Molecular Systems Biology
@molsystbiol.org
#OpenAccess @embopress.org journal publishing pioneering research in systems & synthetic biology, systems medicine
Pinned
2/2026 Issue ➡️ link.springer.com/journal/4432...
expansion microscopy, spatial omics and gene networks, cell population control by cell cycle, #IBD heterogeneity, aging monkey lipid signatures
Cover: single-cell loss-of-function screening in human pluripotent stem cells from @berterolab.bsky.social
expansion microscopy, spatial omics and gene networks, cell population control by cell cycle, #IBD heterogeneity, aging monkey lipid signatures
Cover: single-cell loss-of-function screening in human pluripotent stem cells from @berterolab.bsky.social
iPS2-seq is a clone-aware platform for #singlecell loss-of-function screening in #hiPSCs and derivatives including #organoids, here revealing SMAD2 role in cardiac progenitor specification from @berterolab.bsky.social @mendjanlab.bsky.social #functionalgenomics ➡️ link.springer.com/article/10.1...
February 3, 2026 at 3:20 PM
iPS2-seq is a clone-aware platform for #singlecell loss-of-function screening in #hiPSCs and derivatives including #organoids, here revealing SMAD2 role in cardiac progenitor specification from @berterolab.bsky.social @mendjanlab.bsky.social #functionalgenomics ➡️ link.springer.com/article/10.1...
2/2026 Issue ➡️ link.springer.com/journal/4432...
expansion microscopy, spatial omics and gene networks, cell population control by cell cycle, #IBD heterogeneity, aging monkey lipid signatures
Cover: single-cell loss-of-function screening in human pluripotent stem cells from @berterolab.bsky.social
expansion microscopy, spatial omics and gene networks, cell population control by cell cycle, #IBD heterogeneity, aging monkey lipid signatures
Cover: single-cell loss-of-function screening in human pluripotent stem cells from @berterolab.bsky.social
February 3, 2026 at 2:46 PM
2/2026 Issue ➡️ link.springer.com/journal/4432...
expansion microscopy, spatial omics and gene networks, cell population control by cell cycle, #IBD heterogeneity, aging monkey lipid signatures
Cover: single-cell loss-of-function screening in human pluripotent stem cells from @berterolab.bsky.social
expansion microscopy, spatial omics and gene networks, cell population control by cell cycle, #IBD heterogeneity, aging monkey lipid signatures
Cover: single-cell loss-of-function screening in human pluripotent stem cells from @berterolab.bsky.social
Reposted by Molecular Systems Biology
📣 #paper "Uncovering actionable trade-offs of antifungal resistance in a yeast pathogen"
Check out our new publication in @molsystbiol.org where we systematically map stress-related trade-off associated with drug resistance in Candida glabrata (N. glabratus)
link.springer.com/article/10.1...
Check out our new publication in @molsystbiol.org where we systematically map stress-related trade-off associated with drug resistance in Candida glabrata (N. glabratus)
link.springer.com/article/10.1...
January 18, 2026 at 3:24 PM
📣 #paper "Uncovering actionable trade-offs of antifungal resistance in a yeast pathogen"
Check out our new publication in @molsystbiol.org where we systematically map stress-related trade-off associated with drug resistance in Candida glabrata (N. glabratus)
link.springer.com/article/10.1...
Check out our new publication in @molsystbiol.org where we systematically map stress-related trade-off associated with drug resistance in Candida glabrata (N. glabratus)
link.springer.com/article/10.1...
Reposted by Molecular Systems Biology
On the heels of the release of #AlphaGenome, we have written up a review on 🧬genomic language models for DNA/RNA, out in EMBO @molsystbiol.org journal
🔖"The DNA dialect: a comprehensive guide to pretrained genomic language models" by Marcell Veiner👏 & yours truly👇
link.springer.com/article/10.1...
🔖"The DNA dialect: a comprehensive guide to pretrained genomic language models" by Marcell Veiner👏 & yours truly👇
link.springer.com/article/10.1...
February 2, 2026 at 11:30 AM
On the heels of the release of #AlphaGenome, we have written up a review on 🧬genomic language models for DNA/RNA, out in EMBO @molsystbiol.org journal
🔖"The DNA dialect: a comprehensive guide to pretrained genomic language models" by Marcell Veiner👏 & yours truly👇
link.springer.com/article/10.1...
