Serge McGraw
@sergemcgraw.bsky.social
Associate prof @UMontreal. Quebec Canada. Developmental Biologist & Epigeneticist. Mouse Embryos | Embryonic & Pluripotent Stem Cells | Cortical Organoids | Omics | NeuroDev | #DoHAD #TBRS #FASD Research.
Pinned
Serge McGraw
@sergemcgraw.bsky.social
· Feb 27
Rescuing DNMT1 fails to fully reverse the molecular and functional repercussions of its loss in mouse embryonic stem cells
Abstract. Epigenetic mechanisms are crucial for developmental programming and can be disrupted by environmental stressors, increasing susceptibility to dis
doi.org
Happy to share the lab's latest publication from @eli-elder.bsky.social and team in @narjournal.bsky.social ! What happens when #DNAmethylation maintenance is transiently interrupted in mouse embryonic stem cells? Let's dive in (1/11). doi.org/10.1093/nar/...
Reposted by Serge McGraw
Now had a chance to read through this pre-print. Interesting and unexpected findings! Increasing DNMT1 expression leads to remodelling of the methylome in mouse ES cells including gains and losses 😮 🧵 1/2
#epigenetics
#epigenetics
🚨 New preprint alert!
DNMT1 is often elevated in cancer, but its direct impact on DNA methylation regulation has been hard to isolate in tumours full of confounding processes.
Using a clean genetic system in mESCs, we asked:
What does excess DNMT1 by itself do to the methylome?
Let’s dive in 🧵
1/9
DNMT1 is often elevated in cancer, but its direct impact on DNA methylation regulation has been hard to isolate in tumours full of confounding processes.
Using a clean genetic system in mESCs, we asked:
What does excess DNMT1 by itself do to the methylome?
Let’s dive in 🧵
1/9
Mouse embryonic stem cells exhibit cancer-like DNA methylation landscapes upon DNMT1 overexpression https://www.biorxiv.org/content/10.64898/2026.01.26.701550v1
February 9, 2026 at 9:54 AM
Now had a chance to read through this pre-print. Interesting and unexpected findings! Increasing DNMT1 expression leads to remodelling of the methylome in mouse ES cells including gains and losses 😮 🧵 1/2
#epigenetics
#epigenetics
Reposted by Serge McGraw
Please share: we're hiring a new tenure-track faculty member to our Department of Genetics at Albert Einstein College of Medicine.
faculty-einstein.icims.com/jobs/17847/a...
faculty-einstein.icims.com/jobs/17847/a...
Albert Einstein College of Medicine | Medical Education | Biomedical Research
faculty-einstein.icims.com
February 5, 2026 at 10:14 PM
Please share: we're hiring a new tenure-track faculty member to our Department of Genetics at Albert Einstein College of Medicine.
faculty-einstein.icims.com/jobs/17847/a...
faculty-einstein.icims.com/jobs/17847/a...
🚨 New preprint alert!
DNMT1 is often elevated in cancer, but its direct impact on DNA methylation regulation has been hard to isolate in tumours full of confounding processes.
Using a clean genetic system in mESCs, we asked:
What does excess DNMT1 by itself do to the methylome?
Let’s dive in 🧵
1/9
DNMT1 is often elevated in cancer, but its direct impact on DNA methylation regulation has been hard to isolate in tumours full of confounding processes.
Using a clean genetic system in mESCs, we asked:
What does excess DNMT1 by itself do to the methylome?
Let’s dive in 🧵
1/9
Mouse embryonic stem cells exhibit cancer-like DNA methylation landscapes upon DNMT1 overexpression https://www.biorxiv.org/content/10.64898/2026.01.26.701550v1
February 2, 2026 at 2:24 PM
🚨 New preprint alert!
DNMT1 is often elevated in cancer, but its direct impact on DNA methylation regulation has been hard to isolate in tumours full of confounding processes.
Using a clean genetic system in mESCs, we asked:
What does excess DNMT1 by itself do to the methylome?
Let’s dive in 🧵
1/9
DNMT1 is often elevated in cancer, but its direct impact on DNA methylation regulation has been hard to isolate in tumours full of confounding processes.
