Sandra McAllister, PhD
@sandramcallister.bsky.social
Dedicated to improving breast cancer outcomes across all age groups | tumor immune macroenvironment | immune age | systemic instigation | Harvard Medical School | MGB | passionate about dogs, tennis, health, life
Reposted by Sandra McAllister, PhD
🚨 Last chance to submit! 🚨
Short talk abstracts & scholarships for the Keystone Symposium on Tumor Microenvironment are due Feb 18 (11:59 PM MST).
Join @laurakiessling.bsky.social @coussenslab.bsky.social @sandramcallister.bsky.social in Whistler, BC.
🔗 keysym.us/KSTumorMicro26
#KSTumorMicro26
Short talk abstracts & scholarships for the Keystone Symposium on Tumor Microenvironment are due Feb 18 (11:59 PM MST).
Join @laurakiessling.bsky.social @coussenslab.bsky.social @sandramcallister.bsky.social in Whistler, BC.
🔗 keysym.us/KSTumorMicro26
#KSTumorMicro26
Tumor Microenvironment: Identifying Drivers of Progression and Resistance | Keystone Symposia
Join us at the Keystone Symposia on Tumor Microenvironment: Identifying Drivers of Progression and Resistance, May 2026, in Whistler, with field leaders!
keysym.us
February 16, 2026 at 5:23 PM
🚨 Last chance to submit! 🚨
Short talk abstracts & scholarships for the Keystone Symposium on Tumor Microenvironment are due Feb 18 (11:59 PM MST).
Join @laurakiessling.bsky.social @coussenslab.bsky.social @sandramcallister.bsky.social in Whistler, BC.
🔗 keysym.us/KSTumorMicro26
#KSTumorMicro26
Short talk abstracts & scholarships for the Keystone Symposium on Tumor Microenvironment are due Feb 18 (11:59 PM MST).
Join @laurakiessling.bsky.social @coussenslab.bsky.social @sandramcallister.bsky.social in Whistler, BC.
🔗 keysym.us/KSTumorMicro26
#KSTumorMicro26
So happy to see that the team’s tour de force sparked interest!!! Hope it’s informative and inspires more people to study #agingandcancer
Melissa Dolan
Kendra Libby
Alison Ringel
@vangalenlab.bsky.social
Melissa Dolan
Kendra Libby
Alison Ringel
@vangalenlab.bsky.social
🥳 First up in #NRCtop10of2025:
#10) Ageing, immune fitness and cancer
#ageing #aging #ageingandcancer #agingandcancer @NatResCancer
#NRCtop10of2025
#10) Ageing, immune fitness and cancer
#ageing #aging #ageingandcancer #agingandcancer @NatResCancer
#NRCtop10of2025
Ageing, immune fitness and cancer - Nature Reviews Cancer
Ageing reshapes immune composition, function and regenerative capacity, with profound effects on tumour immunity, cancer progression and treatment outcomes. In this Review, Dolan and colleagues examine how age-resolved immunoprofiling, insights from ageing haematopoiesis and preclinical modelling are uncovering immune ageing dynamics and therapeutic challenges — revealing new opportunities to optimize cancer therapy across diverse age groups.
dlvr.it
February 5, 2026 at 5:10 PM
So happy to see that the team’s tour de force sparked interest!!! Hope it’s informative and inspires more people to study #agingandcancer
Melissa Dolan
Kendra Libby
Alison Ringel
@vangalenlab.bsky.social
Melissa Dolan
Kendra Libby
Alison Ringel
@vangalenlab.bsky.social
What happens when #TumorMicroenvironment🔬🧬 meets #InflammationResolution🔥?
We’re excited to co-organize a joint Keystone Symposia uniting these 2 vibrant fields!!! 🔬🧬🔥
Don’t miss the chance to share your work with BOTH communities!
ABSTRACTS DUE TOMORROW 1/14
We’re excited to co-organize a joint Keystone Symposia uniting these 2 vibrant fields!!! 🔬🧬🔥
Don’t miss the chance to share your work with BOTH communities!
