Liz Tseng
@magdoll.bsky.social
Product manager @PacBio / RNA / bioinformatics / aerialist & pole dancer / opinions are my own and do not reflect views of my employer
PangyPlot: a new #bioinformatics tools for visualizing pangenomes that supports linear coordinates and large graphs. Applied to @pacbio.bsky.social HiFi genomes to visualize two cystic fibrosis-relevant region not possible to resolve with short read genomes. www.biorxiv.org/content/10.1...
November 10, 2025 at 6:33 PM
PangyPlot: a new #bioinformatics tools for visualizing pangenomes that supports linear coordinates and large graphs. Applied to @pacbio.bsky.social HiFi genomes to visualize two cystic fibrosis-relevant region not possible to resolve with short read genomes. www.biorxiv.org/content/10.1...
How does @pacbio.bsky.social long-read RNA-Seq help explain response difference through RNA splicing regulation in immunotherapy? Check out the Dec webinar with @olgaanczukow.bsky.social and Ryan Englander and I! www.the-scientist.com/long-read-rn...
Long-Read RNA Sequencing Reveals a Regulatory Role for Splicing in Immunotherapy Responses
Olga Anczukow and Ryan Englander discuss how transcriptome splicing affects immune system function in lung cancer.
www.the-scientist.com
November 6, 2025 at 9:35 PM
How does @pacbio.bsky.social long-read RNA-Seq help explain response difference through RNA splicing regulation in immunotherapy? Check out the Dec webinar with @olgaanczukow.bsky.social and Ryan Englander and I! www.the-scientist.com/long-read-rn...
New @pacbio.bsky.social #bioinformatics spotlight video is up! SQANTI-QC: a multi-sample long-read RNA-Seq QC tool! Demo included. Check it out and give it a try! www.youtube.com/watch?v=83XL...
Using SQANTI-reads for long-read RNA-Seq quality control
YouTube video by PacBio
www.youtube.com
November 5, 2025 at 9:33 PM
New @pacbio.bsky.social #bioinformatics spotlight video is up! SQANTI-QC: a multi-sample long-read RNA-Seq QC tool! Demo included. Check it out and give it a try! www.youtube.com/watch?v=83XL...
Reposted by Liz Tseng
A new multi-center study from the EMEA HiFi Solves Consortium shows the clinical research potential of HiFi. Combined with our latest informatics pipeline, HiFi identified 100% of clinically relevant variants across 11 complex regions, including those short reads missed.
👉 bit.ly/4oqMWCY
👉 bit.ly/4oqMWCY
November 5, 2025 at 4:40 PM
A new multi-center study from the EMEA HiFi Solves Consortium shows the clinical research potential of HiFi. Combined with our latest informatics pipeline, HiFi identified 100% of clinically relevant variants across 11 complex regions, including those short reads missed.
👉 bit.ly/4oqMWCY
👉 bit.ly/4oqMWCY
Wonder how @pacbio.bsky.social long read sequencing is transforming how clinical and translational labs approach genomics? Hear from panelists from Myriad Genetics, GeneDx, Karolina and Radboudumc discuss rare disease testing, carrier screening, and more! programs.pacb.com/l/1652/2025-...
October 27, 2025 at 11:58 PM
Wonder how @pacbio.bsky.social long read sequencing is transforming how clinical and translational labs approach genomics? Hear from panelists from Myriad Genetics, GeneDx, Karolina and Radboudumc discuss rare disease testing, carrier screening, and more! programs.pacb.com/l/1652/2025-...
Want a rare look inside @pacbio.bsky.social facility and hear how customers use HiFi for HLA typing and PGx? We made a 6-min documentary this summer. Check it out! www.youtube.com/watch?si=nXb...
Advancing human health with HiFi long-read sequencing
YouTube video by PacBio
www.youtube.com
October 23, 2025 at 4:15 PM
Want a rare look inside @pacbio.bsky.social facility and hear how customers use HiFi for HLA typing and PGx? We made a 6-min documentary this summer. Check it out! www.youtube.com/watch?si=nXb...
Reposted by Liz Tseng
Just published an interactive article about a magical algorithm known as the Burrows-Wheeler Transform, which powers sequence alignment tools like bowtie and bwa: sandbox.bio/concepts/bwt
It's also notoriously unintuitive so I'm hoping this article helps you build that intuition.
It's also notoriously unintuitive so I'm hoping this article helps you build that intuition.
October 9, 2025 at 5:05 PM
Just published an interactive article about a magical algorithm known as the Burrows-Wheeler Transform, which powers sequence alignment tools like bowtie and bwa: sandbox.bio/concepts/bwt
It's also notoriously unintuitive so I'm hoping this article helps you build that intuition.
