Sandra McAllister, PhD
@sandramcallister.bsky.social
Dedicated to improving breast cancer outcomes across all age groups | tumor immune macroenvironment | immune age | systemic instigation | Harvard Medical School | MGB | passionate about dogs, tennis, health, life
Breast cancer landscapes differ with age in a subtype-specific way!
A rewarding collaboration across disciplines 🧬🔬💻 institutions 🏨🏢 and continents 🌎
ASPEN computational pipeline & insights should provide a roadmap for understanding how age impacts cancer biology and outcomes.
Open access!
A rewarding collaboration across disciplines 🧬🔬💻 institutions 🏨🏢 and continents 🌎
ASPEN computational pipeline & insights should provide a roadmap for understanding how age impacts cancer biology and outcomes.
Open access!
November 5, 2025 at 7:54 PM
Breast cancer landscapes differ with age in a subtype-specific way!
A rewarding collaboration across disciplines 🧬🔬💻 institutions 🏨🏢 and continents 🌎
ASPEN computational pipeline & insights should provide a roadmap for understanding how age impacts cancer biology and outcomes.
Open access!
A rewarding collaboration across disciplines 🧬🔬💻 institutions 🏨🏢 and continents 🌎
ASPEN computational pipeline & insights should provide a roadmap for understanding how age impacts cancer biology and outcomes.
Open access!
Reposted by Sandra McAllister, PhD
Our November issue is online! 🧣 🍂 ☕ It's pt. 2 of our Focus issue on #AgeingandCancer and features articles on:
- The genetics & epigenetics of the ageing TME
- Ageing, immune fitness & cancer
- The evolution of cancer & ageing
Check it out 👇
http://bit.ly/4oUyzq...
- The genetics & epigenetics of the ageing TME
- Ageing, immune fitness & cancer
- The evolution of cancer & ageing
Check it out 👇
http://bit.ly/4oUyzq...
October 24, 2025 at 2:24 PM
Our November issue is online! 🧣 🍂 ☕ It's pt. 2 of our Focus issue on #AgeingandCancer and features articles on:
- The genetics & epigenetics of the ageing TME
- Ageing, immune fitness & cancer
- The evolution of cancer & ageing
Check it out 👇
http://bit.ly/4oUyzq...
- The genetics & epigenetics of the ageing TME
- Ageing, immune fitness & cancer
- The evolution of cancer & ageing
Check it out 👇
http://bit.ly/4oUyzq...
Loved working with the @theaacr.bsky.social team, Steering Committee, and Dr Lillian Siu on the 15th AACR Cancer Progress Report.
I was honored to present scientific progress and represent the cancer research community, working hard on behalf of all patients, at the press conference in DC.
I was honored to present scientific progress and represent the cancer research community, working hard on behalf of all patients, at the press conference in DC.
At the AACR Cancer Progress Report 2025 release, Sandra McAllister touches on her paper in Cancer Discovery, "Interferon Signaling Is Diminished with Age and Is Associated with Immune Checkpoint Blockade Efficacy in Triple-Negative Breast Cancer."
Read the article: buff.ly/fYyGBgI
Read the article: buff.ly/fYyGBgI
September 19, 2025 at 1:18 PM
Loved working with the @theaacr.bsky.social team, Steering Committee, and Dr Lillian Siu on the 15th AACR Cancer Progress Report.
I was honored to present scientific progress and represent the cancer research community, working hard on behalf of all patients, at the press conference in DC.
I was honored to present scientific progress and represent the cancer research community, working hard on behalf of all patients, at the press conference in DC.
Reposted by Sandra McAllister, PhD
At the AACR Cancer Progress Report 2025 release, Sandra McAllister touches on her paper in Cancer Discovery, "Interferon Signaling Is Diminished with Age and Is Associated with Immune Checkpoint Blockade Efficacy in Triple-Negative Breast Cancer."
Read the article: buff.ly/fYyGBgI
Read the article: buff.ly/fYyGBgI
September 17, 2025 at 11:02 PM
At the AACR Cancer Progress Report 2025 release, Sandra McAllister touches on her paper in Cancer Discovery, "Interferon Signaling Is Diminished with Age and Is Associated with Immune Checkpoint Blockade Efficacy in Triple-Negative Breast Cancer."
