Takashi Fukaya
@fukayalab.bsky.social
Institute for Quantitative Biosciences, UTokyo. We study the mechanism of transcriptional regulation in the Drosophila embryo.
https://sites.google.com/view/fukaya-lab-iqb/home
https://sites.google.com/view/fukaya-lab-iqb/home
Pinned
Takashi Fukaya
@fukayalab.bsky.social
· Nov 11
Functional coordination between transcription factor clustering and gene activity
The dynamic assembly and disassembly of transcription factor (TF) clusters at enhancers
is a major source of transcriptional bursting in developing Drosophila embryos. Formation
of shared TF clusters ...
www.cell.com
How do distal enhancers control transcription dynamics in living cells? Check out our work published in
@MolecularCell!! We show that the dynamic assembly and disassembly of TF clusters at enhancers are a major source of transcriptional bursting. www.cell.com/molecular-ce...
@MolecularCell!! We show that the dynamic assembly and disassembly of TF clusters at enhancers are a major source of transcriptional bursting. www.cell.com/molecular-ce...
Reposted by Takashi Fukaya
Become our colleague at @fmiscience.bsky.social! The FMI is a very special place to start your lab: a vibrant international institute with world-class research groups and facilities, core funding, fantastic trainees, great colleagues😅, and a collegial culture. Get in touch if you're interested!
🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
September 8, 2025 at 8:41 AM
Become our colleague at @fmiscience.bsky.social! The FMI is a very special place to start your lab: a vibrant international institute with world-class research groups and facilities, core funding, fantastic trainees, great colleagues😅, and a collegial culture. Get in touch if you're interested!
Fun visit to Rockefeller after the CSHL transcription meeting. It was great to catch up with Bob Roeder since his visit to Japan for the Kyoto Prize!
August 31, 2025 at 2:48 PM
Fun visit to Rockefeller after the CSHL transcription meeting. It was great to catch up with Bob Roeder since his visit to Japan for the Kyoto Prize!
Reposted by Takashi Fukaya
Japan is the only country in the world that legally requires married couples to share the same family name
https://go.nature.com/4lfbXPL
https://go.nature.com/4lfbXPL
Japan requires name change after marriage — with big effects on female scientists
Nature - Survey finds law requiring married couples to share the same family name causes havoc for researchers.
go.nature.com
July 7, 2025 at 10:26 AM
Japan is the only country in the world that legally requires married couples to share the same family name
https://go.nature.com/4lfbXPL
https://go.nature.com/4lfbXPL
Delighted to share a new review paper from the lab. We summarized/discussed recent key findings in enhancer biology. Thanks Dan Larson and @tinekelenstra.bsky.social for this opportunity!!
www.sciencedirect.com/journal/jour...
www.sciencedirect.com/journal/jour...
July 6, 2025 at 12:59 AM
Delighted to share a new review paper from the lab. We summarized/discussed recent key findings in enhancer biology. Thanks Dan Larson and @tinekelenstra.bsky.social for this opportunity!!
www.sciencedirect.com/journal/jour...
www.sciencedirect.com/journal/jour...
Reposted by Takashi Fukaya
A dream come true: my first first-author publication! 🧬 🎉 Working to unravel the mysteries of long-range gene regulation has been an incredible journey. Endless gratitude to Evgeny, the lab, and all of the amazing collaborators who helped make this happen 🙌
Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/
Range extender mediates long-distance enhancer activity - Nature
The REX element is associated with long-range enhancer–promoter interactions.
www.nature.com
July 2, 2025 at 7:54 PM
A dream come true: my first first-author publication! 🧬 🎉 Working to unravel the mysteries of long-range gene regulation has been an incredible journey. Endless gratitude to Evgeny, the lab, and all of the amazing collaborators who helped make this happen 🙌
Looks like I’m going to miss my flight from Frankfurt to Tokyo because of a delay at Basel airport🥺
June 28, 2025 at 5:29 PM
Looks like I’m going to miss my flight from Frankfurt to Tokyo because of a delay at Basel airport🥺
Thanks Luca @lucagiorgetti.bsky.social for hosting me at FMI. It was absolutely a fun visit and I got many nice feedback!
June 27, 2025 at 8:05 PM
Thanks Luca @lucagiorgetti.bsky.social for hosting me at FMI. It was absolutely a fun visit and I got many nice feedback!
Giving a seminar at FMI Basel tomorrow! Looking forward to it!!
June 26, 2025 at 8:30 PM
Giving a seminar at FMI Basel tomorrow! Looking forward to it!!
Reposted by Takashi Fukaya
Curious about epigenetics, gene regulation, and developmental biology?
Apply for the PhD position in Mannervik lab at Stockholm University!
