Ralph Stadhouders
@r-stadhouders.bsky.social
Biologist studying gene regulation in immune cells 🔬Associate Professor @ErasmusMC
Reposted by Ralph Stadhouders
In @jem.org, Metzemaekers et al review how memory T cells fight infections & cancer by retaining epigenetic “memories” that enable rapid reactivation of inflammatory genes, & how such epigenetic mechanisms may fuel T cell dysfunction in disease rupress.org/jem/article/...
@r-stadhouders.bsky.social
@r-stadhouders.bsky.social
July 31, 2025 at 6:31 PM
In @jem.org, Metzemaekers et al review how memory T cells fight infections & cancer by retaining epigenetic “memories” that enable rapid reactivation of inflammatory genes, & how such epigenetic mechanisms may fuel T cell dysfunction in disease rupress.org/jem/article/...
@r-stadhouders.bsky.social
@r-stadhouders.bsky.social
Reposted by Ralph Stadhouders
Epigenetic priming as a driver of memory recall and dysfunction in T cells. A new review from Mieke Metzemaekers, Niels Rinzema, and Ralph Stadhouders @r-stadhouders.bsky.social: rupress.org/jem/article/...
#LymphocyteBiology #MucosalImmunology #TumorImmunology #Epigenetics #Cancer
#LymphocyteBiology #MucosalImmunology #TumorImmunology #Epigenetics #Cancer
August 7, 2025 at 2:45 PM
Epigenetic priming as a driver of memory recall and dysfunction in T cells. A new review from Mieke Metzemaekers, Niels Rinzema, and Ralph Stadhouders @r-stadhouders.bsky.social: rupress.org/jem/article/...
#LymphocyteBiology #MucosalImmunology #TumorImmunology #Epigenetics #Cancer
#LymphocyteBiology #MucosalImmunology #TumorImmunology #Epigenetics #Cancer
Reposted by Ralph Stadhouders
BPL-inactivated SARS-CoV-2 vaccines exist e.g., CoronaVac. The challenge with most means to inactivate microbes is that you want to do this in a manner that does not meaningfully change the structural information being provided to the immune system so that when it encounters the real thing...
May 1, 2025 at 7:41 PM
BPL-inactivated SARS-CoV-2 vaccines exist e.g., CoronaVac. The challenge with most means to inactivate microbes is that you want to do this in a manner that does not meaningfully change the structural information being provided to the immune system so that when it encounters the real thing...
Reposted by Ralph Stadhouders
Sounds interesting! www.science.org/doi/10.1126/...
Transcription factor networks disproportionately enrich for heritability of blood cell phenotypes
Most phenotype-associated genetic variants map to noncoding regulatory regions of the human genome, but their mechanisms remain elusive in most cases. We developed a highly efficient strategy, Perturb...
www.science.org
April 3, 2025 at 8:17 PM
Sounds interesting! www.science.org/doi/10.1126/...
Reposted by Ralph Stadhouders
March 10, 2025 at 5:12 PM
Reposted by Ralph Stadhouders
Reposted by Ralph Stadhouders
FFS, these appear to be studies that try to determine, for example, if feminizing hormone therapy is associated with asthma (the largest grant) to determine if estrogen is causal in the higher asthma rates seen in women. Idiots.
March 6, 2025 at 8:41 PM
FFS, these appear to be studies that try to determine, for example, if feminizing hormone therapy is associated with asthma (the largest grant) to determine if estrogen is causal in the higher asthma rates seen in women. Idiots.
Reposted by Ralph Stadhouders
Reposted by Ralph Stadhouders
The analogy of omics data normalization and cooking:
some processing is usually necessary, overcooking makes it bland, highly over-processed foods are unhealthy, and the quality of the ingredients matters.
some processing is usually necessary, overcooking makes it bland, highly over-processed foods are unhealthy, and the quality of the ingredients matters.
February 27, 2025 at 8:01 AM
The analogy of omics data normalization and cooking:
some processing is usually necessary, overcooking makes it bland, highly over-processed foods are unhealthy, and the quality of the ingredients matters.
some processing is usually necessary, overcooking makes it bland, highly over-processed foods are unhealthy, and the quality of the ingredients matters.
Reposted by Ralph Stadhouders
Disease diagnostics using machine learning of B cell and T cell receptor sequences
www.science.org/doi/10.1126/...
