Daniel MK Lee
@dannimklee.bsky.social
Postdoc in Max Planck Institute for Molecular Genetics.
PhD alumnus in Institut Curie.
Epigenetics, dev bio, transcriptional regulation
PhD alumnus in Institut Curie.
Epigenetics, dev bio, transcriptional regulation
Reposted by Daniel MK Lee
Happy to see Atsuhiro Taguchi's work on genes involved in liver zonation published in Dev @cellpress.bsky.social. Kudos to all authors at @molgen.mpg.de #MeissnerLab #HniszLab. Grateful for the opportunity to help!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Single-cell activation screen identifies hepatic maturation regulators with zonal resolution
The maturation of lineage-committed embryonic hepatocytes requires both the timed activation of metabolic gene regulatory networks (GRNs) and silencin…
www.sciencedirect.com
November 21, 2025 at 10:45 AM
Happy to see Atsuhiro Taguchi's work on genes involved in liver zonation published in Dev @cellpress.bsky.social. Kudos to all authors at @molgen.mpg.de #MeissnerLab #HniszLab. Grateful for the opportunity to help!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Daniel MK Lee
IMPRS-BAC Open Call: Current IMPRS student Marcel Wittmund talks about what pursuing a PhD means to him and how the IMPRS program supports his doctoral studies at the MPIMG.
Apply by Jan 7th, 2026! www.molgen.mpg.de/IMPRSPhDproj...
#IMPRSBAC @freieuniversitaet.bsky.social @maxplanck.de
Apply by Jan 7th, 2026! www.molgen.mpg.de/IMPRSPhDproj...
#IMPRSBAC @freieuniversitaet.bsky.social @maxplanck.de
October 23, 2025 at 3:00 PM
IMPRS-BAC Open Call: Current IMPRS student Marcel Wittmund talks about what pursuing a PhD means to him and how the IMPRS program supports his doctoral studies at the MPIMG.
Apply by Jan 7th, 2026! www.molgen.mpg.de/IMPRSPhDproj...
#IMPRSBAC @freieuniversitaet.bsky.social @maxplanck.de
Apply by Jan 7th, 2026! www.molgen.mpg.de/IMPRSPhDproj...
#IMPRSBAC @freieuniversitaet.bsky.social @maxplanck.de
Reposted by Daniel MK Lee
My lab is seeking two PhD candidates to investigate the function and regulation of endogenous retroviruses in the early stages of human development 🦠👩🔬. Apply through the International Max Planck Research School (IMPRS) program: www.molgen.mpg.de/IMPRS/applic.... www.molgen.mpg.de/5094682/Fuey...
[2026] – Endogenous retroviruses in human embryogenesis
www.molgen.mpg.de
October 23, 2025 at 8:31 PM
My lab is seeking two PhD candidates to investigate the function and regulation of endogenous retroviruses in the early stages of human development 🦠👩🔬. Apply through the International Max Planck Research School (IMPRS) program: www.molgen.mpg.de/IMPRS/applic.... www.molgen.mpg.de/5094682/Fuey...
Reposted by Daniel MK Lee
Genes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...
HDAC3 prevents enhancer hyperactivation to enable developmental transitions
Dynamic gene regulation requires precise cooperation between transcription factors and chromatin modifiers at regulatory elements to achieve not only activation or repression, but also appropriate tra...
www.biorxiv.org
September 18, 2025 at 9:55 AM
Genes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...
Reposted by Daniel MK Lee
Excited for a major milestone in our efforts to map enhancers and interpret variants in the human genome:
The E2G Portal! e2g.stanford.edu
This collates our predictions of enhancer-gene regulatory interactions across >1,600 cell types and tissues.
Uses cases 👇
1/
The E2G Portal! e2g.stanford.edu
This collates our predictions of enhancer-gene regulatory interactions across >1,600 cell types and tissues.
Uses cases 👇
1/
September 18, 2025 at 4:14 PM
Excited for a major milestone in our efforts to map enhancers and interpret variants in the human genome:
The E2G Portal! e2g.stanford.edu
This collates our predictions of enhancer-gene regulatory interactions across >1,600 cell types and tissues.
Uses cases 👇
1/
The E2G Portal! e2g.stanford.edu
This collates our predictions of enhancer-gene regulatory interactions across >1,600 cell types and tissues.
Uses cases 👇
1/
Congratulations @julianeg.bsky.social ! Very happy for your grant and looking forward to seeing more cool stuff from your lab!
🥳 Very grateful for the support of the ERC Starting Grant for my newly established lab! We will study how transposable elements contribute to mammalian embryonic development.