Using a clean genetic system in mESCs, we asked:
What does excess DNMT1 by itself do to the methylome?
Let’s dive in 🧵
1/9
New work from the lab by @eli-elder.bsky.social !! Tread to follow shortly...
Mouse embryonic stem cells exhibit cancer-like DNA methylation landscapes upon DNMT1 overexpression https://www.biorxiv.org/content/10.64898/2026.01.26.701550v1
January 28, 2026 at 10:32 PM
New work from the lab by @eli-elder.bsky.social !! Tread to follow shortly...
The recruitment campaign is on! We’re seeking outstanding MSc, PhD, and Postdoctoral candidates to join @cra-chusj.bsky.social . If you’re passionate about epigenetics, development, and neurodevelopment, consider exploring the opportunities available in my lab.
event.fourwaves.com/campagnerecr...
event.fourwaves.com/campagnerecr...
event.fourwaves.com
October 8, 2025 at 7:47 PM
The recruitment campaign is on! We’re seeking outstanding MSc, PhD, and Postdoctoral candidates to join @cra-chusj.bsky.social . If you’re passionate about epigenetics, development, and neurodevelopment, consider exploring the opportunities available in my lab.
event.fourwaves.com/campagnerecr...
event.fourwaves.com/campagnerecr...
Reposted by Serge McGraw
My Canadian university, Queen's, is offering TWENTY 4-year funded PhDs (40k CAD/yr) for a student of ANY citizenship who has been accepted at a top 100 US university but have had offer rescinded OR are reconsidering offer due to US policy.
Details found here👇
www.queensu.ca/grad-postdoc...
Details found here👇
www.queensu.ca/grad-postdoc...
Queen’s Special U.S. Doctoral Recruitment Initiative | School of Graduate Studies and Postdoctoral AffairsDown arrowDown arrowDown arrowDown arrowDown arrowDown arrowDown arrowDown arrowDown arrowDown...
Queen’s University is a globally engaged, research-intensive institution dedicated to attracting and supporting exceptional PhD students who will significantly advance our research mission.
www.queensu.ca
June 5, 2025 at 3:31 PM
My Canadian university, Queen's, is offering TWENTY 4-year funded PhDs (40k CAD/yr) for a student of ANY citizenship who has been accepted at a top 100 US university but have had offer rescinded OR are reconsidering offer due to US policy.
Details found here👇
www.queensu.ca/grad-postdoc...
Details found here👇
www.queensu.ca/grad-postdoc...
Reposted by Serge McGraw
EMBO is delighted to announce that this year the EMBO Gold Medal is awarded to Tanmay Bharat @tbharat-lab.bsky.social @mrclmb.bsky.social and David Bikard @dbikard.bsky.social @pasteur.fr for their remarkable contributions to the #LifeSciences.
www.embo.org/press-releas...
#award 🧪
www.embo.org/press-releas...
#award 🧪
EMBO Gold Medal 2025 awarded to Tanmay Bharat and David Bikard – Press releases – EMBO
Every year, EMBO awards the Gold Medal to group leaders in the early stages of their careers for their remarkable contributions to the life sciences in
www.embo.org
June 5, 2025 at 12:05 PM
EMBO is delighted to announce that this year the EMBO Gold Medal is awarded to Tanmay Bharat @tbharat-lab.bsky.social @mrclmb.bsky.social and David Bikard @dbikard.bsky.social @pasteur.fr for their remarkable contributions to the #LifeSciences.
www.embo.org/press-releas...
#award 🧪
www.embo.org/press-releas...
#award 🧪
Congrats to all winners! ...but especially to own, Michelle Robb, for the Best Poster Award at #DOHaDCanada2025! Michelle presented our recent advances on Early Embryonic Alcohol Exposure ! 🏆
Congratulations to the 8th DOHaD Canada Annual Scientific Meeting presentation winners:
Jade Gamelin Kao – Best Oral Presentation
Michelle Robb – Best Poster
Dana Watts – 2nd Place Poster
Flore Lavoie – 3rd Place Poster
Maurya Hart – 3rd Place Poster
Thank you to all the participants!
