Patrick Murphy
@pjmurphy249.bsky.social
Associate Professor @Cornell #Genetics #Epigenetics #Chromatin #Zebrafish #Development #Reproduction #EvoDevo #Bioinformatics #ZGA #StemCells #Regeneration #GoBills #BillsMafia
https://blogs.cornell.edu/murphylab/
🦬🏈💪
https://blogs.cornell.edu/murphylab/
🦬🏈💪
Pinned
CUT&Tag Overcomes Biases of ChIP and Establishes Chromatin Patterns for Repetitive Genomic Loci
New in situ chromatin profiling methods, such as CUT&Tag, have streamlined studies
of chromatin features by eliminating the need for up-front purification, but we find
that some features are not equal...
www.cell.com
New Paper from the Murphy Lab - A Collaboration w Mitch O'Connell's group at URMC. Led by our joint student Brandon Park. Check it out!!
CUT&Tag Overcomes Biases of ChIP and Establishes Chromatin Patterns for Repetitive Genomic Loci: iScience www.cell.com/iscience/ful...
CUT&Tag Overcomes Biases of ChIP and Establishes Chromatin Patterns for Repetitive Genomic Loci: iScience www.cell.com/iscience/ful...
Something to add to my reading list. www.biorxiv.org/content/10.1...
CFDP1 is required for histone variant H2A.Z deposition by the human SRCAP chromatin remodeling complex
Craniofacial Developmental Protein 1 (CFDP1) is a member of the evolutionarily conserved family of Bucentaur (BCNT) proteins and was originally classified as a protein required for cell survival and d...
www.biorxiv.org
November 4, 2025 at 6:42 PM
Something to add to my reading list. www.biorxiv.org/content/10.1...
If you want to be truly inspired, take some time and read the beautiful mechanisms described in one of Steve’s discussion sections. He’s a master, a technician, and an artists all wrapped into one. One of my idols.
Dr. Steven Henikoff receives the 55th Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research.
www.brandeis.edu/rosenstiel/r...
(Personal note: I continue to be inspired and astonished by my postdoctoral mentor & current colleague)
www.brandeis.edu/rosenstiel/r...
(Personal note: I continue to be inspired and astonished by my postdoctoral mentor & current colleague)
Brandeis University honors Fred Hutch molecular biologist
Dr. Steven Henikoff, a molecular biologist at Fred Hutch Cancer Center, has won the prestigious Rosenstiel Award for Distinguished Work in Basic Medical Research from Brandeis University recognizing h...
www.fredhutch.org
October 31, 2025 at 1:16 AM
If you want to be truly inspired, take some time and read the beautiful mechanisms described in one of Steve’s discussion sections. He’s a master, a technician, and an artists all wrapped into one. One of my idols.
It’s like nails on a chalkboard everytime I hear a scientist pronounce nuclear as ‘nuc-you-lar’ instead of ‘new-clear’ or when I hear ‘A-tack-seq’ instead of ‘attack-seq’… arrgghhh
a person is writing on a blackboard with their hands and the website makeagif.com is visible in the corner
ALT: a person is writing on a blackboard with their hands and the website makeagif.com is visible in the corner
media.tenor.com
October 22, 2025 at 8:12 PM
It’s like nails on a chalkboard everytime I hear a scientist pronounce nuclear as ‘nuc-you-lar’ instead of ‘new-clear’ or when I hear ‘A-tack-seq’ instead of ‘attack-seq’… arrgghhh
New Paper from the Murphy Lab - A Collaboration w Mitch O'Connell's group at URMC. Led by our joint student Brandon Park. Check it out!!
CUT&Tag Overcomes Biases of ChIP and Establishes Chromatin Patterns for Repetitive Genomic Loci: iScience www.cell.com/iscience/ful...
CUT&Tag Overcomes Biases of ChIP and Establishes Chromatin Patterns for Repetitive Genomic Loci: iScience www.cell.com/iscience/ful...
CUT&Tag Overcomes Biases of ChIP and Establishes Chromatin Patterns for Repetitive Genomic Loci
New in situ chromatin profiling methods, such as CUT&Tag, have streamlined studies
of chromatin features by eliminating the need for up-front purification, but we find
that some features are not equal...
www.cell.com
October 17, 2025 at 5:48 PM
New Paper from the Murphy Lab - A Collaboration w Mitch O'Connell's group at URMC. Led by our joint student Brandon Park. Check it out!!
CUT&Tag Overcomes Biases of ChIP and Establishes Chromatin Patterns for Repetitive Genomic Loci: iScience www.cell.com/iscience/ful...
