Rob Beagrie
@rbeagrie.bsky.social
Group leader and Wellcome Sir Henry Dale Fellow based at the Centre for Human Genetics at Oxford University. Interested in genomics, single-cell technologies, 3D DNA folding and chromatin disruption in human disease. He/him.
Reposted by Rob Beagrie
Last few days to apply for this PhD project in our lab. Mix of biochemistry and structural biology, DNA replication and ubiquitin signalling. Get in touch if interested. Full application through official university portal. Deadline on 27th of November!
Fully-funded 4-years competitive PhD project in our lab (MIBTP-doctoral-training-programme. p97 unfoldase functions during DNA replication. Open to UK/international candidates. Please get in touch for informal enquiries. Deadline 27th of November. Please share.
warwick.ac.uk/fac/cross_fa...
warwick.ac.uk/fac/cross_fa...
Professor Aga Gambus
Professor Aga Gambus
warwick.ac.uk
November 22, 2025 at 8:44 AM
Last few days to apply for this PhD project in our lab. Mix of biochemistry and structural biology, DNA replication and ubiquitin signalling. Get in touch if interested. Full application through official university portal. Deadline on 27th of November!
Reposted by Rob Beagrie
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
November 5, 2025 at 5:20 PM
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
Reposted by Rob Beagrie
don't release preprints without a Methods section
don't release preprints with a Supplementary Materials section
don't release preprints without data
don't release preprints without code
use preprint servers to share your science, not advertisements
don't release preprints with a Supplementary Materials section
don't release preprints without data
don't release preprints without code
use preprint servers to share your science, not advertisements
September 21, 2025 at 5:41 PM
don't release preprints without a Methods section
don't release preprints with a Supplementary Materials section
don't release preprints without data
don't release preprints without code
use preprint servers to share your science, not advertisements
don't release preprints with a Supplementary Materials section
don't release preprints without data
don't release preprints without code
use preprint servers to share your science, not advertisements
Reposted by Rob Beagrie
(1/n) DNA-PAINT imaging inside the nucleus at single antibody resolution using TIRF? Ultrathin sectioning makes it happen!
Grateful to share my postdoctoral work introducing “tomographic & kinetically-enhanced DNA-PAINT” or in brief: tkPAINT. Out in @pnas.org!
doi.org/10.1073/pnas...
👇🧵
Grateful to share my postdoctoral work introducing “tomographic & kinetically-enhanced DNA-PAINT” or in brief: tkPAINT. Out in @pnas.org!
doi.org/10.1073/pnas...
👇🧵
August 13, 2025 at 2:19 PM
(1/n) DNA-PAINT imaging inside the nucleus at single antibody resolution using TIRF? Ultrathin sectioning makes it happen!
Grateful to share my postdoctoral work introducing “tomographic & kinetically-enhanced DNA-PAINT” or in brief: tkPAINT. Out in @pnas.org!
doi.org/10.1073/pnas...
👇🧵
Grateful to share my postdoctoral work introducing “tomographic & kinetically-enhanced DNA-PAINT” or in brief: tkPAINT. Out in @pnas.org!
doi.org/10.1073/pnas...
👇🧵
Reposted by Rob Beagrie
New paper on the role of H3K4me3 at enhancers! We (led by Haoming Yu) used dCas9 epigenome editing to add H3K4me3 to intergenic enhancers. This was (1) sufficient to turn up transcription at open, active regions and (2) has no effect on target gene transcription. genesdev.cshlp.org/content/earl...
H3K4me3 amplifies transcription at intergenic active regulatory elements
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
genesdev.cshlp.org
August 20, 2025 at 1:29 AM
New paper on the role of H3K4me3 at enhancers! We (led by Haoming Yu) used dCas9 epigenome editing to add H3K4me3 to intergenic enhancers. This was (1) sufficient to turn up transcription at open, active regions and (2) has no effect on target gene transcription. genesdev.cshlp.org/content/earl...