🔖"The DNA dialect: a comprehensive guide to pretrained genomic language models" by Marcell Veiner👏 & yours truly👇
link.springer.com/article/10.1...
12/2025 Issue ➡️ link.springer.com/journal/4432... MSB 20th anniversary editorial, transposable elements in human craniofacial development, engineered paediatric tumor models, personalized signalling models, and more
Cover (www.scistories.com): ancestry shapes prostate tumour methylation patterns
Cover (www.scistories.com): ancestry shapes prostate tumour methylation patterns
December 19, 2025 at 12:21 AM
12/2025 Issue ➡️ link.springer.com/journal/4432... MSB 20th anniversary editorial, transposable elements in human craniofacial development, engineered paediatric tumor models, personalized signalling models, and more
Cover (www.scistories.com): ancestry shapes prostate tumour methylation patterns
Cover (www.scistories.com): ancestry shapes prostate tumour methylation patterns
Reposted by Molecular Systems Biology
Reposted by Molecular Systems Biology
We can know more than we can tell, but now Al can capture it. Our multimodal agent analyzes lab videos to generate protocols & catch common lab errors. Preserving tacit knowledge in proteomics. Now in @molsystbiol.org @patiskowronek.bsky.social #Google
link.springer.com/10.1038/s443...
link.springer.com/10.1038/s443...
December 16, 2025 at 9:29 AM
We can know more than we can tell, but now Al can capture it. Our multimodal agent analyzes lab videos to generate protocols & catch common lab errors. Preserving tacit knowledge in proteomics. Now in @molsystbiol.org @patiskowronek.bsky.social #Google
link.springer.com/10.1038/s443...
link.springer.com/10.1038/s443...
Reposted by Molecular Systems Biology
We just published in @molsystbiol.org with the Mugler lab (UPitt) on bacterial population dynamics during tumor colonization (mouse model). Our study was guided by a Luria–Delbrück-style idea: infer mechanism from statistics (1/7) 🧪🦠
doi.org/10.1038/s443...
doi.org/10.1038/s443...
December 17, 2025 at 6:52 PM
We just published in @molsystbiol.org with the Mugler lab (UPitt) on bacterial population dynamics during tumor colonization (mouse model). Our study was guided by a Luria–Delbrück-style idea: infer mechanism from statistics (1/7) 🧪🦠
doi.org/10.1038/s443...
doi.org/10.1038/s443...
Early Registration deadline Nov 20th for @keystonesymposia.bsky.social #Microbiome Metabolism & #Metabolites, joint with Human #Microbiome, Jan 19-23 in Banff! See upcoming deadlines: keysym.us/KSMicroMetab26 keysym.us/KSMicrobiome26 #KSMicroMetab26 #KSMicrobiome26
Microbiome Metabolism and Metabolites: Discovery and Function in Health and Disease | Keystone Symposia
Join us at the Keystone Symposia on Microbiome Metabolism and Metabolites: Discovery and Function in Health and Disease, January 2026, in Banff, with field leaders!
keysym.us
November 17, 2025 at 6:05 PM
Early Registration deadline Nov 20th for @keystonesymposia.bsky.social #Microbiome Metabolism & #Metabolites, joint with Human #Microbiome, Jan 19-23 in Banff! See upcoming deadlines: keysym.us/KSMicroMetab26 keysym.us/KSMicrobiome26 #KSMicroMetab26 #KSMicrobiome26
11/2025 Issue ➡️ www.embopress.org/toc/17444292...
overflow metabolism, asymptomatic malaria, yeast variation, conserved PPI interfaces, persisters, base editing, immune signatures and cell patterning, viral protein structure prediction, GRN tool
Cover: vascular site-specific regulatory enhancers
overflow metabolism, asymptomatic malaria, yeast variation, conserved PPI interfaces, persisters, base editing, immune signatures and cell patterning, viral protein structure prediction, GRN tool
Cover: vascular site-specific regulatory enhancers
November 7, 2025 at 6:02 PM
11/2025 Issue ➡️ www.embopress.org/toc/17444292...
overflow metabolism, asymptomatic malaria, yeast variation, conserved PPI interfaces, persisters, base editing, immune signatures and cell patterning, viral protein structure prediction, GRN tool
Cover: vascular site-specific regulatory enhancers
overflow metabolism, asymptomatic malaria, yeast variation, conserved PPI interfaces, persisters, base editing, immune signatures and cell patterning, viral protein structure prediction, GRN tool
Cover: vascular site-specific regulatory enhancers
Reposted by Molecular Systems Biology
Explore emerging research with field leaders @keystonesymposia.bsky.social #Microbiome Metabolism & #Metabolites, this January in Banff! @molsystbiol.org scientific editor Poonam Bheda will attend.