Jade Gamelin Kao – Best Oral Presentation
Michelle Robb – Best Poster
Dana Watts – 2nd Place Poster
Flore Lavoie – 3rd Place Poster
Maurya Hart – 3rd Place Poster
Thank you to all the participants!
May 14, 2025 at 8:28 PM
Congrats to all winners! ...but especially to own, Michelle Robb, for the Best Poster Award at #DOHaDCanada2025! Michelle presented our recent advances on Early Embryonic Alcohol Exposure ! 🏆
Thank you, #DOHaDCanada2025, for organizing and for the invitation to present our work on Early Embryonic Prenatal Alcohol Exposure! #FASD #DOHaD #communautéFRQ
Thank you to everyone who attended the 8th DOHaD Canada Annual Scientific Meeting. A special thanks to our outstanding co-chairs, Dr. Tina Montreuil and Dr. Sarah Lippé, for organizing the event. Here are some highlights. #DOHaDCanada2025 #ScientificMeeting #Gratitude #EventRecap
May 14, 2025 at 8:28 PM
Thank you, #DOHaDCanada2025, for organizing and for the invitation to present our work on Early Embryonic Prenatal Alcohol Exposure! #FASD #DOHaD #communautéFRQ
Reposted by Serge McGraw
Congratulations to our co-president, Dr. Kristin Connor (@kconnor.bsky.social), for being awarded the Nick Hales Award by the International DOHaD Society. #DOHaD2025
May 13, 2025 at 7:35 PM
Congratulations to our co-president, Dr. Kristin Connor (@kconnor.bsky.social), for being awarded the Nick Hales Award by the International DOHaD Society. #DOHaD2025
Reposted by Serge McGraw
Come join us at @mcgill.ca as an assistant professor in virus-host interactions! Please share widely.
mcgill.wd3.myworkdayjobs.com/en-US/McGill...
mcgill.wd3.myworkdayjobs.com/en-US/McGill...
Assistant Professor (Research), Department of Microbiology & Immunology, (C2-240724)
Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...
mcgill.wd3.myworkdayjobs.com
April 24, 2025 at 8:17 PM
Come join us at @mcgill.ca as an assistant professor in virus-host interactions! Please share widely.
mcgill.wd3.myworkdayjobs.com/en-US/McGill...
mcgill.wd3.myworkdayjobs.com/en-US/McGill...
Reposted by Serge McGraw
Paper Out👇🥳 thanks to ALL authors, Nakatani-san @tamas-schauer.bsky.social @palmrinmoy.bsky.social and bluesky-less
RIF1 regulates Replication Timing in mouse embryos & (suprising) findings disentangling effects on transcription and LADs...lots to think about 🙄👍🤔
👉 www.cell.com/developmenta...
RIF1 regulates Replication Timing in mouse embryos & (suprising) findings disentangling effects on transcription and LADs...lots to think about 🙄👍🤔
👉 www.cell.com/developmenta...
April 21, 2025 at 2:47 PM
Paper Out👇🥳 thanks to ALL authors, Nakatani-san @tamas-schauer.bsky.social @palmrinmoy.bsky.social and bluesky-less
RIF1 regulates Replication Timing in mouse embryos & (suprising) findings disentangling effects on transcription and LADs...lots to think about 🙄👍🤔
👉 www.cell.com/developmenta...
RIF1 regulates Replication Timing in mouse embryos & (suprising) findings disentangling effects on transcription and LADs...lots to think about 🙄👍🤔
👉 www.cell.com/developmenta...
Reposted by Serge McGraw
Sophie Petropoulos, chercheuse au CRCHUM, et son équipe révèlent pour la première fois que l’embryon préimplantatoire de cochon d’Inde est très similaire à l’embryon humain, ce qui ouvre la voie à une meilleure compréhension de l’infertilité et du développement humain précoce.
Le cochon d’Inde : un modèle animal prometteur pour l’étude de l’embryon humain
Sophie Petropoulos, chercheuse au CRCHUM, et son équipe révèlent pour la première fois que l’embryon préimplantatoire de cochon d’Inde est très similaire à l’embryon humain, ce qui ouvre la voie à une...
bit.ly
April 10, 2025 at 3:46 PM
Sophie Petropoulos, chercheuse au CRCHUM, et son équipe révèlent pour la première fois que l’embryon préimplantatoire de cochon d’Inde est très similaire à l’embryon humain, ce qui ouvre la voie à une meilleure compréhension de l’infertilité et du développement humain précoce.