Reposted by Rob Beagrie
Our work bridging enhancer-promoter proximity to phenotypic outcomes in vivo is out! Shout out to @olimpiabompadre.bsky.social, to Marie Kmita's lab, and to all the co-authors. www.nature.com/articles/s41...
Liebenberg syndrome severity arises from variations in Pitx1 locus topology and proportion of ectopically transcribing cells - Nature Communications
Here the authors show that reducing enhancer-promoter distance at the Pitx1 locus increases proportion of Pitx1 forelimb expressing cells, worsening skeletal defects in Liebenberg syndrome. They also ...
www.nature.com
July 9, 2025 at 11:58 AM
Our work bridging enhancer-promoter proximity to phenotypic outcomes in vivo is out! Shout out to @olimpiabompadre.bsky.social, to Marie Kmita's lab, and to all the co-authors. www.nature.com/articles/s41...
Reposted by Rob Beagrie
Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/
Range extender mediates long-distance enhancer activity - Nature
The REX element is associated with long-range enhancer–promoter interactions.
www.nature.com
July 2, 2025 at 4:17 PM
Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/
Reposted by Rob Beagrie
This is the type of transgender mouse research that would get its money stripped away in the US... (jk jk) www.nature.com/articles/s41...
Maternal iron deficiency causes male-to-female sex reversal in mouse embryos - Nature
Iron-deficient conditions in pregnant mice can cause XY mouse embryos to develop female rather than male genitalia, revealing that iron metabolism has a role in determining male sex in mice.
www.nature.com
June 6, 2025 at 7:46 AM
This is the type of transgender mouse research that would get its money stripped away in the US... (jk jk) www.nature.com/articles/s41...
Reposted by Rob Beagrie
Extensive differences observed in 3D genome structure between homologous heterozygous chromosomes revealed by Genome Architecture Mapping #GAM in the @apombo1.bsky.social lab ➡️ www.embopress.org/doi/full/10....
May 15, 2025 at 5:32 PM
Extensive differences observed in 3D genome structure between homologous heterozygous chromosomes revealed by Genome Architecture Mapping #GAM in the @apombo1.bsky.social lab ➡️ www.embopress.org/doi/full/10....
Reposted by Rob Beagrie
Systematic identification of disease-causing promoter and untranslated region variants in 8040 undiagnosed individuals with rare disease #RareDisease #Genetics genomemedicine.biomedcentral.com/articles/10....
April 16, 2025 at 4:02 PM
Systematic identification of disease-causing promoter and untranslated region variants in 8040 undiagnosed individuals with rare disease #RareDisease #Genetics genomemedicine.biomedcentral.com/articles/10....
Reposted by Rob Beagrie
My favorite science is the kind that makes you says, "Man, I wish I thought of that!" This is such a paper.
Mass action turns an eraser into a pen. HDACs are metabolite-dependent histone acyltransferases.
@dremilygoldberg.bsky.social @gburslem.bsky.social
www.nature.com/articles/s41...
Mass action turns an eraser into a pen. HDACs are metabolite-dependent histone acyltransferases.
@dremilygoldberg.bsky.social @gburslem.bsky.social
www.nature.com/articles/s41...
Reversible histone deacetylase activity catalyzes lysine acylation - Nature Chemical Biology
Tsusaka et al. discover that histone deacetylases, which are well known to remove protein modifications, such as lysine acetylation and β-hydroxybutyrylation, can also reverse their chemical activity ...
www.nature.com
March 30, 2025 at 5:28 PM
My favorite science is the kind that makes you says, "Man, I wish I thought of that!" This is such a paper.
Mass action turns an eraser into a pen. HDACs are metabolite-dependent histone acyltransferases.
@dremilygoldberg.bsky.social @gburslem.bsky.social
www.nature.com/articles/s41...
Mass action turns an eraser into a pen. HDACs are metabolite-dependent histone acyltransferases.
@dremilygoldberg.bsky.social @gburslem.bsky.social
www.nature.com/articles/s41...
