Molecular Systems Biology
@molsystbiol.org
#OpenAccess @embopress.org journal publishing pioneering research in systems & synthetic biology, systems medicine
11/2025 Issue ➡️ www.embopress.org/toc/17444292...
overflow metabolism, asymptomatic malaria, yeast variation, conserved PPI interfaces, persisters, base editing, immune signatures and cell patterning, viral protein structure prediction, GRN tool
Cover: vascular site-specific regulatory enhancers
overflow metabolism, asymptomatic malaria, yeast variation, conserved PPI interfaces, persisters, base editing, immune signatures and cell patterning, viral protein structure prediction, GRN tool
Cover: vascular site-specific regulatory enhancers
November 7, 2025 at 6:02 PM
11/2025 Issue ➡️ www.embopress.org/toc/17444292...
overflow metabolism, asymptomatic malaria, yeast variation, conserved PPI interfaces, persisters, base editing, immune signatures and cell patterning, viral protein structure prediction, GRN tool
Cover: vascular site-specific regulatory enhancers
overflow metabolism, asymptomatic malaria, yeast variation, conserved PPI interfaces, persisters, base editing, immune signatures and cell patterning, viral protein structure prediction, GRN tool
Cover: vascular site-specific regulatory enhancers
10/2025 Issue ➡️ www.embopress.org/toc/17444292...
reduced genomes, adaptive mutations under stress, xenobiotics and gut microbiome, DMS analysis, TF effector metabolites
Cover: proteins can agglomerate with limited impact on cell by @elevylab.bsky.social
reduced genomes, adaptive mutations under stress, xenobiotics and gut microbiome, DMS analysis, TF effector metabolites
Cover: proteins can agglomerate with limited impact on cell by @elevylab.bsky.social
October 7, 2025 at 6:16 PM
10/2025 Issue ➡️ www.embopress.org/toc/17444292...
reduced genomes, adaptive mutations under stress, xenobiotics and gut microbiome, DMS analysis, TF effector metabolites
Cover: proteins can agglomerate with limited impact on cell by @elevylab.bsky.social
reduced genomes, adaptive mutations under stress, xenobiotics and gut microbiome, DMS analysis, TF effector metabolites
Cover: proteins can agglomerate with limited impact on cell by @elevylab.bsky.social
9/2025 Issue ➡️ www.embopress.org/toc/17444292...
mutational bursts in subsets of yeast, directed evolution with optogenetics, mouse gut biosensor screening, gene program dysregulation analysis
Cover: AlphaDesign to generate various protein structures, e.g. protein site-specific binders and oligomers
mutational bursts in subsets of yeast, directed evolution with optogenetics, mouse gut biosensor screening, gene program dysregulation analysis
Cover: AlphaDesign to generate various protein structures, e.g. protein site-specific binders and oligomers
September 8, 2025 at 11:32 AM
9/2025 Issue ➡️ www.embopress.org/toc/17444292...
mutational bursts in subsets of yeast, directed evolution with optogenetics, mouse gut biosensor screening, gene program dysregulation analysis
Cover: AlphaDesign to generate various protein structures, e.g. protein site-specific binders and oligomers
mutational bursts in subsets of yeast, directed evolution with optogenetics, mouse gut biosensor screening, gene program dysregulation analysis
Cover: AlphaDesign to generate various protein structures, e.g. protein site-specific binders and oligomers
A. Mardinoglu et al. explore how AI + systems biology are transforming multi-omics integration for precision health and medicine ➡️ www.embopress.org/doi/full/10....
August 8, 2025 at 11:31 AM
A. Mardinoglu et al. explore how AI + systems biology are transforming multi-omics integration for precision health and medicine ➡️ www.embopress.org/doi/full/10....
AlphaDesign uses hallucination + sequence generation to create diverse proteins—from monomers to oligomers to site-specific binders ➡️ www.embopress.org/doi/full/10....
August 8, 2025 at 11:30 AM
AlphaDesign uses hallucination + sequence generation to create diverse proteins—from monomers to oligomers to site-specific binders ➡️ www.embopress.org/doi/full/10....
generative AI model PerturbNet predicts changes in gene expression and cell state in response to unseen chemical and genetic perturbations ➡️ www.embopress.org/doi/full/10....
August 4, 2025 at 1:55 PM
generative AI model PerturbNet predicts changes in gene expression and cell state in response to unseen chemical and genetic perturbations ➡️ www.embopress.org/doi/full/10....
8/2025 Issue ➡️ www.embopress.org/toc/17444292... spatial metabolomics, protein compensation upon gene loss, ancient yeast gene family evolution, prion-like protein fibrils in the gut
Cover: PerturbNet deep generative model predicts states of cells perturbed by chemicals or genetics
Cover: PerturbNet deep generative model predicts states of cells perturbed by chemicals or genetics
August 4, 2025 at 1:52 PM
8/2025 Issue ➡️ www.embopress.org/toc/17444292... spatial metabolomics, protein compensation upon gene loss, ancient yeast gene family evolution, prion-like protein fibrils in the gut
Cover: PerturbNet deep generative model predicts states of cells perturbed by chemicals or genetics
Cover: PerturbNet deep generative model predicts states of cells perturbed by chemicals or genetics
@skamrad.bsky.social @kiranrpatil.bsky.social show xenobiotics impact growth of gut bacteria and their metabolic homeostasis by affecting amine metabolism ➡️ www.embopress.org/doi/full/10....