Read the article: buff.ly/fYyGBgI
Read the article: buff.ly/fYyGBgI
Reposted by Sandra McAllister, PhD
The American Association for Cancer Research (AACR) will release the 15th edition of the AACR Cancer Progress Report tomorrow at 12 p.m. ET. Register for free to watch the livestream. buff.ly/zE9wZnZ
September 16, 2025 at 7:53 PM
The American Association for Cancer Research (AACR) will release the 15th edition of the AACR Cancer Progress Report tomorrow at 12 p.m. ET. Register for free to watch the livestream. buff.ly/zE9wZnZ
Reposted by Sandra McAllister, PhD
The American Association for Cancer Research (AACR) will release the 15th edition of the AACR Cancer Progress Report at 12 p.m. ET on Wednesday, September 17, 2025. Register for free to attend in person or watch the livestream. buff.ly/zE9wZnZ
September 9, 2025 at 6:28 PM
The American Association for Cancer Research (AACR) will release the 15th edition of the AACR Cancer Progress Report at 12 p.m. ET on Wednesday, September 17, 2025. Register for free to attend in person or watch the livestream. buff.ly/zE9wZnZ
It’s almost here!!!
Tune in Wed 9/17, 12pm (ET) for the 15th edition of the AACR Cancer Progress Report
The report highlights advances of the past year and celebrates 15 years of transformative research
A powerful testament to how investment in cancer research saves lives.
@theaacr.bsky.social
Tune in Wed 9/17, 12pm (ET) for the 15th edition of the AACR Cancer Progress Report
The report highlights advances of the past year and celebrates 15 years of transformative research
A powerful testament to how investment in cancer research saves lives.
@theaacr.bsky.social
The American Association for Cancer Research (AACR) will release the 15th edition of the AACR Cancer Progress Report at 12 p.m. ET on Wednesday, September 17, 2025. Register for free to attend in person or watch the livestream. buff.ly/zE9wZnZ
September 10, 2025 at 12:16 PM
It’s almost here!!!
Tune in Wed 9/17, 12pm (ET) for the 15th edition of the AACR Cancer Progress Report
The report highlights advances of the past year and celebrates 15 years of transformative research
A powerful testament to how investment in cancer research saves lives.
@theaacr.bsky.social
Tune in Wed 9/17, 12pm (ET) for the 15th edition of the AACR Cancer Progress Report
The report highlights advances of the past year and celebrates 15 years of transformative research
A powerful testament to how investment in cancer research saves lives.
@theaacr.bsky.social
Reposted by Sandra McAllister, PhD
🚨 REVIEW 🚨
#Ageing alters immune function and cancer outcomes. McAllister et al. explore how age-resolved immunoprofiling and models of ageing haematopoiesis reveal immune dynamics and new paths to optimize cancer therapy across age groups.
#Ageing alters immune function and cancer outcomes. McAllister et al. explore how age-resolved immunoprofiling and models of ageing haematopoiesis reveal immune dynamics and new paths to optimize cancer therapy across age groups.
Ageing, immune fitness and cancer - Nature Reviews Cancer
Ageing reshapes immune composition, function and regenerative capacity, with profound effects on tumour immunity, cancer progression and treatment outcomes. In this Review, Dolan and colleagues examine how age-resolved immunoprofiling, insights from ageing haematopoiesis and preclinical modelling are uncovering immune ageing dynamics and therapeutic challenges — revealing new opportunities to optimize cancer therapy across diverse age groups.
bit.ly
August 19, 2025 at 2:19 PM
🚨 REVIEW 🚨
#Ageing alters immune function and cancer outcomes. McAllister et al. explore how age-resolved immunoprofiling and models of ageing haematopoiesis reveal immune dynamics and new paths to optimize cancer therapy across age groups.
#Ageing alters immune function and cancer outcomes. McAllister et al. explore how age-resolved immunoprofiling and models of ageing haematopoiesis reveal immune dynamics and new paths to optimize cancer therapy across age groups.