ABSTRACTS DUE TOMORROW 1/14
⏳ Deadline Jan. 14 (11:59 PM MST)! Submit abstracts/apply for scholarships for Tumor Microenvironment / Inflammation Resolution.
🔗 keysym.us/KSTumorMicro26
| keysym.us/KSInflammati...
@coussenslab.bsky.social @sandramcallister.bsky.social @laurakiessling.bsky.social @magarianblander.bsky.social
🔗 keysym.us/KSTumorMicro26
| keysym.us/KSInflammati...
@coussenslab.bsky.social @sandramcallister.bsky.social @laurakiessling.bsky.social @magarianblander.bsky.social
January 13, 2026 at 7:13 PM
What happens when #TumorMicroenvironment🔬🧬 meets #InflammationResolution🔥?
We’re excited to co-organize a joint Keystone Symposia uniting these 2 vibrant fields!!! 🔬🧬🔥
Don’t miss the chance to share your work with BOTH communities!
ABSTRACTS DUE TOMORROW 1/14
We’re excited to co-organize a joint Keystone Symposia uniting these 2 vibrant fields!!! 🔬🧬🔥
Don’t miss the chance to share your work with BOTH communities!
ABSTRACTS DUE TOMORROW 1/14
👇👇👇 👍
🟣🟣🟣 Check out this straightforward method of improving human hematopoietic stem cell expansion by inhibiting ferroptosis 🟣🟣🟣 thanks for including me @bloodgenes.bsky.social #hemesky 🧬🔬🧪
Excited to share our new study, led by @dellaVolpe_L, now out in @natcellbio.nature.com! Blocking #ferroptosis enhances human 🩸 stem cell expansion, with implications for transplantation and gene therapy. www.nature.com/articles/s41...
December 15, 2025 at 4:12 PM
👇👇👇 👍
🎀 Age influences breast cancer cell and molecular features 🎀
Congrats to our international team for the work featured in the December @nataging.nature.com issue!
@vangalenlab.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social
Congrats to our international team for the work featured in the December @nataging.nature.com issue!
@vangalenlab.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social
🗞️Our December issue is live, featuring the identification of age-related cell states in breast cancer on the cover!📷The issue also includes work on ECM aging, somatic mutations, epigenetic drift, intrinsic capacity and much more. Read it all here: nature.com/nataging/vol...
December 15, 2025 at 4:09 PM
🎀 Age influences breast cancer cell and molecular features 🎀
Congrats to our international team for the work featured in the December @nataging.nature.com issue!
@vangalenlab.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social
Congrats to our international team for the work featured in the December @nataging.nature.com issue!
@vangalenlab.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social
Breast cancer landscapes differ with age in a subtype-specific way!
A rewarding collaboration across disciplines 🧬🔬💻 institutions 🏨🏢 and continents 🌎
ASPEN computational pipeline & insights should provide a roadmap for understanding how age impacts cancer biology and outcomes.
Open access!
A rewarding collaboration across disciplines 🧬🔬💻 institutions 🏨🏢 and continents 🌎
ASPEN computational pipeline & insights should provide a roadmap for understanding how age impacts cancer biology and outcomes.
Open access!
November 5, 2025 at 7:54 PM
Breast cancer landscapes differ with age in a subtype-specific way!
A rewarding collaboration across disciplines 🧬🔬💻 institutions 🏨🏢 and continents 🌎
ASPEN computational pipeline & insights should provide a roadmap for understanding how age impacts cancer biology and outcomes.
Open access!
A rewarding collaboration across disciplines 🧬🔬💻 institutions 🏨🏢 and continents 🌎
ASPEN computational pipeline & insights should provide a roadmap for understanding how age impacts cancer biology and outcomes.
Open access!
Reposted by Sandra McAllister, PhD
Our November issue is online! 🧣 🍂 ☕ It's pt. 2 of our Focus issue on #AgeingandCancer and features articles on:
- The genetics & epigenetics of the ageing TME
- Ageing, immune fitness & cancer
- The evolution of cancer & ageing
Check it out 👇
http://bit.ly/4oUyzq...
