Juliane Glaser
julianeg.bsky.social
Juliane Glaser
@julianeg.bsky.social
Independent Group Leader at the MPI-IE passionate about mechanisms governing embryonic development with a focus on transposable elements🧬 Postdoc @MundlosLab 🇩🇪| PhD from @Bourchis lab 🇫🇷| She/her
https://www.julianeglaserlab.com/
Pinned
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics
Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...
www.nature.com
Reposted by Juliane Glaser
We're recruiting a PhD student to try and understand stress memory and gene function, using gene editing, in trees! #plantscience
PhD opening
Join a collaborative, interdisciplinary project the Excellence Cluster Future Forests @uni-freiburg.de, working on CRISPR/Cas in poplar to understand how trees cope with climate stress.
Apply here: uni-freiburg.de/en/job/00004...
@dompsfr.bsky.social @biologyunifreiburg.bsky.social
University of Freiburg
uni-freiburg.de
February 11, 2026 at 10:02 AM
Reposted by Juliane Glaser
To turn spatial data into a 3D object, check our protocol (open source, napari plug-in). @guignardlab.bsky.social @adrianobolondi.bsky.social @ibdm.bsky.social
For example, if you have spatial RNA-seq as sections, you can align them automatically to analyse directly in 3D.
bio-protocol.org/e5607
February 6, 2026 at 2:13 PM
Reposted by Juliane Glaser
During germline epigenetic reprogramming, Polycomb must be restricted in the gametes to ensure proper genome regulation in the fertilized embryo. 2 must-read papers assess what happens when Ezhip (Polycomb antagonist) is lost. They come to highly similar conclusions and should be read in tandem 1/4
February 3, 2026 at 9:35 AM
Reposted by Juliane Glaser
New preprint from the lab! We dig into the regulatory roles of TEs in the mouse placenta, with some surprising findings. Led by the awesome @smamante.bsky.social. Particular kudos to him for navigating the many twists and turns of the project.
www.biorxiv.org
February 2, 2026 at 10:25 AM
Reposted by Juliane Glaser
It is finally out! If you are interested in TE-derived CREs, and newly described, but evolutionary old KZFP-TE mechanistic modalities, read it at www.cell.com/cell-reports....
Thankful to everyone who took part in this work, namely @orpsf.bsky.social and other @trono-lab.bsky.social members. 🫀🧬✨
Tissue-specific restriction of transposon-derived regulatory elements safeguards cell-type identity
Milovanović et al. uncover a mechanism by which KZFPs restrict the activity of transposon-derived cis-regulatory elements to safeguard cardiomyocyte functionality. This work extends the classical TE-K...
www.cell.com
January 29, 2026 at 2:20 PM
Reposted by Juliane Glaser
⚠️ The final work of two former PhD students Till @tschwammle.bsky.social and Verena @verenamutzel.bsky.social is out!
➡️⬅️ They dissect how memory can arise from antisense transcription using mathematical modelling 💻, genomics 🧬 and synthetic biology ⚒️! link.springer.com/article/10.1...
Antisense transcription can induce expression memory via stable promoter repression - Genome Biology
Background The capacity of cells to retain a memory of previous signals enables acquisition of unique fates and adaptation to their environment. The underlying gene expression memory can arise from mu...
link.springer.com
January 20, 2026 at 11:02 AM
Reposted by Juliane Glaser
Would anyone out there be able to share some Mus Spretus DNA with us? 🐀🧬 Any tissue of origin, for PCR amplification of selected genomic regions. Many thanks in advance!
January 20, 2026 at 12:59 PM
Reposted by Juliane Glaser
🧬 We’re #Hiring a #Bioinformatician/ Computational Biologist!
#Single-cell genomics, #Epigenomics & #3Dgenome biology in #Zebrafish #DevBio 🐟
📍 @cabd-upo-csic.bsky.social, CABD, Seville (Spain)
🕒 Full-time, 3-year position (start March 2026)
📅 Apply by Feb 15, 2026
👉 drive.google.com/file/d/1M8rp...
Job offer 2026.pdf
drive.google.com
January 12, 2026 at 3:57 PM
Reposted by Juliane Glaser
#APPLYNOW
📣 The CIBSS Team is hiring! We are looking for someone passionate about helping early-career researchers develop their skills, qualifications and career prospects🧑🏽🔬🧬
➡️ Coordinator of Early-Career Programs and Diversity Management
🗓️Deadline: Jan 18, 2026
🔗 uni-freiburg.de/en/job/00004767/
January 12, 2026 at 8:01 AM
Reposted by Juliane Glaser
Our work on #RegulatoryTrajectories is out today in Nat. Comms: www.nature.com/articles/s41...
Led by @raquelrouco.bsky.social, this study establishes a new framework to study how enhancer landscapes act sequentially at developmental loci and are silenced to shape gene expression patterns. (1/n)
Client Challenge
www.nature.com
January 12, 2026 at 11:48 AM
🚨Application for the MPI-IE international PhD program is ongoing🚨
If you are interested in #epigenetics #genomics #cellbiology #devbio & more, apply before February 6th!
My lab will recruit a student to work on the contribution of #transposable elements in development and disease 🧬🦠
Fully-funded #PhD positions in #epigenetics, #biophysics & #metabolism, gene regulation, cell biology and more…