TL;DR: BCRs ARE ALL YOU NEED!
(Well actually .... keep reading) 1/
www.science.org/doi/10.1126/...
TL;DR: BCRs ARE ALL YOU NEED!
(Well actually .... keep reading) 1/
Disease diagnostics using machine learning of B cell and T cell receptor sequences
Clinical diagnosis typically incorporates physical examination, patient history, various laboratory tests, and imaging studies but makes limited use of the human immune system’s own record of antigen ...
www.science.org
February 21, 2025 at 1:12 AM
Disease diagnostics using machine learning of B cell and T cell receptor sequences
www.science.org/doi/10.1126/...
TL;DR: BCRs ARE ALL YOU NEED!
(Well actually .... keep reading) 1/
www.science.org/doi/10.1126/...
TL;DR: BCRs ARE ALL YOU NEED!
(Well actually .... keep reading) 1/
Reposted by Ralph Stadhouders
Seems like people are dealing with a lot.
If you go to this link, you can ask me anything anonymously. I will try to give my best answers for all questions
ngl.link/deplatformdi...
If you go to this link, you can ask me anything anonymously. I will try to give my best answers for all questions
ngl.link/deplatformdi...
Anonymous messages!
Anonymous messages!
ngl.link
February 22, 2025 at 3:16 AM
Seems like people are dealing with a lot.
If you go to this link, you can ask me anything anonymously. I will try to give my best answers for all questions
ngl.link/deplatformdi...
If you go to this link, you can ask me anything anonymously. I will try to give my best answers for all questions
ngl.link/deplatformdi...
Reposted by Ralph Stadhouders
#Immunology out now @science.org
Machine learning, using the sequences of an individual's B and T cell receptors, has the potential to diagnose immune-related diseases.
https://buff.ly/3QvxSVf
By Maxim Zaslavsky, Erin Craig, @anshulkundaje.bsky.social , @scottboydlab.bsky.social et al.
Machine learning, using the sequences of an individual's B and T cell receptors, has the potential to diagnose immune-related diseases.
https://buff.ly/3QvxSVf
By Maxim Zaslavsky, Erin Craig, @anshulkundaje.bsky.social , @scottboydlab.bsky.social et al.
February 20, 2025 at 7:35 PM
#Immunology out now @science.org
Machine learning, using the sequences of an individual's B and T cell receptors, has the potential to diagnose immune-related diseases.
https://buff.ly/3QvxSVf
By Maxim Zaslavsky, Erin Craig, @anshulkundaje.bsky.social , @scottboydlab.bsky.social et al.
Machine learning, using the sequences of an individual's B and T cell receptors, has the potential to diagnose immune-related diseases.
https://buff.ly/3QvxSVf
By Maxim Zaslavsky, Erin Craig, @anshulkundaje.bsky.social , @scottboydlab.bsky.social et al.
Reposted by Ralph Stadhouders
Very promising news and an honor to be a part of this report! @bcmhouston.bsky.social @texaschildrens.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Long-term outcomes of GD2-directed CAR-T cell therapy in patients with neuroblastoma - Nature Medicine
In an extended follow-up of a phase 1 trial evaluating a first-generation GD2-directed CAR-T cell therapy in patients with neuroblastoma, one patient has had a sustained clinical response for over 18 ...
www.nature.com
February 19, 2025 at 5:00 PM
Very promising news and an honor to be a part of this report! @bcmhouston.bsky.social @texaschildrens.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ralph Stadhouders
Large epidemiologic studies have consistently shown an association between coffee and improved health outcomes. This may be one of the reasons: favorable changes to the gut microbiome 🏢🏢
www.scientificamerican.com/article/coff...
www.scientificamerican.com/article/coff...
Coffee Boosts Beneficial Gut Bacterium
Researchers found a strong connection between coffee and the gut microbiome
www.scientificamerican.com
February 20, 2025 at 2:58 AM
Large epidemiologic studies have consistently shown an association between coffee and improved health outcomes. This may be one of the reasons: favorable changes to the gut microbiome 🏢🏢
www.scientificamerican.com/article/coff...
www.scientificamerican.com/article/coff...
Reposted by Ralph Stadhouders
I love this.... there doesn't even need to be point 2 or more (which there are, and they're also great). The insanity of this proposal is mind-boggling.