CUT&Tag Overcomes Biases of ChIP and Establishes Chromatin Patterns for Repetitive Genomic Loci: iScience www.cell.com/iscience/ful...
The frig in my basement has a magic gene editing drawer.
September 17, 2025 at 12:18 AM
The frig in my basement has a magic gene editing drawer.
Big day for the new Cornell version of the Murph lab. Our first gel… woohooo!!!! Science Baby!!!
August 21, 2025 at 8:53 PM
Big day for the new Cornell version of the Murph lab. Our first gel… woohooo!!!! Science Baby!!!
Reposted by Patrick Murphy
Very happy to see our preprint on how the mechanosensitive ion channel Piezo1 controls intercellular junction maturation by balancing cortex and membrane tension now published in @jcellsci.bsky.social Congratulations to Ahsan & team! journals.biologists.com/jcs/article/...
August 7, 2025 at 6:13 AM
Very happy to see our preprint on how the mechanosensitive ion channel Piezo1 controls intercellular junction maturation by balancing cortex and membrane tension now published in @jcellsci.bsky.social Congratulations to Ahsan & team! journals.biologists.com/jcs/article/...
The “Ins and Outs and What-Abouts” of H2A.Z: A tribute to C. David Allis - Journal of Biological Chemistry www.jbc.org/article/S002...
July 17, 2025 at 4:03 PM
The “Ins and Outs and What-Abouts” of H2A.Z: A tribute to C. David Allis - Journal of Biological Chemistry www.jbc.org/article/S002...
Check out the new chalk art outside the lab at Cornell!
July 11, 2025 at 4:56 PM
Check out the new chalk art outside the lab at Cornell!
Please RT: Published today, a super fun collaboration w/ @fanjumeng.bsky.social and Marnie Halpern's lab to establish methods for transgene mapping in zebrafish - TransTag enables simple and efficient transgene mapping in zebrafish via tagmentation: Cell Reports Methods www.cell.com/cell-reports...
TransTag enables simple and efficient transgene mapping in zebrafish via tagmentation
Meng et al. develop a method called TransTag for simple and efficient mapping of Tol2-based
transgenes in zebrafish. TransTag robustly identifies transgene insertion sites and
offers an alignment-free...
www.cell.com
July 8, 2025 at 5:07 PM
Please RT: Published today, a super fun collaboration w/ @fanjumeng.bsky.social and Marnie Halpern's lab to establish methods for transgene mapping in zebrafish - TransTag enables simple and efficient transgene mapping in zebrafish via tagmentation: Cell Reports Methods www.cell.com/cell-reports...
TransTag enables simple and efficient transgene mapping in zebrafish via tagmentation: Cell Reports Methods www.cell.com/cell-reports...
TransTag enables simple and efficient transgene mapping in zebrafish via tagmentation
Meng et al. develop a method called TransTag for simple and efficient mapping of Tol2-based
transgenes in zebrafish. TransTag robustly identifies transgene insertion sites and
offers an alignment-free...
www.cell.com
July 8, 2025 at 4:42 PM
TransTag enables simple and efficient transgene mapping in zebrafish via tagmentation: Cell Reports Methods www.cell.com/cell-reports...
Congrats Shan. It was wonderful to participate in the graduation ceremony with you! @urochester.bsky.social
May 22, 2025 at 12:48 AM
Congrats Shan. It was wonderful to participate in the graduation ceremony with you! @urochester.bsky.social
Reposted by Patrick Murphy
Great event. Great trainees. Thank you!
Such an awesome day! It was wonderful to host Marisa Bartolomei @marisa-bartolomei.bsky.social as the Keynote speaker our annual Genetics Day symposium.
April 30, 2025 at 12:21 PM
Great event. Great trainees. Thank you!
Such an awesome day! It was wonderful to host Marisa Bartolomei @marisa-bartolomei.bsky.social as the Keynote speaker our annual Genetics Day symposium.
April 29, 2025 at 8:51 PM
Such an awesome day! It was wonderful to host Marisa Bartolomei @marisa-bartolomei.bsky.social as the Keynote speaker our annual Genetics Day symposium.
Congrats!!
🎉Congratulations to our @idajentoft.bsky.social, postdoc in the @pauligroup.bsky.social on being awarded a HFSP fellowship!
The funding will support her research into the molecular mechanisms that regulate translation during embryonic diapause.
More about the project: www.imp.ac.at/news/article...
The funding will support her research into the molecular mechanisms that regulate translation during embryonic diapause.
More about the project: www.imp.ac.at/news/article...
April 5, 2025 at 12:25 AM
Congrats!!