We will have positions available next year. Stay tuned!
We will have positions available next year. Stay tuned!
📣 The ERC Starting Grant call results are out!
Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!
➡️ buff.ly/IsafuFh
#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!
➡️ buff.ly/IsafuFh
#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
September 8, 2025 at 8:45 AM
Congratulations @julianeg.bsky.social ! Very happy for your grant and looking forward to seeing more cool stuff from your lab!
During Cassandra Extavour's visit to the MPIMG, I was honored to chair a session discussing how we can collectively improve diversity and inclusion in science.
As a next generation of scientist, it was truly inspiring and empowering.
Kudos to all the organizers that make it happen!
As a next generation of scientist, it was truly inspiring and empowering.
Kudos to all the organizers that make it happen!
At our #DahlemColloquium Postdoc Daniel Ming-Kang Lee spoke with Cassandra Extavour from Harvard University about her scientific journey, inclusion in academia, and how her second career as a part-time soprano singer shapes her scientific work.
Interview 👉 www.molgen.mpg.de/news-2025-me...
Interview 👉 www.molgen.mpg.de/news-2025-me...
June 18, 2025 at 4:04 PM
During Cassandra Extavour's visit to the MPIMG, I was honored to chair a session discussing how we can collectively improve diversity and inclusion in science.
As a next generation of scientist, it was truly inspiring and empowering.
Kudos to all the organizers that make it happen!
As a next generation of scientist, it was truly inspiring and empowering.
Kudos to all the organizers that make it happen!
Reposted by Daniel MK Lee
What controls condensate composition and function beyond binding stoichiometry? We show that condensate microenvironments play a key role, and can be probed by a micropeptide killswitch in live cells. www.nature.com/articles/s41... in @nature.com with @yaotianzhang.bsky.social Denes Hnisz & team.
www.nature.com
June 4, 2025 at 3:29 PM
What controls condensate composition and function beyond binding stoichiometry? We show that condensate microenvironments play a key role, and can be probed by a micropeptide killswitch in live cells. www.nature.com/articles/s41... in @nature.com with @yaotianzhang.bsky.social Denes Hnisz & team.
Reposted by Daniel MK Lee
Delighted to share a new preprint from the lab!
We identified zinc-finger associated domain (ZAD)-containing C2H2 zinc-finger proteins (ZAD-ZnFs) as insulator-binding proteins in Drosophila.
www.biorxiv.org/content/10.1...
We identified zinc-finger associated domain (ZAD)-containing C2H2 zinc-finger proteins (ZAD-ZnFs) as insulator-binding proteins in Drosophila.
www.biorxiv.org/content/10.1...
May 22, 2025 at 12:30 AM
Delighted to share a new preprint from the lab!
We identified zinc-finger associated domain (ZAD)-containing C2H2 zinc-finger proteins (ZAD-ZnFs) as insulator-binding proteins in Drosophila.
www.biorxiv.org/content/10.1...
We identified zinc-finger associated domain (ZAD)-containing C2H2 zinc-finger proteins (ZAD-ZnFs) as insulator-binding proteins in Drosophila.
www.biorxiv.org/content/10.1...
Reposted by Daniel MK Lee
Check out this 🧵 from @eimearlagan.bsky.social on our new Molecular Cell @cp-molcell.bsky.social paper! We show how the H3K27M Oncohistone reprograms chromatin in DMG, creating a specific dependency on CBX4/PCGF4-containing forms of cPRC1 👇
Excited to share our new paper out today in @cp-molcell.bsky.social! We show that the H3K27M oncohistone rewires cPRC1, creating a unique dependency on CBX4/PCGF4-containing complexes, and also reveal a previously unknown function of CBX4. Highlights below (1/11).
May 21, 2025 at 5:22 PM
Check out this 🧵 from @eimearlagan.bsky.social on our new Molecular Cell @cp-molcell.bsky.social paper! We show how the H3K27M Oncohistone reprograms chromatin in DMG, creating a specific dependency on CBX4/PCGF4-containing forms of cPRC1 👇
Reposted by Daniel MK Lee
Out @nature.com: Clonal tracing with somatic epimutations
🧬 Single cell methylome encodes cell state & clonal identity
🔨 EPI-Clone reads out both (+mutations, +RNA) at scale
🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations
doi.org/10.1038/s415...
🧵
🧬 Single cell methylome encodes cell state & clonal identity
🔨 EPI-Clone reads out both (+mutations, +RNA) at scale
🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations
doi.org/10.1038/s415...