July 3, 2025 at 12:44 PM
@skamrad.bsky.social @kiranrpatil.bsky.social show xenobiotics impact growth of gut bacteria and their metabolic homeostasis by affecting amine metabolism ➡️ www.embopress.org/doi/full/10....
@mariananatalin6.bsky.social @marcofumasoni.bsky.social show evolutionary repair in response to DNA replication stress in yeast is predictable and consistent across different environments #CompensatoryEvolution #NutrientAvailability #ReplicationStress #GxE ➡️ www.embopress.org/doi/full/10....
July 3, 2025 at 12:39 PM
@mariananatalin6.bsky.social @marcofumasoni.bsky.social show evolutionary repair in response to DNA replication stress in yeast is predictable and consistent across different environments #CompensatoryEvolution #NutrientAvailability #ReplicationStress #GxE ➡️ www.embopress.org/doi/full/10....
A bacterial synthetic memory system is used to enhance screening for new biosensors in the mouse gut by @driglar.bsky.social @clare-r.bsky.social ➡️ www.embopress.org/doi/full/10....
July 3, 2025 at 12:36 PM
A bacterial synthetic memory system is used to enhance screening for new biosensors in the mouse gut by @driglar.bsky.social @clare-r.bsky.social ➡️ www.embopress.org/doi/full/10....
integrated temporally resolved transcriptomic, proteomic, and secretomic profiling of human kidney mesenchymal cells from @savitski-lab.bsky.social @saezlab.bsky.social @miraburtscher.bsky.social identify dynamic changes upon TGF-beta stimulation ➡️ www.embopress.org/doi/full/10....
July 3, 2025 at 12:30 PM
integrated temporally resolved transcriptomic, proteomic, and secretomic profiling of human kidney mesenchymal cells from @savitski-lab.bsky.social @saezlab.bsky.social @miraburtscher.bsky.social identify dynamic changes upon TGF-beta stimulation ➡️ www.embopress.org/doi/full/10....
Latent Graph-based individuAl Causal Effect Estimation (LaGrACE) is a new method from @benoslab.bsky.social lab to uncover gene program dysregulation and disease subtypes ➡️ www.embopress.org/doi/full/10....
July 3, 2025 at 12:24 PM
Latent Graph-based individuAl Causal Effect Estimation (LaGrACE) is a new method from @benoslab.bsky.social lab to uncover gene program dysregulation and disease subtypes ➡️ www.embopress.org/doi/full/10....
OptoRep continuous directed evolution method employs an optogenetic system to evolve proteins with new essential functions from the lab of @javalospu.bsky.social ➡️ www.embopress.org/doi/full/10....
July 3, 2025 at 12:17 PM
OptoRep continuous directed evolution method employs an optogenetic system to evolve proteins with new essential functions from the lab of @javalospu.bsky.social ➡️ www.embopress.org/doi/full/10....
reactant and product metabolite ratios revealed metabolic pathways differences between cancer subtypes and noncancer cell lines by @hoylipidlab.bsky.social @sydneyprecisionds.bsky.social @nancyts.bsky.social ➡️ www.embopress.org/doi/full/10....
July 3, 2025 at 10:11 AM
reactant and product metabolite ratios revealed metabolic pathways differences between cancer subtypes and noncancer cell lines by @hoylipidlab.bsky.social @sydneyprecisionds.bsky.social @nancyts.bsky.social ➡️ www.embopress.org/doi/full/10....
prion-like proteins in the worm gut can form amyloid fibrils and are linked to memory impairment and oxidative stress #Amyloid #Prion #Neurodegeneration #Microbiome #Gut #UABBarcelona ➡️ www.embopress.org/doi/full/10....
July 3, 2025 at 9:31 AM
prion-like proteins in the worm gut can form amyloid fibrils and are linked to memory impairment and oxidative stress #Amyloid #Prion #Neurodegeneration #Microbiome #Gut #UABBarcelona ➡️ www.embopress.org/doi/full/10....
Enzyme kinetic data mapped onto a yeast genome-scale metabolic model reveals interactions between enzymes and metabolites/metabolic reactions ➡️ www.embopress.org/doi/full/10....
July 3, 2025 at 9:08 AM
Enzyme kinetic data mapped onto a yeast genome-scale metabolic model reveals interactions between enzymes and metabolites/metabolic reactions ➡️ www.embopress.org/doi/full/10....