Reposted by Serge McGraw
🥂Congratulations to Petropoulos & co for their new Open Access study in our journal (@naturecellbiology.bsky.social): single-cell #transcriptomics, spatial, functional and comparative analyses show that the guinea pig presents high similarity with early human #embryogenesis.
bit.ly/3RaRwWY
bit.ly/3RaRwWY
The guinea pig serves as an alternative model to study human preimplantation development - Nature Cell Biology
Petropoulos and colleagues perform single-cell transcriptomics, spatial, functional and comparative analyses, and show that the guinea pig presents high similarity with early human embryogenesis.
bit.ly
April 9, 2025 at 8:21 PM
🥂Congratulations to Petropoulos & co for their new Open Access study in our journal (@naturecellbiology.bsky.social): single-cell #transcriptomics, spatial, functional and comparative analyses show that the guinea pig presents high similarity with early human #embryogenesis.
bit.ly/3RaRwWY
bit.ly/3RaRwWY
Reposted by Serge McGraw
The Lim Lab at the @crchum.bsky.social is recruiting PhD students or Postdoctoral Fellows to study the roles of 14-3-3zeta in #adipocytes or pancreatic #betacells.
Projects are supported by CIHR, NSERC, or Diabetes Canada.
Please share with people who might be interested!
Thanks!
Projects are supported by CIHR, NSERC, or Diabetes Canada.
Please share with people who might be interested!
Thanks!
April 13, 2025 at 5:43 PM
The Lim Lab at the @crchum.bsky.social is recruiting PhD students or Postdoctoral Fellows to study the roles of 14-3-3zeta in #adipocytes or pancreatic #betacells.
Projects are supported by CIHR, NSERC, or Diabetes Canada.
Please share with people who might be interested!
Thanks!
Projects are supported by CIHR, NSERC, or Diabetes Canada.
Please share with people who might be interested!
Thanks!
Reposted by Serge McGraw
I urge folks to sign this letter and share it with their university colleagues to get critical mass.
Dear Canadian researchers, faculty, RAs, PDFs and grad students, this letter is for the federal party leaders asking them to defend and expand Canadian research sovereignty with a historic investment in science, please sign and share
docs.google.com/document/d/1...
docs.google.com/document/d/1...
National Letter
Open Letter from Canadian Researchers to the Federal party leaders Click here to sign this letter See who has signed - version française se trouve à page 3 - Dear Party Leaders We, the undersigne...
docs.google.com
April 12, 2025 at 5:18 PM
I urge folks to sign this letter and share it with their university colleagues to get critical mass.
Reposted by Serge McGraw
🔊Share widely!
Were looking for a Tier 2 CRC in Human Metabolic Disease!
Just posted but hurry as app deadline is May 15!
Got expertise in #obesity or #diabetes and are an emerging expert in your field?
Apply now!!!!
carleton.ca/deputyprovos...
Were looking for a Tier 2 CRC in Human Metabolic Disease!
Just posted but hurry as app deadline is May 15!
Got expertise in #obesity or #diabetes and are an emerging expert in your field?
Apply now!!!!
carleton.ca/deputyprovos...
Assistant or Associate Professor and Canada Research Chair, Tier 2, Biology or Health Sciences or Neuroscience (Human Metabolic Disease) - Office of the Deputy Provost (Academic Operations and Plannin...
About the Position The Faculty of Science invites applications for a Canadian Institute of Health Research (CIHR) Tier 2 Canada Research Chair (CRC) appointment in Biology, as applicable to Human Meta...
carleton.ca
April 8, 2025 at 10:44 PM
🔊Share widely!
Were looking for a Tier 2 CRC in Human Metabolic Disease!
Just posted but hurry as app deadline is May 15!
Got expertise in #obesity or #diabetes and are an emerging expert in your field?
Apply now!!!!
carleton.ca/deputyprovos...