Early registration deadline is Nov 20th => keysym.us/KSMicroMetab26 #KSMicroMetab26
Early registration deadline is Nov 20th => keysym.us/KSMicroMetab26 #KSMicroMetab26
Microbiome Metabolism and Metabolites: Discovery and Function in Health and Disease | Keystone Symposia
Join us at the Keystone Symposia on Microbiome Metabolism and Metabolites: Discovery and Function in Health and Disease, January 2026, in Banff, with field leaders!
keysym.us
October 23, 2025 at 12:12 PM
Explore emerging research with field leaders @keystonesymposia.bsky.social #Microbiome Metabolism & #Metabolites, this January in Banff! @molsystbiol.org scientific editor Poonam Bheda will attend.
Early registration deadline is Nov 20th => keysym.us/KSMicroMetab26 #KSMicroMetab26
Early registration deadline is Nov 20th => keysym.us/KSMicroMetab26 #KSMicroMetab26
Reposted by Molecular Systems Biology
Paper alert! doi.org/10.1038/s443... - "A scheduler for rhythmic gene expression". We show how 9 txn factors suffice for rhythmic gene expression of thousands of genes with any phase or amplitude in #Celegans larvae (and also look at the tissues where oscillations happen) 1/n
October 10, 2025 at 2:17 PM
Paper alert! doi.org/10.1038/s443... - "A scheduler for rhythmic gene expression". We show how 9 txn factors suffice for rhythmic gene expression of thousands of genes with any phase or amplitude in #Celegans larvae (and also look at the tissues where oscillations happen) 1/n
Reposted by Molecular Systems Biology
10/2025 Issue ➡️ www.embopress.org/toc/17444292...
reduced genomes, adaptive mutations under stress, xenobiotics and gut microbiome, DMS analysis, TF effector metabolites
Cover: proteins can agglomerate with limited impact on cell by @elevylab.bsky.social
reduced genomes, adaptive mutations under stress, xenobiotics and gut microbiome, DMS analysis, TF effector metabolites
Cover: proteins can agglomerate with limited impact on cell by @elevylab.bsky.social
October 7, 2025 at 6:16 PM
10/2025 Issue ➡️ www.embopress.org/toc/17444292...
reduced genomes, adaptive mutations under stress, xenobiotics and gut microbiome, DMS analysis, TF effector metabolites
Cover: proteins can agglomerate with limited impact on cell by @elevylab.bsky.social
reduced genomes, adaptive mutations under stress, xenobiotics and gut microbiome, DMS analysis, TF effector metabolites
Cover: proteins can agglomerate with limited impact on cell by @elevylab.bsky.social
Reposted by Molecular Systems Biology
🚨 New Web Resource Alert! 🚨 We're delighted to share Viro3D a database of >85000 viral protein structure predictions from >4400 human & animal viruses.
🔗 viro3d.cvr.gla.ac.uk
📄 www.embopress.org/doi/full/10....
@molsystbiol.org @cvrinfo.bsky.social @uofgmvls.bsky.social #Virology #AlphaFold 🧪 🦠
🔗 viro3d.cvr.gla.ac.uk
📄 www.embopress.org/doi/full/10....
@molsystbiol.org @cvrinfo.bsky.social @uofgmvls.bsky.social #Virology #AlphaFold 🧪 🦠
Viro3D
viro3d.cvr.gla.ac.uk
September 26, 2025 at 11:36 AM
🚨 New Web Resource Alert! 🚨 We're delighted to share Viro3D a database of >85000 viral protein structure predictions from >4400 human & animal viruses.
🔗 viro3d.cvr.gla.ac.uk
📄 www.embopress.org/doi/full/10....
