Pearl Freier
@pearlf.bsky.social
From Boston, MA. I'm @pearlf on the other blue-colored place. Founder of Cambridge BioPartners, Inc. I post mostly healthcare-related and biotech-related news items.
Reposted by Pearl Freier
Top 5 stem cell good news stories of 2025 ipscell.com/2025/12/top-... Duchenne, diabetes, vision loss, and more #stemcells #stemcell
Top 5 stem cell good news stories of 2025 - The Niche
Biologist discusses the stem cell good news stories of 2025 including encouraging clinical trial results around the world.
ipscell.com
December 29, 2025 at 5:17 PM
Top 5 stem cell good news stories of 2025 ipscell.com/2025/12/top-... Duchenne, diabetes, vision loss, and more #stemcells #stemcell
Sarah Cooper posted a new video—"How to MRI"
Sarah Cooper nails it: I had an MRI. The doctor
said it was the best result he has ever
seen as a doctor. That's it.
Uh I have no idea what they analyzed,
but whatever they analyzed, they analyzed
it well and they said that I had as good
a result as they've ever seen. www.youtube.com/watch?v=DZHd...
said it was the best result he has ever
seen as a doctor. That's it.
Uh I have no idea what they analyzed,
but whatever they analyzed, they analyzed
it well and they said that I had as good
a result as they've ever seen. www.youtube.com/watch?v=DZHd...
How to MRI
YouTube video by Sarah Cooper
www.youtube.com
December 29, 2025 at 7:55 PM
Sarah Cooper posted a new video—"How to MRI"
Biogen's Qalsody (tofersen) was the first gene-based therapy for ALS that received FDA approval (accelerated approval in '23) & the first ALS treatment based on a biomarker. Mutations in the SOD1 gene impact approx 2% of ALS patients but it's a breakthrough in targeting genetic causes of ALS
Biogen's ALS gene therapy received accelerated FDA approval in '23 4 rare form of ALS in adults w/mutations in SOD1 gene. Follow up from Ph 3 trial published in 12/22 JAMA Neurology said drug not only delays disease progression & helps patients regain lost function medicine.washu.edu/news/new-als...
December 29, 2025 at 5:51 PM
Biogen's Qalsody (tofersen) was the first gene-based therapy for ALS that received FDA approval (accelerated approval in '23) & the first ALS treatment based on a biomarker. Mutations in the SOD1 gene impact approx 2% of ALS patients but it's a breakthrough in targeting genetic causes of ALS
"new data on the long-term use of tofersen suggest that over about 3 years of treatment, roughly 1/4 of participants in 1 study group experienced stabilization of symptoms & even functional improvement in grip strength & respiratory function." Mutations in SOD1 gene impact approx 2% of ALS patients
Biogen's ALS gene therapy received accelerated FDA approval in '23 4 rare form of ALS in adults w/mutations in SOD1 gene. Follow up from Ph 3 trial published in 12/22 JAMA Neurology said drug not only delays disease progression & helps patients regain lost function medicine.washu.edu/news/new-als...
December 29, 2025 at 5:44 PM
"new data on the long-term use of tofersen suggest that over about 3 years of treatment, roughly 1/4 of participants in 1 study group experienced stabilization of symptoms & even functional improvement in grip strength & respiratory function." Mutations in SOD1 gene impact approx 2% of ALS patients
"Stopping disease progression & making improvements over 3 to 5 years is unheard of in this type of ALS,” said 1st author Tim Miller WashU Neurology professor & co-dir of the ALS Center. Tofersen shows benefits compared with what we expect to see for these participants, with 25% of participants 1/n
Biogen's ALS gene therapy received accelerated FDA approval in '23 4 rare form of ALS in adults w/mutations in SOD1 gene. Follow up from Ph 3 trial published in 12/22 JAMA Neurology said drug not only delays disease progression & helps patients regain lost function medicine.washu.edu/news/new-als...
December 29, 2025 at 5:40 PM
"Stopping disease progression & making improvements over 3 to 5 years is unheard of in this type of ALS,” said 1st author Tim Miller WashU Neurology professor & co-dir of the ALS Center. Tofersen shows benefits compared with what we expect to see for these participants, with 25% of participants 1/n
Biogen's ALS gene therapy received accelerated FDA approval in '23 4 rare form of ALS in adults w/mutations in SOD1 gene. Follow up from Ph 3 trial published in 12/22 JAMA Neurology said drug not only delays disease progression & helps patients regain lost function medicine.washu.edu/news/new-als...
December 29, 2025 at 5:34 PM
Biogen's ALS gene therapy received accelerated FDA approval in '23 4 rare form of ALS in adults w/mutations in SOD1 gene. Follow up from Ph 3 trial published in 12/22 JAMA Neurology said drug not only delays disease progression & helps patients regain lost function medicine.washu.edu/news/new-als...