It's also notoriously unintuitive so I'm hoping this article helps you build that intuition.
How does @pacbio.bsky.social long-read sequencing and AI interact to assess AAV genome integrity? Find out at this Catalent webinar on 10/29! event.on24.com/wcc/r/509468...
Integrating DNA Sequencing and AI for AAV Genome Integrity
Wednesday, October 29, 2025 at 2:00 PM Eastern Daylight Time.
event.on24.com
October 9, 2025 at 10:24 PM
How does @pacbio.bsky.social long-read sequencing and AI interact to assess AAV genome integrity? Find out at this Catalent webinar on 10/29! event.on24.com/wcc/r/509468...
Why it's good to incorporate @pacbio.bsky.social long-read bacterial WGS into routine hospital surveillance for AMR tracking: 540 multidrug-resistant Gram-negative bacterial genomes revealed extensive and previously missed plasmid-mediated transmission events. journals.asm.org/doi/10.1128/...
The dark matter of bacterial genomic surveillance—antimicrobial resistance plasmid transmissions in the hospital setting | Journal of Clinical Microbiology
Antimicrobial resistance (AMR) poses a significant threat to human health. Most AMR
determinants are encoded extra-chromosomally on plasmids. Although current infection
control strategies primarily fo...
journals.asm.org
October 6, 2025 at 6:12 PM
Why it's good to incorporate @pacbio.bsky.social long-read bacterial WGS into routine hospital surveillance for AMR tracking: 540 multidrug-resistant Gram-negative bacterial genomes revealed extensive and previously missed plasmid-mediated transmission events. journals.asm.org/doi/10.1128/...
Unlock the power of #PacBio HiFi whole genome sequencing in our 4-part video series.
Learn from PacBio scientists as they walk through tools and examples for variant calling, tandem repeat analysis, paralogous gene resolution, and star (*)-allele calling.
Sign up: bit.ly/3HV8Fmh
Learn from PacBio scientists as they walk through tools and examples for variant calling, tandem repeat analysis, paralogous gene resolution, and star (*)-allele calling.
Sign up: bit.ly/3HV8Fmh
September 15, 2025 at 8:40 PM
How do you prep 1,000 @pacbio.bsky.social Kinnex bulk RNA-Seq samples consistently? With @sptlabtech.bsky.social Firefly for automation! Join this @selectscience.bsky.social webinar next week to hear about it! www.selectscience.net/webinar/auto...
Automating large-scale isoform discovery at Seattle Children’s Genomics and Spatial Biology CoLab
Join Rebecca Martin, PhD, Scientific Lead of the Genomics and Spatial Biology CoLab at Seattle Children’s Research Institute, for an in-depth webinar on how automation is transforming long-read transc...
www.selectscience.net
September 15, 2025 at 3:53 PM
How do you prep 1,000 @pacbio.bsky.social Kinnex bulk RNA-Seq samples consistently? With @sptlabtech.bsky.social Firefly for automation! Join this @selectscience.bsky.social webinar next week to hear about it! www.selectscience.net/webinar/auto...
Reposted by Liz Tseng
The human #microbiome holds enormous potential, but only if we can see it clearly.
Join this webinar to learn how #PacBio HiFi sequencing delivers accurate, high-resolution insights with 16S rRNA sequencing and shotgun metagenomics.
Secure your spot: bit.ly/4mYmK1G
Join this webinar to learn how #PacBio HiFi sequencing delivers accurate, high-resolution insights with 16S rRNA sequencing and shotgun metagenomics.
Secure your spot: bit.ly/4mYmK1G
September 8, 2025 at 7:34 PM
The human #microbiome holds enormous potential, but only if we can see it clearly.
Join this webinar to learn how #PacBio HiFi sequencing delivers accurate, high-resolution insights with 16S rRNA sequencing and shotgun metagenomics.
Secure your spot: bit.ly/4mYmK1G
Join this webinar to learn how #PacBio HiFi sequencing delivers accurate, high-resolution insights with 16S rRNA sequencing and shotgun metagenomics.
Secure your spot: bit.ly/4mYmK1G
If DNA sequencing technologies had dating profiles 😜🧪
🚩 Short reads for big SVs
🚩 Long reads with tradeoffs
🟢 Tech with large variant detection, haplotyping, epigenetics + exceptional accuracy.
See how to get green flags from the start...There's HiFi for That: bit.ly/3JminPa
#PacBio #ScienceHumor #TheresHiFiForThat #HiFisequencing
🚩 Long reads with tradeoffs
🟢 Tech with large variant detection, haplotyping, epigenetics + exceptional accuracy.
