Gutmann Lab
@gutmannlab.bsky.social
We study the genetic, cellular, and molecular causes for brain tumors and neurodevelopmental disabilities in children and adults with Neurofibromatosis (NF).
To learn more: https://gutmannlab.wustl.edu and https://nfcenter.wustl.edu
To learn more: https://gutmannlab.wustl.edu and https://nfcenter.wustl.edu
Wishing you a boo-tiful Halloween from the lab! 🧪🎃 May your experiments work and your candy be plentiful. 👻
November 1, 2025 at 1:27 PM
Wishing you a boo-tiful Halloween from the lab! 🧪🎃 May your experiments work and your candy be plentiful. 👻
Last Friday,we welcomed our friends from Forward Strides 4NF,an amazing family-founded charity that brings awareness and support to the NF center with their fundraising opportunities,like the fun annual family walk you shouldn't miss! We are grateful for their endorsement and opportunity to connect💙
October 27, 2025 at 3:35 PM
Last Friday,we welcomed our friends from Forward Strides 4NF,an amazing family-founded charity that brings awareness and support to the NF center with their fundraising opportunities,like the fun annual family walk you shouldn't miss! We are grateful for their endorsement and opportunity to connect💙
Reposted by Gutmann Lab
The FDA approved a new cancer drug by SpringWorks Therapeutics— MEK inhibitor mirdametinib (brand name Gomekli) for adult & pediatric patients (> age 2) w/ neurofibromatosis type 1-associated plexiform neurofibromas (NF1-PN) not amenable to complete resection www.cancernetwork.com/view/fda-app...
February 11, 2025 at 9:43 PM
The FDA approved a new cancer drug by SpringWorks Therapeutics— MEK inhibitor mirdametinib (brand name Gomekli) for adult & pediatric patients (> age 2) w/ neurofibromatosis type 1-associated plexiform neurofibromas (NF1-PN) not amenable to complete resection www.cancernetwork.com/view/fda-app...
Excited to share our latest work in Neuro-Oncology Advances! 🥳 After comparing several potential therapies, we identified lamotrigine as a promising therapy for NF1 optic glioma, showing both tumor reduction and vision protection. Check out the work of our great team!
Head-to-head preclinical treatment design prioritizes promising therapies for neurofibromatosis type 1 optic glioma clinical translation
AbstractBackground. Authenticated preclinical brain tumor models provide unprecedented opportunities to evaluate next-generation treatments. However, some
academic.oup.com
October 5, 2025 at 11:21 PM
Excited to share our latest work in Neuro-Oncology Advances! 🥳 After comparing several potential therapies, we identified lamotrigine as a promising therapy for NF1 optic glioma, showing both tumor reduction and vision protection. Check out the work of our great team!
Exciting news! Our new paper is out in Neuron! We discovered how neurons drive brain tumor growth through aberrant glutamate–tyrosine kinase signaling, uncovering novel mechanisms that shape tumor progression. Grateful to our team & collaborators for making this breakthrough possible! 🧠✨
Aberrant coupling of glutamate and tyrosine kinase receptors enables neuronal control of brain-tumor growth
Anastasaki and colleagues establish a previously unknown glutamate growth dependency
in pediatric low-grade brain tumors (gliomas). Glioma cells hijack normal neuron-glial
molecular circuits present d...
www.cell.com
September 3, 2025 at 2:22 PM
Exciting news! Our new paper is out in Neuron! We discovered how neurons drive brain tumor growth through aberrant glutamate–tyrosine kinase signaling, uncovering novel mechanisms that shape tumor progression. Grateful to our team & collaborators for making this breakthrough possible! 🧠✨
We are so proud of Rasha and Rui's new paper! Their single cell reveals hidden diversity in CD8+ exhausted T cells across cancers, shedding light on why patients respond differently to immunotherapy and bringing us closer to more effective therapies. Don’t miss this exciting advance from our team!
Pan-cancer single cell transcriptomic clustering reveals heterogeneous CD8+ exhausted T cell populations with different immune checkpoint inhibitor responses
In most cancers, T lymphocytes comprise an essential cellular component of the non-neoplastic microenvironment, where they have the capacity to both suppress and support tumor growth. One specializ...
www.tandfonline.com
August 4, 2025 at 2:41 PM
We are so proud of Rasha and Rui's new paper! Their single cell reveals hidden diversity in CD8+ exhausted T cells across cancers, shedding light on why patients respond differently to immunotherapy and bringing us closer to more effective therapies. Don’t miss this exciting advance from our team!
We were thrilled to welcome Girl Scout Troop 222 to the lab this week! They explored science hands-on and got a glimpse of the work we do. Grateful for their curios minds and amazing energy—let’s keep inspiring the next generation of scientists! 🔬💫 #GirlsInSTEM #Troop222
August 1, 2025 at 12:24 AM
We were thrilled to welcome Girl Scout Troop 222 to the lab this week! They explored science hands-on and got a glimpse of the work we do. Grateful for their curios minds and amazing energy—let’s keep inspiring the next generation of scientists! 🔬💫 #GirlsInSTEM #Troop222
This past weekend we celebrated the 3rd Annual NF Family Day - a special time to honor our patients and families, build community, and have fun! From shaved ice and giant slides to visits from the St. Louis Fire and Police Department, we’re grateful for the support and another year moving forward.
July 22, 2025 at 6:24 PM
This past weekend we celebrated the 3rd Annual NF Family Day - a special time to honor our patients and families, build community, and have fun! From shaved ice and giant slides to visits from the St. Louis Fire and Police Department, we’re grateful for the support and another year moving forward.