@molsystbiol.org @cvrinfo.bsky.social @uofgmvls.bsky.social #Virology #AlphaFold 🧪 🦠
🔗 viro3d.cvr.gla.ac.uk
📄 www.embopress.org/doi/full/10....
@molsystbiol.org @cvrinfo.bsky.social @uofgmvls.bsky.social #Virology #AlphaFold 🧪 🦠
Reposted by Molecular Systems Biology
Our latest paper just came out in Molecular Systems Biology !
Transition between cell states of sensitivity reveals molecular vulnerability of drug-tolerant cells @molsystbiol.org
www.embopress.org/doi/full/10....
Transition between cell states of sensitivity reveals molecular vulnerability of drug-tolerant cells @molsystbiol.org
www.embopress.org/doi/full/10....
October 1, 2025 at 2:12 PM
Our latest paper just came out in Molecular Systems Biology !
Transition between cell states of sensitivity reveals molecular vulnerability of drug-tolerant cells @molsystbiol.org
www.embopress.org/doi/full/10....
Transition between cell states of sensitivity reveals molecular vulnerability of drug-tolerant cells @molsystbiol.org
www.embopress.org/doi/full/10....
Reposted by Molecular Systems Biology
🏎️ We wrote a N&Vs on the great new work from Shalev Itzkovitz lab in @molsystbiol.org. Barkai et al. calculate a turnover score and map it into spatial transcriptomics maps of intestinal tissues, informing us about dynamic biological processes in static atlases: www.embopress.org/do... 🧪
October 3, 2025 at 7:27 AM
🏎️ We wrote a N&Vs on the great new work from Shalev Itzkovitz lab in @molsystbiol.org. Barkai et al. calculate a turnover score and map it into spatial transcriptomics maps of intestinal tissues, informing us about dynamic biological processes in static atlases: www.embopress.org/do... 🧪
Reposted by Molecular Systems Biology
@molsystbiol.org picked a neat cover for this month's issue 🙃 - Great work from Tal Levin, Hector Garcia-Seisdedos, many more colleagues (doi.org/10.1038/s443...) and great matching cover, too!
October 5, 2025 at 7:40 PM
@molsystbiol.org picked a neat cover for this month's issue 🙃 - Great work from Tal Levin, Hector Garcia-Seisdedos, many more colleagues (doi.org/10.1038/s443...) and great matching cover, too!
Reposted by Molecular Systems Biology
Years ago we discovered that missense mutations in homomeric proteins often induces their supramolecular assembly, as in the 📽️👇 - Are such aberrant assemblies of *folded* proteins toxic? Surprisingly, NO. Cells are amazingly robust systems! Paper now online @molsystbiol.org doi.org/10.1038/s443...
September 16, 2025 at 4:22 PM
Years ago we discovered that missense mutations in homomeric proteins often induces their supramolecular assembly, as in the 📽️👇 - Are such aberrant assemblies of *folded* proteins toxic? Surprisingly, NO. Cells are amazingly robust systems! Paper now online @molsystbiol.org doi.org/10.1038/s443...
Reposted by Molecular Systems Biology
👏 Congratulations @elevylab.bsky.social for your latest publication in @molsystbiol.org: Mutation-induced filaments of folded proteins are inert and non-toxic in a cellular system @mocel.bsky.social #UNIGE
Years ago we discovered that missense mutations in homomeric proteins often induces their supramolecular assembly, as in the 📽️👇 - Are such aberrant assemblies of *folded* proteins toxic? Surprisingly, NO. Cells are amazingly robust systems! Paper now online @molsystbiol.org doi.org/10.1038/s443...
September 17, 2025 at 7:28 AM
👏 Congratulations @elevylab.bsky.social for your latest publication in @molsystbiol.org: Mutation-induced filaments of folded proteins are inert and non-toxic in a cellular system @mocel.bsky.social #UNIGE
Reposted by Molecular Systems Biology
Our study on the role of LTR5HS and SVAs in regulation of human neural crest migration is now published as peer-reviewed paper on @molsystbiol.org!
Congrats to first author brilliant postdoc Laura Deelen, and all the authors involved! @imperialsci.bsky.social
www.embopress.org/doi/full/10....