We use single-cell genomics and genetic approaches to uncover how cells acquire their identities during development. Explore the chromatin landscape with us!
Apply for the PhD position in Mannervik lab at Stockholm University!
We use single-cell genomics and genetic approaches to uncover how cells acquire their identities during development. Explore the chromatin landscape with us!
June 18, 2025 at 2:25 PM
Curious about epigenetics, gene regulation, and developmental biology?
Apply for the PhD position in Mannervik lab at Stockholm University!
We use single-cell genomics and genetic approaches to uncover how cells acquire their identities during development. Explore the chromatin landscape with us!
Apply for the PhD position in Mannervik lab at Stockholm University!
We use single-cell genomics and genetic approaches to uncover how cells acquire their identities during development. Explore the chromatin landscape with us!
Look forward to visiting University of Lausanne next week!
June 20, 2025 at 2:56 PM
Look forward to visiting University of Lausanne next week!
Pachypodium gracilius has finally bloomed with yellow flowers after seven years of growing it from seed.
パキポディウム グラキリス、種から育てて7年、黄色い花が咲きました。
パキポディウム グラキリス、種から育てて7年、黄色い花が咲きました。
May 25, 2025 at 5:45 AM
Pachypodium gracilius has finally bloomed with yellow flowers after seven years of growing it from seed.
パキポディウム グラキリス、種から育てて7年、黄色い花が咲きました。
パキポディウム グラキリス、種から育てて7年、黄色い花が咲きました。
Delighted to share a new preprint from the lab!
We identified zinc-finger associated domain (ZAD)-containing C2H2 zinc-finger proteins (ZAD-ZnFs) as insulator-binding proteins in Drosophila.
www.biorxiv.org/content/10.1...
We identified zinc-finger associated domain (ZAD)-containing C2H2 zinc-finger proteins (ZAD-ZnFs) as insulator-binding proteins in Drosophila.
www.biorxiv.org/content/10.1...
May 22, 2025 at 12:30 AM
Delighted to share a new preprint from the lab!
We identified zinc-finger associated domain (ZAD)-containing C2H2 zinc-finger proteins (ZAD-ZnFs) as insulator-binding proteins in Drosophila.
www.biorxiv.org/content/10.1...
We identified zinc-finger associated domain (ZAD)-containing C2H2 zinc-finger proteins (ZAD-ZnFs) as insulator-binding proteins in Drosophila.
www.biorxiv.org/content/10.1...
Reposted by Takashi Fukaya
Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!!
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...
Rules of Engagement
YouTube video by Johan Gibcus
www.youtube.com
April 11, 2025 at 7:45 AM
Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!!
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...
Nice to catch up with Luca @lucagiorgetti.bsky.social in Tokyo!
April 13, 2025 at 12:44 PM
Nice to catch up with Luca @lucagiorgetti.bsky.social in Tokyo!
Reposted by Takashi Fukaya
So excited to host my friend and former labmate @laghalab.bsky.social as a ... (drumroll) Special Guest at our institute! Mark your calendars and expect a great talk with beautiful live imaging.
We are excited. Mounia Lagha will be our 1st Special Guest in 2025.🤗
📆 March 20, 1pm
The Lagha lab (@igmm-montpel.bsky.social) uses live imaging to study mechanisms of transcription & translation in living embryos. Join us for an enlightening talk next Thursday.
(Host: @hilgerslab.bsky.social)
📆 March 20, 1pm
The Lagha lab (@igmm-montpel.bsky.social) uses live imaging to study mechanisms of transcription & translation in living embryos. Join us for an enlightening talk next Thursday.
(Host: @hilgerslab.bsky.social)
March 14, 2025 at 1:13 PM
So excited to host my friend and former labmate @laghalab.bsky.social as a ... (drumroll) Special Guest at our institute! Mark your calendars and expect a great talk with beautiful live imaging.
Reposted by Takashi Fukaya
Only one week left to submit your abstract to the @embo.org workshop on "Enhancer mechanics and Enhanceropathies". Submit now and present your latest work in one of our short talks.
Together with @smandrup.bsky.social and Minna Kaikkonen we are happy to announce the 3rd Edition of the EMBO Workshop on #Enhancers and #Enhanceropathies. This time we will meet during the beautiful Danish summer (June 16-21).
Book the dates and register soon!!!
meetings.embo.org/event/25-enh...
Book the dates and register soon!!!
meetings.embo.org/event/25-enh...
Enhancer Mechanics and Enhanceropathies
Join us for the highly anticipated third EMBO workshop on Enhancer Mechanics and Enhanceropathies! Building on the success of our previous meetings in Santander (2021) and Marseilles (2023), this eve…
meetings.embo.org
March 10, 2025 at 9:06 AM
Only one week left to submit your abstract to the @embo.org workshop on "Enhancer mechanics and Enhanceropathies". Submit now and present your latest work in one of our short talks.