Are you already on track to start an exciting research career @maxplanck.de & @uni-freiburg.de?

This is your timeline. Apply by February 6th, 2026
www.ie-freiburg.mpg.de/apply-imprs-...
January 8, 2026 at 3:41 PM
Reposted by Juliane Glaser
🧬 Join our Deep Sequencing Facility! 🧬

We are looking for a Scientist as Application Specialist »Next Generation Sequencing« (m/f/div) to work with cutting-edge tech like AVITI24 & NovaSeq.

📍 Freiburg, Germany 🇩🇪
📅 Apply by Feb 2, 2026
🔗 jobs.ie-freiburg.mpg.de/jobposting/d...
December 19, 2025 at 2:02 PM
Reposted by Juliane Glaser
🎄🌟 Season’s greetings from the entire team of the Max Planck Institute of Immunobiology and Epigenetics in Freiburg … with a few impressions from our Winter Cookie Fair on December 11. ❄️

We wish you Happy Holidays and best wishes for 2026!
December 19, 2025 at 10:02 AM
Reposted by Juliane Glaser
Activator-promoter compatibility in mammals - Hcfc1 is a key and intrinsically CGI-promoter-specific co-activator that cannot activate non-CGI promoters. Lead by @nemcko.bsky.social & Kevin Sabath in collab. with @plaschkalab.bsky.social @impvienna.bsky.social www.biorxiv.org/content/10.6... (1/2)
Activator-promoter compatibility in mammals: a CpG-Island-specific co-activator directly bridges transcription factors to TFIID
Transcription from CpG island (CGI) promoters controls the expression of two-thirds of mammalian genes, yet despite their prevalence, it remains unknown whether CGI-specific co-activators with intrins...
www.biorxiv.org
December 30, 2025 at 8:02 AM
Reposted by Juliane Glaser
Our preprint "Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo" is on bioRxiv: www.biorxiv.org/content/10.6... . Amazing collaboration by @shenzhichen1999.bsky.social, Vincent Loubiere (@impvienna.bsky.social,@viennabiocenter.bsky.social),... (1/2)
Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo
Enhancers control tissue-specific gene expression across metazoans. Although deep learning has enabled enhancer prediction and design in mammalian cell lines and invertebrate systems, it remains uncle...
www.biorxiv.org
December 24, 2025 at 3:06 PM
Reposted by Juliane Glaser
Do you want to play a key role in running a cutting-edge stem cell and embryology lab at reNEW @ucph.bsky.social ? We’re hiring a Lab Manager to support our team and help with stem cell and animal work. Apply before Feb. 1st : rb.gy/d5uf17
Academic employee for Research Group, Dept. of Biomedical Sciences, reNEW
rb.gy
December 17, 2025 at 12:53 PM
Reposted by Juliane Glaser
🚨We are recruiting two PhD students 🚨

