Jongmin Kim
@jongminkmg.bsky.social
Assistant Professor @Cornell University
- Germline gene regulation, gene silencing, chromatin
- jongminkimlab.org
- Germline gene regulation, gene silencing, chromatin
- jongminkimlab.org
We did journal club today on this preprint - interesting parallels that CHD4 and its partners block aberrant TF binding in mESCs (this preprint), human cells (PMID:38281186), and fly testis (PMID:28522526).
Fascinated by how CHD4 controls cryptic regulatory elements without a strong presence there.
Fascinated by how CHD4 controls cryptic regulatory elements without a strong presence there.
Check it out, Chromatin Kids!
Chromatin remodeller does stuff to Transcription Factors!
Functions where it is seldom seen!
Both decreases and increases chromatin accessibility!
How cool is that?
Chromatin remodeller does stuff to Transcription Factors!
Functions where it is seldom seen!
Both decreases and increases chromatin accessibility!
How cool is that?
The chromatin remodeller CHD4 controls both nucleosome integrity and transcription factor binding to promote activity of active regulatory elements and to prevent activation of silent enhancers https://www.biorxiv.org/content/10.1101/2025.08.29.672645v1
October 23, 2025 at 1:59 AM
We did journal club today on this preprint - interesting parallels that CHD4 and its partners block aberrant TF binding in mESCs (this preprint), human cells (PMID:38281186), and fly testis (PMID:28522526).
Fascinated by how CHD4 controls cryptic regulatory elements without a strong presence there.
Fascinated by how CHD4 controls cryptic regulatory elements without a strong presence there.
Exciting work on orphan genes in fertilization and evolution!
Excited to share that our new NSF RUI grant was funded! 🎉🪰 We'll be looking into Drosophila fertilization proteins and studying how orphan genes function in non-model fly species. We're hiring for a 3-year lab manager/staff scientist position: app.jobvite.com/j/?cj=oGzWxf... Shares/RTs appreciated!
College of the Holy Cross is looking for Lab Manager / Staff Scientist.
College of the Holy Cross is looking for Lab Manager / Staff Scientist. Learn more or Jobvite a friend.
app.jobvite.com
September 18, 2025 at 2:40 AM
Exciting work on orphan genes in fertilization and evolution!
Avidity.
In plants, PRC2 accessory VEL proteins polymerize much like PRC1 subunits in animals, reinforcing silencing. Multimerization - overcoming weak affinity through 'avidity' - seems to be an important conserved principle in chromatin regulation.
pubmed.ncbi.nlm.nih.gov/40858112/
In plants, PRC2 accessory VEL proteins polymerize much like PRC1 subunits in animals, reinforcing silencing. Multimerization - overcoming weak affinity through 'avidity' - seems to be an important conserved principle in chromatin regulation.
pubmed.ncbi.nlm.nih.gov/40858112/
VEL-dependent polymerization maintains the chromatin association of Polycomb proteins for the switch to epigenetic silencing - PubMed
Multivalent protein-chromatin interactions facilitated by higher-order protein assemblies are emerging as a crucial theme in eukaryotic gene regulation. However, understanding the underlying mechanism...
pubmed.ncbi.nlm.nih.gov
August 31, 2025 at 12:49 PM
Avidity.
In plants, PRC2 accessory VEL proteins polymerize much like PRC1 subunits in animals, reinforcing silencing. Multimerization - overcoming weak affinity through 'avidity' - seems to be an important conserved principle in chromatin regulation.
pubmed.ncbi.nlm.nih.gov/40858112/
In plants, PRC2 accessory VEL proteins polymerize much like PRC1 subunits in animals, reinforcing silencing. Multimerization - overcoming weak affinity through 'avidity' - seems to be an important conserved principle in chromatin regulation.
pubmed.ncbi.nlm.nih.gov/40858112/
Donated. FlyBase is a truly essential resource!
FlyBase needs your help! We ask that European labs continue to contribute to Cambridge, UK FlyBase, whereas US and other non-European labs can contribute to US FlyBase. For more information and how to donate: wiki.flybase.org/wiki/FlyBase...
FlyBase:Contribute to FlyBase - FlyBase Wiki
wiki.flybase.org
August 25, 2025 at 3:11 AM
Donated. FlyBase is a truly essential resource!
A brief mountain break.
July 15, 2025 at 1:23 AM
A brief mountain break.
Reducing H1 levels (by CRAMP1 KD) derepresses PRC2 target genes without reducing H3K27me3. It was interesting:
1) once again, H3K27me3 mark alone seems not sufficient for gene repression,
2) how is H1 deposited at Polycomb target sites?
Congrats, Iva!
1) once again, H3K27me3 mark alone seems not sufficient for gene repression,
2) how is H1 deposited at Polycomb target sites?
Congrats, Iva!
CRAMP! SO ANNOYING BUT NEEDS TO KEEP LINKER HISTONES! EPIGENETIC HULK DO WITHOUT! UNLESS IT THE BAND SO THEN COOL! www.cell.com/molecular-ce...
