Bluma Lesch
@ambystoma22.bsky.social
Genetics faculty @ Yale: genetics, genomics, chromatin, reproduction, and evolution. Or really, just trying to see where the next result takes us.
Reposted by Bluma Lesch
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
November 6, 2025 at 2:49 PM
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
Reposted by Bluma Lesch
RESEARCH COMMUNICATION: H3K4me3 amplifies transcription at intergenic active regulatory elements
By Yu et. al and Bluma Lesch
➡️ https://genesdev.cshlp.org/content/39/21-22/1290.full
Bluma Lesch
@haomingyu.bsky.social
#transcription #epigenetics #histones #histonePTMs #methylation #enhancers
By Yu et. al and Bluma Lesch
➡️ https://genesdev.cshlp.org/content/39/21-22/1290.full
Bluma Lesch
@haomingyu.bsky.social
#transcription #epigenetics #histones #histonePTMs #methylation #enhancers
November 4, 2025 at 4:01 PM
RESEARCH COMMUNICATION: H3K4me3 amplifies transcription at intergenic active regulatory elements
By Yu et. al and Bluma Lesch
➡️ https://genesdev.cshlp.org/content/39/21-22/1290.full
Bluma Lesch
@haomingyu.bsky.social
#transcription #epigenetics #histones #histonePTMs #methylation #enhancers
By Yu et. al and Bluma Lesch
➡️ https://genesdev.cshlp.org/content/39/21-22/1290.full
Bluma Lesch
@haomingyu.bsky.social
#transcription #epigenetics #histones #histonePTMs #methylation #enhancers
#QEDscience has been great! We’ve used it for a few manuscripts and it helped us really improve them before submission. Definitely recommend!
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
October 15, 2025 at 3:48 PM
#QEDscience has been great! We’ve used it for a few manuscripts and it helped us really improve them before submission. Definitely recommend!
Reposted by Bluma Lesch
💡 Cancer cells don’t just mutate—they reorganize their DNA in 3D space.
Our new study shows how the genome’s folding pattern shifts as tumors progress, cell by cell 🧩🧬.
It’s the first 3D genome atlas of cancer progression.
Thread 👇
Our new study shows how the genome’s folding pattern shifts as tumors progress, cell by cell 🧩🧬.
It’s the first 3D genome atlas of cancer progression.
Thread 👇
August 26, 2025 at 1:20 PM
💡 Cancer cells don’t just mutate—they reorganize their DNA in 3D space.
Our new study shows how the genome’s folding pattern shifts as tumors progress, cell by cell 🧩🧬.
It’s the first 3D genome atlas of cancer progression.
Thread 👇
Our new study shows how the genome’s folding pattern shifts as tumors progress, cell by cell 🧩🧬.
It’s the first 3D genome atlas of cancer progression.
Thread 👇
New paper on the role of H3K4me3 at enhancers! We (led by Haoming Yu) used dCas9 epigenome editing to add H3K4me3 to intergenic enhancers. This was (1) sufficient to turn up transcription at open, active regions and (2) has no effect on target gene transcription. genesdev.cshlp.org/content/earl...
H3K4me3 amplifies transcription at intergenic active regulatory elements
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
genesdev.cshlp.org
August 20, 2025 at 1:29 AM
New paper on the role of H3K4me3 at enhancers! We (led by Haoming Yu) used dCas9 epigenome editing to add H3K4me3 to intergenic enhancers. This was (1) sufficient to turn up transcription at open, active regions and (2) has no effect on target gene transcription. genesdev.cshlp.org/content/earl...
Agreed, truly a team effort - but a huge amount of credit to @kataruka.bsky.social for her leadership. Smarca5 is important for chromatin remodeling in DNA damage repair during male meiosis (among other things!)
Truly a team effort from the Lesch lab @ambystoma22.bsky.social Happy to share this paper where we study the role of Smarca5 in spermatogenesis.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
SMARCA5 restricts chromatin accessibility to promote male meiosis and fertility in mammals | PNAS
Establishment of correct chromatin configuration in male meiosis is essential for
sperm formation and male fertility. However, how chromatin remode...
www.pnas.org
August 2, 2025 at 4:17 AM
Agreed, truly a team effort - but a huge amount of credit to @kataruka.bsky.social for her leadership. Smarca5 is important for chromatin remodeling in DNA damage repair during male meiosis (among other things!)
Reposted by Bluma Lesch
It seems that only the science community is noticing that NIH and NSF budgets are cut 40% and 55% in the budget bill, respectively. If you live in Maine, West Va, Pennsylvania, Alabama, or Louisiana, CALL YOUR SENATOR as they could make a difference. See below.
prospect.org/politics/202...
prospect.org/politics/202...
Will the Senate Save NIH?
Rescuing biomedical research is every bit as important as saving Medicaid.
prospect.org
June 29, 2025 at 3:17 AM
It seems that only the science community is noticing that NIH and NSF budgets are cut 40% and 55% in the budget bill, respectively. If you live in Maine, West Va, Pennsylvania, Alabama, or Louisiana, CALL YOUR SENATOR as they could make a difference. See below.
prospect.org/politics/202...
prospect.org/politics/202...
Reposted by Bluma Lesch
I am heartbroken about the loss of many labs at the Weizmann Institute yesterday in the missile attack. Dear scientists there: please know that you are not alone. Like many many others, I support you and am standing by to help you in any way I can.
June 16, 2025 at 12:19 PM
I am heartbroken about the loss of many labs at the Weizmann Institute yesterday in the missile attack. Dear scientists there: please know that you are not alone. Like many many others, I support you and am standing by to help you in any way I can.
Happy to be here!
April 3, 2025 at 11:35 PM
Happy to be here!
Starting fresh! With the best kind of post: congrats to (social media-free) grad student Kira Marshall on an awesome paper comparing opossum and placental mammal transcriptomes: www.cell.com/developmenta...
Evolutionary innovations in germline biology of placental mammals identified by transcriptomics of first-wave spermatogenesis in opossum
Marshall et al. combine high-resolution bulk and single-cell RNA-seq data from mouse
and opossum to analyze patterns of gene regulatory evolution during mammalian spermatogenesis.
They discover genes ...
www.cell.com
November 15, 2024 at 3:33 AM
Starting fresh! With the best kind of post: congrats to (social media-free) grad student Kira Marshall on an awesome paper comparing opossum and placental mammal transcriptomes: www.cell.com/developmenta...