Ruth Franklin
@ruthfranklinlab.bsky.social
Assistant Professor | Harvard Stem Cell & Regenerative Biology | Immunologist and Tissue biologist | Proud mama
www.ruthfranklinlab.com
www.ruthfranklinlab.com
Pinned
Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage
Tissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM) counteracted the patho...
www.science.org
🎉 Over the moon to share the first paper from my lab!! We discovered an unexpected role for the cytokine OSM in lung epithelial homeostasis and repair. 🧵 1/n www.science.org/doi/10.1126/...
So exciting to see this out!! More cool biology sure to come!! 🤩👀
Lab’s 1st preprint!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
October 10, 2025 at 6:44 PM
So exciting to see this out!! More cool biology sure to come!! 🤩👀
Had a fantastic visit @roswellpark.bsky.social for the Post-Doctoral Symposium!! So many inspiring scientists doing cool work! Grateful for the invitation!
Very excited to hear from Dr Ruth Franklin as the keynote speaker at the 6th Annual Post-Doctoral Symposium at Roswell Park! @ruthfranklinlab.bsky.social
September 14, 2025 at 12:39 PM
Had a fantastic visit @roswellpark.bsky.social for the Post-Doctoral Symposium!! So many inspiring scientists doing cool work! Grateful for the invitation!
Can’t wait to read this!! Sure to be a fantastic resource! #InterferonPower
#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...
August 21, 2025 at 4:54 PM
Can’t wait to read this!! Sure to be a fantastic resource! #InterferonPower
Exciting week! Congrats to @xuzhoulab.bsky.social, Ruslan Medzhitov, & coauthors on discovering a new mechanism to regulate inflammation!! 🎉 www.sciencedirect.com/science/arti...
Regulation of inflammatory responses by pH-dependent transcriptional condensates
Inflammation is an essential defense response but operates at the cost of normal tissue functions. Whether and how the negative impact of inflammation…
www.sciencedirect.com
July 18, 2025 at 11:14 PM
Exciting week! Congrats to @xuzhoulab.bsky.social, Ruslan Medzhitov, & coauthors on discovering a new mechanism to regulate inflammation!! 🎉 www.sciencedirect.com/science/arti...
Reposted by Ruth Franklin
#WeekendRead! #InterferonsFriendsOrFoes?! @ruthfranklinlab.bsky.social, Medzhitov, Hoagland, Rodriguez-Morales &co show @science.org that macrophage-derived oncostatin M overcomes type I IFN detrimental responses during severe influenza lung infection by driving AT-II epithelial cell proliferation!
Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage
Tissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM) counteracted the patho...
www.science.org
July 12, 2025 at 2:10 PM
#WeekendRead! #InterferonsFriendsOrFoes?! @ruthfranklinlab.bsky.social, Medzhitov, Hoagland, Rodriguez-Morales &co show @science.org that macrophage-derived oncostatin M overcomes type I IFN detrimental responses during severe influenza lung infection by driving AT-II epithelial cell proliferation!
Reposted by Ruth Franklin
I’m so proud to have been able to contribute to this story! Check it out for a cool tale about tissue repair under inflammatory conditions! Congrats @daisyah.bsky.social and @ruthfranklinlab.bsky.social on putting out the lab’s first paper 🫁🐁🦠
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage
Tissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM) counteracted the patho...
www.science.org
July 10, 2025 at 6:30 PM
I’m so proud to have been able to contribute to this story! Check it out for a cool tale about tissue repair under inflammatory conditions! Congrats @daisyah.bsky.social and @ruthfranklinlab.bsky.social on putting out the lab’s first paper 🫁🐁🦠
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
🎉 Over the moon to share the first paper from my lab!! We discovered an unexpected role for the cytokine OSM in lung epithelial homeostasis and repair. 🧵 1/n www.science.org/doi/10.1126/...
Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage
Tissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM) counteracted the patho...
www.science.org
July 11, 2025 at 1:03 AM
🎉 Over the moon to share the first paper from my lab!! We discovered an unexpected role for the cytokine OSM in lung epithelial homeostasis and repair. 🧵 1/n www.science.org/doi/10.1126/...
Was so much fun to catch up with some of my IMP family!!
Wonderful to catch up with two former @wcm-imp.bsky.social grad students at this @faseborg.bsky.social meeting! So proud of alum who are now faculty running their own labs- Priya Issuree (U Iowa) and Ruth Franklin @ruthfranklinlab.bsky.social (Harvard). Nothing makes a program director more happy!