Reposted by Rob Beagrie
A really nice paper by @drghawkes.bsky.social et al. argues that rare and common genetic associations converge on the same genes.
While this seems at odds with our recent work about how burden tests and GWAS prioritize different genes, our results agree (🧬🧪🧵 1/6)
www.biorxiv.org/content/10.1...
While this seems at odds with our recent work about how burden tests and GWAS prioritize different genes, our results agree (🧬🧪🧵 1/6)
www.biorxiv.org/content/10.1...
Whole-genome sequencing analysis of anthropometric traits in 672,976 individuals reveals convergence between rare and common genetic associations
Genetic association studies have mostly focussed on common variants from genotyping arrays or rare protein-coding variants from exome sequencing. Here, we used whole-genome sequence (WGS) data in 672,...
www.biorxiv.org
March 28, 2025 at 1:22 AM
A really nice paper by @drghawkes.bsky.social et al. argues that rare and common genetic associations converge on the same genes.
While this seems at odds with our recent work about how burden tests and GWAS prioritize different genes, our results agree (🧬🧪🧵 1/6)
www.biorxiv.org/content/10.1...
While this seems at odds with our recent work about how burden tests and GWAS prioritize different genes, our results agree (🧬🧪🧵 1/6)
www.biorxiv.org/content/10.1...
Delighted to have been able to help out with this project - congratulations Ali and the rest of the @drakesmith-lab.bsky.social - such a fascinating #genetics and #GeneRegulation story 🧪
Wonderful to see this out, a big effort led by Alexandra Preston and fun for the lab to do something new (and very very old); plus it’s only slightly iron-related! 😳😱😀 www.nature.com/articles/s41...
Ancient genomic linkage of α-globin and Nprl3 couples metabolism with erythropoiesis - Nature Communications
Nprl3 controls erythroblast metabolism and is upregulated by α -globin enhancers sited within its introns. This arrangement couples metabolic and developmental control during erythropoiesis and may ex...
www.nature.com
March 27, 2025 at 8:58 PM
Delighted to have been able to help out with this project - congratulations Ali and the rest of the @drakesmith-lab.bsky.social - such a fascinating #genetics and #GeneRegulation story 🧪
Reposted by Rob Beagrie
This is going to be such a disaster. Cis-women will be outed as trans for genetics they had no idea about. What then?
World Athletics to introduce mandatory sex testing for female competitions
World Athletics to introduce mandatory sex testing for female competitions
World Athletics will introduce mandatory testing for anyone entering female competitions to verify their biological sex, insisting they are necessary to protect women's sport.
news.sky.com
March 26, 2025 at 10:25 AM
This is going to be such a disaster. Cis-women will be outed as trans for genetics they had no idea about. What then?
Reposted by Rob Beagrie
Pet peeve: I hate how often ppl claim “all the researchers will just move to Europe/Canada!” You vastly under-estimate how little money there is there vs the USA- and unless that changes ASAP this loss is just going to decimate global science, full stop. 🧪🔭
March 16, 2025 at 4:11 PM
Pet peeve: I hate how often ppl claim “all the researchers will just move to Europe/Canada!” You vastly under-estimate how little money there is there vs the USA- and unless that changes ASAP this loss is just going to decimate global science, full stop. 🧪🔭
Reposted by Rob Beagrie
I wrote up some thoughts on the idea of recruiting embattled American scientists to Europe. My main point: it would work best to keep the talent pipeline going, but not to salvage individual careers, especially mature ones. The barriers are many.
michaelerard.com/blog/a-few-t...
michaelerard.com/blog/a-few-t...
Michael Erard
would it work to recruit American scientists to Europe?
michaelerard.com
March 15, 2025 at 11:51 AM
I wrote up some thoughts on the idea of recruiting embattled American scientists to Europe. My main point: it would work best to keep the talent pipeline going, but not to salvage individual careers, especially mature ones. The barriers are many.
michaelerard.com/blog/a-few-t...
michaelerard.com/blog/a-few-t...