7/2025 Issue ➡️ www.embopress.org/toc/17444292...
proteomics of human protein complexes and colorectal tumors, cryptic antimicrobial peptides, transferable plasmids, gene buffering, metabolic pathway crosstalk
Cover (www.scistories.com): 3D genome variance between homologous heterozygous chromosomes
proteomics of human protein complexes and colorectal tumors, cryptic antimicrobial peptides, transferable plasmids, gene buffering, metabolic pathway crosstalk
Cover (www.scistories.com): 3D genome variance between homologous heterozygous chromosomes
July 3, 2025 at 9:03 AM
7/2025 Issue ➡️ www.embopress.org/toc/17444292...
proteomics of human protein complexes and colorectal tumors, cryptic antimicrobial peptides, transferable plasmids, gene buffering, metabolic pathway crosstalk
Cover (www.scistories.com): 3D genome variance between homologous heterozygous chromosomes
proteomics of human protein complexes and colorectal tumors, cryptic antimicrobial peptides, transferable plasmids, gene buffering, metabolic pathway crosstalk
Cover (www.scistories.com): 3D genome variance between homologous heterozygous chromosomes
6/2025 Issue ➡️ www.embopress.org/toc/17444292...
spatial proteomics, metabolic reactions in coronary artery disease, gastrointestinal cancer super-enhancer, #T2D metabolic modeling
Cover: resources for human solute carrier superfamily @supertifurgalab.bsky.social @giuliosupertifurga.bsky.social
spatial proteomics, metabolic reactions in coronary artery disease, gastrointestinal cancer super-enhancer, #T2D metabolic modeling
Cover: resources for human solute carrier superfamily @supertifurgalab.bsky.social @giuliosupertifurga.bsky.social
June 3, 2025 at 4:00 PM
6/2025 Issue ➡️ www.embopress.org/toc/17444292...
spatial proteomics, metabolic reactions in coronary artery disease, gastrointestinal cancer super-enhancer, #T2D metabolic modeling
Cover: resources for human solute carrier superfamily @supertifurgalab.bsky.social @giuliosupertifurga.bsky.social
spatial proteomics, metabolic reactions in coronary artery disease, gastrointestinal cancer super-enhancer, #T2D metabolic modeling
Cover: resources for human solute carrier superfamily @supertifurgalab.bsky.social @giuliosupertifurga.bsky.social
Proteomics-driven subtyping of pre-metastatic colorectal cancer reveals CAVIN1 as a key player in relapse ➡️ www.embopress.org/doi/full/10....
May 19, 2025 at 8:21 PM
Proteomics-driven subtyping of pre-metastatic colorectal cancer reveals CAVIN1 as a key player in relapse ➡️ www.embopress.org/doi/full/10....
A novel computational method for gene buffering prediction using DepMap data ➡️ www.embopress.org/doi/full/10....
May 19, 2025 at 8:20 PM
A novel computational method for gene buffering prediction using DepMap data ➡️ www.embopress.org/doi/full/10....
A novel super-enhancer driving MYB expression identified in gastrointestinal cancers ➡️ www.embopress.org/doi/full/10....
May 19, 2025 at 8:19 PM
A novel super-enhancer driving MYB expression identified in gastrointestinal cancers ➡️ www.embopress.org/doi/full/10....
New research reveals that metabolic reactions can amplify or buffer the impact of coronary artery disease risk alleles on susceptibility ➡️ www.embopress.org/doi/full/10....
May 19, 2025 at 8:17 PM
New research reveals that metabolic reactions can amplify or buffer the impact of coronary artery disease risk alleles on susceptibility ➡️ www.embopress.org/doi/full/10....
Fabian Coscia @coscialab.bsky.social & Peter Horvath explore cutting-edge advances in spatial proteomics and highlight their translational potential in medicine ➡️ www.embopress.org/doi/full/10....
May 19, 2025 at 8:16 PM
Fabian Coscia @coscialab.bsky.social & Peter Horvath explore cutting-edge advances in spatial proteomics and highlight their translational potential in medicine ➡️ www.embopress.org/doi/full/10....
A comprehensive human solute carrier (#SLC) transporter database annotating substrates, classifying SLCs, revealing potential disease associations from @supertifurgalab.bsky.social @giuliosupertifurga.bsky.social @oeaw.bsky.social ky.social @ihieurope.bsky.social ➡️ www.embopress.org/doi/full/10....
May 15, 2025 at 6:47 PM
A comprehensive human solute carrier (#SLC) transporter database annotating substrates, classifying SLCs, revealing potential disease associations from @supertifurgalab.bsky.social @giuliosupertifurga.bsky.social @oeaw.bsky.social ky.social @ihieurope.bsky.social ➡️ www.embopress.org/doi/full/10....
A systematic proteomics-based protein-protein interaction mapping of the human solute carrier (SLC) transporter superfamily by @supertifurgalab.bsky.social as part of @ihieurope.bsky.social ➡️ www.embopress.org/doi/full/10....
May 15, 2025 at 6:39 PM
A systematic proteomics-based protein-protein interaction mapping of the human solute carrier (SLC) transporter superfamily by @supertifurgalab.bsky.social as part of @ihieurope.bsky.social ➡️ www.embopress.org/doi/full/10....