Eric Van Nostrand Lab @ BCM
@evannostrandlab.bsky.social
Eric Van Nostrand Lab
Therapeutic Innovation Center & the BMP Department, Baylor College of Medicine
Uncovering how RNA binding proteins control RNA processing
Therapeutic Innovation Center & the BMP Department, Baylor College of Medicine
Uncovering how RNA binding proteins control RNA processing
Some cool work with the www.daughertylab.org at UCSD is up! Started by looking at how IFIT2/3 inhibit VSV infection, wound up uncovering a new mechanism for translation inhibition of mRNAs with short 5'UTRs pubmed.ncbi.nlm.nih.gov/41093992
Daugherty Lab @ UCSD
www.daughertylab.org
October 16, 2025 at 4:20 PM
Some cool work with the www.daughertylab.org at UCSD is up! Started by looking at how IFIT2/3 inhibit VSV infection, wound up uncovering a new mechanism for translation inhibition of mRNAs with short 5'UTRs pubmed.ncbi.nlm.nih.gov/41093992
Reposted by Eric Van Nostrand Lab @ BCM
Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites
During organogenesis, precise pre-mRNA splicing is essential to assemble tissue architecture. Many developmentally essential exons bear weak 5'splice sites (5'SS) yet are spliced with high precision, ...
www.biorxiv.org
September 8, 2025 at 6:12 AM
Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Excited to share some new work from our group - www.biorxiv.org/content/10.1...
A great collaboration with @kurianlab.bsky.social that began with how an RBP (QKI) controls cardiomyocyte function, and led to uncovering a unique mechanism of direct interaction with U6 & the tri-snRNP at weak 5'SS
A great collaboration with @kurianlab.bsky.social that began with how an RBP (QKI) controls cardiomyocyte function, and led to uncovering a unique mechanism of direct interaction with U6 & the tri-snRNP at weak 5'SS
QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites
During organogenesis, precise pre-mRNA splicing is essential to assemble tissue architecture. Many developmentally essential exons bear weak 5'splice sites (5'SS) yet are spliced with high precision, ...
www.biorxiv.org
September 8, 2025 at 4:43 PM
Excited to share some new work from our group - www.biorxiv.org/content/10.1...
A great collaboration with @kurianlab.bsky.social that began with how an RBP (QKI) controls cardiomyocyte function, and led to uncovering a unique mechanism of direct interaction with U6 & the tri-snRNP at weak 5'SS
A great collaboration with @kurianlab.bsky.social that began with how an RBP (QKI) controls cardiomyocyte function, and led to uncovering a unique mechanism of direct interaction with U6 & the tri-snRNP at weak 5'SS
If you’re interested in the interplay between regulation (or mis-regulation) of RNA processing and cancer, please check out the 2025 FASEB RNA Processing in Cancer meeting Oct 5-9 2025 in Sacramento CA!
events.faseb.org/event/RNA-Pr...
events.faseb.org/event/RNA-Pr...
RNA Processing in Cancer: From Bench to Bedside
events.faseb.org
August 12, 2025 at 9:08 PM
If you’re interested in the interplay between regulation (or mis-regulation) of RNA processing and cancer, please check out the 2025 FASEB RNA Processing in Cancer meeting Oct 5-9 2025 in Sacramento CA!
events.faseb.org/event/RNA-Pr...
events.faseb.org/event/RNA-Pr...
From our lab, Joey will be presenting her snoRNA work in Concurrent session 5 (5/28 afternoon), and Maureen & Jen-Yun have posters on Wed evening
Also check out talks from other THINC RNA folks @amustoe.bsky.social lab (sessions 6 and 13) and Fazal lab (session 14)!
Also check out talks from other THINC RNA folks @amustoe.bsky.social lab (sessions 6 and 13) and Fazal lab (session 14)!
May 27, 2025 at 7:39 PM
From our lab, Joey will be presenting her snoRNA work in Concurrent session 5 (5/28 afternoon), and Maureen & Jen-Yun have posters on Wed evening
Also check out talks from other THINC RNA folks @amustoe.bsky.social lab (sessions 6 and 13) and Fazal lab (session 14)!
Also check out talks from other THINC RNA folks @amustoe.bsky.social lab (sessions 6 and 13) and Fazal lab (session 14)!
Looking forward to seeing everyone at the @rnasociety.bsky.social meeting!
May 27, 2025 at 7:37 PM
Looking forward to seeing everyone at the @rnasociety.bsky.social meeting!
Happy to say our paper with the Whipple lab on snoRNA target profiling with chimeric eCLIP is now out! Great work by co-first authors Joey & Min with the help of a bunch of other folks!
genomebiology.biomedcentral.com/articles/10....
genomebiology.biomedcentral.com/articles/10....
Mapping snoRNA-target RNA interactions in an RNA-binding protein-dependent manner with chimeric eCLIP - Genome Biology
Background Small nucleolar RNAs (snoRNAs) are non-coding RNAs that function in ribosome and spliceosome biogenesis, primarily by guiding modifying enzymes to specific sites on ribosomal RNA (rRNA) and...
genomebiology.biomedcentral.com
February 25, 2025 at 6:17 PM
Happy to say our paper with the Whipple lab on snoRNA target profiling with chimeric eCLIP is now out! Great work by co-first authors Joey & Min with the help of a bunch of other folks!
genomebiology.biomedcentral.com/articles/10....
genomebiology.biomedcentral.com/articles/10....
(re-post) Happy to share that our preprint on using chimeric eCLIP to map snoRNA interactions (and find new non-canonical snoRNA:RBP subnetworks) is now up! A fun co-collaboration with the great @LabWhipple lab, and great work by Joey, Min, and others!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Mapping snoRNA-target RNA interactions in an RNA binding protein-dependent manner with chimeric eCLIP
Small nucleolar RNAs (snoRNAs) are non-coding RNAs that function in ribosome and spliceosome biogenesis, primarily by guiding modifying enzymes to specific sites on ribosomal RNA (rRNA) and spliceosom...
www.biorxiv.org
November 10, 2024 at 4:46 AM
(re-post) Happy to share that our preprint on using chimeric eCLIP to map snoRNA interactions (and find new non-canonical snoRNA:RBP subnetworks) is now up! A fun co-collaboration with the great @LabWhipple lab, and great work by Joey, Min, and others!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Good to be here!
November 10, 2024 at 4:45 AM
Good to be here!