Reposted by Rob Beagrie
A few weeks ago, I had an incredibly emotional call with James Coney, a writer for the Sunday Times whose son Charlie was in the @genomicsengland.bsky.social 100k project and was recently diagnosed with ReNU syndrome. This beautiful article tells their story ❤️ www.thetimes.com/article/0bcc...
My son Charlie — and the breakthrough that changed our lives
James Coney and his wife, Sarah, struggled not knowing why their 12-year-old was born with a severe learning disability. In their darkest moments, they blamed themselves. Then, out of the blue, came a...
www.thetimes.com
March 2, 2025 at 12:06 PM
A few weeks ago, I had an incredibly emotional call with James Coney, a writer for the Sunday Times whose son Charlie was in the @genomicsengland.bsky.social 100k project and was recently diagnosed with ReNU syndrome. This beautiful article tells their story ❤️ www.thetimes.com/article/0bcc...
Reposted by Rob Beagrie
Here is the peer-reviewed version of our study showing how some TAD borders are essential for gene regulation and development.
Loss of a single CTCF motif is sufficient to cause embryonic lethality.
www.sciencedirect.com/science/arti...
Loss of a single CTCF motif is sufficient to cause embryonic lethality.
www.sciencedirect.com/science/arti...
Deletion of a single CTCF motif at the boundary of a chromatin domain with three FGF genes disrupts gene expression and embryonic development
Chromatin domains delimited by CTCF can restrict the range of enhancer action. However, disruption of some domain boundaries results in mild gene dysr…
www.sciencedirect.com
February 26, 2025 at 9:22 PM
Here is the peer-reviewed version of our study showing how some TAD borders are essential for gene regulation and development.
Loss of a single CTCF motif is sufficient to cause embryonic lethality.
www.sciencedirect.com/science/arti...
Loss of a single CTCF motif is sufficient to cause embryonic lethality.
www.sciencedirect.com/science/arti...
Reposted by Rob Beagrie
Prenatal DNA screening successfully predicts preeclampsia risk early in pregnancy, identifying tissue dysfunction months before onset.
by Adil M, Kolarova TR (...) Shree R et 15 al. in Nat Med #MedSky
📖 read the article:
by Adil M, Kolarova TR (...) Shree R et 15 al. in Nat Med #MedSky
📖 read the article:
Preeclampsia risk prediction from prenatal cell-free DNA screening - Nature Medicine
Using 1,854 routinely collected clinical samples from early in pregnancy, with validation in an external cohort, low-coverage cfDNA sequence data identified distinctive features among those who developed preeclampsia.
www.nature.com
February 21, 2025 at 4:34 PM
Prenatal DNA screening successfully predicts preeclampsia risk early in pregnancy, identifying tissue dysfunction months before onset.
by Adil M, Kolarova TR (...) Shree R et 15 al. in Nat Med #MedSky
📖 read the article:
by Adil M, Kolarova TR (...) Shree R et 15 al. in Nat Med #MedSky
📖 read the article:
Reposted by Rob Beagrie
📢 Our lab is looking for a bioinformatics postdoc. We have lots of exciting projects to work on, including single cell (epi-)genomics, microglia xenotransplantations and nanopore long reads splicing analysis. Look out for the official advert next week and get in touch in the meantime 🧬🧠
February 12, 2025 at 1:42 PM
📢 Our lab is looking for a bioinformatics postdoc. We have lots of exciting projects to work on, including single cell (epi-)genomics, microglia xenotransplantations and nanopore long reads splicing analysis. Look out for the official advert next week and get in touch in the meantime 🧬🧠
Reposted by Rob Beagrie
Reminder of an exciting conference 'Hidden Cell, Dark Genome', Edinburgh 3-4th April 2025!
Sessions:
• Regulatory functions of the dark genome
• Uncharted proteins and RNA complexity
• Cellular diversity
• Atomic structures at the cellular scale
Early bird and registration deadline: 28th February!