- The genetics & epigenetics of the ageing TME
- Ageing, immune fitness & cancer
- The evolution of cancer & ageing
Check it out 👇
http://bit.ly/4oUyzq...
October 24, 2025 at 2:24 PM
Our November issue is online! 🧣 🍂 ☕ It's pt. 2 of our Focus issue on #AgeingandCancer and features articles on:
- The genetics & epigenetics of the ageing TME
- Ageing, immune fitness & cancer
- The evolution of cancer & ageing
Check it out 👇
http://bit.ly/4oUyzq...
- The genetics & epigenetics of the ageing TME
- Ageing, immune fitness & cancer
- The evolution of cancer & ageing
Check it out 👇
http://bit.ly/4oUyzq...
Loved working with the @theaacr.bsky.social team, Steering Committee, and Dr Lillian Siu on the 15th AACR Cancer Progress Report.
I was honored to present scientific progress and represent the cancer research community, working hard on behalf of all patients, at the press conference in DC.
I was honored to present scientific progress and represent the cancer research community, working hard on behalf of all patients, at the press conference in DC.
At the AACR Cancer Progress Report 2025 release, Sandra McAllister touches on her paper in Cancer Discovery, "Interferon Signaling Is Diminished with Age and Is Associated with Immune Checkpoint Blockade Efficacy in Triple-Negative Breast Cancer."
Read the article: buff.ly/fYyGBgI
Read the article: buff.ly/fYyGBgI
September 19, 2025 at 1:18 PM
Loved working with the @theaacr.bsky.social team, Steering Committee, and Dr Lillian Siu on the 15th AACR Cancer Progress Report.
I was honored to present scientific progress and represent the cancer research community, working hard on behalf of all patients, at the press conference in DC.
I was honored to present scientific progress and represent the cancer research community, working hard on behalf of all patients, at the press conference in DC.
Reposted by Sandra McAllister, PhD
At the AACR Cancer Progress Report 2025 release, Sandra McAllister touches on her paper in Cancer Discovery, "Interferon Signaling Is Diminished with Age and Is Associated with Immune Checkpoint Blockade Efficacy in Triple-Negative Breast Cancer."
Read the article: buff.ly/fYyGBgI
Read the article: buff.ly/fYyGBgI
September 17, 2025 at 11:02 PM
At the AACR Cancer Progress Report 2025 release, Sandra McAllister touches on her paper in Cancer Discovery, "Interferon Signaling Is Diminished with Age and Is Associated with Immune Checkpoint Blockade Efficacy in Triple-Negative Breast Cancer."
Read the article: buff.ly/fYyGBgI
Read the article: buff.ly/fYyGBgI
Reposted by Sandra McAllister, PhD
The American Association for Cancer Research (AACR) will release the 15th edition of the AACR Cancer Progress Report tomorrow at 12 p.m. ET. Register for free to watch the livestream. buff.ly/zE9wZnZ
September 16, 2025 at 7:53 PM
The American Association for Cancer Research (AACR) will release the 15th edition of the AACR Cancer Progress Report tomorrow at 12 p.m. ET. Register for free to watch the livestream. buff.ly/zE9wZnZ
Reposted by Sandra McAllister, PhD
The American Association for Cancer Research (AACR) will release the 15th edition of the AACR Cancer Progress Report at 12 p.m. ET on Wednesday, September 17, 2025. Register for free to attend in person or watch the livestream. buff.ly/zE9wZnZ
September 9, 2025 at 6:28 PM
The American Association for Cancer Research (AACR) will release the 15th edition of the AACR Cancer Progress Report at 12 p.m. ET on Wednesday, September 17, 2025. Register for free to attend in person or watch the livestream. buff.ly/zE9wZnZ
It’s almost here!!!
Tune in Wed 9/17, 12pm (ET) for the 15th edition of the AACR Cancer Progress Report
The report highlights advances of the past year and celebrates 15 years of transformative research
A powerful testament to how investment in cancer research saves lives.