🧵
Clonal tracing with somatic epimutations reveals dynamics of blood ageing - Nature
The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing th...
doi.org
May 21, 2025 at 3:44 PM
Out @nature.com: Clonal tracing with somatic epimutations
🧬 Single cell methylome encodes cell state & clonal identity
🔨 EPI-Clone reads out both (+mutations, +RNA) at scale
🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations
doi.org/10.1038/s415...
🧵
🧬 Single cell methylome encodes cell state & clonal identity
🔨 EPI-Clone reads out both (+mutations, +RNA) at scale
🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations
doi.org/10.1038/s415...
🧵
Reposted by Daniel MK Lee
Excited to share a preprint from my lab on distinct specificity and functions of PRC2 subcomplexes: www.biorxiv.org/content/10.1...
Macromolecular interactions dictate Polycomb-mediated epigenetic repression
The dynamic regulation of epigenetic states relies on complex macromolecular interactions. PRC2, the methyltransferase complex responsible for depositing H3K27me3, interacts with distinct accessory pr...
www.biorxiv.org
May 16, 2025 at 5:33 PM
Excited to share a preprint from my lab on distinct specificity and functions of PRC2 subcomplexes: www.biorxiv.org/content/10.1...
Reposted by Daniel MK Lee
I am thrilled to share our preprint where we take advantage of the unique opportunities offered by human blastoids to uncover a human-specific mechanism potentially playing a role in preimplantation 🧵. www.biorxiv.org/content/10.1...
May 12, 2025 at 8:25 PM
I am thrilled to share our preprint where we take advantage of the unique opportunities offered by human blastoids to uncover a human-specific mechanism potentially playing a role in preimplantation 🧵. www.biorxiv.org/content/10.1...
Congrats to the very talented @oozguc.bsky.social 🔬
The Node-FocalPlane image competition at #biologists100.
All the votes are now in, and we can announce our three prize winners: @oozguc.bsky.social, @allancarbal.bsky.social and @jupeloggia.bsky.social.
Read more ⤵️: focalplane.biologists.com/2025/03/27/a...
All the votes are now in, and we can announce our three prize winners: @oozguc.bsky.social, @allancarbal.bsky.social and @jupeloggia.bsky.social.
Read more ⤵️: focalplane.biologists.com/2025/03/27/a...
Announcing the winners of the Node–FocalPlane image competition. - FocalPlane
Announcing the winners of the Node–FocalPlane image competition. - News
focalplane.biologists.com
March 27, 2025 at 4:48 PM
Congrats to the very talented @oozguc.bsky.social 🔬
Reposted by Daniel MK Lee
Happy to share the lab's latest publication from @eli-elder.bsky.social and team in @narjournal.bsky.social ! What happens when #DNAmethylation maintenance is transiently interrupted in mouse embryonic stem cells? Let's dive in (1/11). doi.org/10.1093/nar/...
Rescuing DNMT1 fails to fully reverse the molecular and functional repercussions of its loss in mouse embryonic stem cells
Abstract. Epigenetic mechanisms are crucial for developmental programming and can be disrupted by environmental stressors, increasing susceptibility to dis
doi.org
February 27, 2025 at 5:21 PM
Happy to share the lab's latest publication from @eli-elder.bsky.social and team in @narjournal.bsky.social ! What happens when #DNAmethylation maintenance is transiently interrupted in mouse embryonic stem cells? Let's dive in (1/11). doi.org/10.1093/nar/...
Reposted by Daniel MK Lee
1/ H3K27me3 mimicry has repeatedly emerged through evolution, but what's the physiological relevance?
We show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2 in vivo and restrict the spread of Polycomb domains.
🧵
www.biorxiv.org/content/10.1...
We show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2 in vivo and restrict the spread of Polycomb domains.
🧵
www.biorxiv.org/content/10.1...
March 15, 2025 at 12:12 AM
1/ H3K27me3 mimicry has repeatedly emerged through evolution, but what's the physiological relevance?
We show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2 in vivo and restrict the spread of Polycomb domains.
🧵
www.biorxiv.org/content/10.1...
We show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2 in vivo and restrict the spread of Polycomb domains.
🧵
www.biorxiv.org/content/10.1...
Very happy that I attended the amazing SY-Stem symposium. I received so many nice feedback on my project and good to have another Curie BDD reunion.
@deborahbourchis.bsky.social
@dianapinheiro.bsky.social
@deborahbourchis.bsky.social
@dianapinheiro.bsky.social
March 15, 2025 at 9:06 AM
Very happy that I attended the amazing SY-Stem symposium. I received so many nice feedback on my project and good to have another Curie BDD reunion.