Were looking for a Tier 2 CRC in Human Metabolic Disease!
Just posted but hurry as app deadline is May 15!
Got expertise in #obesity or #diabetes and are an emerging expert in your field?
Apply now!!!!
carleton.ca/deputyprovos...
Reposted by Serge McGraw
Dear USA colleagues, paradoxically the environment is warmer for doing science north of the border.♥️
April 8, 2025 at 12:45 AM
Dear USA colleagues, paradoxically the environment is warmer for doing science north of the border.♥️
Reposted by Serge McGraw
This should save grant reviewers a lot of time on some of those proposals…..
April 4, 2025 at 5:02 PM
This should save grant reviewers a lot of time on some of those proposals…..
www.nature.com/naturecareer... UBC LSI Job!!
Assistant Professor (tenure track) – Chromatin, Epigenetics - Vancouver, British Columbia (CA) job with The University of British Columbia (UBC) | 12837841
Assistant Professor (tenure track) - Chromatin Regulation, Genetic Regulatory Mechanisms, Epigenetics, Epigenomics
www.nature.com
April 4, 2025 at 10:29 AM
This is a devastating and essential read. Here is a gift link for those without subs. The part about outside perceptions of scientists compared with almost a blue-collar reality is spot on (without even mentioning meager salaries). www.nytimes.com/2025/04/03/o...
April 4, 2025 at 10:17 AM
Reposted by Serge McGraw
Argonautes 2025 will cover progress in:
Structural insights
Effector complexes: formation, composition & function
Post-transcriptional silencing
Transcriptional silencing & DNA cleavage
Post-translational modifications and regulations
Medical aspects
27-30/8/2025
argonautes.img.cas.cz
Pls RT!
Structural insights
Effector complexes: formation, composition & function
Post-transcriptional silencing
Transcriptional silencing & DNA cleavage
Post-translational modifications and regulations
Medical aspects
27-30/8/2025
argonautes.img.cas.cz
Pls RT!
April 4, 2025 at 12:55 AM
Argonautes 2025 will cover progress in:
Structural insights
Effector complexes: formation, composition & function
Post-transcriptional silencing
Transcriptional silencing & DNA cleavage
Post-translational modifications and regulations
Medical aspects
27-30/8/2025
argonautes.img.cas.cz
Pls RT!
Structural insights
Effector complexes: formation, composition & function
Post-transcriptional silencing
Transcriptional silencing & DNA cleavage
Post-translational modifications and regulations
Medical aspects
27-30/8/2025
argonautes.img.cas.cz
Pls RT!
Reposted by Serge McGraw
For Canadian cancer researchers concerned about travelling to the US (🙋🏼♂️), please check out and plan to be at the Canadian Cancer Research Conference in Calgary this November. All welcome. www.ccra-acrc.ca/conference/
Conference - CCRA
www.ccra-acrc.ca
April 3, 2025 at 9:48 PM
For Canadian cancer researchers concerned about travelling to the US (🙋🏼♂️), please check out and plan to be at the Canadian Cancer Research Conference in Calgary this November. All welcome. www.ccra-acrc.ca/conference/
Thank you @stemcellnetwork.ca for internship scholarship to the lab to support the next generation of stem cell scientists!!
a baby is saying thank you with a serious look on his face .
ALT: a baby is saying thank you with a serious look on his face .
media.tenor.com
March 30, 2025 at 4:55 PM
Thank you @stemcellnetwork.ca for internship scholarship to the lab to support the next generation of stem cell scientists!!
Reposted by Serge McGraw
A few days left to apply for exciting PhD and Postdoc opportunities in wonderful Copenhagen and join our efforts in understanding Epigenetic Cell Memory.
🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!
6 Postdoctoral and PhD positions in Center for Epigenetic Cell Memory (EpiC)
The Center for Epigenetic Cell Memory (EpiC) is a new Center of Excellence that will be established based on funding by the Danish National Research Foundation.
tinyurl.com
March 28, 2025 at 3:51 PM
A few days left to apply for exciting PhD and Postdoc opportunities in wonderful Copenhagen and join our efforts in understanding Epigenetic Cell Memory.