We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease.
www.nature.com/articles/s41...

⚠️ I am really excited to share the work of Anastasios Balaskas, an excellent PhD candidate in the lab, with the wider world. Tasos made a significant advance: generating a stem cell-based embryo model that contains both posterior and anterior neural tissues of the late-stage gastrulating embryo.

This is a piece that I and @karsten-rippe.bsky.social discussing a lot, and a topic that is very close to my heart. The editors @naturerevgenet.bsky.social gave us the stage to do so, and the final version of our review is now available under this link: rdcu.be/erP1u

A short thread follows 1/n

Check out a technology feature in @nature.com by Elie Dolgin regarding our recent 'Killswitch' publication
www.nature.com/articles/d41...

Thank you for the comments and first impressions by Rick Young, Isaac Klein, @danfengcai.bsky.social @superscijew.bsky.social
@yaotianzhang.bsky.social

Nature research paper: Probing condensate microenvironments with a micropeptide killswitch

https://go.nature.com/4mMlGyc

Work is a collaboration with @matthewkraushar.bsky.social, @aktast.bsky.social and the MPIMG Service Groups FACS, microscopy, sequencing and mass spec, as well as researchers from Austria, the US and Switzerland. Link to the publication:
www.nature.com/articles/s41...

In @nature.com Yaotian Zhang and @henriniskanen.bsky.social from the Hnisz Lab discovered a micropeptide, the "Killswitch," which alters the physical state of biomolecules in condensates. This tool solidifies dynamic, liquid-like droplets, affecting their function.
--> www.molgen.mpg.de/4884827

A bottleneck for studying the biological function of biomolecular condensates is unavailability of tools to selectively probe them within living cells. @nature, researchers report one such tool, showcasing its use in various contexts including disease. www.nature.com/articles/s41...

What controls condensate composition and function beyond binding stoichiometry? We show that condensate microenvironments play a key role, and can be probed by a micropeptide killswitch in live cells. www.nature.com/articles/s41... in @nature.com ‬ with @yaotianzhang.bsky.social Denes Hnisz & team.