Does the FDA know that the Chief AI Officer they hired in April says that he left the position in June? Below is a link to one of the stories from last spring (Fierce Biotech) www.fiercebiotech.com/medtech/fda-... #medsky #biosky
The FDA's press release on 12/19 included a quote from a Chief AI Officer, Jeremy Walsh. Walsh's Linked In profile says he hasn't been the FDA's Chief AI Officer since June when he left after just 3 months (according to LI). Did they ask him to come back to FDA? www.fda.gov/news-events/... #medsky
December 29, 2025 at 4:57 PM
Does the FDA know that the Chief AI Officer they hired in April says that he left the position in June? Below is a link to one of the stories from last spring (Fierce Biotech) www.fiercebiotech.com/medtech/fda-... #medsky #biosky
The FDA's press release on 12/19 included a quote from a Chief AI Officer, Jeremy Walsh. Walsh's Linked In profile says he hasn't been the FDA's Chief AI Officer since June when he left after just 3 months (according to LI). Did they ask him to come back to FDA? www.fda.gov/news-events/... #medsky
December 29, 2025 at 4:37 PM
The FDA's press release on 12/19 included a quote from a Chief AI Officer, Jeremy Walsh. Walsh's Linked In profile says he hasn't been the FDA's Chief AI Officer since June when he left after just 3 months (according to LI). Did they ask him to come back to FDA? www.fda.gov/news-events/... #medsky
After you read the list of medical & research breakthrus, see the note on the medical setbacks too incl US cuts to PEPFAR—the US’s largest global health program which supplied HIV treatment to > 20 million people worldwide. And death estimates due to US foreign aid cuts. Read the whole post #medsky
Inspiring post below listing medical breakthroughs in '25 incl clinical stage drugs w/ promising data from large randomized controlled trials published in papers in '25, some record-breaking achievements & the 1st patients to receive new treatment methods & research breakthroughs to watch #medsky
New post!
There was a lot of innovation in medicine and biomedical research this year, and I've tried to summarize the biggest ones in this blogpost.
Medical breakthroughs in 2025. Plus a serious note at the end.
www.scientificdiscovery.dev/p/medical-br...
There was a lot of innovation in medicine and biomedical research this year, and I've tried to summarize the biggest ones in this blogpost.
Medical breakthroughs in 2025. Plus a serious note at the end.
www.scientificdiscovery.dev/p/medical-br...
December 28, 2025 at 9:06 PM
After you read the list of medical & research breakthrus, see the note on the medical setbacks too incl US cuts to PEPFAR—the US’s largest global health program which supplied HIV treatment to > 20 million people worldwide. And death estimates due to US foreign aid cuts. Read the whole post #medsky
Inspiring post below listing medical breakthroughs in '25 incl clinical stage drugs w/ promising data from large randomized controlled trials published in papers in '25, some record-breaking achievements & the 1st patients to receive new treatment methods & research breakthroughs to watch #medsky
New post!
There was a lot of innovation in medicine and biomedical research this year, and I've tried to summarize the biggest ones in this blogpost.
Medical breakthroughs in 2025. Plus a serious note at the end.
www.scientificdiscovery.dev/p/medical-br...
There was a lot of innovation in medicine and biomedical research this year, and I've tried to summarize the biggest ones in this blogpost.
Medical breakthroughs in 2025. Plus a serious note at the end.
www.scientificdiscovery.dev/p/medical-br...
Medical breakthroughs in 2025
... and a happy new year.
www.scientificdiscovery.dev
December 28, 2025 at 8:51 PM
Inspiring post below listing medical breakthroughs in '25 incl clinical stage drugs w/ promising data from large randomized controlled trials published in papers in '25, some record-breaking achievements & the 1st patients to receive new treatment methods & research breakthroughs to watch #medsky
Reposted by Pearl Freier
Imagine if just by refusing to comment, you could stop any story from running. You would literally never find out anything unflattering about anybody. It amounts to asking people for their blessing to publish your reporting about them.
CBS News chief Bari Weiss pulls 60 Minutes story
Weiss said investigation had to include comments from Trump administration
60M's Sharyn Alfonsi said multiple US agencies refused to comment - and this lets WH veto coverage
My NPR story
www.npr.org/2025/12/22/g...
Weiss said investigation had to include comments from Trump administration
60M's Sharyn Alfonsi said multiple US agencies refused to comment - and this lets WH veto coverage
My NPR story
www.npr.org/2025/12/22/g...