@theaacr.bsky.social
Tune in Wed 9/17, 12pm (ET) for the 15th edition of the AACR Cancer Progress Report
The report highlights advances of the past year and celebrates 15 years of transformative research
A powerful testament to how investment in cancer research saves lives.
@theaacr.bsky.social
The American Association for Cancer Research (AACR) will release the 15th edition of the AACR Cancer Progress Report at 12 p.m. ET on Wednesday, September 17, 2025. Register for free to attend in person or watch the livestream. buff.ly/zE9wZnZ
September 10, 2025 at 12:16 PM
It’s almost here!!!
Tune in Wed 9/17, 12pm (ET) for the 15th edition of the AACR Cancer Progress Report
The report highlights advances of the past year and celebrates 15 years of transformative research
A powerful testament to how investment in cancer research saves lives.
@theaacr.bsky.social
Tune in Wed 9/17, 12pm (ET) for the 15th edition of the AACR Cancer Progress Report
The report highlights advances of the past year and celebrates 15 years of transformative research
A powerful testament to how investment in cancer research saves lives.
@theaacr.bsky.social
Reposted by Sandra McAllister, PhD
🚨 REVIEW 🚨
#Ageing alters immune function and cancer outcomes. McAllister et al. explore how age-resolved immunoprofiling and models of ageing haematopoiesis reveal immune dynamics and new paths to optimize cancer therapy across age groups.
#Ageing alters immune function and cancer outcomes. McAllister et al. explore how age-resolved immunoprofiling and models of ageing haematopoiesis reveal immune dynamics and new paths to optimize cancer therapy across age groups.
Ageing, immune fitness and cancer - Nature Reviews Cancer
Ageing reshapes immune composition, function and regenerative capacity, with profound effects on tumour immunity, cancer progression and treatment outcomes. In this Review, Dolan and colleagues examine how age-resolved immunoprofiling, insights from ageing haematopoiesis and preclinical modelling are uncovering immune ageing dynamics and therapeutic challenges — revealing new opportunities to optimize cancer therapy across diverse age groups.
bit.ly
August 19, 2025 at 2:19 PM
🚨 REVIEW 🚨
#Ageing alters immune function and cancer outcomes. McAllister et al. explore how age-resolved immunoprofiling and models of ageing haematopoiesis reveal immune dynamics and new paths to optimize cancer therapy across age groups.
#Ageing alters immune function and cancer outcomes. McAllister et al. explore how age-resolved immunoprofiling and models of ageing haematopoiesis reveal immune dynamics and new paths to optimize cancer therapy across age groups.
Reposted by Sandra McAllister, PhD
Online today! *Aging, Immune Fitness and Cancer* 🔬 Learn the latest about the intersection between these processes in
@natrevcancer.nature.com 🧬 Great to work with
@sandramcallister.bsky.social lab again 😁 doi.org/10.1038/s415...
@natrevcancer.nature.com 🧬 Great to work with
@sandramcallister.bsky.social lab again 😁 doi.org/10.1038/s415...
August 15, 2025 at 2:57 PM
Online today! *Aging, Immune Fitness and Cancer* 🔬 Learn the latest about the intersection between these processes in
@natrevcancer.nature.com 🧬 Great to work with
@sandramcallister.bsky.social lab again 😁 doi.org/10.1038/s415...
@natrevcancer.nature.com 🧬 Great to work with
@sandramcallister.bsky.social lab again 😁 doi.org/10.1038/s415...
It’s out!!!!! We hope our review on aging, immunity, and cancer is helpful.
Such a rewarding group effort led by Melissa Dolan, with Kendra Libby, Alison Ringle, and @vangalenlab.bsky.social
So grateful to @gabriellebrewer.bsky.social @natrevcancer.nature.com for her efforts and support
Such a rewarding group effort led by Melissa Dolan, with Kendra Libby, Alison Ringle, and @vangalenlab.bsky.social
So grateful to @gabriellebrewer.bsky.social @natrevcancer.nature.com for her efforts and support
August 14, 2025 at 1:17 PM
It’s out!!!!! We hope our review on aging, immunity, and cancer is helpful.