It was great to see my long-time friend from graduate school, Takashi Akera
@takashiakeralab.bsky.social
@takashiakeralab.bsky.social
March 6, 2025 at 10:17 AM
It was great to see my long-time friend from graduate school, Takashi Akera
@takashiakeralab.bsky.social
@takashiakeralab.bsky.social
Reposted by Takashi Fukaya
Do you have an exciting story about #enhancers or #enhanceropathies?. Then submit your abstract to the @embo.org workshop on "Enhancer mechanics and Enhanceropathies" in Denmark before is too late: the deadline for abstract submissions is in two weeks (March 17th)!
meetings.embo.org/event/25-enh...
meetings.embo.org/event/25-enh...
March 3, 2025 at 10:02 AM
Do you have an exciting story about #enhancers or #enhanceropathies?. Then submit your abstract to the @embo.org workshop on "Enhancer mechanics and Enhanceropathies" in Denmark before is too late: the deadline for abstract submissions is in two weeks (March 17th)!
meetings.embo.org/event/25-enh...
meetings.embo.org/event/25-enh...
Reposted by Takashi Fukaya
Excited to share our work on archaeal 3D genome! This paper revealed how an archaeal SMC complex sculpts TAD-like domains by cooperating with a roadblock NAP and physical properties of DNA. Many congrats to our talented PhD student Kodai!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Chromosomal domain formation by archaeal SMC, a roadblock protein, and DNA structure - Nature Communications
Eukaryotic chromosomes are organized into arrays of compact domain structures called TADs. Here the authors show that a member of the Archaea, the prokaryotic domain closest to the Eukarya, uses a euk...
www.nature.com
February 19, 2025 at 12:20 PM
Excited to share our work on archaeal 3D genome! This paper revealed how an archaeal SMC complex sculpts TAD-like domains by cooperating with a roadblock NAP and physical properties of DNA. Many congrats to our talented PhD student Kodai!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Takashi Fukaya
Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 12, 2025 at 6:28 AM
Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Takashi Fukaya
1/n Excited to share our new preprint! Using live imaging in Drosophila embryos, we show that RNA Pol II clusters switch from sites of initiation to elongation during zygotic genome activation and that they are stably associated with an active gene: www.biorxiv.org/content/10.1...
February 12, 2025 at 11:36 AM
1/n Excited to share our new preprint! Using live imaging in Drosophila embryos, we show that RNA Pol II clusters switch from sites of initiation to elongation during zygotic genome activation and that they are stably associated with an active gene: www.biorxiv.org/content/10.1...
Looking forward to it!! Abstract submission deadline: 17 March 2025.
February 9, 2025 at 2:47 AM
Looking forward to it!! Abstract submission deadline: 17 March 2025.
Job alert: My collaborator, Camilla Björkegren at Karolinska Institutet, is looking for a postdoc to study the mechanisms of chromosome organization!
ki.varbi.com/en/what:job/...
ki.varbi.com/en/what:job/...
Postdoctoral Researcher in chromosome organization and function
Do you want to contribute to top quality medical research? Join the lab of Camilla Björkegren at the Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden, to study molec
ki.varbi.com
February 3, 2025 at 7:15 AM
Job alert: My collaborator, Camilla Björkegren at Karolinska Institutet, is looking for a postdoc to study the mechanisms of chromosome organization!
ki.varbi.com/en/what:job/...
ki.varbi.com/en/what:job/...
Reposted by Takashi Fukaya
Hello Bluesky. For my first post here, I am happy to share that our paper is finally out in Nucleic Acids Research, highlighting how collision between transcription machinery and arrested replication fork triggers circular rDNA formation in budding yeast.
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Transcription near arrested DNA replication forks triggers ribosomal DNA copy number changes
Abstract. DNA copy number changes via chromosomal rearrangements or the production of extrachromosomal circular DNA. Here, we demonstrate that the histone
academic.oup.com
January 29, 2025 at 12:11 AM
Hello Bluesky. For my first post here, I am happy to share that our paper is finally out in Nucleic Acids Research, highlighting how collision between transcription machinery and arrested replication fork triggers circular rDNA formation in budding yeast.
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Reposted by Takashi Fukaya
Very excited to share our paper on Gene and Transposable Element expression in mammalian preimplantation development, online today! www.cell.com/cell/fulltex...
A short thread to highlight some of our findings 🧵
A short thread to highlight some of our findings 🧵
January 20, 2025 at 8:29 PM
Very excited to share our paper on Gene and Transposable Element expression in mammalian preimplantation development, online today! www.cell.com/cell/fulltex...
A short thread to highlight some of our findings 🧵
A short thread to highlight some of our findings 🧵