CBS News chief Bari Weiss pulls '60 Minutes' story, sparking outcry
CBS News Editor-in-Chief Bari Weiss pulled a 60 Minutes segment on allegations of abuses at an El Salvador detention center where the Trump administration sent hundreds of Venezuelan migrants.
www.npr.org
December 22, 2025 at 12:40 PM
Imagine if just by refusing to comment, you could stop any story from running. You would literally never find out anything unflattering about anybody. It amounts to asking people for their blessing to publish your reporting about them.
I was surprised to see posts like below on Linked In & to learn that Linked In doesn't have a way to label misinformation about drugs & vaccines especially during disease outbreaks. Whooping cough cases in '25 (>26,000) are 4X higher than '23 in US said University of Minnesota's CIDRAP #medsky
December 22, 2025 at 1:53 PM
I was surprised to see posts like below on Linked In & to learn that Linked In doesn't have a way to label misinformation about drugs & vaccines especially during disease outbreaks. Whooping cough cases in '25 (>26,000) are 4X higher than '23 in US said University of Minnesota's CIDRAP #medsky
Reposted by Pearl Freier
“.. based on the data we have to date; it looks like manufacturing is experiencing more of a slump than is generally recognized ..”
@deanbaker13.bsky.social
cepr.net/publications...
@deanbaker13.bsky.social
cepr.net/publications...
December 21, 2025 at 5:53 PM
“.. based on the data we have to date; it looks like manufacturing is experiencing more of a slump than is generally recognized ..”
@deanbaker13.bsky.social
cepr.net/publications...
@deanbaker13.bsky.social
cepr.net/publications...
A startup investor shared how he was targeted on Telegram by a deepfake of a friend of his who is overseas. He described in a Linked In post how he was tricked into doing a Zoom w/the fake & why he clicked on an "updated link." Sharing below as a PSA www.linkedin.com/posts/elijah... #medsky
December 21, 2025 at 2:34 PM
A startup investor shared how he was targeted on Telegram by a deepfake of a friend of his who is overseas. He described in a Linked In post how he was tricked into doing a Zoom w/the fake & why he clicked on an "updated link." Sharing below as a PSA www.linkedin.com/posts/elijah... #medsky
The new CBS News—post sale to Ellison. Below is the next show after the EK town hall. Looks like the news division is going to focus less on news & isn't featuring topics like the economy, job losses, or a debate re: AI or the rise in measles & whooping cough outbreaks in US or inflation or tariffs
December 19, 2025 at 1:16 PM
The new CBS News—post sale to Ellison. Below is the next show after the EK town hall. Looks like the news division is going to focus less on news & isn't featuring topics like the economy, job losses, or a debate re: AI or the rise in measles & whooping cough outbreaks in US or inflation or tariffs
On FDA & Prasad's 11/28 memo, Bloomberg's 12/15 show asked Makary to address leaks to press & podcasts re: plans 4 "black box" warning on Covid vaccines based on unverified data. MM said at 2:20: "when it comes to the black box warning, we have no plans to put that on the Covid vaccine." #medsky 1/n
December 16, 2025 at 2:13 PM
On FDA & Prasad's 11/28 memo, Bloomberg's 12/15 show asked Makary to address leaks to press & podcasts re: plans 4 "black box" warning on Covid vaccines based on unverified data. MM said at 2:20: "when it comes to the black box warning, we have no plans to put that on the Covid vaccine." #medsky 1/n
Reposted by Pearl Freier
Thank you @governor.ca.gov for the opportunity to elevate the important work of public health in California, across the region, and globally
Dr. Houry, a physician, public health exec, & former CDC Chief Medical Officer under the Trump admin, will serve as a Senior Advisor for PHNIX. Dr. Houry will engage existing public health alliances & organizations to develop a sustainable public health network across the local to global spectrum
December 16, 2025 at 2:53 AM
Thank you @governor.ca.gov for the opportunity to elevate the important work of public health in California, across the region, and globally
Reposted by Pearl Freier
BREAKING
I was hoping this wasn’t true when I heard it two hours ago….
But now People Magazine has confirmed with multiple sources that Nick Reiner, Rob and Michele’s son, is the suspect in their murder.
I was hoping this wasn’t true when I heard it two hours ago….
But now People Magazine has confirmed with multiple sources that Nick Reiner, Rob and Michele’s son, is the suspect in their murder.
BREAKING
Rob Reiner and his wife Michele have been found dead in their Los Angeles home.
TMZ reports their bodies were found with knife wounds.
Rob Reiner and his wife Michele have been found dead in their Los Angeles home.
TMZ reports their bodies were found with knife wounds.
BREAKING: Rob Reiner and Wife Michele Found Dead
Rob Reiner, the legendary actor, director, and political activist, along with his wife Michele, the photographer and activist, were found dead in their home in Los Angeles.
bit.ly
December 15, 2025 at 4:07 AM
BREAKING
I was hoping this wasn’t true when I heard it two hours ago….