Reposted by Sandra McAllister, PhD
Online today! *Aging, Immune Fitness and Cancer* 🔬 Learn the latest about the intersection between these processes in
@natrevcancer.nature.com 🧬 Great to work with
@sandramcallister.bsky.social lab again 😁 doi.org/10.1038/s415...
@natrevcancer.nature.com 🧬 Great to work with
@sandramcallister.bsky.social lab again 😁 doi.org/10.1038/s415...
August 15, 2025 at 2:57 PM
Online today! *Aging, Immune Fitness and Cancer* 🔬 Learn the latest about the intersection between these processes in
@natrevcancer.nature.com 🧬 Great to work with
@sandramcallister.bsky.social lab again 😁 doi.org/10.1038/s415...
@natrevcancer.nature.com 🧬 Great to work with
@sandramcallister.bsky.social lab again 😁 doi.org/10.1038/s415...
It’s out!!!!! We hope our review on aging, immunity, and cancer is helpful.
Such a rewarding group effort led by Melissa Dolan, with Kendra Libby, Alison Ringle, and @vangalenlab.bsky.social
So grateful to @gabriellebrewer.bsky.social @natrevcancer.nature.com for her efforts and support
Such a rewarding group effort led by Melissa Dolan, with Kendra Libby, Alison Ringle, and @vangalenlab.bsky.social
So grateful to @gabriellebrewer.bsky.social @natrevcancer.nature.com for her efforts and support
August 14, 2025 at 1:17 PM
It’s out!!!!! We hope our review on aging, immunity, and cancer is helpful.
Such a rewarding group effort led by Melissa Dolan, with Kendra Libby, Alison Ringle, and @vangalenlab.bsky.social
So grateful to @gabriellebrewer.bsky.social @natrevcancer.nature.com for her efforts and support
Such a rewarding group effort led by Melissa Dolan, with Kendra Libby, Alison Ringle, and @vangalenlab.bsky.social
So grateful to @gabriellebrewer.bsky.social @natrevcancer.nature.com for her efforts and support
Reposted by Sandra McAllister, PhD
NEW content online!
Cancer progression through the lens of age-induced metabolic reprogramming
Nature Reviews Cancer, Published online: 11 July 2025; doi:10.1038/s41568-025-00845-4In this Perspective, Lazure and Gomes argue that metabolic changes that occur as a result of ageing may shape tumour initiation and progression and the development of metastatic disease.
www.nature.com
July 11, 2025 at 1:32 PM
NEW content online!
Reposted by Sandra McAllister, PhD
#Review 🚨
Henry & DeGregori @jdegregori.bsky.social discuss models and methods used to study the connection between ageing and cancer, advocating advocating for the wider adoption of age-appropriate models of cancer to improve clinical translation
📖⬇️
Henry & DeGregori @jdegregori.bsky.social discuss models and methods used to study the connection between ageing and cancer, advocating advocating for the wider adoption of age-appropriate models of cancer to improve clinical translation
📖⬇️
Modelling the ageing dependence of cancer evolutionary trajectories - Nature Reviews Cancer
In this Review, Henry and DeGregori discuss the contributions of the various models and methods used to study the connection between ageing and cancer, highlighting the strengths and limitations of those models and technologies, as well as advocating for the wider adoption of age-appropriate models of cancer to improve our clinical translation of approaches to prevent and treat human cancers.
bit.ly
July 17, 2025 at 2:25 PM
#Review 🚨
Henry & DeGregori @jdegregori.bsky.social discuss models and methods used to study the connection between ageing and cancer, advocating advocating for the wider adoption of age-appropriate models of cancer to improve clinical translation
📖⬇️
Henry & DeGregori @jdegregori.bsky.social discuss models and methods used to study the connection between ageing and cancer, advocating advocating for the wider adoption of age-appropriate models of cancer to improve clinical translation
📖⬇️
Reposted by Sandra McAllister, PhD
#Perspective 🚨
Lazure and Gomes argue that metabolic changes that occur as a result of #ageing may shape tumour initiation and progression and the development of metastatic disease.
⬇️ 📖
https://bit.ly/3IkNY...
@moffittnews.bsky.social
Lazure and Gomes argue that metabolic changes that occur as a result of #ageing may shape tumour initiation and progression and the development of metastatic disease.
⬇️ 📖
https://bit.ly/3IkNY...