Having an awesome time at the Tri-Repro meeting @pennmedicine.bsky.social @pennepigenetics.bsky.social with my good bud @themodzlab.bsky.social
April 4, 2025 at 1:48 AM
Having an awesome time at the Tri-Repro meeting @pennmedicine.bsky.social @pennepigenetics.bsky.social with my good bud @themodzlab.bsky.social
Reposted by Patrick Murphy
I had a hypothesis that vitamin D prevents cancer. I worked on this for > 10 years, had 3 NIH-funded grants, and published >30 papers on this topic. Based on our work and that of my esteemed colleagues, I concluded that the evidence does not support the hypothesis.
RFK Jr., we are not the same.
RFK Jr., we are not the same.
March 28, 2025 at 3:57 PM
I had a hypothesis that vitamin D prevents cancer. I worked on this for > 10 years, had 3 NIH-funded grants, and published >30 papers on this topic. Based on our work and that of my esteemed colleagues, I concluded that the evidence does not support the hypothesis.
RFK Jr., we are not the same.
RFK Jr., we are not the same.
Had a wonderful time visiting the Genetics Department at the University of Georgia. Great food! Great conversation! Great company! and Excellent weather! Thanks for the invite @gollmg.bsky.social
February 28, 2025 at 12:56 AM
Had a wonderful time visiting the Genetics Department at the University of Georgia. Great food! Great conversation! Great company! and Excellent weather! Thanks for the invite @gollmg.bsky.social
Reposted by Patrick Murphy
Congratulations to @flashes.blue for their official launch on the App Store 🎉🎉🎉
It’s an instagram alternative built on the AT protocol 🙌 all the visual scrolling with none of the Meta algorithm
It’s an instagram alternative built on the AT protocol 🙌 all the visual scrolling with none of the Meta algorithm
February 25, 2025 at 7:34 AM
Congratulations to @flashes.blue for their official launch on the App Store 🎉🎉🎉
It’s an instagram alternative built on the AT protocol 🙌 all the visual scrolling with none of the Meta algorithm
It’s an instagram alternative built on the AT protocol 🙌 all the visual scrolling with none of the Meta algorithm
Congrats Brandon! So proud of your accomplishments.
February 20, 2025 at 6:43 PM
Congrats Brandon! So proud of your accomplishments.
We all know the story of Henrietta Lacks, but there are countless other examples when biomedical research advanced with a little regard for morals or ethics - often at the expense of poor, disadvantaged, or minority individuals. This book has been enlightening. A good read for current scientists.
February 12, 2025 at 2:35 PM
We all know the story of Henrietta Lacks, but there are countless other examples when biomedical research advanced with a little regard for morals or ethics - often at the expense of poor, disadvantaged, or minority individuals. This book has been enlightening. A good read for current scientists.
Reposted by Patrick Murphy
CONGRATS to all!!
Congrats to the 2025 SDB Award Winners!
Conklin Medal: Blanche Capel
DB-SDB Lifetime Achievement Award: Billie Swalla
Hamburger Outstanding Educator Prize: Erica Crespi
Hay New Investigator Award: Mubarak Syed
SDB Trainee Science Communication Award: Joaquin Navajas Acedo
bit.ly/4bcrFap
Conklin Medal: Blanche Capel
DB-SDB Lifetime Achievement Award: Billie Swalla
Hamburger Outstanding Educator Prize: Erica Crespi
Hay New Investigator Award: Mubarak Syed
SDB Trainee Science Communication Award: Joaquin Navajas Acedo
bit.ly/4bcrFap
February 11, 2025 at 5:31 PM
CONGRATS to all!!
Reposted by Patrick Murphy
Now that I have read this paper, my lab has new findings based on CUT&Tag data that challenge the traditional view of euchromatic and repressive factors. I have started doubting all previous ChIPseq-based conclusions for many targets we are interested in. Thanks for publishing the preprint
February 6, 2025 at 5:55 PM
Now that I have read this paper, my lab has new findings based on CUT&Tag data that challenge the traditional view of euchromatic and repressive factors. I have started doubting all previous ChIPseq-based conclusions for many targets we are interested in. Thanks for publishing the preprint
Reposted by Patrick Murphy
CUT&Tag Identifies Repetitive Genomic Loci that are Excluded from ChIP Assays https://www.biorxiv.org/content/10.1101/2025.02.03.636299v1
February 5, 2025 at 4:38 PM
CUT&Tag Identifies Repetitive Genomic Loci that are Excluded from ChIP Assays https://www.biorxiv.org/content/10.1101/2025.02.03.636299v1