See how to get green flags from the start...There's HiFi for That: bit.ly/3JminPa
#PacBio #ScienceHumor #TheresHiFiForThat #HiFisequencing
August 20, 2025 at 8:27 PM
If DNA sequencing technologies had dating profiles 😜🧪
Learn from about @pacbio.bsky.social HiFi and then have a chance to WIN some!
Too many tabs.
Password resets.
47 unread notifications before 9 a.m.
Some struggles are inevitable. The ones in your lab? You can fix those with #PacBio.
#TheresHiFiForThat launches today with free tools, guides, and a shot at a 2026 genomics conference.
🔗Join in: bit.ly/3JminPa
Password resets.
47 unread notifications before 9 a.m.
Some struggles are inevitable. The ones in your lab? You can fix those with #PacBio.
#TheresHiFiForThat launches today with free tools, guides, and a shot at a 2026 genomics conference.
🔗Join in: bit.ly/3JminPa
August 19, 2025 at 7:30 PM
Learn from about @pacbio.bsky.social HiFi and then have a chance to WIN some!
Rarely do I get this excited about a @pacbio.bsky.social Iso-Seq study! 🧠 Come hear how the Tripathy lab used long-read multiomics to study neuron development—finding new isoforms suggesting some non-coding ASD variants may disrupt splicing & protein function. programs.pacb.com/l/1652/2025-...
August 14, 2025 at 5:42 PM
Rarely do I get this excited about a @pacbio.bsky.social Iso-Seq study! 🧠 Come hear how the Tripathy lab used long-read multiomics to study neuron development—finding new isoforms suggesting some non-coding ASD variants may disrupt splicing & protein function. programs.pacb.com/l/1652/2025-...
AI saves elephants from being hit by trains in India. You can use AI for good! 🐘💫 timesofindia.indiatimes.com/india/ai-sav...
AI saves elephants: 6,592 safe elephant crossings on Tamil Nadu railway tracks; no fatalities in nine months | India News - Times of India
India News: Tamil Nadu Forest Department has successfully implemented an AI-powered early warning system to protect elephants crossing railway tracks in Madukkara.
timesofindia.indiatimes.com
August 13, 2025 at 7:13 PM
AI saves elephants from being hit by trains in India. You can use AI for good! 🐘💫 timesofindia.indiatimes.com/india/ai-sav...
Just released @pacbio.bsky.social Kinnex-10x GEM-X single cell data for both Revio and Vega! Go check out the updated app note and dataset URL!
App note: www.pacb.com/wp-content/u...
Dataset: downloads.pacbcloud.com/public/datas...
App note: www.pacb.com/wp-content/u...
Dataset: downloads.pacbcloud.com/public/datas...
www.pacb.com
August 7, 2025 at 4:54 PM
Just released @pacbio.bsky.social Kinnex-10x GEM-X single cell data for both Revio and Vega! Go check out the updated app note and dataset URL!
App note: www.pacb.com/wp-content/u...
Dataset: downloads.pacbcloud.com/public/datas...
App note: www.pacb.com/wp-content/u...
Dataset: downloads.pacbcloud.com/public/datas...
Reposted by Liz Tseng
Project JAGUAR, led by the @sangerinstitute.bsky.social and Latin American researchers, aims to build the first immune cell atlas representing Latin American populations—addressing equity and ancestry in genomics.
#PacBio is proud to support with #HiFiSequencing.
Read the blog: bit.ly/4l63Kwz
#PacBio is proud to support with #HiFiSequencing.
Read the blog: bit.ly/4l63Kwz
Making genomics data more representative through Latin American research - Wellcome Sanger Institute Blog
Genomic research is lacking representative data, which limits our ability to understand diseases and develop treatments. To fix this, we need to prioritise local leadership, capacity building, and equ...
bit.ly
July 28, 2025 at 6:17 PM
Project JAGUAR, led by the @sangerinstitute.bsky.social and Latin American researchers, aims to build the first immune cell atlas representing Latin American populations—addressing equity and ancestry in genomics.
#PacBio is proud to support with #HiFiSequencing.
Read the blog: bit.ly/4l63Kwz
#PacBio is proud to support with #HiFiSequencing.
Read the blog: bit.ly/4l63Kwz
Reposted by Liz Tseng
#PacBio is contributing Iso-Seq data to the 1000 Genomes Long Read Sequencing Project using #Kinnex kits and the #Revio system.
This data from 1,000 globally diverse samples will help advance transcript-level insights across populations.
