev...
www.medrxiv.org
September 5, 2025 at 3:32 PM
After our study on RNU4-2 and RNU5B-1 published in May (Nava et al, Nature Genetics 2025), I am excited to share our new preprint reporting dominant and recessive variants in RNU2-2 as a frequent cause of developmental and epileptic encephalopathy (DEE).
📄 www.medrxiv.org/content/10.1...
📄 www.medrxiv.org/content/10.1...
Reposted by Olga Anczukow
Excited to share some new work from our group - www.biorxiv.org/content/10.1...
A great collaboration with @kurianlab.bsky.social that began with how an RBP (QKI) controls cardiomyocyte function, and led to uncovering a unique mechanism of direct interaction with U6 & the tri-snRNP at weak 5'SS
A great collaboration with @kurianlab.bsky.social that began with how an RBP (QKI) controls cardiomyocyte function, and led to uncovering a unique mechanism of direct interaction with U6 & the tri-snRNP at weak 5'SS
QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites
During organogenesis, precise pre-mRNA splicing is essential to assemble tissue architecture. Many developmentally essential exons bear weak 5'splice sites (5'SS) yet are spliced with high precision, ...
www.biorxiv.org
September 8, 2025 at 4:43 PM
Excited to share some new work from our group - www.biorxiv.org/content/10.1...
A great collaboration with @kurianlab.bsky.social that began with how an RBP (QKI) controls cardiomyocyte function, and led to uncovering a unique mechanism of direct interaction with U6 & the tri-snRNP at weak 5'SS
A great collaboration with @kurianlab.bsky.social that began with how an RBP (QKI) controls cardiomyocyte function, and led to uncovering a unique mechanism of direct interaction with U6 & the tri-snRNP at weak 5'SS
Reposted by Olga Anczukow
We are proud to present a Special Issue on Cancer Neuroscience, curated by editors Bennie Babayan & Ted Dobie. This issue offers a snapshot of the field through a collection of Perspectives, Reviews, and NeuroViews: cell.com/neuron/issue.... See below for details on the pieces:
September 3, 2025 at 3:52 PM
We are proud to present a Special Issue on Cancer Neuroscience, curated by editors Bennie Babayan & Ted Dobie. This issue offers a snapshot of the field through a collection of Perspectives, Reviews, and NeuroViews: cell.com/neuron/issue.... See below for details on the pieces:
Reposted by Olga Anczukow
Finally officially out in the latest issue of @cp-cell.bsky.social as a #free #featured #LeadingEdge paper: everything you wanted to know about #InterferonPower! ❤️ @danielboehmer.bsky.social @bostonchildrens.bsky.social @harvardmed.bsky.social www.cell.com/cell/fulltex...
Interferons in health and disease
The cytokine messenger proteins known as interferons are central to protective immune
responses against infections, but they are also involved in inflammatory and autoimmune
diseases. This review maps...
www.cell.com
September 3, 2025 at 4:55 PM
Finally officially out in the latest issue of @cp-cell.bsky.social as a #free #featured #LeadingEdge paper: everything you wanted to know about #InterferonPower! ❤️ @danielboehmer.bsky.social @bostonchildrens.bsky.social @harvardmed.bsky.social www.cell.com/cell/fulltex...
Reposted by Olga Anczukow
RNA is far more than a messenger.
Its structures regulate, evolve, and catalyze — carrying out functions DNA alone cannot.
But predicting #RNA structure from sequence is still extremely difficult.
In our recently published paper in @narjournal.bsky.social we present a way forward.
🧵 ⤵️
Its structures regulate, evolve, and catalyze — carrying out functions DNA alone cannot.
But predicting #RNA structure from sequence is still extremely difficult.
In our recently published paper in @narjournal.bsky.social we present a way forward.
🧵 ⤵️
August 25, 2025 at 3:02 AM
RNA is far more than a messenger.
Its structures regulate, evolve, and catalyze — carrying out functions DNA alone cannot.
But predicting #RNA structure from sequence is still extremely difficult.
In our recently published paper in @narjournal.bsky.social we present a way forward.
🧵 ⤵️
Its structures regulate, evolve, and catalyze — carrying out functions DNA alone cannot.
But predicting #RNA structure from sequence is still extremely difficult.
In our recently published paper in @narjournal.bsky.social we present a way forward.