@moffittnews.bsky.social
Cancer progression through the lens of age-induced metabolic reprogramming - Nature Reviews Cancer
In this Perspective, Lazure and Gomes argue that metabolic changes that occur as a result of ageing may shape tumour initiation and progression and the development of metastatic disease.
bit.ly
July 18, 2025 at 10:29 AM
#Perspective 🚨
Lazure and Gomes argue that metabolic changes that occur as a result of #ageing may shape tumour initiation and progression and the development of metastatic disease.
⬇️ 📖
https://bit.ly/3IkNY...
@moffittnews.bsky.social
Lazure and Gomes argue that metabolic changes that occur as a result of #ageing may shape tumour initiation and progression and the development of metastatic disease.
⬇️ 📖
https://bit.ly/3IkNY...
@moffittnews.bsky.social
Reposted by Sandra McAllister, PhD
NEW content online!
Stromal senescence contributes to age-related increases in cancer
Nature Reviews Cancer, Published online: 04 August 2025; doi:10.1038/s41568-025-00840-9Ageing influences cancer risk through cellular and environmental changes, including the induction of cellular senescence. In this Review, Ye, Melam and Stewart highlight the role of senescent stromal cells in cancer and the therapeutic implications of this.
www.nature.com
August 5, 2025 at 12:24 AM
NEW content online!
Reposted by Sandra McAllister, PhD
🎉 Over the moon to share the first paper from my lab!! We discovered an unexpected role for the cytokine OSM in lung epithelial homeostasis and repair. 🧵 1/n www.science.org/doi/10.1126/...
Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage
Tissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM) counteracted the patho...
www.science.org
July 11, 2025 at 1:03 AM
🎉 Over the moon to share the first paper from my lab!! We discovered an unexpected role for the cytokine OSM in lung epithelial homeostasis and repair. 🧵 1/n www.science.org/doi/10.1126/...
Reposted by Sandra McAllister, PhD
The purpose of the #ASPRIA trial is to determine if a combination of two drugs, #Atezolizumab and #SacituzumabGovitecan, can be used to prevent recurrence in #TripleNegativeBreastCancer.
For more information call 877-338-7425 or visit:
www.dana-farber.org/clinical-tri...
#BreastCancer #TNBC
For more information call 877-338-7425 or visit:
www.dana-farber.org/clinical-tri...
#BreastCancer #TNBC
May 20, 2025 at 2:45 PM
The purpose of the #ASPRIA trial is to determine if a combination of two drugs, #Atezolizumab and #SacituzumabGovitecan, can be used to prevent recurrence in #TripleNegativeBreastCancer.
For more information call 877-338-7425 or visit:
www.dana-farber.org/clinical-tri...
#BreastCancer #TNBC
For more information call 877-338-7425 or visit:
www.dana-farber.org/clinical-tri...
#BreastCancer #TNBC
Reposted by Sandra McAllister, PhD
Join Dana-Farber’s Young and Strong and Young Adult Programs for a free, family-friendly workshop on May 31 at the Yawkey Center.
For parents with #BreastCancer: Get guidance on talking to your kids, managing home life, and caring for yourself.
youngandstrong.dana-farber.org/upcoming-eve...
For parents with #BreastCancer: Get guidance on talking to your kids, managing home life, and caring for yourself.
youngandstrong.dana-farber.org/upcoming-eve...
May 7, 2025 at 2:25 PM
Join Dana-Farber’s Young and Strong and Young Adult Programs for a free, family-friendly workshop on May 31 at the Yawkey Center.
For parents with #BreastCancer: Get guidance on talking to your kids, managing home life, and caring for yourself.
youngandstrong.dana-farber.org/upcoming-eve...
For parents with #BreastCancer: Get guidance on talking to your kids, managing home life, and caring for yourself.
youngandstrong.dana-farber.org/upcoming-eve...
👏👏👏🙏🏻🙏🏻🙏🏻
Today, the American Association for Cancer Research (AACR) called on Congress to reject the Administration's nearly 40% cut to the NIH budget and allocate a bipartisan funding increase to $51.3 billion for the agency to accelerate progress for patients. www.aacr.org/about-the-aa...