Sessions:
• Regulatory functions of the dark genome
• Uncharted proteins and RNA complexity
• Cellular diversity
• Atomic structures at the cellular scale
Early bird and registration deadline: 28th February!
February 9, 2025 at 12:08 PM
Reminder of an exciting conference 'Hidden Cell, Dark Genome', Edinburgh 3-4th April 2025!
Sessions:
• Regulatory functions of the dark genome
• Uncharted proteins and RNA complexity
• Cellular diversity
• Atomic structures at the cellular scale
Early bird and registration deadline: 28th February!
Sessions:
• Regulatory functions of the dark genome
• Uncharted proteins and RNA complexity
• Cellular diversity
• Atomic structures at the cellular scale
Early bird and registration deadline: 28th February!
Reposted by Rob Beagrie
When asked to draw a scientist, school-age kids in the United States are increasingly sketching women, according to a study from 2018.
Read more on #WomenInScienceDay: https://scim.ag/4hOUuvx
Read more on #WomenInScienceDay: https://scim.ag/4hOUuvx
February 11, 2025 at 5:10 PM
When asked to draw a scientist, school-age kids in the United States are increasingly sketching women, according to a study from 2018.
Read more on #WomenInScienceDay: https://scim.ag/4hOUuvx
Read more on #WomenInScienceDay: https://scim.ag/4hOUuvx
Reposted by Rob Beagrie
Today is International Day of Women & Girls in Science.
Marie Curie, the first woman to win a Nobel Prize. Her contributions have left an indelible mark on the world of science & health & continue to inspire generations of scientists & innovators. 🔬 #WomenInScience #WomenInSTEM
Marie Curie, the first woman to win a Nobel Prize. Her contributions have left an indelible mark on the world of science & health & continue to inspire generations of scientists & innovators. 🔬 #WomenInScience #WomenInSTEM
February 11, 2025 at 7:52 AM
Today is International Day of Women & Girls in Science.
Marie Curie, the first woman to win a Nobel Prize. Her contributions have left an indelible mark on the world of science & health & continue to inspire generations of scientists & innovators. 🔬 #WomenInScience #WomenInSTEM
Marie Curie, the first woman to win a Nobel Prize. Her contributions have left an indelible mark on the world of science & health & continue to inspire generations of scientists & innovators. 🔬 #WomenInScience #WomenInSTEM
Anyone else worried about what might happen if funding gets pulled for the Gene Expression Omnibus? Is everything mirrored at EBI or only some of it? #genomics #bioinformatics
February 10, 2025 at 10:23 AM
Anyone else worried about what might happen if funding gets pulled for the Gene Expression Omnibus? Is everything mirrored at EBI or only some of it? #genomics #bioinformatics
Reposted by Rob Beagrie
Prenatal stress effects on the placenta.
Maternal stress is a critical factor in the long-term health of offspring. A recent study (below) profiled the effects of prenatal stress on DNA methylation + gene expression in rat placenta & fetal brain.
🧪🧠🐀 #neuroskyence
www.nature.com/articles/s41...
Maternal stress is a critical factor in the long-term health of offspring. A recent study (below) profiled the effects of prenatal stress on DNA methylation + gene expression in rat placenta & fetal brain.
🧪🧠🐀 #neuroskyence
www.nature.com/articles/s41...
Prenatal stress effects on the placenta - Nature Neuroscience
Nature Neuroscience - Prenatal stress effects on the placenta
www.nature.com
February 7, 2025 at 8:36 AM
Prenatal stress effects on the placenta.
Maternal stress is a critical factor in the long-term health of offspring. A recent study (below) profiled the effects of prenatal stress on DNA methylation + gene expression in rat placenta & fetal brain.
🧪🧠🐀 #neuroskyence
www.nature.com/articles/s41...
Maternal stress is a critical factor in the long-term health of offspring. A recent study (below) profiled the effects of prenatal stress on DNA methylation + gene expression in rat placenta & fetal brain.
🧪🧠🐀 #neuroskyence
www.nature.com/articles/s41...