🧵 ⤵️
Reposted by Olga Anczukow
Our paper using Oxford #Nanopore direct RNA sequencing to identify m6A modifications on RNA isoforms in human brain is now out in Science Advances. 🧪
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Isoform-level profiling of m6A epitranscriptomic signatures in human brain
Direct RNA-seq in brain reveals RNA isoform and region-specific m6A modifications, highlighting their role in gene regulation.
www.science.org
August 12, 2025 at 2:30 AM
Our paper using Oxford #Nanopore direct RNA sequencing to identify m6A modifications on RNA isoforms in human brain is now out in Science Advances. 🧪
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Olga Anczukow
It’s out!!!!! We hope our review on aging, immunity, and cancer is helpful.
Such a rewarding group effort led by Melissa Dolan, with Kendra Libby, Alison Ringle, and @vangalenlab.bsky.social
So grateful to @gabriellebrewer.bsky.social @natrevcancer.nature.com for her efforts and support
Such a rewarding group effort led by Melissa Dolan, with Kendra Libby, Alison Ringle, and @vangalenlab.bsky.social
So grateful to @gabriellebrewer.bsky.social @natrevcancer.nature.com for her efforts and support
August 14, 2025 at 1:17 PM
It’s out!!!!! We hope our review on aging, immunity, and cancer is helpful.
Such a rewarding group effort led by Melissa Dolan, with Kendra Libby, Alison Ringle, and @vangalenlab.bsky.social
So grateful to @gabriellebrewer.bsky.social @natrevcancer.nature.com for her efforts and support
Such a rewarding group effort led by Melissa Dolan, with Kendra Libby, Alison Ringle, and @vangalenlab.bsky.social
So grateful to @gabriellebrewer.bsky.social @natrevcancer.nature.com for her efforts and support
Reposted by Olga Anczukow
Excited to announce a new paper in @aacrjournals.bsky.social with Junwei Shi and Tony Daniyan. We perform screens of GAPs and GEFs in AML and discover a hematopoietic-specific GAP (ARHGAP45) required in a variety of hematologic malignancies:
aacrjournals.org/cancerdiscov...
aacrjournals.org/cancerdiscov...
August 12, 2025 at 5:09 PM
Excited to announce a new paper in @aacrjournals.bsky.social with Junwei Shi and Tony Daniyan. We perform screens of GAPs and GEFs in AML and discover a hematopoietic-specific GAP (ARHGAP45) required in a variety of hematologic malignancies:
aacrjournals.org/cancerdiscov...
aacrjournals.org/cancerdiscov...
Reposted by Olga Anczukow
MechanoAge, a machine learning platform to identify individuals susceptible to breast cancer based on mechanical properties of single cells https://www.biorxiv.org/content/10.1101/2025.08.08.668946v1
August 12, 2025 at 5:48 PM
MechanoAge, a machine learning platform to identify individuals susceptible to breast cancer based on mechanical properties of single cells https://www.biorxiv.org/content/10.1101/2025.08.08.668946v1
Reposted by Olga Anczukow
Delighted to see this story out and collaborate with amazing teams led by @jdegregori.bsky.social Mercedes Rincon & @roelvermeulen.bsky.social. Proud to see science propelled by our lab @cdi-einstein.bsky.social expanded to better understand cancer dormancy. Congrats! www.nature.com/articles/s41...
Respiratory viral infections awaken metastatic breast cancer cells in lungs - Nature
Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological d...
www.nature.com
July 30, 2025 at 4:15 PM
Delighted to see this story out and collaborate with amazing teams led by @jdegregori.bsky.social Mercedes Rincon & @roelvermeulen.bsky.social. Proud to see science propelled by our lab @cdi-einstein.bsky.social expanded to better understand cancer dormancy. Congrats! www.nature.com/articles/s41...
Reposted by Olga Anczukow
With super Roman Chabanon and Sophie Postal Vinay, we show that inhibition of RNA editor ADAR1 causes a new form of BRCA synthetic lethality>autocrine inferferon poisoning. Relevant for ADAR1 drug discovery. Could provide a mechanistically different approach than PARPi. rdcu.be/eyo6t
Autocrine interferon poisoning mediates ADAR1-dependent synthetic lethality in BRCA1/2-mutant cancers
Nature Communications - The RNA editing enzyme ADAR1 blocks interferon responses triggered by cytosolic RNA sensors, and has been proposed as a potential target in immuno-oncology. Here, the...
rdcu.be
July 30, 2025 at 8:29 AM
With super Roman Chabanon and Sophie Postal Vinay, we show that inhibition of RNA editor ADAR1 causes a new form of BRCA synthetic lethality>autocrine inferferon poisoning. Relevant for ADAR1 drug discovery. Could provide a mechanistically different approach than PARPi. rdcu.be/eyo6t