Such a rewarding group effort led by Melissa Dolan, with Kendra Libby, Alison Ringle, and @vangalenlab.bsky.social
So grateful to @gabriellebrewer.bsky.social @natrevcancer.nature.com for her efforts and support
Such a rewarding group effort led by Melissa Dolan, with Kendra Libby, Alison Ringle, and @vangalenlab.bsky.social
So grateful to @gabriellebrewer.bsky.social @natrevcancer.nature.com for her efforts and support
Reposted by Sandra McAllister, PhD
NEW content online!
Cancer progression through the lens of age-induced metabolic reprogramming
Nature Reviews Cancer, Published online: 11 July 2025; doi:10.1038/s41568-025-00845-4In this Perspective, Lazure and Gomes argue that metabolic changes that occur as a result of ageing may shape tumour initiation and progression and the development of metastatic disease.
www.nature.com
July 11, 2025 at 1:32 PM
NEW content online!
Reposted by Sandra McAllister, PhD
#Review 🚨
Henry & DeGregori @jdegregori.bsky.social discuss models and methods used to study the connection between ageing and cancer, advocating advocating for the wider adoption of age-appropriate models of cancer to improve clinical translation
📖⬇️
Henry & DeGregori @jdegregori.bsky.social discuss models and methods used to study the connection between ageing and cancer, advocating advocating for the wider adoption of age-appropriate models of cancer to improve clinical translation
📖⬇️
Modelling the ageing dependence of cancer evolutionary trajectories - Nature Reviews Cancer
In this Review, Henry and DeGregori discuss the contributions of the various models and methods used to study the connection between ageing and cancer, highlighting the strengths and limitations of those models and technologies, as well as advocating for the wider adoption of age-appropriate models of cancer to improve our clinical translation of approaches to prevent and treat human cancers.
bit.ly
July 17, 2025 at 2:25 PM
#Review 🚨
Henry & DeGregori @jdegregori.bsky.social discuss models and methods used to study the connection between ageing and cancer, advocating advocating for the wider adoption of age-appropriate models of cancer to improve clinical translation
📖⬇️
Henry & DeGregori @jdegregori.bsky.social discuss models and methods used to study the connection between ageing and cancer, advocating advocating for the wider adoption of age-appropriate models of cancer to improve clinical translation
📖⬇️
Reposted by Sandra McAllister, PhD
#Perspective 🚨
Lazure and Gomes argue that metabolic changes that occur as a result of #ageing may shape tumour initiation and progression and the development of metastatic disease.
⬇️ 📖
https://bit.ly/3IkNY...
@moffittnews.bsky.social
Lazure and Gomes argue that metabolic changes that occur as a result of #ageing may shape tumour initiation and progression and the development of metastatic disease.
⬇️ 📖
https://bit.ly/3IkNY...
@moffittnews.bsky.social
Cancer progression through the lens of age-induced metabolic reprogramming - Nature Reviews Cancer
In this Perspective, Lazure and Gomes argue that metabolic changes that occur as a result of ageing may shape tumour initiation and progression and the development of metastatic disease.
bit.ly
July 18, 2025 at 10:29 AM
#Perspective 🚨
Lazure and Gomes argue that metabolic changes that occur as a result of #ageing may shape tumour initiation and progression and the development of metastatic disease.
⬇️ 📖
https://bit.ly/3IkNY...
@moffittnews.bsky.social
Lazure and Gomes argue that metabolic changes that occur as a result of #ageing may shape tumour initiation and progression and the development of metastatic disease.
⬇️ 📖
https://bit.ly/3IkNY...
@moffittnews.bsky.social
Reposted by Sandra McAllister, PhD
NEW content online!
Stromal senescence contributes to age-related increases in cancer
Nature Reviews Cancer, Published online: 04 August 2025; doi:10.1038/s41568-025-00840-9Ageing influences cancer risk through cellular and environmental changes, including the induction of cellular senescence. In this Review, Ye, Melam and Stewart highlight the role of senescent stromal cells in cancer and the therapeutic implications of this.
www.nature.com
August 5, 2025 at 12:24 AM
NEW content online!