June 30, 2025 at 10:28 PM
Was so much fun to catch up with some of my IMP family!!
Reposted by Ruth Franklin
"The money the government sends to Harvard is, in effect, not a subsidy to advance the university’s mission. It’s a payment for the role Harvard plays in advancing the research mission of the United States." www.nytimes.com/interactive/...
Here Is All the Science at Risk in Trump’s Clash With Harvard (Gift Article)
More than 900 research grants worth $2.6 billion are in jeopardy. So is the 80-year-old model of American science.
www.nytimes.com
June 23, 2025 at 6:48 PM
"The money the government sends to Harvard is, in effect, not a subsidy to advance the university’s mission. It’s a payment for the role Harvard plays in advancing the research mission of the United States." www.nytimes.com/interactive/...
Today was a happy day!! Very proud of Dr. Rodríguez-Morales and very proud to be a professor at Harvard!!
May 30, 2025 at 12:56 AM
Today was a happy day!! Very proud of Dr. Rodríguez-Morales and very proud to be a professor at Harvard!!
Reposted by Ruth Franklin
🚨 Action alert: Two days left!!
Help protect NSF/NIH from political interference.
👎 A new rule (Sched. F) would allow for replacing career program officers with political appointees.
➡️ Action: Object here by THIS FRIDAY. Comments can be brief and/or anonymous. Helps future litigation.
Help protect NSF/NIH from political interference.
👎 A new rule (Sched. F) would allow for replacing career program officers with political appointees.
➡️ Action: Object here by THIS FRIDAY. Comments can be brief and/or anonymous. Helps future litigation.
Improving Performance, Accountability and Responsiveness in the Civil Service
The Office of Personnel Management (OPM) is proposing a rule to increase career employee accountability. Agency supervisors report great difficulty removing employees for poor performance or misconduc...
www.federalregister.gov
May 21, 2025 at 10:31 PM
🚨 Action alert: Two days left!!
Help protect NSF/NIH from political interference.
👎 A new rule (Sched. F) would allow for replacing career program officers with political appointees.
➡️ Action: Object here by THIS FRIDAY. Comments can be brief and/or anonymous. Helps future litigation.
Help protect NSF/NIH from political interference.
👎 A new rule (Sched. F) would allow for replacing career program officers with political appointees.
➡️ Action: Object here by THIS FRIDAY. Comments can be brief and/or anonymous. Helps future litigation.
Reposted by Ruth Franklin
On a day when all research grants at Harvard were terminated, and in a context where Congress seems to broadly accept the notion that destroying science and health research in the US is fine, it’s worth noting that this is not what the public wants.
The American public is broadly supportive of maintaining federal science and medical research funding, and against punishing universities by taking their funding away, according to a new poll:
Few support punitive funding cuts to colleges and universities - AP-NORC
Most of the public believes that colleges and universities make significant contributions to scientific and technological advancement and think their federal research funding should be maintained.
apnorc.org
May 15, 2025 at 9:54 PM
On a day when all research grants at Harvard were terminated, and in a context where Congress seems to broadly accept the notion that destroying science and health research in the US is fine, it’s worth noting that this is not what the public wants.
Just said goodbye to my NIH MIRA award. Really hurts to see the word “terminated” in writing. Even worse to see it next to the F31 awarded to a fantastic PhD student in my lab @aybv.bsky.social. I REFUSE to let this stop us!!!
May 15, 2025 at 10:53 PM
Just said goodbye to my NIH MIRA award. Really hurts to see the word “terminated” in writing. Even worse to see it next to the F31 awarded to a fantastic PhD student in my lab @aybv.bsky.social. I REFUSE to let this stop us!!!
Our paper was accepted!!!!!! 🎉🥳 I can’t wait to share it with you all soon!!!
May 10, 2025 at 4:54 PM
Our paper was accepted!!!!!! 🎉🥳 I can’t wait to share it with you all soon!!!
Reposted by Ruth Franklin
Misinformation is winning not because it's true, but because it’s loud, emotional, and everywhere.
It’s time for science to fight back. Aaron Mertz and I dissect the issue and offer solutions 👇
📖 www.nature.com/articles/s41...
#SciComm @sinaiimmuno.bsky.social @aspeninstitute.bsky.social
It’s time for science to fight back. Aaron Mertz and I dissect the issue and offer solutions 👇
📖 www.nature.com/articles/s41...