CRAMP1 drives linker histone expression to enable Polycomb repression
Challenging the prevailing view that H1 linker histones represent a general feature
of repressed chromatin, Matthews et al. show a specific requirement for H1 in epigenetic
repression by PRC2. Ablatio...
www.cell.com
June 18, 2025 at 1:47 AM
Reducing H1 levels (by CRAMP1 KD) derepresses PRC2 target genes without reducing H3K27me3. It was interesting:
1) once again, H3K27me3 mark alone seems not sufficient for gene repression,
2) how is H1 deposited at Polycomb target sites?
Congrats, Iva!
1) once again, H3K27me3 mark alone seems not sufficient for gene repression,
2) how is H1 deposited at Polycomb target sites?
Congrats, Iva!
True: my ESI MIRA, submitted last February, was withdrawn three weeks before the study section because of a support letter. No sub-award, no expected co-authorship, just a letter. So be careful - their definition of 'collaboration' is very broad.
NIH APPLICANTS:
Your application will be WITHDRAWN BEFORE REVIEW if you have an international collaboration and do not include a Foreign Justification.
Normally this could be provided after review as JIT but NOT ANYMORE.
You have been warned.
Your application will be WITHDRAWN BEFORE REVIEW if you have an international collaboration and do not include a Foreign Justification.
Normally this could be provided after review as JIT but NOT ANYMORE.
You have been warned.
June 13, 2025 at 10:25 PM
True: my ESI MIRA, submitted last February, was withdrawn three weeks before the study section because of a support letter. No sub-award, no expected co-authorship, just a letter. So be careful - their definition of 'collaboration' is very broad.
I find unstructured regions in proteins enigmatic and very interesting.
Great to see @jongminkmg.bsky.social’s preview of our work in @cp-molcell.bsky.social today!
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Not all CBXs are created equal: A role for the disordered central region of CBX4 in pediatric glioma
In this issue, Lagan et al.1 apply genome-wide and tiling-scan CRISPR screens to uncover
a key role for CBX4 and its central region in promoting the growth of diffuse midline
glioma cells bearing the ...
www.cell.com
June 6, 2025 at 8:51 PM
I find unstructured regions in proteins enigmatic and very interesting.
" The common genetic marker Stubble influences Fab2L transgene expression" - balancer and marker mutations are not always inert.
1/10 Excited to share our recent work with @psarkies.bsky.social out in Open Biology today.
We follow up on a case of Drosophila epigenetic inheritance and find no evidence of sRNA involvement. Plus a surprising result of interest to Drosophilists!
royalsocietypublishing.org/doi/10.1098/...
We follow up on a case of Drosophila epigenetic inheritance and find no evidence of sRNA involvement. Plus a surprising result of interest to Drosophilists!
royalsocietypublishing.org/doi/10.1098/...
Polycomb-mediated transgenerational epigenetic inheritance of Drosophila eye colour is independent of small RNAs | Open Biology
Transgenerational epigenetic inheritance (TEI) describes the process whereby distinct
epigenetic states are transmitted between generations, resulting in heritable gene
expression and phenotypic diffe...
royalsocietypublishing.org
March 13, 2025 at 3:48 AM
" The common genetic marker Stubble influences Fab2L transgene expression" - balancer and marker mutations are not always inert.
Reposted by Jongmin Kim
Today’s the day! I’m happy to announce that the Murphy Lab will be moving to Cornell this July! The lab will be in Biotech and I’ll be joining the Department of Molecular Biology and Genetics. There will be lots of recruiting soon, including students and postdocs. Please RT. 🙏 TY.
January 28, 2025 at 7:40 PM
Today’s the day! I’m happy to announce that the Murphy Lab will be moving to Cornell this July! The lab will be in Biotech and I’ll be joining the Department of Molecular Biology and Genetics. There will be lots of recruiting soon, including students and postdocs. Please RT. 🙏 TY.
Great opportunity for postbacs to do exciting research and gain experience before graduate school!
My lab is looking to hire a research technician!
Techs in my group run their own projects and participate fully in the scientific discussions in the lab (this is not a wash glassware, make media position). Ideal for someone looking to get a bit more research experience before applying for a PhD.
Techs in my group run their own projects and participate fully in the scientific discussions in the lab (this is not a wash glassware, make media position). Ideal for someone looking to get a bit more research experience before applying for a PhD.
January 22, 2025 at 3:15 AM
Great opportunity for postbacs to do exciting research and gain experience before graduate school!
The sun has been rather scarce in Ithaca lately. Nice to see some sunrise this morning.
January 21, 2025 at 2:41 AM
The sun has been rather scarce in Ithaca lately. Nice to see some sunrise this morning.
Reposted by Jongmin Kim
Hello Bluesky friends! I am a #newPI starting at UC Irvine in April, interested in gene regulation and functional genomics in stem cell models of development (esp neural crest). We are hiring at all levels – please reach out/spread the word! sskimlab.org
Kim Lab at UC Irvine
Visit the post for more.
sskimlab.org
January 20, 2025 at 11:08 PM
Hello Bluesky friends! I am a #newPI starting at UC Irvine in April, interested in gene regulation and functional genomics in stem cell models of development (esp neural crest). We are hiring at all levels – please reach out/spread the word! sskimlab.org