Congrats to first author brilliant postdoc Laura Deelen, and all the authors involved! @imperialsci.bsky.social
www.embopress.org/doi/full/10....
September 22, 2025 at 11:24 AM
Our study on the role of LTR5HS and SVAs in regulation of human neural crest migration is now published as peer-reviewed paper on @molsystbiol.org!
Congrats to first author brilliant postdoc Laura Deelen, and all the authors involved! @imperialsci.bsky.social
www.embopress.org/doi/full/10....
Congrats to first author brilliant postdoc Laura Deelen, and all the authors involved! @imperialsci.bsky.social
www.embopress.org/doi/full/10....
9/2025 Issue ➡️ www.embopress.org/toc/17444292...
mutational bursts in subsets of yeast, directed evolution with optogenetics, mouse gut biosensor screening, gene program dysregulation analysis
Cover: AlphaDesign to generate various protein structures, e.g. protein site-specific binders and oligomers
mutational bursts in subsets of yeast, directed evolution with optogenetics, mouse gut biosensor screening, gene program dysregulation analysis
Cover: AlphaDesign to generate various protein structures, e.g. protein site-specific binders and oligomers
September 8, 2025 at 11:32 AM
9/2025 Issue ➡️ www.embopress.org/toc/17444292...
mutational bursts in subsets of yeast, directed evolution with optogenetics, mouse gut biosensor screening, gene program dysregulation analysis
Cover: AlphaDesign to generate various protein structures, e.g. protein site-specific binders and oligomers
mutational bursts in subsets of yeast, directed evolution with optogenetics, mouse gut biosensor screening, gene program dysregulation analysis
Cover: AlphaDesign to generate various protein structures, e.g. protein site-specific binders and oligomers
Reposted by Molecular Systems Biology
Identifying genes essential to survival of bacteria Mycoplasma pneumoniae – the relevant new treatment targets
📷 Maria Lluch-Senar, research Samuel Miravet-Verde & Raul Burgos et al Serrano lab @crg.eu in @molsystbiol.org
➡️ bpod.org.uk/archive/2025... with
@rooph.bsky.social
📷 Maria Lluch-Senar, research Samuel Miravet-Verde & Raul Burgos et al Serrano lab @crg.eu in @molsystbiol.org
➡️ bpod.org.uk/archive/2025... with
@rooph.bsky.social
August 29, 2025 at 8:17 AM
Identifying genes essential to survival of bacteria Mycoplasma pneumoniae – the relevant new treatment targets
📷 Maria Lluch-Senar, research Samuel Miravet-Verde & Raul Burgos et al Serrano lab @crg.eu in @molsystbiol.org
➡️ bpod.org.uk/archive/2025... with
@rooph.bsky.social
📷 Maria Lluch-Senar, research Samuel Miravet-Verde & Raul Burgos et al Serrano lab @crg.eu in @molsystbiol.org
➡️ bpod.org.uk/archive/2025... with
@rooph.bsky.social
Reposted by Molecular Systems Biology
#ResultatScientifique 🔎 | Saviez-vous que l’IA peut aider à prévoir comment un organisme réagit à son environnement ? Des scientifiques utilisent la levure comme modèle et réussissent à prédire plus de 200 traits grâce au machine learning
✍️ @litinice.bsky.social
📕 @molsystbiol.org | buff.ly/MliXXKz
✍️ @litinice.bsky.social
📕 @molsystbiol.org | buff.ly/MliXXKz
September 1, 2025 at 4:01 PM
#ResultatScientifique 🔎 | Saviez-vous que l’IA peut aider à prévoir comment un organisme réagit à son environnement ? Des scientifiques utilisent la levure comme modèle et réussissent à prédire plus de 200 traits grâce au machine learning
✍️ @litinice.bsky.social
📕 @molsystbiol.org | buff.ly/MliXXKz
✍️ @litinice.bsky.social
📕 @molsystbiol.org | buff.ly/MliXXKz
A. Mardinoglu et al. explore how AI + systems biology are transforming multi-omics integration for precision health and medicine ➡️ www.embopress.org/doi/full/10....
August 8, 2025 at 11:31 AM
A. Mardinoglu et al. explore how AI + systems biology are transforming multi-omics integration for precision health and medicine ➡️ www.embopress.org/doi/full/10....