#SciComm @sinaiimmuno.bsky.social @aspeninstitute.bsky.social
Beyond the lab: trust, storytelling and the fight for America’s attention - Nature Reviews Immunology
Shruti Naik, an immunologist and a strong advocate for diversity in science, has joined forces with Aaron Mertz, who leads programmes that help to explain, connect and maximize the benefits of science...
www.nature.com
May 8, 2025 at 4:36 PM
Misinformation is winning not because it's true, but because it’s loud, emotional, and everywhere.
It’s time for science to fight back. Aaron Mertz and I dissect the issue and offer solutions 👇
📖 www.nature.com/articles/s41...
#SciComm @sinaiimmuno.bsky.social @aspeninstitute.bsky.social
It’s time for science to fight back. Aaron Mertz and I dissect the issue and offer solutions 👇
📖 www.nature.com/articles/s41...
#SciComm @sinaiimmuno.bsky.social @aspeninstitute.bsky.social
The first student from my lab defended her thesis today!!! Huge congratulations to Patricia Rodríguez-Morales, PhD!!!!! 🎉
May 3, 2025 at 2:02 AM
The first student from my lab defended her thesis today!!! Huge congratulations to Patricia Rodríguez-Morales, PhD!!!!! 🎉
Reposted by Ruth Franklin
Hey #immunosky Looking at the AAI website for advocacy website I found this very easy letter you can send to your congressional reps by filling in your information. It's easily modifiable for non-immunologists 🧪 every small action matters
www.aai.org/Public-Affai...
www.aai.org/Public-Affai...
The American Association of Immunologists - Take Action
www.aai.org
May 2, 2025 at 12:27 AM
Hey #immunosky Looking at the AAI website for advocacy website I found this very easy letter you can send to your congressional reps by filling in your information. It's easily modifiable for non-immunologists 🧪 every small action matters
www.aai.org/Public-Affai...
www.aai.org/Public-Affai...
Reposted by Ruth Franklin
Excited to share the work of Jonathan Perr where he uncovered a surprisingly common feature of cell surfaces - the presentation and clustering of RNA binding proteins with #glycoRNA.
Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...
Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...
RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry
Mammalian cells present RNA-binding proteins on the cell surface that form clustered
domains containing glycoRNAs.
www.cell.com
February 27, 2025 at 3:48 PM
Excited to share the work of Jonathan Perr where he uncovered a surprisingly common feature of cell surfaces - the presentation and clustering of RNA binding proteins with #glycoRNA.
Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...
Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...
What a fantastic idea!!
Join us! Science Homecoming helps scientists reconnect with communities by writing about the importance of science funding in their hometown newspapers. We’ve mapped every small newspaper in the U.S. and provide resources to get you started. Help science get back home 🧪🔬🧬 🏠
sciencehomecoming.com
sciencehomecoming.com
Science Homecoming
sciencehomecoming.com
February 19, 2025 at 12:57 AM
What a fantastic idea!!
Today I did the same! First post on Facebook in years to share what we will lose and why everyone should care!
I am starting this morning by reaching outside of my science echo chamber (posting on facebook) to explain why the NIH matters and why the new indirect rate policy will be catastrophic to everyone
February 15, 2025 at 4:48 AM
Today I did the same! First post on Facebook in years to share what we will lose and why everyone should care!
Reposted by Ruth Franklin
From Harold Varmus (Former NIH and NCI Director and Nobel laureate)
Why Would We Undermine the Marvel of American Science?
www.nytimes.com/2025/02/14/o...
Why Would We Undermine the Marvel of American Science?
www.nytimes.com/2025/02/14/o...
Opinion | American Science is Under Attack (Gift Article)
The Trump administration hobbles research and endangers the public health.
www.nytimes.com
February 14, 2025 at 3:48 PM
From Harold Varmus (Former NIH and NCI Director and Nobel laureate)
Why Would We Undermine the Marvel of American Science?
www.nytimes.com/2025/02/14/o...
Why Would We Undermine the Marvel of American Science?
www.nytimes.com/2025/02/14/o...
In honor of International Day of Women & Girls in Science, call your reps & remind them the importance of scientific research, innovation, and education (cuts & freezes affect everyone, not just scientists and universities!) Research=lifesaving treatments, medical care, clinical trials, jobs & more!
FASEB Home
www.votervoice.net
February 11, 2025 at 5:19 PM
In honor of International Day of Women & Girls in Science, call your reps & remind them the importance of scientific research, innovation, and education (cuts & freezes affect everyone, not just scientists and universities!) Research=lifesaving treatments, medical care, clinical trials, jobs & more!