RFK Jr. thinks that a clinical trial should be done for the entire childhood vaccine schedule. Here’s why that will never happen.
1. You can’t do a randomized trial of something that we already know is safe and effective. There would have to be a placebo group that didn’t get vaxxed. Unethical.
1. You can’t do a randomized trial of something that we already know is safe and effective. There would have to be a placebo group that didn’t get vaxxed. Unethical.
February 20, 2025 at 3:07 AM
I love this.... there doesn't even need to be point 2 or more (which there are, and they're also great). The insanity of this proposal is mind-boggling.
Reposted by Ralph Stadhouders
Functional memory T cells are derived from exhausted clones and expanded by checkpoint blockade https://www.biorxiv.org/content/10.1101/2025.02.10.637523v1
February 16, 2025 at 2:15 AM
Functional memory T cells are derived from exhausted clones and expanded by checkpoint blockade https://www.biorxiv.org/content/10.1101/2025.02.10.637523v1
Reposted by Ralph Stadhouders
KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection
www.science.org/doi/10.1126/...
@science.org @nikjoshilabyale.bsky.social
www.science.org/doi/10.1126/...
@science.org @nikjoshilabyale.bsky.social
February 13, 2025 at 7:51 PM
KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection
www.science.org/doi/10.1126/...
@science.org @nikjoshilabyale.bsky.social
www.science.org/doi/10.1126/...
@science.org @nikjoshilabyale.bsky.social
Reposted by Ralph Stadhouders
#CellPlasticity—the ability of cells to change their identity—is vital for tissue growth and repair. But when it goes unchecked, it can fuel #cancer. Our latest study examines how to block #LiverCancer by actively suppressing plasticity. www.nature.com/articles/s41... #CancerBiology
February 13, 2025 at 12:16 PM
#CellPlasticity—the ability of cells to change their identity—is vital for tissue growth and repair. But when it goes unchecked, it can fuel #cancer. Our latest study examines how to block #LiverCancer by actively suppressing plasticity. www.nature.com/articles/s41... #CancerBiology
Reposted by Ralph Stadhouders
Hardly new info, but BSky should know:
Warsaw's water quality is monitored by eight clams with magnets attached to their shells. If contamination in the water causes the clams to close, the magnets trigger an alarm and shut off the city's water supply.
Thank you, little guardian molluscs.
🧪🌏🚰
Warsaw's water quality is monitored by eight clams with magnets attached to their shells. If contamination in the water causes the clams to close, the magnets trigger an alarm and shut off the city's water supply.
Thank you, little guardian molluscs.
🧪🌏🚰
February 7, 2025 at 12:39 PM
Hardly new info, but BSky should know:
Warsaw's water quality is monitored by eight clams with magnets attached to their shells. If contamination in the water causes the clams to close, the magnets trigger an alarm and shut off the city's water supply.
Thank you, little guardian molluscs.
🧪🌏🚰
Warsaw's water quality is monitored by eight clams with magnets attached to their shells. If contamination in the water causes the clams to close, the magnets trigger an alarm and shut off the city's water supply.
Thank you, little guardian molluscs.
🧪🌏🚰
Reposted by Ralph Stadhouders
Excited to post my first #skySplain about our recent work published yesterday in Nature Genetics! www.nature.com/articles/s41.... One of the first authors of this study - Annika Vannan – actually wrote this breakdown, but she's not yet over here on bluesky and asked me to post!
Spatial transcriptomics identifies molecular niche dysregulation associated with distal lung remodeling in pulmonary fibrosis - Nature Genetics
Xenium spatial transcriptomic profiling of pulmonary fibrosis characterizes cell composition dynamics and histopathological features associated with the disease.
www.nature.com
February 4, 2025 at 2:11 PM
Excited to post my first #skySplain about our recent work published yesterday in Nature Genetics! www.nature.com/articles/s41.... One of the first authors of this study - Annika Vannan – actually wrote this breakdown, but she's not yet over here on bluesky and asked me to post!
Reposted by Ralph Stadhouders
Congrats to the @jbuenrostro.bsky.social lab on this recent paper.
www.nature.com/articles/s41...
Unfortunately, it makes several misleading claims that we disagree with. We will address these technical & other issues with this work over the next few months.
www.nature.com/articles/s41...