Today we celebrated two incredible members of the Gutmann lab. We'll miss Alex’s cooking tips and Talia’s humor, but we’re excited for all that lies ahead on their next adventures!
July 16, 2025 at 10:52 PM
Today we celebrated two incredible members of the Gutmann lab. We'll miss Alex’s cooking tips and Talia’s humor, but we’re excited for all that lies ahead on their next adventures!
Another year, another cherised lab photo! We are excited to see some colleagues embark on new journeys and we warmly welcome our newest members. What never changes is our commitment to a happy and collaborative research environment. #Researchteam #lablife
June 20, 2025 at 7:40 PM
Another year, another cherised lab photo! We are excited to see some colleagues embark on new journeys and we warmly welcome our newest members. What never changes is our commitment to a happy and collaborative research environment. #Researchteam #lablife
This week we have said, "See you later" (never goodbye) to an incredible lab member! Chloe has brought joy and amazing work to the lab since her undergrad for more than 4 years. We wish her the best in NYC and her journey to med school.
June 4, 2025 at 8:31 PM
This week we have said, "See you later" (never goodbye) to an incredible lab member! Chloe has brought joy and amazing work to the lab since her undergrad for more than 4 years. We wish her the best in NYC and her journey to med school.
We are so happy to have our friends from Penny's Flight Foundation visit last week! It was wonderful sharing the exciting NF1 research currently happening in the lab. We're so grateful for their dedication to raising NF awareness, supporting patients, and championing research. #nf1 🦋
May 12, 2025 at 8:50 PM
We are so happy to have our friends from Penny's Flight Foundation visit last week! It was wonderful sharing the exciting NF1 research currently happening in the lab. We're so grateful for their dedication to raising NF awareness, supporting patients, and championing research. #nf1 🦋
Another celebration for the Gutmann Lab! Today, one of our newest undergrads, Paulina, makes her debut into the 20s. We are excited to have her for the summer and support her on her scientific journey next year. Happy Birthday Paulina! 🎉
April 22, 2025 at 7:19 PM
Another celebration for the Gutmann Lab! Today, one of our newest undergrads, Paulina, makes her debut into the 20s. We are excited to have her for the summer and support her on her scientific journey next year. Happy Birthday Paulina! 🎉
Today, we celebrate the journey of two amazing trainees in the lab. They have great things coming into their future, and we are equally sad and proud to see them go. Wherever their paths may take them, the Gutmann lab will always be their home.
Good luck, Laura and Xuanwei!
Good luck, Laura and Xuanwei!
April 11, 2025 at 11:15 PM
Today, we celebrate the journey of two amazing trainees in the lab. They have great things coming into their future, and we are equally sad and proud to see them go. Wherever their paths may take them, the Gutmann lab will always be their home.
Good luck, Laura and Xuanwei!
Good luck, Laura and Xuanwei!
The Gutmann Lab celebrates Giving Day at WashU Medical Campus!
In these hard times, our gratitude and donations are more important than ever. A community that supports and helps each other can handle anything that comes their way. #givingday
In these hard times, our gratitude and donations are more important than ever. A community that supports and helps each other can handle anything that comes their way. #givingday
April 9, 2025 at 8:24 PM
The Gutmann Lab celebrates Giving Day at WashU Medical Campus!
In these hard times, our gratitude and donations are more important than ever. A community that supports and helps each other can handle anything that comes their way. #givingday
In these hard times, our gratitude and donations are more important than ever. A community that supports and helps each other can handle anything that comes their way. #givingday
Reposted by Gutmann Lab
I'm glad to be back in my hometown. Detroit. Michigan. Cliff Bells for jazz.
March 27, 2025 at 3:10 AM
I'm glad to be back in my hometown. Detroit. Michigan. Cliff Bells for jazz.
Reposted by Gutmann Lab
Tesla has recalled... every single Cybertruck. Every one they've ever sold. For a hardware issue
www.carscoops.com/2025/03/tesl...
www.carscoops.com/2025/03/tesl...
Tesla Recalls Every Single Cybertruck Over Stainless Steel Trims Falling Off | Carscoops
151 Cybertruck owners filed warranty claims after noticing the roof trim panel above the windows was coming loose
www.carscoops.com
March 20, 2025 at 12:56 PM
Tesla has recalled... every single Cybertruck. Every one they've ever sold. For a hardware issue
www.carscoops.com/2025/03/tesl...
www.carscoops.com/2025/03/tesl...
Celebrating with #Lars #Danielsson on the stereo!
March 16, 2025 at 9:49 PM
Celebrating with #Lars #Danielsson on the stereo!
Birthday celebrations 🎂 and a sad goodbye. Yeah to Hallie Youker and Desiree Zanetti-Alepuz and thank you Dahlia Qi.
March 14, 2025 at 4:50 PM
Birthday celebrations 🎂 and a sad goodbye. Yeah to Hallie Youker and Desiree Zanetti-Alepuz and thank you Dahlia Qi.
Happy Pi Day from @gutmannlab.bsky.social.
March 14, 2025 at 3:52 PM
Happy Pi Day from @gutmannlab.bsky.social.
Off to @cshlaboratory.bsky.social to speak on cancer neuroscience. Looking forward to a great meeting!
March 9, 2025 at 4:59 PM
Off to @cshlaboratory.bsky.social to speak on cancer neuroscience. Looking forward to a great meeting!
@washuneurology.bsky.social and colleagues marching for science!!!!
March 9, 2025 at 12:07 AM