@deborahbourchis.bsky.social
@dianapinheiro.bsky.social
@deborahbourchis.bsky.social
@dianapinheiro.bsky.social
Reposted by Daniel MK Lee
The Institut Pasteur has decided to leave X (formerly Twitter) to join BlueSky! 🦋
The Institut Pasteur made this decision due to several serious issues observed on the X platform since its acquisition. Join us here to continue advocating for science. www.pasteur.fr/en/home/pres...
The Institut Pasteur made this decision due to several serious issues observed on the X platform since its acquisition. Join us here to continue advocating for science. www.pasteur.fr/en/home/pres...
Institut Pasteur decides to leave X
The Institut Pasteur, a research organization which for more than 130 years has been committed to tackling infectious diseases, sharing knowledge and defending science, has decided to leave X because ...
www.pasteur.fr
January 16, 2025 at 9:18 AM
The Institut Pasteur has decided to leave X (formerly Twitter) to join BlueSky! 🦋
The Institut Pasteur made this decision due to several serious issues observed on the X platform since its acquisition. Join us here to continue advocating for science. www.pasteur.fr/en/home/pres...
The Institut Pasteur made this decision due to several serious issues observed on the X platform since its acquisition. Join us here to continue advocating for science. www.pasteur.fr/en/home/pres...
Reposted by Daniel MK Lee
Come to be our colleague @pasteur.fr! center of Paris, great colleagues, outstanding facilities, permanent position, crème brûlée every Friday - what else could one want?
December 7, 2024 at 9:43 AM
Come to be our colleague @pasteur.fr! center of Paris, great colleagues, outstanding facilities, permanent position, crème brûlée every Friday - what else could one want?
Reposted by Daniel MK Lee
🔺🔺🔺RED TRIANGLE ALERT 🔺🔺🔺
Ever wonder how #TADs compare across the tree of life?Look no further & read our Review!!!
Find out what genes & 3D chromatin can & can't do in Bacteria! Archeae! Yeast! Plants! Animals!
SMCs & RNA-Pol are the only thing they have in common
www.nature.com/articles/s41...
Ever wonder how #TADs compare across the tree of life?Look no further & read our Review!!!
Find out what genes & 3D chromatin can & can't do in Bacteria! Archeae! Yeast! Plants! Animals!
SMCs & RNA-Pol are the only thing they have in common
www.nature.com/articles/s41...
Evolution and function of chromatin domains across the tree of life - Nature Structural & Molecular Biology
Szalay et al. discuss cross-kingdom similarities and differences in 3D chromatin folding in relation to gene regulation, including in bacteria, archaea, mammals and plants. This comparison reveals cer...
www.nature.com
November 28, 2024 at 12:48 PM
🔺🔺🔺RED TRIANGLE ALERT 🔺🔺🔺
Ever wonder how #TADs compare across the tree of life?Look no further & read our Review!!!
Find out what genes & 3D chromatin can & can't do in Bacteria! Archeae! Yeast! Plants! Animals!
SMCs & RNA-Pol are the only thing they have in common
www.nature.com/articles/s41...
Ever wonder how #TADs compare across the tree of life?Look no further & read our Review!!!
Find out what genes & 3D chromatin can & can't do in Bacteria! Archeae! Yeast! Plants! Animals!
SMCs & RNA-Pol are the only thing they have in common
www.nature.com/articles/s41...
Reposted by Daniel MK Lee
Here it is! Congratuations to @jesskelley.bsky.social @edimitrova.bsky.social @neilblackledge.bsky.social @aleksszczurek.bsky.social and the rest of the team (Maciej, Amy, and Hieu). This was a fab collaboration with Arminja Kettenbach. Also see a lovely complementary paper from Fei Chen's group.
Very excited that our paper describing a critical role for the PNUTS-PP1 phosphatase complex in transcription pause release is up online! This was a massive team effort with @edimitrova.bsky.social and the rest of the @robklose.bsky.social lab www.cell.com/molecular-ce... A short thread: (1/8)
The PNUTS phosphatase complex controls transcription pause release
Kelley et al. discover that the PNUTS phosphatase complex plays an essential role
in gene transcription by controlling RNA polymerase II pause release. PNUTS achieves
this through its TND, which recog...
www.cell.com
November 26, 2024 at 5:03 PM
Here it is! Congratuations to @jesskelley.bsky.social @edimitrova.bsky.social @neilblackledge.bsky.social @aleksszczurek.bsky.social and the rest of the team (Maciej, Amy, and Hieu). This was a fab collaboration with Arminja Kettenbach. Also see a lovely complementary paper from Fei Chen's group.