Eimear Lagan
@eimearlagan.bsky.social
Post-doc @ IGC, University of Edinburgh
Epigenetics | Paediatric cancer | Functional genomics
Epigenetics | Paediatric cancer | Functional genomics
Pinned
Eimear Lagan
@eimearlagan.bsky.social
· May 21
Excited to share our new paper out today in @cp-molcell.bsky.social! We show that the H3K27M oncohistone rewires cPRC1, creating a unique dependency on CBX4/PCGF4-containing complexes, and also reveal a previously unknown function of CBX4. Highlights below (1/11).
Reposted by Eimear Lagan
We are excited to share our new preprint demonstrating that nucleic acid interactions with SUZ12 constrain PRC2 activity, establishing a kinetic buffer essential for targeted gene silencing and revealing vulnerabilities in diffuse midline gliomas.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
July 23, 2025 at 11:38 PM
We are excited to share our new preprint demonstrating that nucleic acid interactions with SUZ12 constrain PRC2 activity, establishing a kinetic buffer essential for targeted gene silencing and revealing vulnerabilities in diffuse midline gliomas.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Eimear Lagan
I find unstructured regions in proteins enigmatic and very interesting.
Great to see @jongminkmg.bsky.social’s preview of our work in @cp-molcell.bsky.social today!
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Not all CBXs are created equal: A role for the disordered central region of CBX4 in pediatric glioma
In this issue, Lagan et al.1 apply genome-wide and tiling-scan CRISPR screens to uncover
a key role for CBX4 and its central region in promoting the growth of diffuse midline
glioma cells bearing the ...
www.cell.com
June 6, 2025 at 8:51 PM
I find unstructured regions in proteins enigmatic and very interesting.
Reposted by Eimear Lagan
Great to see @jongminkmg.bsky.social’s preview of our work in @cp-molcell.bsky.social today!
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Not all CBXs are created equal: A role for the disordered central region of CBX4 in pediatric glioma
In this issue, Lagan et al.1 apply genome-wide and tiling-scan CRISPR screens to uncover
a key role for CBX4 and its central region in promoting the growth of diffuse midline
glioma cells bearing the ...
www.cell.com
June 6, 2025 at 8:37 AM
Great to see @jongminkmg.bsky.social’s preview of our work in @cp-molcell.bsky.social today!
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Reposted by Eimear Lagan
Congratulations to everyone involved in this collaborative effort.
Read our web story here: edin.ac/4jeAkLw
@cmvm-edinburghuni.bsky.social
Read our web story here: edin.ac/4jeAkLw
@cmvm-edinburghuni.bsky.social
Researchers uncover key player behind gene repression in rare brain tumour
Researchers have discovered an important molecular mechanism underlying diffuse midline glioma - an aggressive and currently incurable brain tumour that mostly affects children.
edin.ac
May 22, 2025 at 8:54 AM
Congratulations to everyone involved in this collaborative effort.
Read our web story here: edin.ac/4jeAkLw
@cmvm-edinburghuni.bsky.social
Read our web story here: edin.ac/4jeAkLw
@cmvm-edinburghuni.bsky.social
Reposted by Eimear Lagan
Online Now: A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma Online now:
A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma
Lagan, Gannon, et al. reveal that H3K27M-DMGs depend on a specific form of cPRC1 containing CBX4 and PCGF4. H3K27M alters H3K27me3 distribution, causing increased binding of CBX4-PCGF4-cPRC1 and oncogenic gene repression. CBX4’s ability to read H3K27me3 and to form a specific cPRC1 complex with PCGF4 makes it essential in DMG.
dlvr.it
May 21, 2025 at 3:19 PM
Online Now: A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma Online now:
Excited to share our new paper out today in @cp-molcell.bsky.social! We show that the H3K27M oncohistone rewires cPRC1, creating a unique dependency on CBX4/PCGF4-containing complexes, and also reveal a previously unknown function of CBX4. Highlights below (1/11).
May 21, 2025 at 4:13 PM
Excited to share our new paper out today in @cp-molcell.bsky.social! We show that the H3K27M oncohistone rewires cPRC1, creating a unique dependency on CBX4/PCGF4-containing complexes, and also reveal a previously unknown function of CBX4. Highlights below (1/11).