But now People Magazine has confirmed with multiple sources that Nick Reiner, Rob and Michele’s son, is the suspect in their murder.
I was hoping this wasn’t true when I heard it two hours ago….
But now People Magazine has confirmed with multiple sources that Nick Reiner, Rob and Michele’s son, is the suspect in their murder.
“I don’t know how I’m going to explain it to my daughter one day — that she got pepper-sprayed on our way to buy Pampers & milk.” The 1-year-old baby's father works as a sales representative for a Chicago clothing store & was born in the US wrote The Washington Post #medsky
Federal agents appear to have pepper-sprayed a 1 year-old baby in the car with her parents according to video & story by Washington Post. The baby & her parents are also US citizens. Happened at a Sam's Club in Chicago. www.washingtonpost.com/immigration/... #medsky
December 15, 2025 at 4:19 AM
“I don’t know how I’m going to explain it to my daughter one day — that she got pepper-sprayed on our way to buy Pampers & milk.” The 1-year-old baby's father works as a sales representative for a Chicago clothing store & was born in the US wrote The Washington Post #medsky
The 1-year-old baby survived and was rushed to the hospital. A poison control specialist was brought in. Follow-up visits needed to "gauge potential long term damage to the child’s lungs and eyes." #medsky
Federal agents appear to have pepper-sprayed a 1 year-old baby in the car with her parents according to video & story by Washington Post. The baby & her parents are also US citizens. Happened at a Sam's Club in Chicago. www.washingtonpost.com/immigration/... #medsky
December 15, 2025 at 4:07 AM
The 1-year-old baby survived and was rushed to the hospital. A poison control specialist was brought in. Follow-up visits needed to "gauge potential long term damage to the child’s lungs and eyes." #medsky
Federal agents appear to have pepper-sprayed a 1 year-old baby in the car with her parents according to video & story by Washington Post. The baby & her parents are also US citizens. Happened at a Sam's Club in Chicago. www.washingtonpost.com/immigration/... #medsky
December 15, 2025 at 3:49 AM
Federal agents appear to have pepper-sprayed a 1 year-old baby in the car with her parents according to video & story by Washington Post. The baby & her parents are also US citizens. Happened at a Sam's Club in Chicago. www.washingtonpost.com/immigration/... #medsky
Nobel laureate & co-discoverer of CRISPR-Cas9 Jennifer Doudna is this week's guest on the Future of Medicine podcast hosted by @euanashley.bsky.social. Here's a link to the episode: thefutureofmedicine.buzzsprout.com #CRISPR #biosky #medsky
December 15, 2025 at 1:08 AM
Nobel laureate & co-discoverer of CRISPR-Cas9 Jennifer Doudna is this week's guest on the Future of Medicine podcast hosted by @euanashley.bsky.social. Here's a link to the episode: thefutureofmedicine.buzzsprout.com #CRISPR #biosky #medsky
Wakefield, Massachusetts resident Jason Thomas is missing. His photo is below. If you have information, contact info is below. He's a close friend of @dannomura.bsky.social www.facebook.com/story.php?st...
December 14, 2025 at 10:40 PM
Wakefield, Massachusetts resident Jason Thomas is missing. His photo is below. If you have information, contact info is below. He's a close friend of @dannomura.bsky.social www.facebook.com/story.php?st...
Reposted by Pearl Freier
A good man WITHOUT a gun
Incredible footage out of Australia, confirmed by NEWS AU, of a brave bystander neutralizing one of the terrorists in the Bondi Beach attack which took place during a Hanukkah gathering.
Australian authorities say multiple people have been killed.
At least two suspects are in custody.
Australian authorities say multiple people have been killed.
At least two suspects are in custody.
December 14, 2025 at 11:17 AM
A good man WITHOUT a gun
Reposted by Pearl Freier
Student who was shot in the stomach in a mass shooting at her high school in Santa Clarita, CA in 2019 was locked down in her dorm at Brown tonight. "I chose Brown because it was a safe community for me to be in. I liked Rhode Island. I felt safe here."
www.ms.now/the-weekend-...
www.ms.now/the-weekend-...
Brown Univ. junior survived 2019 school shooting: I 'tried everything to figure out this new normal'
Mia Tretta, a junior at Brown University was shot in the stomach during a 2019 high school shooting. On Saturday, she was in her dorm on Brown University's campus when a deadly shooting took place.
www.ms.now
December 14, 2025 at 3:55 AM
Student who was shot in the stomach in a mass shooting at her high school in Santa Clarita, CA in 2019 was locked down in her dorm at Brown tonight. "I chose Brown because it was a safe community for me to be in. I liked Rhode Island. I felt safe here."
www.ms.now/the-weekend-...
www.ms.now/the-weekend-...