Reposted by Sandra McAllister, PhD
🎉 Over the moon to share the first paper from my lab!! We discovered an unexpected role for the cytokine OSM in lung epithelial homeostasis and repair. 🧵 1/n www.science.org/doi/10.1126/...
Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage
Tissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM) counteracted the patho...
www.science.org
July 11, 2025 at 1:03 AM
🎉 Over the moon to share the first paper from my lab!! We discovered an unexpected role for the cytokine OSM in lung epithelial homeostasis and repair. 🧵 1/n www.science.org/doi/10.1126/...
Reposted by Sandra McAllister, PhD
The purpose of the #ASPRIA trial is to determine if a combination of two drugs, #Atezolizumab and #SacituzumabGovitecan, can be used to prevent recurrence in #TripleNegativeBreastCancer.
For more information call 877-338-7425 or visit:
www.dana-farber.org/clinical-tri...
#BreastCancer #TNBC
For more information call 877-338-7425 or visit:
www.dana-farber.org/clinical-tri...
#BreastCancer #TNBC
May 20, 2025 at 2:45 PM
The purpose of the #ASPRIA trial is to determine if a combination of two drugs, #Atezolizumab and #SacituzumabGovitecan, can be used to prevent recurrence in #TripleNegativeBreastCancer.
For more information call 877-338-7425 or visit:
www.dana-farber.org/clinical-tri...
#BreastCancer #TNBC
For more information call 877-338-7425 or visit:
www.dana-farber.org/clinical-tri...
#BreastCancer #TNBC
Reposted by Sandra McAllister, PhD
Join Dana-Farber’s Young and Strong and Young Adult Programs for a free, family-friendly workshop on May 31 at the Yawkey Center.
For parents with #BreastCancer: Get guidance on talking to your kids, managing home life, and caring for yourself.
youngandstrong.dana-farber.org/upcoming-eve...
For parents with #BreastCancer: Get guidance on talking to your kids, managing home life, and caring for yourself.
youngandstrong.dana-farber.org/upcoming-eve...
May 7, 2025 at 2:25 PM
Join Dana-Farber’s Young and Strong and Young Adult Programs for a free, family-friendly workshop on May 31 at the Yawkey Center.
For parents with #BreastCancer: Get guidance on talking to your kids, managing home life, and caring for yourself.
youngandstrong.dana-farber.org/upcoming-eve...
For parents with #BreastCancer: Get guidance on talking to your kids, managing home life, and caring for yourself.
youngandstrong.dana-farber.org/upcoming-eve...
👏👏👏🙏🏻🙏🏻🙏🏻
Today, the American Association for Cancer Research (AACR) called on Congress to reject the Administration's nearly 40% cut to the NIH budget and allocate a bipartisan funding increase to $51.3 billion for the agency to accelerate progress for patients. www.aacr.org/about-the-aa...
May 7, 2025 at 1:58 AM
👏👏👏🙏🏻🙏🏻🙏🏻
Reposted by Sandra McAllister, PhD
Today, the American Association for Cancer Research (AACR) called on Congress to reject the Administration's nearly 40% cut to the NIH budget and allocate a bipartisan funding increase to $51.3 billion for the agency to accelerate progress for patients. www.aacr.org/about-the-aa...
May 6, 2025 at 3:23 PM
Today, the American Association for Cancer Research (AACR) called on Congress to reject the Administration's nearly 40% cut to the NIH budget and allocate a bipartisan funding increase to $51.3 billion for the agency to accelerate progress for patients. www.aacr.org/about-the-aa...
Reposted by Sandra McAllister, PhD
Day 4 of #AACR25 features the Annual Business Meeting of Members, at which Lillian Siu will begin her term as AACR President. In addition, join us this morning for the plenary session on Innovative Technologies Driving Advances in Cancer Research.
April 28, 2025 at 1:12 PM
Day 4 of #AACR25 features the Annual Business Meeting of Members, at which Lillian Siu will begin her term as AACR President. In addition, join us this morning for the plenary session on Innovative Technologies Driving Advances in Cancer Research.