Unfortunately, it makes several misleading claims that we disagree with. We will address these technical & other issues with this work over the next few months.
Multiscale footprints reveal the organization of cis-regulatory elements - Nature
We developed PRINT, a computational method that identifies footprints of DNA–protein interactions from bulk and single-cell chromatin accessibility data across multiple scales of protein size.
www.nature.com
January 23, 2025 at 7:18 PM
Congrats to the @jbuenrostro.bsky.social lab on this recent paper.
www.nature.com/articles/s41...
Unfortunately, it makes several misleading claims that we disagree with. We will address these technical & other issues with this work over the next few months.
www.nature.com/articles/s41...
Unfortunately, it makes several misleading claims that we disagree with. We will address these technical & other issues with this work over the next few months.
Reposted by Ralph Stadhouders
One thing that does not get enough attention I think in all these dialogues is the persistent attempt to dichotomize infectious diseases and chronic illnesses.
- HPV and Hepatitis B are major causes of cancer.
- Many viruses can trigger dilated cardiomyopathy in genetically susceptible people.
- HPV and Hepatitis B are major causes of cancer.
- Many viruses can trigger dilated cardiomyopathy in genetically susceptible people.
January 30, 2025 at 7:28 PM
One thing that does not get enough attention I think in all these dialogues is the persistent attempt to dichotomize infectious diseases and chronic illnesses.
- HPV and Hepatitis B are major causes of cancer.
- Many viruses can trigger dilated cardiomyopathy in genetically susceptible people.
- HPV and Hepatitis B are major causes of cancer.
- Many viruses can trigger dilated cardiomyopathy in genetically susceptible people.
Reposted by Ralph Stadhouders
I am really enjoying the surge of people to bluesky but still kind of missing the VERY early career group of people! (Aging in academia is a funny thing) - I went ahead and made this starter pack go.bsky.app/Jq8YaQM - if you would like to be removed/added please let me know
November 14, 2024 at 8:48 AM
I am really enjoying the surge of people to bluesky but still kind of missing the VERY early career group of people! (Aging in academia is a funny thing) - I went ahead and made this starter pack go.bsky.app/Jq8YaQM - if you would like to be removed/added please let me know
Reposted by Ralph Stadhouders
Today the Trump admin abruptly and indefinitely terminated many of the activities of the National Institutes of Health, the $50B/year collection of agencies that power the US biotech and health ecosystems. Even if these orders were lifted tomorrow, the disruption would be enormous.
Why care? 🧵
Why care? 🧵
Why should the public care about the freeze on the NIH? Aside from the need for scientific pursuits to make our society better…
-For every dollar we invest in NIH research, there is a $2.5 return.
-Research dollars help fund universities that employ non-academics. (1/)
-For every dollar we invest in NIH research, there is a $2.5 return.
-Research dollars help fund universities that employ non-academics. (1/)
January 23, 2025 at 3:14 AM
Today the Trump admin abruptly and indefinitely terminated many of the activities of the National Institutes of Health, the $50B/year collection of agencies that power the US biotech and health ecosystems. Even if these orders were lifted tomorrow, the disruption would be enormous.
Why care? 🧵
Why care? 🧵
Reposted by Ralph Stadhouders
So very cool! An epithelial-microbiota-immune axis controls the susceptibility to food allergy! #gastrosky #innateimmunity
congrats to the Chatila and Rakoff-nahoum lab @bostonchildrens.bsky.social
doi.org/10.1038/s415...
congrats to the Chatila and Rakoff-nahoum lab @bostonchildrens.bsky.social
doi.org/10.1038/s415...
RELMβ sets the threshold for microbiome-dependent oral tolerance - Nature
RELMβ mediates a gut immune–epithelial circuit regulating tolerance to food antigens, offering targetable candidates for the prevention and treatment of food allergies.
doi.org
January 23, 2025 at 3:08 PM
So very cool! An epithelial-microbiota-immune axis controls the susceptibility to food allergy! #gastrosky #innateimmunity
congrats to the Chatila and Rakoff-nahoum lab @bostonchildrens.bsky.social
doi.org/10.1038/s415...
congrats to the Chatila and Rakoff-nahoum lab @bostonchildrens.bsky.social
doi.org/10.1038/s415...