May 7, 2025 at 1:58 AM
👏👏👏🙏🏻🙏🏻🙏🏻
Reposted by Sandra McAllister, PhD
Today, the American Association for Cancer Research (AACR) called on Congress to reject the Administration's nearly 40% cut to the NIH budget and allocate a bipartisan funding increase to $51.3 billion for the agency to accelerate progress for patients. www.aacr.org/about-the-aa...
May 6, 2025 at 3:23 PM
Today, the American Association for Cancer Research (AACR) called on Congress to reject the Administration's nearly 40% cut to the NIH budget and allocate a bipartisan funding increase to $51.3 billion for the agency to accelerate progress for patients. www.aacr.org/about-the-aa...
Reposted by Sandra McAllister, PhD
Day 4 of #AACR25 features the Annual Business Meeting of Members, at which Lillian Siu will begin her term as AACR President. In addition, join us this morning for the plenary session on Innovative Technologies Driving Advances in Cancer Research.
April 28, 2025 at 1:12 PM
Day 4 of #AACR25 features the Annual Business Meeting of Members, at which Lillian Siu will begin her term as AACR President. In addition, join us this morning for the plenary session on Innovative Technologies Driving Advances in Cancer Research.
Reposted by Sandra McAllister, PhD
@jdegregori.bsky.social illuminates how aging and smoking alter tumor adaptive landscapes at #AACR25.
April 26, 2025 at 3:21 PM
@jdegregori.bsky.social illuminates how aging and smoking alter tumor adaptive landscapes at #AACR25.
#AACR25 is here!! Ready to be inspired & humbled learning about life-saving cancer research from our global community.
Our team Drs. Milos Spasic, Adrienne Parsons, Hanna Starobinets @hannastarobin.bsky.social will discuss their work on #Cancer&Aging #TumorMacroenvironment #Biomarker&DrugDiscovery
Our team Drs. Milos Spasic, Adrienne Parsons, Hanna Starobinets @hannastarobin.bsky.social will discuss their work on #Cancer&Aging #TumorMacroenvironment #Biomarker&DrugDiscovery
April 25, 2025 at 3:49 PM
#AACR25 is here!! Ready to be inspired & humbled learning about life-saving cancer research from our global community.
Our team Drs. Milos Spasic, Adrienne Parsons, Hanna Starobinets @hannastarobin.bsky.social will discuss their work on #Cancer&Aging #TumorMacroenvironment #Biomarker&DrugDiscovery
Our team Drs. Milos Spasic, Adrienne Parsons, Hanna Starobinets @hannastarobin.bsky.social will discuss their work on #Cancer&Aging #TumorMacroenvironment #Biomarker&DrugDiscovery
Reposted by Sandra McAllister, PhD
Make the most of your #AACR25 experience with in-person and virtual options, the AACR Runners for Research 5K Run/Walk, a performance by the CheckPoints, and more. Preview highlights in AACR Annual Meeting News: www.aacrmeetingnews.org/news/prepari...
April 13, 2025 at 3:43 PM
Make the most of your #AACR25 experience with in-person and virtual options, the AACR Runners for Research 5K Run/Walk, a performance by the CheckPoints, and more. Preview highlights in AACR Annual Meeting News: www.aacrmeetingnews.org/news/prepari...
Reposted by Sandra McAllister, PhD
Explore the latest scientific progress and promising clinical strategies against blood cancers during #AACR25. Learn more in AACR Annual Meeting News: www.aacrmeetingnews.org/news/special...
April 20, 2025 at 12:31 PM
Explore the latest scientific progress and promising clinical strategies against blood cancers during #AACR25. Learn more in AACR Annual Meeting News: www.aacrmeetingnews.org/news/special...
Reposted by Sandra McAllister, PhD
Learn about exciting topics beyond your areas of expertise by adding the Educational Program Pass to your #AACR25 registration. Find out more in AACR Annual Meeting News: www.aacrmeetingnews.org/news/genomic...
April 16, 2025 at 1:43 PM
Learn about exciting topics beyond your areas of expertise by adding the Educational Program Pass to your #AACR25 registration. Find out more in AACR Annual Meeting News: www.aacrmeetingnews.org/news/genomic...