1) Quantitative & dynamic analysis of limb-regenerative signaling centers w/ @osvaldo-chara.bsky.social 📶🧮💻
🔗https://www.phd.tuebingen.mpg.de/80704/Quantitative-and-dynamic-analysis-of-limb-regenerative-signaling-center-interactions
December 17, 2025 at 7:53 AM
Reposted by Juliane Glaser
Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
Escape from X inactivation is directly modulated by Xist noncoding RNA
Nature Cell Biology - The authors show that increased Xist RNA levels can induce de novo silencing of genes that normally escape X inactivation. SPEN depletion prevents the silencing of escape...
rdcu.be
December 15, 2025 at 4:22 PM
Reposted by Juliane Glaser
New preprint from our lab: ‘Retroviral insertions contributed to the divergence of human and chimpanzee brains’. Very proud of this piece which took almost a decade to finish.

www.biorxiv.org/content/10.6...
Retroviral insertions contributed to the divergence of human and chimpanzee brains
Over the past 5 to 7 million years, humans and chimpanzees have diverged in brain size, structural complexity, and cognitive abilities despite high conservation of protein-coding genes. Notably, the e...
www.biorxiv.org
December 14, 2025 at 8:16 PM
Reposted by Juliane Glaser
Come do your PhD with @stemundi.bsky.social and me to uncover mechanisms of lncRNA function using cutting-edge techniques in vivo! 🧬 Project and application details below 👇
🧬 Are you interested in synthetic biology, CRISPR-Cas9 genome editing and cutting-edge genomics? Apply by 07.01.2026 to join Stefan Mundlos’ lab @stemundi.bsky.social at the MPIMG. #IMPRS-BAC #gradschool! @nataliabenetti.bsky.social
👉 www.molgen.mpg.de/5124667/Mund...
December 11, 2025 at 9:30 PM
Reposted by Juliane Glaser
Join us for tomorrow´s 📢 CIBSS Seminar Series

🗓 09 Dec 2025 | 12:00–13:00
👩‍🔬 @julianeg.bsky.social, (@mpi-ie.bsky.social)
🎙 Endogenous retroviruses and mouse developmental malformations
📍 Lecture Hall, Institute of Biology I, Hauptstr. 1

See more: kurzlinks.de/iplv

#CIBSS #Science #Immunobiology
December 8, 2025 at 10:19 AM
Reposted by Juliane Glaser
🎉 Our deconstructed, stem-cell–based approach to studying signaling centers and limb-development cell types is out! 🥳 So nice to see it in its final form after the preprint— and huge thanks to the community for all the enthusiasm and interest since then!
www.science.org/doi/10.1126/...
Specialized signaling centers direct cell fate and spatial organization in a mesodermal organoid model
Stem cell–derived mesodermal organoids reveal how signaling centers guide cell fate and tissue organization.
www.science.org
December 2, 2025 at 9:15 AM
Reposted by Juliane Glaser
📣We are looking for a Project Assistant to join my group at the Wallenberg Center for Molecular Medicine at Umeå University. Join us if you are interested in transposable elements, epigenetics and human brain aging. 🧠🧬 Dont hesitate to reach out with any questions! 📣
umu.varbi.com/en/what:job/...
Project Assistant
The Department of Medical and Translational Biology at the Faculty of Medicine is now seeking a project assistant for a research project related to human brain aging. The position is full-time and lim
umu.varbi.com
December 6, 2025 at 8:06 PM
Reposted by Juliane Glaser
Applications are open for @dev-journal.bsky.social 2026 Pathway to Independence (PI) programme, supporting postdocs applying for group leader positions:

Mentoring
Profile raising
Leadership training
Network building

Spread the word...

www.biologists.com/grants/devel...
Development's Pathway to Independence Programme
Our grants support and encourage the sharing of knowledge throughout the community by facilitating international collaboration, event attendance and the organisation of scientific meetings, conference...
www.biologists.com
December 3, 2025 at 6:56 AM
Reposted by Juliane Glaser
Here is a copy of last year's Twitter thread explaining our preprint - jump to (21) for the new stuff 👀

Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function

now revised and journal accepted at www.science.org/doi/10.1126/...

🧵👇
November 27, 2025 at 9:59 PM