Press release here: bit.ly/4mdzHEe
This data from 1,000 globally diverse samples will help advance transcript-level insights across populations.
Press release here: bit.ly/4mdzHEe
July 23, 2025 at 3:01 PM
#PacBio is contributing Iso-Seq data to the 1000 Genomes Long Read Sequencing Project using #Kinnex kits and the #Revio system.
This data from 1,000 globally diverse samples will help advance transcript-level insights across populations.
Press release here: bit.ly/4mdzHEe
This data from 1,000 globally diverse samples will help advance transcript-level insights across populations.
Press release here: bit.ly/4mdzHEe
A once-in-a-decade bloom of Chanel the corpse flower (Amorphophallus Titanum) at the San Francisco Conservatory of Flowers and I caught the very tail end of its 48 hour blooming span! 🌸🌸🌷🌷
July 10, 2025 at 5:36 PM
A once-in-a-decade bloom of Chanel the corpse flower (Amorphophallus Titanum) at the San Francisco Conservatory of Flowers and I caught the very tail end of its 48 hour blooming span! 🌸🌸🌷🌷
Learn from the best @pacbio.bsky.social users on their tips and tricks! (fun fact: I interviewed Lutz but I'm behind the camera so you won't see me ;>)
Straight talk from one of the most experienced core lab leads in the game.
See why he thinks PacBio long-reads with SPRQ chemistry are the way to go → bit.ly/4lddmpC
#PacBio #HiFisequencing #PacBioSPRQ
See why he thinks PacBio long-reads with SPRQ chemistry are the way to go → bit.ly/4lddmpC
#PacBio #HiFisequencing #PacBioSPRQ
June 23, 2025 at 9:36 PM
Learn from the best @pacbio.bsky.social users on their tips and tricks! (fun fact: I interviewed Lutz but I'm behind the camera so you won't see me ;>)
Reposted by Liz Tseng
Spotlight on the gut-brain axis
A rapid expansion of new discoveries and knowledge lays the foundation for a new era in medicine
erictopol.substack.com/p/the-gut-br...
A rapid expansion of new discoveries and knowledge lays the foundation for a new era in medicine
erictopol.substack.com/p/the-gut-br...
The Gut-Brain Axis Takes Center Stage
A rapid expansion of new discoveries and knowledge lays the foundation for a new era in medicine
erictopol.substack.com
June 22, 2025 at 5:09 PM
Spotlight on the gut-brain axis
A rapid expansion of new discoveries and knowledge lays the foundation for a new era in medicine
erictopol.substack.com/p/the-gut-br...
A rapid expansion of new discoveries and knowledge lays the foundation for a new era in medicine
erictopol.substack.com/p/the-gut-br...
Deepest long-read RNA-Seq dataset for one single cell line, multiple time points + replicates using @pacbio.bsky.social Kinnex RNA kit! Wissel et al. show that Kinnex can be used for isoform quantitative analyses: www.biorxiv.org/content/10.1...
www.biorxiv.org
June 12, 2025 at 10:15 PM
Deepest long-read RNA-Seq dataset for one single cell line, multiple time points + replicates using @pacbio.bsky.social Kinnex RNA kit! Wissel et al. show that Kinnex can be used for isoform quantitative analyses: www.biorxiv.org/content/10.1...
Really loving this live demo of our @pacbio.bsky.social Vega benchtop sequencer by the one-and-only Sterling Maurer. Vega is so simple...probably I can do it (but I shouldn't XD)
www.youtube.com/watch?v=wK90...
www.youtube.com/watch?v=wK90...
PacBio Vega: Benchtop HiFi Sequencer Demo (ASHG 2024)
YouTube video by PacBio
www.youtube.com
June 10, 2025 at 2:03 AM
Really loving this live demo of our @pacbio.bsky.social Vega benchtop sequencer by the one-and-only Sterling Maurer. Vega is so simple...probably I can do it (but I shouldn't XD)
www.youtube.com/watch?v=wK90...
www.youtube.com/watch?v=wK90...
If you're in the San Francisco bay area and is a 10x single-cell/spatial user, @pacbio.bsky.social will be at the UCSF Gladstone 10x Symposium next week! I'll be there too! Come learn how to power up your 10x data with long reads! tinyurl.com/2mev7pj6
UCSF and Gladstone Institutes Single Cell and Spatial Discovery Symposium
tinyurl.com
June 5, 2025 at 5:53 PM
If you're in the San Francisco bay area and is a 10x single-cell/spatial user, @pacbio.bsky.social will be at the UCSF Gladstone 10x Symposium next week! I'll be there too! Come learn how to power up your 10x data with long reads! tinyurl.com/2mev7pj6